{"id":"https://openalex.org/W7204666668","doi":"https://doi.org/10.64898/2026.08.26.747247","title":"Characterization and pharmacological modulation of Alzheimer\u2019s disease-associated human microglial states","display_name":"Characterization and pharmacological modulation of Alzheimer\u2019s disease-associated human microglial states","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204666668","doi":"https://doi.org/10.64898/2026.08.26.747247"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.26.747247","doi":"https://doi.org/10.64898/2026.08.26.747247","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747247","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.26.747247.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.26.747247.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063244086","display_name":"Gerardo Garcia-D\u00edaz Barriga","orcid":"https://orcid.org/0000-0002-9713-3795","observed_orcids":["https://orcid.org/0000-0002-9713-3795"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerardo Garcia-Diaz Barriga","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9713-3795","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066164969","display_name":"Daniel Rosebrock","orcid":"https://orcid.org/0000-0002-4818-4983","observed_orcids":["https://orcid.org/0000-0002-4818-4983"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Rosebrock","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4818-4983","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029407244","display_name":"Henrik Renner","orcid":"https://orcid.org/0000-0002-9621-4569","observed_orcids":["https://orcid.org/0000-0002-9621-4569"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henrik Renner","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9621-4569","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148577646","display_name":"Isabelle Meyer","orcid":"https://orcid.org/0009-0007-4569-0526","observed_orcids":["https://orcid.org/0009-0007-4569-0526"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Isabelle Meyer","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0007-4569-0526","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082603178","display_name":"Georgina Pe\u00f1alosa-Ruiz","orcid":"https://orcid.org/0000-0002-7148-6613","observed_orcids":["https://orcid.org/0000-0002-7148-6613"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Georgina Pe\u00f1alosa-Ruiz","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-7148-6613","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148596555","display_name":"Mariia M Firulyova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mariia M Firulyova","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032650743","display_name":"Malte Simon","orcid":"https://orcid.org/0000-0003-3959-7978","observed_orcids":["https://orcid.org/0000-0003-3959-7978"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Malte Simon","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048644568","display_name":"Tim Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Yang","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047906303","display_name":"Giulia Maia Serratto","orcid":"https://orcid.org/0000-0001-5281-8996","observed_orcids":["https://orcid.org/0000-0001-5281-8996"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Giulia Maia Serratto","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5281-8996","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148606873","display_name":"Fabrizia Zoppetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabrizia Zoppetti","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148864444","display_name":"Wynona M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wynona M\u00fcller","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006156714","display_name":"Anastasia Illarionova","orcid":"https://orcid.org/0000-0002-1711-7155","observed_orcids":["https://orcid.org/0000-0002-1711-7155"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anastasia Illarionova","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1711-7155","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148595778","display_name":"Katharina Heise","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina Heise","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103539175","display_name":"Rainer R. Kuhn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rainer Kuhn","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113582408","display_name":"Heinz von der Kammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz von der Kammer","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072773886","display_name":"Bastian Zimmer","orcid":"https://orcid.org/0000-0003-0004-4890","observed_orcids":["https://orcid.org/0000-0003-0004-4890"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bastian Zimmer","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0004-4890","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037535744","display_name":"Doris Gruber-Schoffnegger","orcid":"https://orcid.org/0009-0008-7385-402X","observed_orcids":["https://orcid.org/0009-0008-7385-402X"]},"institutions":[{"id":"https://openalex.org/I4210130816","display_name":"Evotec (Germany)","ror":"https://ror.org/03d3v3e93","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210130816"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Doris Gruber-Schoffnegger","raw_affiliation_strings":["Evotec