{"id":"https://openalex.org/W7204667366","doi":"https://doi.org/10.7759/cureus.115399","title":"Skin Deep: A Case Report of Erythema Nodosum Induced by Dupilumab Therapy","display_name":"Skin Deep: A Case Report of Erythema Nodosum Induced by Dupilumab Therapy","publication_year":2026,"publication_date":"2026-08-29","ids":{"openalex":"https://openalex.org/W7204667366","doi":"https://doi.org/10.7759/cureus.115399","pmid":"https://pubmed.ncbi.nlm.nih.gov/42808045"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.115399","doi":"https://doi.org/10.7759/cureus.115399","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.115399","pdf_url":"https://www.cureus.com/articles/512901-skin-deep-a-case-report-of-erythema-nodosum-induced-by-dupilumab-therapy.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/512901-skin-deep-a-case-report-of-erythema-nodosum-induced-by-dupilumab-therapy.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132562313","display_name":"Nisat Tasnim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150312","display_name":"Flushing Hospital Medical Center","ror":"https://ror.org/03ne66j56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nisat Tasnim","raw_affiliation_strings":["Internal Medicine, Flushing Hospital Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Flushing Hospital Medical Center, New York, USA","institution_ids":["https://openalex.org/I4210150312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148611663","display_name":"Jerrin Bawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150312","display_name":"Flushing Hospital Medical Center","ror":"https://ror.org/03ne66j56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerrin Bawa","raw_affiliation_strings":["Internal Medicine, Flushing Hospital Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Flushing Hospital Medical Center, New York, USA","institution_ids":["https://openalex.org/I4210150312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064524809","display_name":"Rasha Alhashimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150312","display_name":"Flushing Hospital Medical Center","ror":"https://ror.org/03ne66j56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rasha Alhashimi","raw_affiliation_strings":["Internal Medicine, Flushing Hospital Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Flushing Hospital Medical Center, New York, USA","institution_ids":["https://openalex.org/I4210150312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013130094","display_name":"Erika Malana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802655110","display_name":"Larkin Community Hospital","ror":"https://ror.org/02wcweb64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802655110"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erika Malana","raw_affiliation_strings":["Dermatology, Larkin Community Hospital, Miami, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Larkin Community Hospital, Miami, USA","institution_ids":["https://openalex.org/I2802655110"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148607415","display_name":"Jobanjit Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150312","display_name":"Flushing Hospital Medical Center","ror":"https://ror.org/03ne66j56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jobanjit Kaur","raw_affiliation_strings":["Internal Medicine, Flushing Hospital Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Flushing Hospital Medical Center, New York, USA","institution_ids":["https://openalex.org/I4210150312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093480794","display_name":"Nailah Sayeed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150312","display_name":"Flushing Hospital Medical Center","ror":"https://ror.org/03ne66j56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nailah Sayeed","raw_affiliation_strings":["Internal Medicine, Flushing Hospital Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Flushing Hospital Medical Center, New York, USA","institution_ids":["https://openalex.org/I4210150312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148590195","display_name":"Aizaaz Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150312","display_name":"Flushing Hospital Medical Center","ror":"https://ror.org/03ne66j56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210150312"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aizaaz Khan","raw_affiliation_strings":["Pulmonary and Critical Care, Flushing Hospital Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary and Critical Care, Flushing Hospital Medical Center, New York, USA","institution_ids":["https://openalex.org/I4210150312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.1878,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.96740319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"18","issue":"8","first_page":"e115399","last_page":"e115399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.2628999948501587,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.1907999962568283,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythema-nodosum","display_name":"erythema nodosum","score":0.9539999961853027},{"id":"https://openalex.org/keywords/dupilumab","display_name":"dupilumab","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eosinophilic-asthma","display_name":"eosinophilic asthma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/il-4-il-13-inhibition","display_name":"IL-4/IL-13 inhibition","score":0.7839999794960022},{"id":"https://openalex.org/keywords/biologic-therapy-adverse-effects","display_name":"biologic therapy adverse effects","score":0.734000027179718},{"id":"https://openalex.org/keywords/blood-eosinophils","display_name":"blood eosinophils","score":0.7910000085830688},{"id":"https://openalex.org/keywords/treatment-interruption","display_name":"treatment