{"id":"https://openalex.org/W7204599655","doi":"https://doi.org/10.64898/2026.08.27.747369","title":"Connexin-43 links Neuromesodermal progenitor states to segmentation clock robustness during vertebrate axis elongation","display_name":"Connexin-43 links Neuromesodermal progenitor states to segmentation clock robustness during vertebrate axis elongation","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204599655","doi":"https://doi.org/10.64898/2026.08.27.747369"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.27.747369","doi":"https://doi.org/10.64898/2026.08.27.747369","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747369","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.27.747369","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119821019","display_name":"Jonas Cruzel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jonas Cruzel","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065446630","display_name":"Romane Bertrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romane Bertrand","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013298880","display_name":"Felipe Maurelia","orcid":"https://orcid.org/0009-0008-7862-985X","observed_orcids":["https://orcid.org/0009-0008-7862-985X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Felipe Maurelia","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116608480","display_name":"Prikshit Prikshit","orcid":"https://orcid.org/0000-0002-9864-1337","observed_orcids":["https://orcid.org/0000-0002-9864-1337"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Prikshit","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France"],"raw_orcid":"https://orcid.org/0000-0002-9864-1337","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148540443","display_name":"Enola Ravier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Enola Ranvier","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082211511","display_name":"Charl\u00e8ne Guillot","orcid":"https://orcid.org/0000-0001-9214-7509","observed_orcids":["https://orcid.org/0000-0001-9214-7509"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I198244214","display_name":"Universit\u00e9 Clermont Auvergne","ror":"https://ror.org/01a8ajp46","country_code":"FR","type":"education","lineage":["https://openalex.org/I198244214"]},{"id":"https://openalex.org/I4210163188","display_name":"Institut G\u00e9n\u00e9tique, Reproduction et D\u00e9veloppement","ror":"https://ror.org/052d1cv78","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210096427","https://openalex.org/I4210163188"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Charl\u00e8ne Guillot","raw_affiliation_strings":["Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France"],"raw_orcid":"https://orcid.org/0000-0001-9214-7509","affiliations":[{"raw_affiliation_string":"Universit\u00e9 Clermont Auvergne, CNRS, INSERM, GReD Institute, Facult\u00e9 de M\u00e9decine, F-63000, Clermont-Ferrand, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5082211511"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I198244214","https://openalex.org/I4210163188"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9140999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.08209999650716782,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/connexin-43","display_name":"connexin 43","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuromesodermal-progenitors","display_name":"neuromesodermal progenitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/segmentation-clock","display_name":"segmentation clock","score":0.7960000038146973},{"id":"https://openalex.org/keywords/somitogenesis","display_name":"somitogenesis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.7770000100135803},{"id":"https://openalex.org/keywords/gap-junctions","display_name":"gap junctions","score":0.925000011920929},{"id":"https://openalex.org/keywords/hemichannels","display_name":"hemichannels","score":0.9950000047683716},{"id":"https://openalex.org/keywords/developmental-robustness","display_name":"developmental robustness","score":0.7099999785423279},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.8700000047683716},{"id":"https://openalex.org/keywords/brachyury","display_name":"Brachyury","score":0.9520000219345093},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.7630000114440918},{"id":"https://openalex.org/keywords/paraxial-mesoderm","display_name":"paraxial mesoderm","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neural-induction","display_name":"neural induction","score":0.5189999938011169},{"id":"https://openalex.org/keywords/axial-elongation","display_name":"axial elongation","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7508999705314636},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.6969000101089478},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6362000107765198},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.58160001039505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5724999904632568},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5220999717712402},{"id":"https://openalex.org/C2779018604","wikidata":"https://www.wikidata.org/wiki/Q1427600","display_name":"Somite","level":4,"score":0.4860999882221222},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4596000015735626},{"id":"https://openalex.org/C122428330","wikidata":"https://www.wikidata.org/wiki/Q3816207","display_name":"Paraxial