{"id":"https://openalex.org/W7204670097","doi":"https://doi.org/10.2139/ssrn.7390760","title":"Levodopa-Induced Dyskinesia in Long-Standing Hemiparkinsonism Secondary to a Midbrain Cavernous Malformation","display_name":"Levodopa-Induced Dyskinesia in Long-Standing Hemiparkinsonism Secondary to a Midbrain Cavernous Malformation","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204670097","doi":"https://doi.org/10.2139/ssrn.7390760"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.7390760","doi":"https://doi.org/10.2139/ssrn.7390760","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7390760","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.7390760","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057033740","display_name":"Ingrid Lorena da Silva Gomes","orcid":"https://orcid.org/0000-0001-6093-7557","observed_orcids":["https://orcid.org/0000-0001-6093-7557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingrid Lorena da Silva Gomes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6093-7557","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013780993","display_name":"Juan Sebasti\u00e1n S\u00e1nchez Le\u00f3n","orcid":"https://orcid.org/0000-0002-9955-7030","observed_orcids":["https://orcid.org/0000-0002-9955-7030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan Sebastian  S\u00e1nchez Leon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9955-7030","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119588246","display_name":"Camila Rafaela Lazaretti","orcid":"https://orcid.org/0009-0002-3394-1846","observed_orcids":["https://orcid.org/0009-0002-3394-1846"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camila Rafaela Lazaretti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-3394-1846","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093579605","display_name":"Thomas Hugentobler Schlickmann","orcid":"https://orcid.org/0009-0009-7549-5195","observed_orcids":["https://orcid.org/0009-0009-7549-5195"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thomas Hugentobler Schlickmann","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) - Post-graduate program in Medical Science"],"raw_orcid":"https://orcid.org/0009-0009-7549-5195","affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) - Post-graduate program in Medical Science","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148586277","display_name":"Helena  D\u00f6rr Toebe","orcid":"https://orcid.org/0009-0009-5151-3176","observed_orcids":["https://orcid.org/0009-0009-5151-3176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helena  D\u00f6rr Toebe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5151-3176","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007273827","display_name":"Bruno Samuel Fraiman de Oliveira","orcid":"https://orcid.org/0000-0002-1525-5183","observed_orcids":["https://orcid.org/0000-0002-1525-5183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Samuel  Fraiman de Oliveira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109266020","display_name":"Tha\u00eds Lampert Monte","orcid":"https://orcid.org/0009-0005-0958-9098","observed_orcids":["https://orcid.org/0009-0005-0958-9098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thais  Lampert Monte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091128752","display_name":"Daniel Teixeira dos Santos","orcid":"https://orcid.org/0000-0003-0182-424X","observed_orcids":["https://orcid.org/0000-0003-0182-424X"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daniel Teixeira-dos-Santos","raw_affiliation_strings":["Universidade Federal do Rio Grande do Sul (UFRGS) - Post-graduate program in Medical Science"],"raw_orcid":"https://orcid.org/0000-0003-0182-424X","affiliations":[{"raw_affiliation_string":"Universidade Federal do Rio Grande do Sul (UFRGS) - Post-graduate program in Medical Science","institution_ids":["https://openalex.org/I130442723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055105219","display_name":"Artur Francisco Schumacher Schuh","orcid":"https://orcid.org/0000-0002-8722-0908","observed_orcids":["https://orcid.org/0000-0002-8722-0908"]},"institutions":[{"id":"https://openalex.org/I4210097146","display_name":"Hospital de Cl\u00ednicas de Porto Alegre","ror":"https://ror.org/010we4y38","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210097146"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Artur Francisco Schumacher Schuh","raw_affiliation_strings":["Hospital de Cl\u00ednicas de Porto Alegre (HCPA) - Neurology Service"],"raw_orcid":"https://orcid.org/0000-0002-8722-0908","affiliations":[{"raw_affiliation_string":"Hospital de Cl\u00ednicas de Porto Alegre (HCPA) - Neurology Service","institution_ids":["https://openalex.org/I4210097146"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091128752"],"corresponding_institution_ids":["https://openalex.org/I130442723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9535999894142151,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13966","display_name":"Neurological and metabolic disorders","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levodopa-induced-dyskinesia","display_name":"levodopa-induced dyskinesia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hemiparkinsonism","display_name":"hemiparkinsonism","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cavernous-hemangioma","display_name":"cavernous hemangioma","score":0.6309999823570251},{"id":"https://openalex.org/keywords/dopaminergic-denervation","display_name":"dopaminergic denervation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.902999997138977},{"id":"https://openalex.org/keywords/transsynaptic-degeneration","display_name":"transsynaptic degeneration","score":0.8569999933242798},{"id":"https://openalex.org/keywords/motor-fluctuations","display_name":"motor fluctuations","score":0.7649999856948853},{"id":"https://openalex.org/keywords/wearing-off-phenomenon","display_name":"wearing-off phenomenon","score":0.6019999980926514},{"id":"https://openalex.org/keywords/peak-dose-dyskinesia","display_name":"peak-dose dyskinesia","score":0.953000009059906},{"id":"https://openalex.org/keywords/amantadine","display_name":"amantadine","score":0.878000020980835},{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.8190000057220459},{"id":"https://openalex.org/keywords/pallidotomy","display_name":"pallidotomy","score":0.8289999961853027},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"deep brain stimulation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/subthalamic-nucleus","display_name":"subthalamic nucleus","score":0.8980000019073486},{"id":"https://openalex.org/keywords/globus-pallidus-internus","display_name":"globus pallidus internus","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dystonia","display_name":"dystonia","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.6776000261306763},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.6686999797821045},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.6650000214576721},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6624000072479248},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.661300003528595},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.6197999715805054},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.5796999931335449},{"id":"https://openalex.org/C2781083702","wikidata":"https://www.wikidata.org/wiki/Q3892641","display_name":"Pallidotomy","level":5,"score":0.5730000138282776},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.5342000126838684},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.4657999873161316},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4465999901294708},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42500001192092896},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.3718999922275543},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C2776805190","wikidata":"https://www.wikidata.org/wiki/Q1187030","display_name":"Denervation","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.30309998989105225},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.3021000027656555},{"id":"https://openalex.org/C24566897","wikidata":"https://www.wikidata.org/wiki/Q943621","display_name":"Tegmentum","level":4,"score":0.2971999943256378},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C2778559928","wikidata":"https://www.wikidata.org/wiki/Q906492","display_name":"Dystonia","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.27059999108314514},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.2667999863624573},{"id":"https://openalex.org/C2778717949","wikidata":"https://www.wikidata.org/wiki/Q415752","display_name":"Pergolide","level":5,"score":0.26460000872612},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2139/ssrn.7390760","doi":"https://doi.org/10.2139/ssrn.7390760","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7390760","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.2139/ssrn.7366641","doi":"https://doi.org/10.2139/ssrn.7366641","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7366641","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.2139/ssrn.7354953","doi":"https://doi.org/10.2139/ssrn.7354953","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7354953","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.7390760","doi":"https://doi.org/10.2139/ssrn.7390760","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7390760","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393375434","https://openalex.org/W2132953671","https://openalex.org/W3163447194","https://openalex.org/W1978846856","https://openalex.org/W1963518196","https://openalex.org/W2327729611","https://openalex.org/W1966381172","https://openalex.org/W1938255637","https://openalex.org/W2080128010","https://openalex.org/W2079595809"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-30T00:00:00"}