{"id":"https://openalex.org/W7204652911","doi":"https://doi.org/10.64898/2026.08.25.746692","title":"Chemosensory ERP Suggest Peripherally Driven Olfactory-Trigeminal Interactions in Healthy Older Adults","display_name":"Chemosensory ERP Suggest Peripherally Driven Olfactory-Trigeminal Interactions in Healthy Older Adults","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204652911","doi":"https://doi.org/10.64898/2026.08.25.746692"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.25.746692","doi":"https://doi.org/10.64898/2026.08.25.746692","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746692","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.25.746692.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.25.746692.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092991813","display_name":"Sarah Brosse","orcid":"https://orcid.org/0009-0003-8474-3652","observed_orcids":["https://orcid.org/0009-0003-8474-3652"]},"institutions":[{"id":"https://openalex.org/I63341726","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res","ror":"https://ror.org/02xrw9r68","country_code":"CA","type":"education","lineage":["https://openalex.org/I49663120","https://openalex.org/I63341726"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sarah Brosse","raw_affiliation_strings":["Department of Anatomy, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada"],"raw_orcid":"https://orcid.org/0009-0003-8474-3652","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada","institution_ids":["https://openalex.org/I63341726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070616112","display_name":"Olivier Fortier-Lebel","orcid":"https://orcid.org/0009-0007-4384-6347","observed_orcids":["https://orcid.org/0009-0007-4384-6347"]},"institutions":[{"id":"https://openalex.org/I63341726","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res","ror":"https://ror.org/02xrw9r68","country_code":"CA","type":"education","lineage":["https://openalex.org/I49663120","https://openalex.org/I63341726"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Olivier Fortier-Lebel","raw_affiliation_strings":["Department of Psychology, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada"],"raw_orcid":"https://orcid.org/0009-0007-4384-6347","affiliations":[{"raw_affiliation_string":"Department of Psychology, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada","institution_ids":["https://openalex.org/I63341726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103156052","display_name":"\u00c9milie Hudon","orcid":"https://orcid.org/0009-0008-0133-6768","observed_orcids":["https://orcid.org/0009-0008-0133-6768"]},"institutions":[{"id":"https://openalex.org/I63341726","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res","ror":"https://ror.org/02xrw9r68","country_code":"CA","type":"education","lineage":["https://openalex.org/I49663120","https://openalex.org/I63341726"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"\u00c9milie Hudon","raw_affiliation_strings":["Department of Psychology, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada"],"raw_orcid":"https://orcid.org/0009-0008-0133-6768","affiliations":[{"raw_affiliation_string":"Department of Psychology, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada","institution_ids":["https://openalex.org/I63341726"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117302404","display_name":"Keven Lapointe","orcid":"https://orcid.org/0009-0002-1865-1875","observed_orcids":["https://orcid.org/0009-0002-1865-1875"]},"institutions":[{"id":"https://openalex.org/I63341726","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res","ror":"https://ror.org/02xrw9r68","country_code":"CA","type":"education","lineage":["https://openalex.org/I49663120","https://openalex.org/I63341726"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Keven Lapointe","raw_affiliation_strings":["Department of Anatomy, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada"],"raw_orcid":"https://orcid.org/0009-0002-1865-1875","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada","institution_ids":["https://openalex.org/I63341726"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025008377","display_name":"Johannes Frasnelli","orcid":"https://orcid.org/0000-0002-8863-3982","observed_orcids":["https://orcid.org/0000-0002-8863-3982"]},"institutions":[{"id":"https://openalex.org/I4210126907","display_name":"Institut Universitaire de G\u00e9riatrie de