{"id":"https://openalex.org/W7204625320","doi":"https://doi.org/10.1038/s41598-026-68224-z","title":"Direct recording of electrically-evoked auditory brainstem responses (CI-eABR) using Advanced Bionics cochlear implants: a feasibility study","display_name":"Direct recording of electrically-evoked auditory brainstem responses (CI-eABR) using Advanced Bionics cochlear implants: a feasibility study","publication_year":2026,"publication_date":"2026-08-29","ids":{"openalex":"https://openalex.org/W7204625320","doi":"https://doi.org/10.1038/s41598-026-68224-z"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-68224-z","doi":"https://doi.org/10.1038/s41598-026-68224-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68224-z","pdf_url":"https://www.nature.com/articles/s41598-026-68224-z_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-68224-z_reference.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064064829","display_name":"Mehrangiz Ashiri","orcid":"https://orcid.org/0000-0002-8289-4786","observed_orcids":["https://orcid.org/0000-0002-8289-4786","https://orcid.org/0009-0002-9900-6770"]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mehrangiz Ashiri","raw_affiliation_strings":["Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148587246","display_name":"Chen Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011340275","display_name":"Gunnar Gei\u00dfler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gunnar Geissler","raw_affiliation_strings":["Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148575883","display_name":"Emily Gibson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Gibson","raw_affiliation_strings":["Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148584907","display_name":"Miriam Glicksberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Glicksberg","raw_affiliation_strings":["Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148600640","display_name":"Kayli Silverstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayli Silverstein","raw_affiliation_strings":["Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148609366","display_name":"Emily Cardenas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Cardenas","raw_affiliation_strings":["Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Bionics LLC, Clinical Product Research, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091318048","display_name":"Kanth Koka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268104","display_name":"Advanced Bionics (United States)","ror":"https://ror.org/05thjzm58","country_code":"US","type":"company","lineage":["https://openalex.org/I4405268104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanth Koka","raw_affiliation_strings":["Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Technology, Advanced Bionics LLC, Valencia, CA, 91355, USA","institution_ids":["https://openalex.org/I4405268104"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064064829"],"corresponding_institution_ids":["https://openalex.org/I4405268104"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.056299999356269836,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrically-evoked-auditory-brainstem-response","display_name":"electrically evoked auditory brainstem response","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cochlear-implants","display_name":"cochlear implants","score":0.9660000205039978},{"id":"https://openalex.org/keywords/intracochlear-electrodes","display_name":"intracochlear electrodes","score":0.9139999747276306},{"id":"https://openalex.org/keywords/auditory-nerve","display_name":"auditory nerve","score":0.460999995470047},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.4399999976158142},{"id":"https://openalex.org/keywords/artifact-rejection","display_name":"artifact rejection","score":0.6159999966621399},{"id":"https://openalex.org/keywords/advanced-bionics","display_name":"Advanced Bionics","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2778515351","wikidata":"https://www.wikidata.org/wiki/Q9622","display_name":"Scalp","level":2,"score":0.6164000034332275},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.6039000153541565},{"id":"https://openalex.org/C2778882171","wikidata":"https://www.wikidata.org/wiki/Q724965","display_name":"Cochlear implant","level":2,"score":0.5986999869346619},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.5924000144004822},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.508899986743927},{"id":"https://openalex.org/C197525751","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neuroprosthetics","level":2,"score":0.5054000020027161},{"id":"https://openalex.org/C197424946","wikidata":"https://www.wikidata.org/wiki/Q1165717","display_name":"Waveform","level":3,"score":0.48649999499320984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4722999930381775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4611000120639801},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C43791021","wikidata":"https://www.wikidata.org/wiki/Q608256","display_name":"Auditory brainstem response","level":3,"score":0.3995000123977661},{"id":"https://openalex.org/C2777443451","wikidata":"https://www.wikidata.org/wiki/Q821413","display_name":"Auditory