{"id":"https://openalex.org/W7204591313","doi":"https://doi.org/10.1016/j.ijid.2026.109084","title":"Factors associated with death in severe dengue: a retrospective cohort study in Esp\u00edrito Santo, Brazil, 2020-2024","display_name":"Factors associated with death in severe dengue: a retrospective cohort study in Esp\u00edrito Santo, Brazil, 2020-2024","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204591313","doi":"https://doi.org/10.1016/j.ijid.2026.109084","pmid":"https://pubmed.ncbi.nlm.nih.gov/42660408"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijid.2026.109084","doi":"https://doi.org/10.1016/j.ijid.2026.109084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2026.109084","pdf_url":"https://www.ijidonline.com/article/S1201-9712(26)00719-8/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ijidonline.com/article/S1201-9712(26)00719-8/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018470675","display_name":"Creuza Rachel Vicente","orcid":"https://orcid.org/0000-0003-0182-7969","observed_orcids":["https://orcid.org/0000-0003-0182-7969"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Creuza Rachel Vicente","raw_affiliation_strings":["Department of Public Health, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-0182-7969","affiliations":[{"raw_affiliation_string":"Department of Public Health, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001977553","display_name":"Jo\u00e3o Paulo Cola","orcid":"https://orcid.org/0000-0003-4972-4686","observed_orcids":["https://orcid.org/0000-0003-4972-4686"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Paulo Cola","raw_affiliation_strings":["Health Surveillance Sector, Health Department of Esp\u00edrito Santo State, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Surveillance Sector, Health Department of Esp\u00edrito Santo State, Vit\u00f3ria, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018182588","display_name":"Ana Paula Brioschi dos Santos","orcid":"https://orcid.org/0000-0002-9701-0314","observed_orcids":["https://orcid.org/0000-0002-9701-0314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Paula Brioschi dos Santos","raw_affiliation_strings":["Health Surveillance Sector, Health Department of Esp\u00edrito Santo State, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Surveillance Sector, Health Department of Esp\u00edrito Santo State, Vit\u00f3ria, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148536152","display_name":"Theresa Cristina Cardoso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theresa Cristina Cardoso","raw_affiliation_strings":["Health Surveillance Sector, Health Department of Esp\u00edrito Santo State, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Surveillance Sector, Health Department of Esp\u00edrito Santo State, Vit\u00f3ria, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073138437","display_name":"Crispim Cerutti","orcid":"https://orcid.org/0000-0002-9485-4191","observed_orcids":["https://orcid.org/0000-0002-9485-4191"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Crispim Cerutti Junior","raw_affiliation_strings":["Department of Public Health, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041001904","display_name":"Eng Eong Ooi","orcid":"https://orcid.org/0000-0002-0520-1544","observed_orcids":["https://orcid.org/0000-0002-0520-1544"]},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Eng Eong Ooi","raw_affiliation_strings":["Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087964035","display_name":"Stefano Gobbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Stefano Gobbi","raw_affiliation_strings":["Medical School, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088153222","display_name":"JULIA LUCH DOS SANTOS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Julia Luch dos Santos","raw_affiliation_strings":["Medical School, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030995018","display_name":"Ang\u00e9lica Espinosa Miranda","orcid":"https://orcid.org/0000-0002-5556-8379","observed_orcids":["https://orcid.org/0000-0002-5556-8379"]},"institutions":[{"id":"https://openalex.org/I51235708","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28","country_code":"BR","type":"education","lineage":["https://openalex.org/I51235708"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Angelica Espinosa Miranda","raw_affiliation_strings":["Department of Public Health, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Esp\u00edrito Santo, Vit\u00f3ria, Brazil","institution_ids":["https://openalex.org/I51235708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012990960","display_name":"Kuan Rong Chan","orcid":"https://orcid.org/0000-0002-2427-671X","observed_orcids":["https://orcid.org/0000-0002-2427-671X"]},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Kuan Rong Chan","raw_affiliation_strings":["Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore. Electronic address: kuanrong.chan@duke-nus.edu.sg"],"raw_orcid":"https://orcid.org/0000-0002-2427-671X","affiliations":[{"raw_affiliation_string":"Emerging Infectious Diseases Program, Duke-NUS Medical School, Singapore, Singapore. Electronic address: kuanrong.chan@duke-nus.edu.sg","institution_ids":["https://openalex.org/I4210126319"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5012990960"],"corresponding_institution_ids":["https://openalex.org/I4210126319"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":{"value":2900,"currency":"USD","value_usd":2900},"fwci":5.0263,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95770991,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"172","issue":null,"first_page":"109084","last_page":"109084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14053","display_name":"Dengue and Mosquito Control Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-dengue","display_name":"severe dengue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dengue-mortality","display_name":"dengue mortality","score":0.9660000205039978},{"id":"https://openalex.org/keywords/risk-factors-for-mortality","display_name":"mortality risk factors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.734000027179718},{"id":"https://openalex.org/keywords/platelet-count","display_name":"platelet count","score":0.8799999952316284},{"id":"https://openalex.org/keywords/altered-level-of-consciousness","display_name":"altered level of consciousness","score":0.8330000042915344},{"id":"https://openalex.org/keywords/fever","display_name":"fever","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hemodynamic-instability","display_name":"hemodynamic