mesoderm","level":5,"score":0.429500013589859},{"id":"https://openalex.org/C2778961482","wikidata":"https://www.wikidata.org/wiki/Q25241","display_name":"Vertebrate","level":3,"score":0.41620001196861267},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3813999891281128},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.37560001015663147},{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.3495999872684479},{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.34279999136924744},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3246999979019165},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.3237000107765198},{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.2969000041484833},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.26019999384880066},{"id":"https://openalex.org/C45472230","wikidata":"https://www.wikidata.org/wiki/Q1447198","display_name":"Cytokinesis","level":4,"score":0.25929999351501465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2556999921798706},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.27.747369","doi":"https://doi.org/10.64898/2026.08.27.747369","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747369","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.27.747369","doi":"https://doi.org/10.64898/2026.08.27.747369","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.27.747369","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4109922684","display_name":null,"funder_award_id":"ANR-22-CPJ2-0084-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1634376377","https://openalex.org/W1980845430","https://openalex.org/W1993000387","https://openalex.org/W2000707285","https://openalex.org/W2006612479","https://openalex.org/W2017203200","https://openalex.org/W2019015469","https://openalex.org/W2022731947","https://openalex.org/W2026840137","https://openalex.org/W2034609545","https://openalex.org/W2044436799","https://openalex.org/W2050354723","https://openalex.org/W2068859526","https://openalex.org/W2075895263","https://openalex.org/W2088925327","https://openalex.org/W2093958758","https://openalex.org/W2098872610","https://openalex.org/W2100898236","https://openalex.org/W2102910500","https://openalex.org/W2109480236","https://openalex.org/W2135447402","https://openalex.org/W2163056759","https://openalex.org/W2266186567","https://openalex.org/W2289750443","https://openalex.org/W2592095613","https://openalex.org/W2607832145","https://openalex.org/W2747297590","https://openalex.org/W2756839240","https://openalex.org/W2788408124","https://openalex.org/W2808627733","https://openalex.org/W2886748056","https://openalex.org/W2950975998","https://openalex.org/W2953223235","https://openalex.org/W2963480388","https://openalex.org/W3000631101","https://openalex.org/W3037816506","https://openalex.org/W3180864422","https://openalex.org/W3208782662","https://openalex.org/W4313544794","https://openalex.org/W4399009803","https://openalex.org/W4415253103"],"related_works":["https://openalex.org/W3016874122","https://openalex.org/W3002383470","https://openalex.org/W2053962901","https://openalex.org/W1970279448","https://openalex.org/W2118078032","https://openalex.org/W2036930489","https://openalex.org/W1992774400","https://openalex.org/W2215627070","https://openalex.org/W3176458092","https://openalex.org/W2011007333"],"abstract_inverted_index":{"ABSTRACT":[0],"Neuromesodermal":[1],"progenitors":[2],"(NMPs)":[3],"sustain":[4],"vertebrate":[5,217],"body-axis":[6],"elongation":[7],"by":[8],"generating":[9],"both":[10],"neural":[11],"and":[12,18,34,62,70,135,163,175,203,212],"paraxial":[13],"mesodermal":[14,122],"tissues.":[15],"Although":[16],"signaling":[17],"metabolic":[19],"pathways":[20],"regulate":[21],"NMP":[22,68,103],"states,":[23],"whether":[24],"intercellular":[25,210],"communication":[26,96,148,211],"contributes":[27],"to":[28,98,153],"the":[29,52,57,67,80,102,128,132,137,167],"coordination":[30],"of":[31,56,86,94,131,140,146,156,199],"progenitor":[32,112,133,201],"behaviour":[33],"developmental":[35,189],"timing":[36,162],"remains":[37],"unclear.":[38],"Here,":[39],"we":[40],"identify":[41,194],"GJA1,":[42],"encoding":[43],"connexin-43":[44,195],"(Cx43),":[45],"as":[46,196],"a":[47,71,182,197,205],"gene":[48],"dynamically":[49],"enriched":[50],"within":[51,66,79,111],"neuromesodermal":[53,200],"competent":[54],"domain":[55],"chick":[58],"embryo.":[59],"Cx43-associated":[60],"channels":[61],"hemichannels":[63,87],"accumulate":[64],"preferentially":[65],"population,":[69],"photoactivatable":[72],"tracer":[73],"assay":[74],"demonstrates":[75],"enhanced":[76],"connexin-mediated":[77,147],"exchange":[78],"posterior":[81],"growth":[82],"zone.":[83],"Pharmacological":[84],"inhibition":[85,106,116,125],"or":[88],"gap":[89],"junctions":[90],"revealed":[91],"distinct":[92],"contributions":[93],"these":[95],"modes":[97],"transcriptional":[99],"regulation":[100],"across":[101],"continuum.":[104],"Gap-junction":[105],"primarily":[107],"altered":[108,136],"SOX2":[109],"expression":[110,120],"populations,":[113],"whereas":[114],"hemichannel":[115],"selectively":[117],"affected":[118],"TBXT":[119],"in":[121,187],"cells.":[123],"Connexin":[124],"also":[126],"reduced":[127],"relative":[129],"size":[130],"compartment":[134],"spatial":[138],"organization":[139],"newly":[141],"formed":[142],"somites.":[143],"Strikingly,":[144],"disruption":[145],"impaired":[149],"segmentation":[150,158,161,169,179,213],"dynamics,":[151],"leading":[152],"increased":[154],"frequencies":[155],"off-pace":[157],"events,":[159],"accelerated":[160],"progressive":[164],"deviation":[165],"from":[166],"expected":[168],"program.":[170],"These":[171],"defects":[172],"emerged":[173],"rapidly":[174],"accumulated":[176],"over":[177],"successive":[178],"cycles,":[180],"indicating":[181],"requirement":[183],"for":[184],"connexin":[185],"activity":[186],"maintaining":[188],"robustness.":[190],"Together,":[191],"our":[192],"findings":[193],"regulator":[198],"states":[202],"reveal":[204],"previously":[206],"unrecognized":[207],"link":[208],"between":[209],"clock":[214],"robustness":[215],"during":[216],"axis":[218],"elongation.":[219]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-29T00:00:00"}
