{"id":"https://openalex.org/W7204604419","doi":"https://doi.org/10.64898/2026.08.25.26361322","title":"White Matter Microstructural Alterations and Symptom Correlates in Functional Motor Disorder","display_name":"White Matter Microstructural Alterations and Symptom Correlates in Functional Motor Disorder","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204604419","doi":"https://doi.org/10.64898/2026.08.25.26361322"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.25.26361322","doi":"https://doi.org/10.64898/2026.08.25.26361322","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.26361322","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/28/2026.08.25.26361322.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/28/2026.08.25.26361322.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016215610","display_name":"Christiana Westlin","orcid":"https://orcid.org/0000-0001-9127-0847","observed_orcids":["https://orcid.org/0000-0001-9127-0847"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christiana Westlin","raw_affiliation_strings":["Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;"],"raw_orcid":"https://orcid.org/0000-0001-9127-0847","affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"raw_affiliation_string":"Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071659777","display_name":"Cristina Bleier","orcid":"https://orcid.org/0009-0003-6306-8811","observed_orcids":["https://orcid.org/0009-0003-6306-8811"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Bleier","raw_affiliation_strings":["Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;"],"raw_orcid":"https://orcid.org/0009-0003-6306-8811","affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006033873","display_name":"Andrew J. Guthrie","orcid":"https://orcid.org/0000-0001-6501-7805","observed_orcids":["https://orcid.org/0000-0001-6501-7805"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J. Guthrie","raw_affiliation_strings":["Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064421957","display_name":"Sara A. Finkelstein","orcid":"https://orcid.org/0000-0003-3578-9593","observed_orcids":["https://orcid.org/0000-0003-3578-9593"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara A. Finkelstein","raw_affiliation_strings":["Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024032501","display_name":"Julie Maggio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Maggio","raw_affiliation_strings":["Department of Physical Therapy, Massachusetts General Hospital, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, Massachusetts General Hospital, Boston, MA, USA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051440733","display_name":"Jessica Ranford","orcid":"https://orcid.org/0000-0002-5682-459X","observed_orcids":["https://orcid.org/0000-0002-5682-459X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Ranford","raw_affiliation_strings":["Department of Occupational Therapy, Massachusetts General Hospital, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational Therapy, Massachusetts General Hospital, Boston, MA, USA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053331697","display_name":"Julie MacLean","orcid":"https://orcid.org/0009-0008-0069-343X","observed_orcids":["https://orcid.org/0009-0008-0069-343X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie MacLean","raw_affiliation_strings":["Department of Occupational Therapy, Massachusetts General Hospital, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational Therapy, Massachusetts General Hospital, Boston, MA, USA;","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048323045","display_name":"Ellen J. Godena","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellen Godena","raw_affiliation_strings":["Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025220706","display_name":"Daniel J. Millstein","orcid":"https://orcid.org/0000-0003-0204-3883","observed_orcids":["https://orcid.org/0000-0003-0204-3883"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Millstein","raw_affiliation_strings":["Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"raw_affiliation_string":"Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022090434","display_name":"Jennifer L. Freeburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Freeburn","raw_affiliation_strings":["Department of Speech, Language, and Swallowing Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Speech, Language, and Swallowing Disorders, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082985758","display_name":"Caitlin N. Adams","orcid":"https://orcid.org/0000-0002-7093-9959","observed_orcids":["https://orcid.org/0000-0002-7093-9959"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin Adams","raw_affiliation_strings":["Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"raw_affiliation_string":"Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034551199","display_name":"Christopher D. Stephen","orcid":"https://orcid.org/0000-0002-4727-192X","observed_orcids":["https://orcid.org/0000-0002-4727-192X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher D. Stephen","raw_affiliation_strings":["Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064963974","display_name":"Marek R. Kubicki","orcid":"https://orcid.org/0000-0002-3989-8212","observed_orcids":["https://orcid.org/0000-0002-3989-8212"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marek Kubicki","raw_affiliation_strings":["Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034263638","display_name":"Ibai Palacio Diez","orcid":"https://orcid.org/0000-0001-5769-0178","observed_orcids":["https://orcid.org/0000-0001-5769-0178"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"Ibai