system","level":2,"score":0.37119999527931213},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36160001158714294},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.3596999943256378},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C2779010991","wikidata":"https://www.wikidata.org/wiki/Q2720909","display_name":"Artifact (error)","level":2,"score":0.3540000021457672},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31630000472068787},{"id":"https://openalex.org/C28490314","wikidata":"https://www.wikidata.org/wiki/Q189436","display_name":"Speech recognition","level":1,"score":0.31040000915527344},{"id":"https://openalex.org/C97562148","wikidata":"https://www.wikidata.org/wiki/Q5357989","display_name":"Electrode array","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.259799987077713},{"id":"https://openalex.org/C91316289","wikidata":"https://www.wikidata.org/wiki/Q189131","display_name":"Bionics","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-68224-z","doi":"https://doi.org/10.1038/s41598-026-68224-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68224-z","pdf_url":"https://www.nature.com/articles/s41598-026-68224-z_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-68224-z","doi":"https://doi.org/10.1038/s41598-026-68224-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-68224-z","pdf_url":"https://www.nature.com/articles/s41598-026-68224-z_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204625320.pdf","grobid_xml":"https://content.openalex.org/works/W7204625320.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1487490912","https://openalex.org/W1986112848","https://openalex.org/W2018372093","https://openalex.org/W2024745240","https://openalex.org/W2027060549","https://openalex.org/W2048042058","https://openalex.org/W2051834262","https://openalex.org/W2051956472","https://openalex.org/W2058286812","https://openalex.org/W2081173744","https://openalex.org/W2089518304","https://openalex.org/W2095505090","https://openalex.org/W2991370782","https://openalex.org/W2999707611","https://openalex.org/W3039372944","https://openalex.org/W3134390657","https://openalex.org/W4220767058","https://openalex.org/W4281790017","https://openalex.org/W4315781143","https://openalex.org/W4388834760","https://openalex.org/W4400118176","https://openalex.org/W4404446652","https://openalex.org/W4404602201","https://openalex.org/W4409092377","https://openalex.org/W4411539987","https://openalex.org/W4411853088","https://openalex.org/W7127042737"],"related_works":["https://openalex.org/W2902351090","https://openalex.org/W2066346455","https://openalex.org/W4400118176","https://openalex.org/W2413523431","https://openalex.org/W2086157456","https://openalex.org/W1994553279","https://openalex.org/W2892450987","https://openalex.org/W4281790017","https://openalex.org/W2420987639","https://openalex.org/W2749904438"],"abstract_inverted_index":{"Abstract":[0],"Electrically-evoked":[1],"auditory":[2,11,19,203],"brainstem":[3],"responses":[4,149],"(eABRs)":[5],"provide":[6],"an":[7],"objective":[8,68,202],"measure":[9],"of":[10,76,189],"pathway":[12],"function,":[13],"reflecting":[14],"neural":[15],"activity":[16],"in":[17,168],"the":[18,56,73,84,187],"nerve":[20],"and":[21,44,65,120,140,171,194],"brainstem.":[22],"To":[23],"date,":[24],"eABRs":[25,95],"have":[26],"been":[27],"predominantly":[28],"acquired":[29],"using":[30,83,99],"conventional":[31,129],"electrophysiological":[32],"(EP)":[33],"systems":[34],"with":[35,107,124,155,163,175,181],"far-field":[36],"scalp":[37,130,164],"electrodes,":[38],"which":[39],"require":[40],"separate":[41],"recording":[42,54,81,193],"hardware":[43],"may":[45],"limit":[46],"clinical":[47,74],"applicability.":[48],"An":[49],"integrated":[50],"framework":[51],"enabling":[52,103],"direct":[53,77,190],"through":[55],"cochlear":[57,78],"implant":[58],"(CI)":[59],"system":[60],"could":[61],"overcome":[62],"these":[63],"limitations":[64],"support":[66,186],"streamlined":[67],"assessment.":[69,204],"This":[70],"study":[71],"evaluates":[72],"feasibility":[75,188],"implant\u2013based":[79],"eABR":[80,192],"(CI-eABR)":[82],"Advanced":[85],"Bionics":[86],"system.":[87],"A":[88],"prototype":[89],"interface":[90],"was":[91,173],"developed":[92],"to":[93,128],"acquire":[94],"via":[96],"intracochlear":[97],"electrodes":[98],"implant-based":[100,191],"back":[101],"telemetry,":[102],"synchronized":[104],"bilateral":[105],"recordings":[106],"stimulation":[108],"from":[109,116,121],"a":[110,125,196],"single":[111],"implant.":[112],"Recordings":[113],"were":[114,150],"obtained":[115],"engineering":[117],"test":[118],"bench,":[119],"CI":[122],"users":[123],"subset":[126],"compared":[127],"recordings.":[131],"Bench":[132],"testing":[133],"demonstrated":[134],"stable":[135],"acquisition,":[136],"effective":[137],"artifact":[138],"rejection,":[139],"reliable":[141],"waveform":[142,169],"extraction.":[143],"In":[144,161],"human":[145],"participants,":[146],"measurable":[147],"ipsilateral":[148],"observed":[151],"at":[152],"comfortable":[153],"levels,":[154],"peak":[156],"latencies":[157],"within":[158],"expected":[159],"ranges.":[160],"subjects":[162],"recordings,":[165],"strong":[166],"agreement":[167],"morphology":[170],"latency":[172],"observed,":[174],"CI-eABR":[176],"showing":[177],"larger":[178],"amplitudes":[179],"consistent":[180],"near-field":[182],"recording.":[183],"These":[184],"findings":[185],"represent":[195],"step":[197],"toward":[198],"rapid,":[199],"clinically":[200],"applicable":[201]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-30T00:00:00"}