{"id":"https://openalex.org/W7204663370","doi":"https://doi.org/10.1111/jpc.70545","title":"Therapeutic Hypothermia Modulates S100B and Oxidative Stress in Neonatal Hypoxic\u2013Ischemic Encephalopathy: Implications of SDF4 as a Novel Biomarker","display_name":"Therapeutic Hypothermia Modulates S100B and Oxidative Stress in Neonatal Hypoxic\u2013Ischemic Encephalopathy: Implications of SDF4 as a Novel Biomarker","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204663370","doi":"https://doi.org/10.1111/jpc.70545","pmid":"https://pubmed.ncbi.nlm.nih.gov/42665783"},"language":"en","primary_location":{"id":"doi:10.1111/jpc.70545","doi":"https://doi.org/10.1111/jpc.70545","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jpc.70545","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jpc.70545","source":{"id":"https://openalex.org/S112538619","display_name":"Journal of Paediatrics and Child Health","issn_l":"1034-4810","issn":["1034-4810","1440-1754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Paediatrics and Child Health","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204663370"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jpc.70545","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088682493","display_name":"Fatih \u0130\u015fleyen","orcid":"https://orcid.org/0000-0002-5015-621X","observed_orcids":["https://orcid.org/0000-0002-5015-621X"]},"institutions":[{"id":"https://openalex.org/I4210125526","display_name":"\u015eanl\u0131urfa Mehmet Akif \u0130nan E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02zv5qf81","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210125526"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Fatih Isleyen","raw_affiliation_strings":["Department of Neonatology Sanliurfa Training and Research Hospital  Sanliurfa Turkey"],"raw_orcid":"https://orcid.org/0000-0002-5015-621X","affiliations":[{"raw_affiliation_string":"Department of Neonatology Sanliurfa Training and Research Hospital  Sanliurfa Turkey","institution_ids":["https://openalex.org/I4210125526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050780749","display_name":"Celil Y\u0131lmaz","orcid":"https://orcid.org/0000-0002-0951-8258","observed_orcids":["https://orcid.org/0000-0002-0951-8258"]},"institutions":[{"id":"https://openalex.org/I4210125526","display_name":"\u015eanl\u0131urfa Mehmet Akif \u0130nan E\u011fitim ve Ara\u015ft\u0131rma Hastanesi","ror":"https://ror.org/02zv5qf81","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210125526"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Celil Yilmaz","raw_affiliation_strings":["Department of Pediatric Neurology Sanliurfa Training and Research Hospital  Sanliurfa Turkey"],"raw_orcid":"https://orcid.org/0000-0002-0951-8258","affiliations":[{"raw_affiliation_string":"Department of Pediatric Neurology Sanliurfa Training and Research Hospital  Sanliurfa Turkey","institution_ids":["https://openalex.org/I4210125526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085388960","display_name":"\u0130smail Koyuncu","orcid":"https://orcid.org/0000-0002-9469-4757","observed_orcids":["https://orcid.org/0000-0002-9469-4757"]},"institutions":[{"id":"https://openalex.org/I80538482","display_name":"Harran University","ror":"https://ror.org/057qfs197","country_code":"TR","type":"education","lineage":["https://openalex.org/I80538482"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ismail Koyuncu","raw_affiliation_strings":["Departments of Medical Biochemistry, Faculty of Medicine; Science and Technology Application and Research Center Harran University  Sanliurfa Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9469-4757","affiliations":[{"raw_affiliation_string":"Departments of Medical Biochemistry, Faculty of Medicine; Science and Technology Application and Research Center Harran University  Sanliurfa Turkey","institution_ids":["https://openalex.org/I80538482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088682493"],"corresponding_institution_ids":["https://openalex.org/I4210125526"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"10","first_page":"2019","last_page":"2028"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12068","display_name":"Neonatal Health and Biochemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/therapeutic-hypothermia","display_name":"therapeutic hypothermia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/neonatal-hypoxic-ischemic-encephalopathy","display_name":"neonatal hypoxic-ischemic encephalopathy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/s100b","display_name":"S100B","score":0.8849999904632568},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.984000027179718},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7839999794960022},{"id":"https://openalex.org/keywords/thiol-disulfide-homeostasis","display_name":"thiol/disulfide homeostasis","score":0.8569999933242798},{"id":"https://openalex.org/keywords/total-antioxidant-status","display_name":"total antioxidant status","score":0.8420000076293945},{"id":"https://openalex.org/keywords/total-oxidant-status","display_name":"total oxidant status","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oxidative-stress-index","display_name":"oxidative stress index","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8450000286102295},{"id":"https://openalex.org/keywords/hie-severity","display_name":"HIE severity","score":0.5389999747276306},{"id":"https://openalex.org/keywords/metabolic-recovery","display_name":"metabolic recovery","score":0.6729999780654907},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9470999836921692},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.8004999756813049},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7037000060081482},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.6800000071525574},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5374000072479248},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4973999857902527},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.4611000120639801},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45419999957084656},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C2909832856","wikidata":"https://www.wikidata.org/wiki/Q2249526","display_name":"Hypoxic