instability","score":0.7860000133514404},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8989999890327454},{"id":"https://openalex.org/keywords/age-stratified-analysis","display_name":"age-stratified analysis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/espirito-santo","display_name":"Esp\u00edrito Santo","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.920199990272522},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.779699981212616},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.6729999780654907},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5375000238418579},{"id":"https://openalex.org/C533803919","wikidata":"https://www.wikidata.org/wiki/Q30953","display_name":"Dengue fever","level":2,"score":0.5185999870300293},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44350001215934753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4221000075340271},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3767000138759613},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.37130001187324524},{"id":"https://openalex.org/C2779936836","wikidata":"https://www.wikidata.org/wiki/Q890200","display_name":"Coagulopathy","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.32420000433921814},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.323199987411499},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26589998602867126},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.2583000063896179}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006400","descriptor_name":"Hematocrit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007022","descriptor_name":"Hypotension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019595","descriptor_name":"Severe Dengue","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijid.2026.109084","doi":"https://doi.org/10.1016/j.ijid.2026.109084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2026.109084","pdf_url":"https://www.ijidonline.com/article/S1201-9712(26)00719-8/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:42660408","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42660408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8255c33e73a94c63bf7b474dd3c1b615","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/8255c33e73a94c63bf7b474dd3c1b615","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Infectious Diseases, Vol 172, Iss , Pp 109084- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ijid.2026.109084","doi":"https://doi.org/10.1016/j.ijid.2026.109084","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ijid.2026.109084","pdf_url":"https://www.ijidonline.com/article/S1201-9712(26)00719-8/pdf","source":{"id":"https://openalex.org/S35071406","display_name":"International Journal of Infectious Diseases","issn_l":"1201-9712","issn":["1201-9712","1878-3511"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1742482641","display_name":null,"funder_award_id":"442106/2023-8","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320331556","display_name":"Universidade Federal do Esp\u00edrito Santo","ror":"https://ror.org/05sxf4h28"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204591313.pdf","grobid_xml":"https://content.openalex.org/works/W7204591313.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W2014213740","https://openalex.org/W2064754444","https://openalex.org/W2084620194","https://openalex.org/W2131222241","https://openalex.org/W2226122726","https://openalex.org/W3015199008","https://openalex.org/W3089648802","https://openalex.org/W3133408366","https://openalex.org/W3207679345","https://openalex.org/W3214076115","https://openalex.org/W4214686793","https://openalex.org/W4283275902","https://openalex.org/W4321765908","https://openalex.org/W4323971917","https://openalex.org/W4385555467","https://openalex.org/W4400057336","https://openalex.org/W4405967312","https://openalex.org/W4406302061","https://openalex.org/W4409472452"],"related_works":["https://openalex.org/W2511423960","https://openalex.org/W2158773979","https://openalex.org/W7097859022","https://openalex.org/W2802906972","https://openalex.org/W4406890376","https://openalex.org/W4297457412","https://openalex.org/W1991733827","https://openalex.org/W7143461604","https://openalex.org/W2120542148","https://openalex.org/W2056246555"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"identify":[2],"factors":[3],"associated":[4,111,138,159,180,192,212],"with":[5,9,112,139,160,181,193,213],"death":[6,165,182,198],"among":[7,184,200,225],"patients":[8],"severe":[10,23,47,54,208],"dengue.":[11],"METHODS:":[12],"We":[13],"conducted":[14],"a":[15,113,126,140,161,194],"population-based":[16],"retrospective":[17],"cohort":[18],"study":[19],"including":[20],"all":[21],"laboratory-confirmed":[22,53],"dengue":[24,48,55,209],"cases":[25,63],"reported":[26],"in":[27,60,93,129,166,173,207],"Esp\u00edrito":[28],"Santo,":[29],"Brazil,":[30],"between":[31],"2020":[32],"and":[33,100,125,154,175,189],"2024.":[34],"Participants":[35],"were":[36,64,110,137,179],"classified":[37],"according":[38],"to":[39],"the":[40,70,146],"recorded":[41],"outcome":[42],"as":[43],"fatal":[44],"or":[45,75,151],"non-fatal":[46],"cases.":[49],"RESULTS:":[50],"Among":[51],"251":[52],"cases,":[56],"117":[57],"(46.6%)":[58],"resulted":[59],"death.":[61,117,144],"Fatal":[62],"significantly":[65],"older":[66,226],"than":[67,220],"survivors.":[68],"In":[69,145],"overall":[71],"multivariable":[72],"model,":[73],"weak":[74,150],"undetectable":[76,152],"pulse":[77,153],"(RR,":[78,86,95,105,120,132],"1.74;":[79],"95%":[80,88,97,107,122,134],"CI:":[81,89,98,108,123,135],"1.34-2.26),":[82],"late-stage":[83,155],"arterial":[84,156],"hypotension":[85,157],"1.80;":[87],"1.34-2.42),":[90],"progressive":[91,171],"increase":[92,172],"hematocrit":[94,174],"1.43;":[96],"1.10-1.85),":[99],"altered":[101],"level":[102],"of":[103,116,143,164,197,215],"consciousness":[104],"1.31;":[106],"1.02-1.67)":[109],"higher":[114,162],"risk":[115,142,163,196],"Conversely,":[118],"fever":[119,190],"0.72;":[121],"0.56-0.92)":[124],"sudden":[127,176],"drop":[128,178],"platelet":[130,177],"count":[131],"0.76;":[133],"0.59-0.91)":[136],"lower":[141,195],"exploratory":[147],"age-stratified":[148],"analyzes,":[149],"remained":[158],"both":[167],"age":[168],"groups,":[169],"while":[170],"only":[183,199],"individuals":[185],"aged":[186,202],"<60":[187],"years,":[188],"was":[191],"those":[201],"\u226560":[203],"years.":[204],"CONCLUSION:":[205],"Mortality":[206],"is":[210],"predominantly":[211],"markers":[214],"advanced":[216],"hemodynamic":[217],"instability":[218],"rather":[219],"early":[221],"warning":[222],"signs,":[223],"particularly":[224],"adults.":[227]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-29T00:00:00"}