Diez","raw_affiliation_strings":["Center for Inflammation Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","Computatonal Neuroimaging Lab, Biobizkaia Health Research Institute, Barakaldo, Spain;","Ikerbasque Baske Foundation for Science, Bilbao, Spain;"],"raw_orcid":"https://orcid.org/0000-0001-5769-0178","affiliations":[{"raw_affiliation_string":"Center for Inflammation Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Computatonal Neuroimaging Lab, Biobizkaia Health Research Institute, Barakaldo, Spain;","institution_ids":[]},{"raw_affiliation_string":"Ikerbasque Baske Foundation for Science, Bilbao, Spain;","institution_ids":["https://openalex.org/I110594554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077957501","display_name":"David L. Perez","orcid":"https://orcid.org/0000-0003-2721-583X","observed_orcids":["https://orcid.org/0000-0003-2721-583X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210127055","display_name":"Athinoula A. Martinos Center for Biomedical Imaging","ror":"https://ror.org/032q5ym94","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I48633490","display_name":"Mass General Brigham","ror":"https://ror.org/04py2rh25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Perez","raw_affiliation_strings":["Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","Mass General Brigham Department of Neurology and Neuroscience Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA;","Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","Mass General Brigham Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA;","Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;"],"raw_orcid":"https://orcid.org/0000-0003-2721-583X","affiliations":[{"raw_affiliation_string":"Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055"]},{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I48633490"]},{"raw_affiliation_string":"Mass General Brigham Department of Neurology and Neuroscience Institute, Massachusetts General Hospital, Harvard Medical School, Boston MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"raw_affiliation_string":"Mass General Brigham Department of Psychiatry, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I48633490"]},{"raw_affiliation_string":"Mass General Brigham Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA;","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I48633490"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5016215610"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210127055","https://openalex.org/I48633490"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.5332000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11334","display_name":"Psychosomatic Disorders and Their Treatments","score":0.43799999356269836,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-motor-disorders","display_name":"functional motor disorders","score":0.9900000095367432},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.9789999723434448},{"id":"https://openalex.org/keywords/middle-cerebellar-peduncle","display_name":"middle cerebellar peduncle","score":0.9129999876022339},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.9139999747276306},{"id":"https://openalex.org/keywords/inferior-longitudinal-fasciculus","display_name":"inferior longitudinal fasciculus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.5410000085830688},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.847000002861023},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neurite-density-index","display_name":"neurite density index","score":0.7620000243186951},{"id":"https://openalex.org/keywords/free-water-fraction","display_name":"free water fraction","score":0.8579999804496765},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"diffusion MRI","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.7986999750137329},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7955999970436096},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.760200023651123},{"id":"https://openalex.org/C2778183499","wikidata":"https://www.wikidata.org/wiki/Q223851","display_name":"Corpus callosum","level":2,"score":0.6995999813079834},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5519000291824341},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.49970000982284546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47589999437332153},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3855000138282776},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3714999854564667},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.351500004529953},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C52338299","wikidata":"https://www.wikidata.org/wiki/Q1004354","display_name":"Functional neuroimaging","level":3,"score":0.3393999934196472},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C2777796809","wikidata":"https://www.wikidata.org/wiki/Q604747","display_name":"Internal capsule","level":4,"score":0.32100000977516174},{"id":"https://openalex.org/C2780317758","wikidata":"https://www.wikidata.org/wiki/Q3339235","display_name":"Neurological disorder","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C2780906641","wikidata":"https://www.wikidata.org/wiki/Q213373","display_name":"Ataxia","level":2,"score":0.29760000109672546},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C2779779279","wikidata":"https://www.wikidata.org/wiki/Q19915308","display_name":"Corticospinal tract","level":4,"score":0.2840999960899353},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.2833999991416931},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C166047926","wikidata":"https://www.wikidata.org/wiki/Q170277","display_name":"Intelligence quotient","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.26030001044273376},{"id":"https://openalex.org/C113062710","wikidata":"https://www.wikidata.org/wiki/Q2463100","display_name":"Motor coordination","level":2,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.25.26361322","doi":"https://doi.org/10.64898/2026.08.25.26361322","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.26361322","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/28/2026.08.25.26361322.