Ischemic Encephalopathy","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28700000047683716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2754000127315521},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2727999985218048},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2680000066757202},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.2522999942302704}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007036","descriptor_name":"Hypothermia, Induced","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020925","descriptor_name":"Hypoxia-Ischemia, Brain","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D054377","descriptor_name":"Chemokine CXCL12","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D064568","descriptor_name":"S100 Calcium Binding Protein beta Subunit","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/jpc.70545","doi":"https://doi.org/10.1111/jpc.70545","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jpc.70545","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jpc.70545","source":{"id":"https://openalex.org/S112538619","display_name":"Journal of Paediatrics and Child Health","issn_l":"1034-4810","issn":["1034-4810","1440-1754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Paediatrics and Child Health","raw_type":"journal-article"},{"id":"pmid:42665783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42665783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of paediatrics and child health","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jpc.70545","doi":"https://doi.org/10.1111/jpc.70545","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jpc.70545","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jpc.70545","source":{"id":"https://openalex.org/S112538619","display_name":"Journal of Paediatrics and Child Health","issn_l":"1034-4810","issn":["1034-4810","1440-1754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Paediatrics and Child Health","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204663370.pdf","grobid_xml":"https://content.openalex.org/works/W7204663370.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1968360617","https://openalex.org/W2051639904","https://openalex.org/W2055738785","https://openalex.org/W2068540155","https://openalex.org/W2157633141","https://openalex.org/W2555794385","https://openalex.org/W2808169131","https://openalex.org/W2883738215","https://openalex.org/W2937649321","https://openalex.org/W2956592480","https://openalex.org/W3080422972","https://openalex.org/W3131453773","https://openalex.org/W3193930020","https://openalex.org/W4318619112","https://openalex.org/W4366603377","https://openalex.org/W4386890209","https://openalex.org/W4399211395","https://openalex.org/W4406274684","https://openalex.org/W4407902868","https://openalex.org/W4408797283"],"related_works":["https://openalex.org/W3210877995","https://openalex.org/W2026899473","https://openalex.org/W4394914828","https://openalex.org/W3023123327","https://openalex.org/W4407556113","https://openalex.org/W4239961968","https://openalex.org/W2159473136","https://openalex.org/W1980730047","https://openalex.org/W2360698333","https://openalex.org/W2055738785"],"abstract_inverted_index":{"AIM:":[0],"This":[1],"study":[2],"investigated":[3],"the":[4,147,151,210],"dynamic":[5,211],"profile":[6],"of":[7,75,218,232],"stromal":[8],"cell-derived":[9],"factor":[10],"4":[11],"(SDF4),":[12],"a":[13,36,202,228],"hypoxia-inducible":[14],"chemokine":[15],"and":[16,49,67,90,98,124,127,131,165,178,209,220,243],"S100B,":[17,77,122],"an":[18],"established":[19],"astroglial":[20],"injury":[21],"marker,":[22],"in":[23,146,163,171,193,223,239],"neonates":[24,60],"with":[25,44,61,65],"hypoxic-ischemic":[26],"encephalopathy":[27],"(HIE)":[28],"undergoing":[29],"therapeutic":[30],"hypothermia":[31],"(TH).":[32],"Its":[33],"potential":[34,237],"as":[35],"biomarker":[37,204],"was":[38],"assessed":[39],"by":[40],"examining":[41],"its":[42],"relationship":[43],"baseline":[45],"severity,":[46],"clinical":[47],"trajectories":[48],"metabolic":[50,241],"recovery.":[51],"METHODS:":[52],"In":[53,158],"this":[54],"prospective":[55],"cohort":[56,153],"study,":[57],"33":[58],"term":[59],"moderate-to-severe":[62],"HIE":[63,116,174,207,226],"treated":[64],"TH":[66,96],"20":[68],"healthy":[69],"controls":[70,134],"were":[71,93,108,167],"enrolled.":[72],"Serum":[73],"levels":[74,126],"SDF4,":[76,121],"total":[78,82,152],"antioxidant":[79],"status":[80,84],"(TAS),":[81],"oxidant":[83],"(TOS),":[85],"oxidative":[86,184],"stress":[87,185],"index":[88],"(OSI)":[89],"thiol-disulphide":[91],"homeostasis":[92],"measured":[94],"before":[95],"(baseline)":[97],"on":[99],"Day":[100],"5":[101],"(after":[102],"rewarming).":[103],"Effect":[104],"sizes":[105],"(Cohen's":[106],"d)":[107],"calculated":[109],"for":[110],"significant":[111,169],"results.":[112],"RESULTS:":[113],"Before":[114],"TH,":[115,140],"infants":[117],"had":[118],"significantly":[119,145,192],"higher":[120],"OSI":[123],"disulphide":[125],"lower":[128],"native":[129,188],"thiol":[130],"TAS":[132],"than":[133],"(all":[135,154],"p":[136,155,179],"<":[137],"0.01).":[138],"Following":[139],"all":[141],"six":[142],"biomarkers":[143],"changed":[144],"anticipated":[148],"direction":[149],"across":[150],"\u2264":[156],"0.020).":[157],"stage-specific":[159],"sub-analysis,":[160],"post-TH":[161],"reductions":[162],"SDF4":[164,198,219],"S100B":[166,221],"statistically":[168],"only":[170],"Stage":[172,224],"2":[173],"(p":[175],"=":[176,180],"0.013":[177],"0.030,":[181],"respectively),":[182],"whereas":[183],"parameters":[186],"(OSI,":[187],"thiol,":[189],"TAS)":[190],"improved":[191],"both":[194,206],"severity":[195,208],"groups.":[196],"CONCLUSION:":[197],"appears":[199],"to":[200,213],"be":[201],"novel":[203],"reflecting":[205],"response":[212],"TH.":[214],"The":[215],"selective":[216],"lack":[217],"clearance":[222],"3":[225],"highlights":[227],"more":[229],"sustained":[230],"pattern":[231],"neuroinflammatory":[233],"injury,":[234],"supporting":[235],"SDF4's":[236],"role":[238],"monitoring":[240],"recovery":[242],"guiding":[244],"individualised":[245],"neuroprotective":[246],"strategies.":[247]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-30T00:00:00"}