SE, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0008-7385-402X","affiliations":[{"raw_affiliation_string":"Evotec SE, Hamburg, Germany","institution_ids":["https://openalex.org/I4210130816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037535744"],"corresponding_institution_ids":["https://openalex.org/I4210130816"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/amyloid-beta-phagocytosis","display_name":"amyloid-beta phagocytosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ferric-ammonium-citrate","display_name":"ferric ammonium citrate","score":0.968999981880188},{"id":"https://openalex.org/keywords/microglial-reprogramming","display_name":"microglial reprogramming","score":0.7369999885559082},{"id":"https://openalex.org/keywords/single-nucleus-transcriptomics","display_name":"single-nucleus transcriptomics","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.8985999822616577},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7749999761581421},{"id":"https://openalex.org/C2780130745","wikidata":"https://www.wikidata.org/wiki/Q1650750","display_name":"Neuropathology","level":3,"score":0.5976999998092651},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5799999833106995},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5406000018119812},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.45820000767707825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44909998774528503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44290000200271606},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43799999356269836},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.40400001406669617},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.37700000405311584},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.3544999957084656},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.3427000045776367},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.34119999408721924},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.29660001397132874},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2939999997615814},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.2847999930381775},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28360000252723694},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.26260000467300415},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.26.747247","doi":"https://doi.org/10.64898/2026.08.26.747247","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747247","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.26.747247.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.26.747247","doi":"https://doi.org/10.64898/2026.08.26.747247","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747247","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.26.747247.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204666668.pdf","grobid_xml":"https://content.openalex.org/works/W7204666668.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1978714931","https://openalex.org/W3212552860","https://openalex.org/W4321019178","https://openalex.org/W4395683480","https://openalex.org/W4408217041","https://openalex.org/W6930850556","https://openalex.org/W7163386725","https://openalex.org/W7163507268"],"related_works":["https://openalex.org/W4387142551","https://openalex.org/W4390195471","https://openalex.org/W4385331538","https://openalex.org/W4406050457","https://openalex.org/W7168240813","https://openalex.org/W7139978124","https://openalex.org/W4378714758","https://openalex.org/W4393225316","https://openalex.org/W7169715563","https://openalex.org/W7164756016"],"abstract_inverted_index":{"Abstract":[0],"Microglia":[1],"are":[2],"central":[3],"mediators":[4],"of":[5],"Alzheimer\u2019s":[6],"disease":[7],"(AD)":[8],"pathogenesis,":[9],"yet":[10],"the":[11,31],"mechanisms":[12],"driving":[13],"disease-associated":[14],"microglial":[15,107],"states":[16],"and":[17,34,37,51,71,89,109],"their":[18],"therapeutic":[19,123],"modulation":[20],"remain":[21],"poorly":[22],"understood.":[23],"Here,":[24],"we":[25,59,98],"integrated":[26],"single-nucleus":[27],"transcriptomic":[28,121],"datasets":[29],"across":[30],"AD":[32],"spectrum":[33],"identified":[35,99],"disease-":[36],"lipid-associated":[38],"microglia":[39,70],"(DLaM)":[40],"as":[41,101],"a":[42,80,94,102,111,118],"major":[43],"AD-enriched":[44],"population":[45],"linked":[46],"to":[47],"genetic":[48],"risk,":[49],"neuropathology":[50],"cognitive":[52],"decline.":[53],"To":[54],"model":[55],"this":[56],"state":[57,82],"experimentally,":[58],"screened":[60],"AD-relevant":[61],"perturbations":[62],"in":[63,125],"human":[64],"induced":[65,79,110],"pluripotent":[66],"stem":[67],"cell":[68],"(hiPSC)-derived":[69],"found":[72],"that":[73,105],"ferric":[74],"ammonium":[75],"citrate":[76],"(FAC)":[77],"reproducibly":[78],"DLaM-like":[81],"characterized":[83],"by":[84],"lipid":[85],"accumulation,":[86],"lysosomal":[87],"dysfunction":[88],"impaired":[90],"A\u03b2":[91],"phagocytosis.":[92],"Using":[93],"transcriptomics-based":[95],"state-reversion":[96],"screen,":[97],"LY2090314":[100],"potent":[103],"modulator":[104],"restored":[106],"function":[108],"distinct":[112],"lysosomal-metabolic":[113],"state.":[114],"These":[115],"findings":[116],"establish":[117],"framework":[119],"for":[120],"disease-state-guided":[122],"discovery":[124],"AD.":[126]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-30T00:00:00"}