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.25.26361322","doi":"https://doi.org/10.64898/2026.08.25.26361322","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.25.26361322","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/08/28/2026.08.25.26361322.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G9000870000","display_name":"Defining Neurobiological Subtypes of Motor Functional Neurological Disorder","funder_award_id":"R01MH125802","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306614","display_name":"Sidney R. Baer, Jr. Foundation","ror":"https://ror.org/05wtm9j71"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204604419.pdf","grobid_xml":"https://content.openalex.org/works/W7204604419.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1998451692","https://openalex.org/W2024729467","https://openalex.org/W2032254014","https://openalex.org/W2174561539","https://openalex.org/W2316878322","https://openalex.org/W2746620361","https://openalex.org/W2766869084","https://openalex.org/W2768271247","https://openalex.org/W2887230240","https://openalex.org/W2897783414","https://openalex.org/W2933775295","https://openalex.org/W2990460470","https://openalex.org/W3081208803","https://openalex.org/W3090823852","https://openalex.org/W3112347592","https://openalex.org/W3135528090","https://openalex.org/W3138102800","https://openalex.org/W4214484921","https://openalex.org/W4223971211","https://openalex.org/W4292475380","https://openalex.org/W4292658370","https://openalex.org/W4361208343","https://openalex.org/W4366602760","https://openalex.org/W4382196162","https://openalex.org/W4400892072","https://openalex.org/W4407933023","https://openalex.org/W4408152387","https://openalex.org/W4409846644","https://openalex.org/W4410576323","https://openalex.org/W4415764350","https://openalex.org/W7167913741"],"related_works":["https://openalex.org/W2990460470","https://openalex.org/W4409846644","https://openalex.org/W4401575006","https://openalex.org/W3097528955","https://openalex.org/W4309160469","https://openalex.org/W2057194894","https://openalex.org/W4416672645","https://openalex.org/W4320033006","https://openalex.org/W2052658506","https://openalex.org/W3036895061"],"abstract_inverted_index":{"ABSTRACT":[0],"Background":[1],"Neuroimaging":[2],"studies":[3],"implicate":[4],"network":[5],"alterations":[6],"in":[7,24,138,177,205,223,242],"functional":[8],"motor":[9],"disorder":[10,60],"(FND-motor),":[11],"yet":[12],"white":[13,21,70,220],"matter":[14,22,71,221],"remains":[15],"poorly":[16],"characterized.":[17],"Objectives":[18],"To":[19],"characterize":[20],"microstructure":[23,222],"FND-motor":[25,130,194,224,243],"relative":[26,225],"to":[27,149,226],"healthy":[28],"(HCs)":[29],"and":[30,34,45,48,57,82,86,97,112,119,134,159,174,181,184,195,202,229,244],"psychiatric":[31],"(PCs)":[32],"controls":[33],"examine":[35],"symptom":[36,166,191,249],"associations.":[37],"Methods":[38],"Fifty":[39],"individuals":[40],"with":[41,116,128,144,170,199,247],"FND-motor,":[42],"50":[43,49],"age-":[44],"sex-matched":[46],"HCs,":[47,129],"PCs":[50,196,230],"matched":[51],"on":[52],"age,":[53],"sex,":[54],"depression,":[55],"anxiety,":[56],"post-traumatic":[58],"stress":[59],"severity":[61,167],"underwent":[62],"multi-shell":[63],"diffusion":[64,73],"MRI.":[65],"Voxel-based":[66],"analyses":[67,111],"examined":[68],"whole-brain":[69],"using":[72,107],"tensor":[74],"imaging":[75,88],"(fractional":[76],"anisotropy":[77],"[FA],":[78],"mean":[79],"diffusivity":[80],"[MD])":[81],"neurite":[83],"orientation":[84,94],"dispersion":[85,95],"density":[87,91],"(NODDI)":[89],"(neurite":[90],"index":[92],"[NDI],":[93],"index,":[96],"free":[98],"water":[99],"fraction":[100],"[FWF])":[101],"metrics.":[102],"Cross-metric":[103],"convergence":[104],"was":[105,168,197],"characterized":[106],"atlas-based":[108],"tract":[109],"overlap":[110],"probabilistic":[113],"tractography.":[114],"Associations":[115],"FND":[117,165],"symptoms":[118,122],"transdiagnostic":[120,189],"physical":[121,190,248],"were":[123,147],"also":[124],"evaluated.":[125],"Results":[126],"Compared":[127,143],"showed":[131],"higher":[132,175,200],"FA/NDI":[133,173],"lower":[135,150,172,203],"MD/FWF,":[136,151],"predominantly":[137],"the":[139,153,178,206,236],"middle":[140,156,207,237],"cerebellar":[141,157,208,238],"peduncle.":[142,209],"PCs,":[145],"differences":[146],"limited":[148],"involving":[152],"corpus":[154,179],"callosum,":[155],"peduncle,":[158],"left":[160],"inferior":[161],"longitudinal":[162],"fasciculus.":[163],"Greater":[164],"associated":[169,198,245],"a":[171,214],"MD/FWF":[176,204],"callosum":[180],"right-lateralized":[182],"association":[183],"projection":[185],"pathways,":[186],"whereas":[187],"greater":[188],"burden":[192],"across":[193],"FA":[201],"Conclusions":[210],"This":[211],"study":[212],"provides":[213],"comprehensive":[215],"multi-metric":[216],"diffusion-weighted":[217],"characterization":[218],"of":[219],"both":[227],"HCs":[228],"\u2013":[231],"highlighting":[232],"cortico-cerebellar":[233],"connections":[234],"via":[235],"peduncle":[239],"as":[240],"distinct":[241],"transdiagnostically":[246],"burden.":[250]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-29T00:00:00"}