{"id":"https://openalex.org/W7204589515","doi":"https://doi.org/10.21203/rs.3.rs-10450694/v1","title":"Delayed umbilical cord clamping and early maternal haematological outcomes: a calendar-time-adjusted cohort of 4,632 deliveries","display_name":"Delayed umbilical cord clamping and early maternal haematological outcomes: a calendar-time-adjusted cohort of 4,632 deliveries","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204589515","doi":"https://doi.org/10.21203/rs.3.rs-10450694/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10450694/v1","doi":"https://doi.org/10.21203/rs.3.rs-10450694/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10450694/v1","pdf_url":"https://www.researchsquare.com/article/rs-10450694/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10450694/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031243015","display_name":"G\u00fcl\u015fah Aynao\u011flu Y\u0131ld\u0131z","orcid":"https://orcid.org/0000-0002-3283-7783","observed_orcids":["https://orcid.org/0000-0002-3283-7783"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcl\u015fah Aynao\u011flu Y\u0131ld\u0131z","raw_affiliation_strings":["Ankara University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067846349","display_name":"G\u00f6ksu G\u00f6\u00e7","orcid":"https://orcid.org/0009-0003-1506-6061","observed_orcids":["https://orcid.org/0009-0003-1506-6061"]},"institutions":[{"id":"https://openalex.org/I4405259541","display_name":"American Hospital Kosovo","ror":"https://ror.org/02chhkx27","country_code":"XK","type":"healthcare","lineage":["https://openalex.org/I4405259541"]}],"countries":["XK"],"is_corresponding":false,"raw_author_name":"Goksu Goc","raw_affiliation_strings":["American Hospital Kosovo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Hospital Kosovo","institution_ids":["https://openalex.org/I4405259541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007032740","display_name":"Hasan S\u00fct","orcid":"https://orcid.org/0000-0003-0982-3356","observed_orcids":["https://orcid.org/0000-0003-0982-3356"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hasan S\u00fct","raw_affiliation_strings":["Ankara University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008311230","display_name":"Batuhan Turgay","orcid":"https://orcid.org/0000-0001-9927-181X","observed_orcids":["https://orcid.org/0000-0001-9927-181X"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Batuhan Turgay","raw_affiliation_strings":["Ankara University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134585309","display_name":"Bircan Yildirim Baydemir","orcid":"https://orcid.org/0000-0002-6950-7614","observed_orcids":["https://orcid.org/0000-0002-6950-7614"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bircan Y\u0131ld\u0131r\u0131m Baydemir","raw_affiliation_strings":["Ankara University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399236","display_name":"Engin \u00d6zt\u00fcrk","orcid":"https://orcid.org/0000-0002-6159-2009","observed_orcids":["https://orcid.org/0000-0002-6159-2009"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Engin \u00d6zt\u00fcrk","raw_affiliation_strings":["Ankara University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010490769","display_name":"Cem Somer Atabeko\u011flu","orcid":"https://orcid.org/0000-0003-0264-0709","observed_orcids":["https://orcid.org/0000-0003-0264-0709"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cem Somer Atabeko\u011flu","raw_affiliation_strings":["Ankara University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.79830002784729,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11389","display_name":"Maternal and fetal healthcare","score":0.13199999928474426,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/delayed-cord-clamping","display_name":"delayed cord clamping","score":0.9990000128746033},{"id":"https://openalex.org/keywords/postpartum-anemia","display_name":"postpartum anemia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/postpartum-hemorrhage","display_name":"postpartum hemorrhage","score":0.9950000047683716},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.9070000052452087},{"id":"https://openalex.org/keywords/maternal-hemoglobin","display_name":"maternal hemoglobin","score":0.6600000262260437},{"id":"https://openalex.org/keywords/propensity-score-matching","display_name":"propensity score matching","score":0.7689999938011169},{"id":"https://openalex.org/keywords/e-values","display_name":"E-value","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8855000138282776},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.65420001745224},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.5746999979019165},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5357000231742859},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5177000164985657},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5152999758720398},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.5012999773025513},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.49549999833106995},{"id":"https://openalex.org/C2780014101","wikidata":"https://www.wikidata.org/wiki/Q183605","display_name":"Blood transfusion","level":2,"score":0.4546000063419342},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.43880000710487366},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.4027999937534332},{"id":"https://openalex.org/C3020256200","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Cord clamping","level":3,"score":0.3765999972820282},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34459999203681946},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.32899999618530273},{"id":"https://openalex.org/C3018745865","wikidata":"https://www.wikidata.org/wiki/Q749115","display_name":"Postpartum