Montr\u00e9al","ror":"https://ror.org/031z68d90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210126907"]},{"id":"https://openalex.org/I4210141135","display_name":"H\u00f4pital du Sacr\u00e9-C\u0153ur de Montr\u00e9al","ror":"https://ror.org/03ey0g045","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210141135"]},{"id":"https://openalex.org/I63341726","display_name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res","ror":"https://ror.org/02xrw9r68","country_code":"CA","type":"education","lineage":["https://openalex.org/I49663120","https://openalex.org/I63341726"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Johannes Frasnelli","raw_affiliation_strings":["Department of Anatomy, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada","Research Center, Institut universitaire de g\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Canada","Research Center, Sacr\u00e9 C\u0153ur Hospital, Montr\u00e9al, Canada"],"raw_orcid":"https://orcid.org/0000-0002-8863-3982","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, Canada","institution_ids":["https://openalex.org/I63341726"]},{"raw_affiliation_string":"Research Center, Institut universitaire de g\u00e9riatrie de Montr\u00e9al, Montr\u00e9al, Canada","institution_ids":["https://openalex.org/I4210126907"]},{"raw_affiliation_string":"Research Center, Sacr\u00e9 C\u0153ur Hospital, Montr\u00e9al, Canada","institution_ids":["https://openalex.org/I4210141135"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025008377"],"corresponding_institution_ids":["https://openalex.org/I4210126907","https://openalex.org/I4210141135","https://openalex.org/I63341726"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5249999761581421},{"id":"https://openalex.org/keywords/carbon-dioxide","display_name":"carbon dioxide","score":0.7129999995231628},{"id":"https://openalex.org/keywords/2-phenylethanol","display_name":"2-phenylethanol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/late-positive-component","display_name":"late positive component","score":0.7639999985694885},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7472000122070312},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6055999994277954},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5559999942779541},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.5361999869346619},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5135999917984009},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5044000148773193},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43459999561309814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4262000024318695},{"id":"https://openalex.org/C2777397368","wikidata":"https://www.wikidata.org/wiki/Q189763","display_name":"Trigeminal nerve","level":2,"score":0.3937999904155731},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.337799996137619},{"id":"https://openalex.org/C2910791027","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfactory perception","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.2854999899864197},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.26649999618530273},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.26190000772476196}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.25.746692","doi":"https://doi.org/10.64898/2026.08.25.746692","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746692","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.25.746692.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.25.746692","doi":"https://doi.org/10.64898/2026.08.25.746692","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.746692","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/28/2026.08.25.746692.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1570268430","display_name":"The trigeminal system: from receptor expression to the interaction with the sense of smell","funder_award_id":"rgpin-2022-04813","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320314129","display_name":"R\u00e9seau qu\u00e9b\u00e9cois de recherche sur le vieillissement","ror":"https://ror.org/05jsjqy14"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204652911.pdf","grobid_xml":"https://content.openalex.org/works/W7204652911.