{"id":"https://openalex.org/W7204659482","doi":"https://doi.org/10.21037/tcr-2026-0796","title":"Apolipoprotein E promotes papillary thyroid carcinoma progression by activating PINK1/Parkin-mediated mitophagy","display_name":"Apolipoprotein E promotes papillary thyroid carcinoma progression by activating PINK1/Parkin-mediated mitophagy","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204659482","doi":"https://doi.org/10.21037/tcr-2026-0796","pmid":"https://pubmed.ncbi.nlm.nih.gov/42724858","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13559676"},"language":"en","primary_location":{"id":"doi:10.21037/tcr-2026-0796","doi":"https://doi.org/10.21037/tcr-2026-0796","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-0796","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204659482"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/tcr-2026-0796","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138659764","display_name":"Sinuo Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sinuo Sun","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138668249","display_name":"Suwei Zuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suwei Zuo","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138684040","display_name":"Yanmeng Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanmeng Zhou","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078182496","display_name":"Jiayin Song","orcid":"https://orcid.org/0009-0003-7741-5685","observed_orcids":["https://orcid.org/0009-0003-7741-5685"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayin Song","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]},{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108117150","display_name":"Yuanyuan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Wang","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365463","display_name":"Shibo Liu","orcid":"https://orcid.org/0009-0006-2265-1762","observed_orcids":["https://orcid.org/0009-0006-2265-1762"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibo Liu","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]},{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693789","display_name":"Gang Xue","orcid":"https://orcid.org/0000-0002-3776-0009","observed_orcids":["https://orcid.org/0000-0002-3776-0009"]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang Xue","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144417078","display_name":"Xu Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xu Lin","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5144431486","display_name":"Jingfang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169071405","display_name":"Hebei North University","ror":"https://ror.org/03hqwnx39","country_code":"CN","type":"education","lineage":["https://openalex.org/I169071405"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jingfang Wu","raw_affiliation_strings":["Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology Laboratory, Hebei North University, Zhangjiakou, China","institution_ids":["https://openalex.org/I169071405"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100693789","https://openalex.org/A5144417078","https://openalex.org/A5144431486"],"corresponding_institution_ids":["https://openalex.org/I169071405"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"8","first_page":"636","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":1.0},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/pink1-parkin-pathway","display_name":"PINK1/Parkin pathway","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ampk-mtor-signaling-pathway","display_name":"AMPK/mTOR signaling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/mitochondrial-homeostasis","display_name":"mitochondrial homeostasis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.828000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8019999861717224},{"id":"https://openalex.org/keywords/autophagosome-biogenesis","display_name":"autophagosome formation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.8080999851226807},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7361999750137329},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7210999727249146},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6514000296592712},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6445000171661377},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5852000117301941},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4927000105381012},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4788999855518341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4659000039100647},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.3926999866962433},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.367900013923645},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3625999987125397},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3587000072002411},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.3366999924182892},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3330000042915344},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.3264999985694885},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2944999933242798},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.275299996137619},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26330000162124634},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2547999918460846}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/tcr-2026-0796","doi":"https://doi.org/10.21037/tcr-2026-0796","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-0796","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13559676","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13559676/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13559676/pdf/tcr-15-08-636.