period","level":3,"score":0.2989000082015991},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.29670000076293945},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.29600000381469727},{"id":"https://openalex.org/C2779632786","wikidata":"https://www.wikidata.org/wiki/Q920297","display_name":"Cord","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.258899986743927}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10450694/v1","doi":"https://doi.org/10.21203/rs.3.rs-10450694/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10450694/v1","pdf_url":"https://www.researchsquare.com/article/rs-10450694/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10450694/v1","doi":"https://doi.org/10.21203/rs.3.rs-10450694/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10450694/v1","pdf_url":"https://www.researchsquare.com/article/rs-10450694/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309936","display_name":"Ankara Universitesi","ror":"https://ror.org/01wntqw50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204589515.pdf","grobid_xml":"https://content.openalex.org/works/W7204589515.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W2013416277","https://openalex.org/W2112669742","https://openalex.org/W2134091451","https://openalex.org/W2275737843","https://openalex.org/W2735301415","https://openalex.org/W2804985670","https://openalex.org/W2989991269","https://openalex.org/W4213283844","https://openalex.org/W4375949635","https://openalex.org/W4388673311","https://openalex.org/W4388673371","https://openalex.org/W4390124454","https://openalex.org/W4390408859","https://openalex.org/W4409563100","https://openalex.org/W4412621015","https://openalex.org/W4415005834","https://openalex.org/W7161764707"],"related_works":["https://openalex.org/W7162571838","https://openalex.org/W7218736793","https://openalex.org/W4414391535","https://openalex.org/W2350876902","https://openalex.org/W3170583187","https://openalex.org/W4416785108","https://openalex.org/W2182217532","https://openalex.org/W3036478027","https://openalex.org/W4412997669","https://openalex.org/W6912059287"],"abstract_inverted_index":{"Abstract":[0],"Background.":[1],"Delayed":[2],"umbilical":[3],"cord":[4],"clamping":[5],"(DCC)":[6],"is":[7,24,287],"recommended":[8],"for":[9,50,79],"neonatal":[10],"benefit,":[11],"but":[12],"maternal":[13,44,280],"haematological":[14,45,281],"safety":[15],"concerns":[16],"persist":[17],"and":[18,41,70,126,141,289],"may":[19],"slow":[20],"uptake.":[21],"Because":[22],"DCC":[23,37,94,180,271],"adopted":[25],"progressively,":[26],"calendar":[27],"time":[28,104],"confounds":[29],"implementation-era":[30],"cohorts.":[31],"We":[32],"estimated":[33],"the":[34,80,137,177],"association":[35],"between":[36,66],"\u2265":[38,62,95,207,272],"60":[39,96,273],"seconds":[40,97,274],"early":[42],"postpartum":[43,150,185,201],"outcomes":[46,282],"with":[47,75,184,278],"explicit":[48],"adjustment":[49],"calendar-time":[51,225],"confounding.":[52,145],"Methods.":[53],"Single-centre":[54],"retrospective":[55],"cohort":[56,303],"of":[57],"4,644":[58],"consecutive":[59],"deliveries":[60],"at":[61,83,157],"22":[63],"weeks\u2019":[64],"gestation":[65],"6":[67,158],"June":[68],"2022":[69,171],"31":[71],"December":[72],"2024":[73],"(4,632":[74],"valid":[76],"delivery":[77,259,263],"dates":[78],"calendar-adjusted":[81],"analysis)":[82],"a":[84,108],"university":[85],"obstetric":[86],"department":[87],"in":[88,170,174,296],"Ankara,":[89],"Turkey.":[90],"The":[91,112,146,284],"exposure":[92],"was":[93,105,149,181,247,275],"versus":[98,232],"immediate":[99],"or":[100,212],"30-second":[101],"clamping.":[102],"Calendar":[103],"modelled":[106],"as":[107],"natural":[109],"cubic":[110],"spline.":[111],"primary":[113,147,178],"analysis":[114,220],"used":[115],"stabilised":[116],"inverse-probability-of-treatment":[117],"weighting":[118,125],"(IPTW);":[119],"covariate-adjusted":[120,195],"modified":[121],"Poisson":[122],"regression,":[123],"overlap":[124,198],"1:1":[127],"propensity-score":[128],"matching":[129],"were":[130],"complementary":[131],"analyses.":[132],"Firth-penalised":[133],"logistic":[134],"regression":[135],"handled":[136],"sparse":[138],"transfusion":[139,214],"outcome,":[140],"E-values":[142],"addressed":[143],"unmeasured":[144],"outcome":[148],"anaemia":[151,186],"(venous":[152],"haemoglobin":[153,205],"<":[154],"10":[155],"g/dL":[156,209],"hours).":[159],"Results.":[160],"1,889":[161],"(40.8%)":[162],"episodes":[163],"received":[164],"DCC;":[165],"adoption":[166],"rose":[167],"from":[168],"10.2%":[169],"to":[172],"62.3%":[173],"2024.":[175],"On":[176],"analysis,":[179,270],"not":[182,223,276],"associated":[183,277],"(stabilised":[187],"IPTW":[188],"risk":[189],"ratio":[190,250],"1.01,":[191],"95%":[192,252],"CI":[193,253],"0.88\u20131.16;":[194],"1.00,":[196],"0.91\u20131.10;":[197],"0.99,":[199],"0.87\u20131.13),":[200],"haemorrhage":[202],"(1.11,":[203],"0.77\u20131.59),":[204],"drop":[206],"2":[208],"(0.98,":[210],"0.81\u20131.18)":[211],"blood":[213],"(0.74,":[215],"0.24\u20132.25).":[216],"A":[217],"propensity-score-matched":[218],"sensitivity":[219],"that":[221],"did":[222],"achieve":[224],"balance":[226],"(maximum":[227],"standardised":[228],"mean":[229],"difference":[230],"0.18,":[231],"0.05":[233],"under":[234],"IPTW)":[235],"gave":[236],"concordant,":[237],"non-significant":[238],"estimates":[239],"(anaemia":[240],"0.93,":[241],"0.82\u20131.07).":[242],"An":[243],"exploratory":[244],"delivery-mode":[245,285],"interaction":[246],"observed":[248],"(interaction":[249],"0.78,":[251],"0.65\u20130.93;":[254],"p":[255],"=":[256],"0.007):":[257],"vaginal":[258],"1.19":[260],"(1.02\u20131.38);":[261],"caesarean":[262],"0.91":[264],"(0.81\u20131.03).":[265],"Conclusions.":[266],"After":[267],"calendar-time-adjusted":[268],"multimethod":[269],"worse":[279],"overall.":[283],"divergence":[286],"hypothesis-generating":[288],"warrants":[290],"prospective":[291],"evaluation":[292],"before":[293],"any":[294],"change":[295],"practice.":[297],"Trial":[298],"registration.":[299],"Not":[300],"applicable":[301],"(observational":[302],"study).":[304]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-29T00:00:00"}