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1794989187","https://openalex.org/W1965455572","https://openalex.org/W1973829120","https://openalex.org/W1974287579","https://openalex.org/W1976237807","https://openalex.org/W1988847283","https://openalex.org/W1993179764","https://openalex.org/W1999637122","https://openalex.org/W2003541405","https://openalex.org/W2014011673","https://openalex.org/W2014502281","https://openalex.org/W2030158257","https://openalex.org/W2030560023","https://openalex.org/W2032525321","https://openalex.org/W2033869362","https://openalex.org/W2037890427","https://openalex.org/W2058382269","https://openalex.org/W2058990105","https://openalex.org/W2060148968","https://openalex.org/W2064079275","https://openalex.org/W2069744008","https://openalex.org/W2073789878","https://openalex.org/W2075064178","https://openalex.org/W2076277079","https://openalex.org/W2076591609","https://openalex.org/W2077638705","https://openalex.org/W2080654327","https://openalex.org/W2081162464","https://openalex.org/W2084393171","https://openalex.org/W2088299881","https://openalex.org/W2089861362","https://openalex.org/W2090762408","https://openalex.org/W2091457171","https://openalex.org/W2092555047","https://openalex.org/W2100918186","https://openalex.org/W2112181639","https://openalex.org/W2114271367","https://openalex.org/W2116858648","https://openalex.org/W2121802292","https://openalex.org/W2123651805","https://openalex.org/W2135894974","https://openalex.org/W2147791159","https://openalex.org/W2165758561","https://openalex.org/W2168835104","https://openalex.org/W2503555492","https://openalex.org/W2521388699","https://openalex.org/W2592090764","https://openalex.org/W2790165137","https://openalex.org/W2808108536","https://openalex.org/W2884121193","https://openalex.org/W2903978256","https://openalex.org/W2909846382","https://openalex.org/W2968081256","https://openalex.org/W2980139509","https://openalex.org/W3014837690","https://openalex.org/W3139694760","https://openalex.org/W4205319828","https://openalex.org/W4221129742","https://openalex.org/W4282571815","https://openalex.org/W4361190211","https://openalex.org/W4387450302","https://openalex.org/W4388304394","https://openalex.org/W4400303757","https://openalex.org/W4400325077","https://openalex.org/W4403243151","https://openalex.org/W4403307676","https://openalex.org/W4403611082","https://openalex.org/W4409211831","https://openalex.org/W4409782388","https://openalex.org/W4416675329"],"related_works":["https://openalex.org/W2171232551","https://openalex.org/W2884121193","https://openalex.org/W2069744008","https://openalex.org/W2121771226","https://openalex.org/W4401769901","https://openalex.org/W2123651805","https://openalex.org/W2061319123","https://openalex.org/W2546189711","https://openalex.org/W4416675329","https://openalex.org/W2097243366"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"olfactory":[2,88],"and":[3,21,40,45,56,63,98,115],"intranasal":[4],"trigeminal":[5,83,112],"systems":[6],"interact":[7],"closely,":[8],"influencing":[9],"chemosensory":[10,60],"perception,":[11],"yet":[12],"the":[13,51,95],"mechanisms":[14],"underlying":[15],"their":[16],"interaction":[17],"remain":[18],"poorly":[19],"understood":[20],"have":[22],"been":[23],"studied":[24],"mainly":[25],"in":[26,35,94,102],"young":[27],"adults.":[28,148],"We":[29],"aimed":[30],"to":[31,49],"characterize":[32],"olfactory-trigeminal":[33,47,109,127],"interactions":[34,128],"aging":[36],"by":[37,132],"comparing":[38],"electrophysiological":[39],"behavioral":[41],"responses":[42],"under":[43,79],"ipsilateral":[44,91],"contralateral":[46,99,108],"co-stimulation,":[48,110],"determine":[50],"relative":[52],"contributions":[53],"of":[54],"peripheral":[55,133],"central":[57,136],"mechanisms.":[58,137],"Using":[59],"event-related":[61],"potentials":[62],"a":[64],"localization":[65,113],"task,":[66],"44":[67],"healthy":[68,146],"older":[69,147],"adults":[70],"(66.3":[71],"\u00b1":[72],"4.6":[73],"years;":[74],"29":[75],"women)":[76],"were":[77],"tested":[78],"four":[80],"conditions:":[81],"pure":[82,87],"(carbon":[84],"dioxide;":[85],"CO\u2082),":[86],"(2-phenylethanol;":[89],"PEA),":[90],"co-stimulation":[92,100],"(PEA+CO\u2082":[93,101],"same":[96],"nostril),":[97],"opposite":[103],"nostrils).":[104],"Ipsilateral,":[105],"but":[106],"not":[107],"improved":[111],"performance":[114],"induced":[116],"larger":[117],"late":[118],"positive":[119],"component":[120],"amplitudes.":[121],"Together,":[122],"these":[123],"findings":[124],"suggest":[125],"that":[126],"are":[129],"driven":[130],"primarily":[131],"rather":[134],"than":[135],"This":[138],"study":[139],"also":[140],"provides":[141],"normative":[142],"CSERP":[143],"data":[144],"for":[145]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-30T00:00:00"}