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Cancer Res","raw_type":"Text"},{"id":"pmid:42724858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42724858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational cancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/tcr-2026-0796","doi":"https://doi.org/10.21037/tcr-2026-0796","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tcr-2026-0796","pdf_url":null,"source":{"id":"https://openalex.org/S2764965054","display_name":"Translational Cancer Research","issn_l":"2218-676X","issn":["2218-676X","2219-6803"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40","russia-white-list-4"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308085","display_name":"Massachusetts Department of Agricultural Resources","ror":"https://ror.org/03wjj7779"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204659482.pdf","grobid_xml":"https://content.openalex.org/works/W7204659482.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W2014918593","https://openalex.org/W2021346090","https://openalex.org/W2069792474","https://openalex.org/W2074318862","https://openalex.org/W2113018780","https://openalex.org/W2119399459","https://openalex.org/W2121429373","https://openalex.org/W2145150141","https://openalex.org/W2146887271","https://openalex.org/W2415023963","https://openalex.org/W2416854880","https://openalex.org/W2754890392","https://openalex.org/W2964186349","https://openalex.org/W2993618214","https://openalex.org/W3012923032","https://openalex.org/W3017234631","https://openalex.org/W3044056525","https://openalex.org/W3111203418","https://openalex.org/W3121008513","https://openalex.org/W3146687755","https://openalex.org/W3164787484","https://openalex.org/W4294167815","https://openalex.org/W4311400625","https://openalex.org/W4313578986","https://openalex.org/W4380355706","https://openalex.org/W4386143460","https://openalex.org/W4389166615","https://openalex.org/W4389185925","https://openalex.org/W4392430691","https://openalex.org/W4393902128","https://openalex.org/W4398147627","https://openalex.org/W4399447095","https://openalex.org/W4400451365","https://openalex.org/W4404187534","https://openalex.org/W4406580139","https://openalex.org/W4407256292","https://openalex.org/W4410104140","https://openalex.org/W4410873517","https://openalex.org/W4412387196","https://openalex.org/W4412506751","https://openalex.org/W4413900451","https://openalex.org/W4413902339"],"related_works":["https://openalex.org/W4399447095","https://openalex.org/W4225557054","https://openalex.org/W2010230585","https://openalex.org/W7164193159","https://openalex.org/W4406403745","https://openalex.org/W3000304073","https://openalex.org/W2344525044","https://openalex.org/W4409715020","https://openalex.org/W4408161605","https://openalex.org/W4391002261"],"abstract_inverted_index":{"Background:":[0],"Increasing":[1],"evidence":[2,93],"supports":[3],"a":[4,17,180,215,325],"progression-related":[5],"role":[6,30,38,190],"of":[7,31,39,53,80,122,155,168,198,220,258,289,297,315],"apolipoprotein":[8],"E":[9],"(APOE)":[10],"in":[11,34,41,57,73,78,115,124,158,165,191,202,308,331],"papillary":[12],"thyroid":[13,74,203],"carcinoma":[14,75,204],"(PTC),":[15],"yet":[16],"clear":[18],"mechanistic":[19],"explanation":[20],"for":[21,145,327],"this":[22,58],"association":[23,131,309],"is":[24],"still":[25],"lacking.":[26],"Considering":[27],"the":[28,36,51,54,143,153,159,164,242,292,316],"pivotal":[29],"mitochondrial":[32,274],"homeostasis":[33],"tumorigenesis,":[35],"potential":[37,87,189,212],"APOE":[40,72,107,123,169,199,221,246,304],"promoting":[42,232],"PTC":[43,116,125,171,207,225,306],"progression":[44,307],"through":[45,179],"mitophagy":[46,175,290,312,321],"regulation":[47],"was":[48,60,76,176,200],"investigated.":[49],"Additionally,":[50,163],"involvement":[52,154],"PINK1/Parkin-associated":[55],"pathway":[56],"process":[59],"examined":[61,114],"to":[62,68,151,241],"provide":[63,324],"insights":[64],"into":[65,187],"its":[66,81,130,188,211],"contribution":[67],"tumor":[69,172,192],"progression.":[70,193],"Methods:":[71],"characterized":[77],"terms":[79],"expression":[82,111,222,268],"profile,":[83],"diagnostic":[84,216],"relevance,":[85],"and":[86,101,108,135,174,206,228,235,254,266,269,283,294,313],"biological":[88],"functions,":[89],"based":[90],"on":[91,129,170],"integrative":[92],"derived":[94],"from":[95],"The":[96,218,319],"Cancer":[97],"Genome":[98],"Atlas":[99],"(TCGA)":[100],"Gene":[102],"Expression":[103],"Omnibus":[104],"(GEO)":[105],"datasets.":[106],"mitophagy-related":[109,156,270],"protein":[110,250],"were":[112,149],"further":[113,177],"tissues":[117,205],"by":[118,263],"immunohistochemistry.":[119],"Further":[120],"evaluation":[121],"cell":[126,208,226,233],"lines":[127],"focused":[128],"with":[132,137,230,310],"proliferation,":[133],"apoptosis,":[134,229,237],"mitophagy,":[136],"bidirectional":[138],"functional":[139],"perturbation":[140],"serving":[141],"as":[142,214],"basis":[144],"assessment.":[146],"Pharmacological":[147,287],"inhibitors":[148],"used":[150],"assess":[152],"signaling":[157],"observed":[160,201],"APOE-dependent":[161],"phenotypes.":[162],"vivo":[166],"impact":[167],"growth":[173],"investigated":[178],"nude":[181],"mouse":[182],"xenograft":[183],"model,":[184],"providing":[185],"insight":[186],"Results:":[194],"A":[195],"significant":[196],"upregulation":[197],"lines,":[209],"supporting":[210],"relevance":[213],"biomarker.":[217],"modulation":[219,314],"significantly":[223],"influenced":[224],"proliferation":[227,234],"overexpression":[231,247],"inhibiting":[236],"while":[238],"knockdown":[239],"led":[240],"opposite":[243],"effects.":[244],"Mechanistically,":[245],"increased":[248,264,284],"AMP-activated":[249],"kinase":[251],"(AMPK)":[252],"phosphorylation":[253],"decreased":[255],"mammalian":[256],"target":[257],"rapamycin":[259],"(mTOR)":[260],"phosphorylation,":[261],"accompanied":[262],"PINK1":[265],"Parkin":[267],"changes,":[271],"including":[272],"altered":[273],"membrane":[275],"potential,":[276],"reduced":[277],"overall":[278],"reactive":[279],"oxygen":[280],"species":[281],"levels,":[282],"autophagosome":[285],"formation.":[286],"inhibition":[288],"attenuated":[291],"proliferative":[293],"antiapoptotic":[295],"effects":[296],"APOE.":[298],"Conclusions:":[299],"These":[300],"findings":[301],"demonstrate":[302],"that":[303],"promotes":[305],"PINK1/Parkin-related":[311],"AMPK/mTOR":[317],"axis.":[318],"APOE-associated":[320],"axis":[322],"may":[323],"rationale":[326],"future":[328],"preclinical":[329],"investigation":[330],"PTC.":[332]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-30T00:00:00"}