interruption","score":0.753000020980835},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9886999726295471},{"id":"https://openalex.org/C2779824493","wikidata":"https://www.wikidata.org/wiki/Q5315925","display_name":"Dupilumab","level":3,"score":0.8062999844551086},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7791000008583069},{"id":"https://openalex.org/C2777410594","wikidata":"https://www.wikidata.org/wiki/Q1363738","display_name":"Erythema nodosum","level":3,"score":0.6075999736785889},{"id":"https://openalex.org/C2779121184","wikidata":"https://www.wikidata.org/wiki/Q1166142","display_name":"Erythema","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C2776485726","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Rescue therapy","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.22050000727176666},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.20600000023841858},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.19679999351501465}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7759/cureus.115399","doi":"https://doi.org/10.7759/cureus.115399","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.115399","pdf_url":"https://www.cureus.com/articles/512901-skin-deep-a-case-report-of-erythema-nodosum-induced-by-dupilumab-therapy.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:42808045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42808045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.7759/cureus.115399","doi":"https://doi.org/10.7759/cureus.115399","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.115399","pdf_url":"https://www.cureus.com/articles/512901-skin-deep-a-case-report-of-erythema-nodosum-induced-by-dupilumab-therapy.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204667366.pdf","grobid_xml":"https://content.openalex.org/works/W7204667366.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1607828984","https://openalex.org/W1895953660","https://openalex.org/W2067978628","https://openalex.org/W2161525566","https://openalex.org/W2342693354","https://openalex.org/W2801759342","https://openalex.org/W2805002966","https://openalex.org/W3202378136","https://openalex.org/W3214130570","https://openalex.org/W4367059339","https://openalex.org/W4386543968"],"related_works":[],"abstract_inverted_index":{"Dupilumab":[0],"is":[1,20,45,93],"a":[2,70,100,109,124,131,150,232],"fully":[3],"human":[4],"monoclonal":[5],"antibody":[6],"that":[7,258,275],"inhibits":[8],"interleukin":[9],"(IL)-4":[10],"and":[11,39,76,88,96,149,161,214,239,251],"IL-13":[12],"signaling,":[13],"thereby":[14],"attenuating":[15],"type":[16],"2":[17],"inflammatory":[18],"pathways.It":[19],"currently":[21],"approved":[22],"for":[23,179],"the":[24,46,61,65,116,128,190,203,208,240,266,285],"treatment":[25,125,153,191],"of":[26,50,64,72,102,118,130,146,205,212,221,243,249,253,268,287],"severe":[27,112,135],"eosinophilic":[28,37,113,136],"asthma,":[29],"atopic":[30],"dermatitis,":[31],"chronic":[32],"rhinosinusitis":[33],"with":[34,83,111,134,156,236],"nasal":[35],"polyps,":[36],"esophagitis,":[38],"other":[40],"allergic":[41],"conditions.Erythema":[42],"nodosum":[43],"(EN)":[44],"most":[47],"common":[48],"form":[49],"panniculitis,":[51],"characterized":[52],"by":[53,228],"tender,":[54],"erythematous":[55],"subcutaneous":[56],"nodules":[57,164],"typically":[58],"distributed":[59],"over":[60],"extensor":[62],"surfaces":[63],"lower":[66,159],"extremities.Drug-induced":[67],"EN":[68,74,92,106,142,225,262],"represents":[69],"minority":[71],"all":[73],"cases":[75],"has":[77],"been":[78,176],"rarely":[79],"described":[80],"in":[81,108,115,265],"association":[82,235],"biologic":[84,293],"therapies":[85],"including":[86],"anti-IL-4/13":[87],"anti-IL-5":[89],"agents.Notably,":[90],"dupilumab-associated":[91,105,224,261],"exceedingly":[94],"rare,":[95],"this":[97],"report":[98],"describes":[99],"case":[101,129,256],"clinically":[103,140,222,259],"suspected":[104,141,223,260],"occurring":[107],"patient":[110],"asthma":[114,137],"setting":[117],"suppressed":[119,196,278],"peripheral":[120,170,269,279],"blood":[121,171,270],"eosinophils":[122],"following":[123,165,247],"interruption.We":[126],"present":[127],"68-year-old":[132],"woman":[133],"who":[138],"developed":[139],"shortly":[143],"after":[144],"initiation":[145,252],"dupilumab":[147,185,213,250],"therapy":[148],"subsequent":[151],"two-month":[152],"interruption.She":[154],"presented":[155],"painful":[157],"bilateral":[158],"extremity":[160],"upper":[162],"arm":[163],"her":[166,169],"fifth":[167],"injection.Notably,":[168],"eosinophil":[172,280],"count,":[173],"which":[174],"had":[175],"persistently":[177],"elevated":[178],"more":[180],"than":[181],"one":[182],"year":[183],"before":[184],"initiation,":[186],"transiently":[187],"rebounded":[188],"during":[189,292],"gap":[192],"but":[193],"was":[194,226],"adequately":[195],"(0.2":[197],"\u00d7":[198],"10":[199],"3":[200],"/\u03bcL)":[201],"at":[202],"time":[204],"presentation,":[206],"reflecting":[207],"combined":[209],"immunomodulatory":[210],"effects":[211],"recent":[215],"short-term":[216],"systemic":[217],"corticosteroid":[218],"therapy.The":[219],"diagnosis":[220],"supported":[227],"characteristic":[229],"clinical":[230],"findings,":[231],"suggestive":[233],"temporal":[234],"drug":[237],"reinitiation,":[238],"systematic":[241],"exclusion":[242],"alternative":[244],"etiologies.Symptoms":[245],"resolved":[246],"discontinuation":[248],"supportive":[254],"management.This":[255],"demonstrates":[257],"may":[263],"occur":[264],"absence":[267],"eosinophilia.Clinicians":[271],"should":[272],"maintain":[273],"awareness":[274],"normal":[276],"or":[277],"counts":[281],"do":[282],"not":[283],"preclude":[284],"development":[286],"paradoxical":[288],"immune-mediated":[289],"cutaneous":[290],"reactions":[291],"therapy.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2026-08-30T00:00:00"}
