{"id":"https://openalex.org/W7204589382","doi":"https://doi.org/10.1111/acel.70692","title":"Shelterin TPP 1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells","display_name":"Shelterin TPP 1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204589382","doi":"https://doi.org/10.1111/acel.70692","pmid":"https://pubmed.ncbi.nlm.nih.gov/42663085","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13522991"},"language":"en","primary_location":{"id":"doi:10.1111/acel.70692","doi":"https://doi.org/10.1111/acel.70692","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70692","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1111/acel.70692","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114334475","display_name":"Lihui Wang","orcid":"https://orcid.org/0000-0003-4038-6473","observed_orcids":["https://orcid.org/0000-0003-4038-6473"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lihui Wang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0003-4038-6473","affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148498425","display_name":"Bihan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bihan Zhao","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015823958","display_name":"Jiahui Yang","orcid":"https://orcid.org/0000-0002-7704-8585","observed_orcids":["https://orcid.org/0000-0002-7704-8585","https://orcid.org/0000-0001-7613-6615"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahui Yang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148517860","display_name":"Ying Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111051346","display_name":"Yitian Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yitian Yao","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148561748","display_name":"Xiao Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Xiao","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148512353","display_name":"Long Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Long Yang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148549857","display_name":"Jinghao Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinghao Xia","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101457908","display_name":"Haoze Li","orcid":"https://orcid.org/0000-0003-0463-7335","observed_orcids":["https://orcid.org/0000-0003-0463-7335"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoze Li","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148480183","display_name":"Ling Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Gao","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148503742","display_name":"Jun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002546584","display_name":"Tianci Su","orcid":"https://orcid.org/0009-0006-6553-0979","observed_orcids":["https://orcid.org/0009-0006-6553-0979"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianci Su","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0009-0006-6553-0979","affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148505783","display_name":"Hao Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Xu","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148526097","display_name":"Jiacheng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiacheng Zhang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]},{"raw_affiliation_string":"Postgraduate Program on Ageing Biology Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359685","display_name":"Hongyan Wang","orcid":"https://orcid.org/0009-0000-3994-5456","observed_orcids":["https://orcid.org/0009-0000-3994-5456"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyan Wang","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361993","display_name":"Jun Liu","orcid":"https://orcid.org/0000-0002-9565-5207","observed_orcids":["https://orcid.org/0000-0002-9565-5207"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Jun Liu","raw_affiliation_strings":["Department of Immunology and Pathology, Central Clinical School, Faculty of Medicine Monash University  Prahran Victoria Australia","Hangzhou Duanli Biotechnology Company Limited  Hangzhou Zhejiang China","Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0002-9565-5207","affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, Central Clinical School, Faculty of Medicine Monash University  Prahran Victoria Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Hangzhou Duanli Biotechnology Company Limited  Hangzhou Zhejiang China","institution_ids":[]},{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076900408","display_name":"Xiaojing Hong","orcid":"https://orcid.org/0000-0002-5007-4572","observed_orcids":["https://orcid.org/0000-0002-5007-4572"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Hong","raw_affiliation_strings":["Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0002-5007-4572","affiliations":[{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100734995","display_name":"Junping Liu","orcid":"https://orcid.org/0000-0001-7442-2116","observed_orcids":["https://orcid.org/0000-0001-7442-2116"]},"institutions":[{"id":"https://openalex.org/I163151501","display_name":"Hangzhou Normal University","ror":"https://ror.org/014v1mr15","country_code":"CN","type":"education","lineage":["https://openalex.org/I163151501"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","CN"],"is_corresponding":false,"raw_author_name":"Jun\u2010Ping Liu","raw_affiliation_strings":["Department of Immunology and Pathology, Central Clinical School, Faculty of Medicine Monash University  Prahran Victoria Australia","Hangzhou Duanli Biotechnology Company Limited  Hangzhou Zhejiang China","Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China"],"raw_orcid":"https://orcid.org/0000-0001-7442-2116","affiliations":[{"raw_affiliation_string":"Department of Immunology and Pathology, Central Clinical School, Faculty of Medicine Monash University  Prahran Victoria Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Hangzhou Duanli Biotechnology Company Limited  Hangzhou Zhejiang China","institution_ids":[]},{"raw_affiliation_string":"Institute of Ageing Research Hangzhou Normal University, School of Basic Medical Sciences  Hangzhou Zhejiang China","institution_ids":["https://openalex.org/I163151501"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5114334475"],"corresponding_institution_ids":["https://openalex.org/I163151501"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.64743412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"9","first_page":"e70692","last_page":"e70692"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tpp1","display_name":"TPP1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/shelterin","display_name":"shelterin","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hair-regrowth","display_name":"hair regrowth","score":0.8199999928474426},{"id":"https://openalex.org/keywords/telomere-capping","display_name":"telomere capping","score":0.9240000247955322},{"id":"https://openalex.org/keywords/telomerase-recruitment","display_name":"telomerase recruitment","score":0.8859999775886536},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.6869999766349792},{"id":"https://openalex.org/keywords/octapeptide","display_name":"octapeptide","score":0.5889999866485596},{"id":"https://openalex.org/keywords/alopecia","display_name":"hair loss","score":0.7620000243186951},{"id":"https://openalex.org/keywords/anagen-induction","display_name":"anagen induction","score":0.5669999718666077},{"id":"https://openalex.org/keywords/stem-cell-mobilization","display_name":"stem cell mobilization","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2776879488","wikidata":"https://www.wikidata.org/wiki/Q3959366","display_name":"Shelterin","level":5,"score":0.8877999782562256},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.8500000238418579},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8238999843597412},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8177000284194946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7627000212669373},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6992999911308289},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6402000188827515},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5485000014305115},{"id":"https://openalex.org/C202265312","wikidata":"https://www.wikidata.org/wiki/Q7697810","display_name":"Telomere-binding protein","level":5,"score":0.5153999924659729},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.49320000410079956},{"id":"https://openalex.org/C2991961867","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair cycle","level":3,"score":0.41440001130104065},{"id":"https://openalex.org/C2776360568","wikidata":"https://www.wikidata.org/wiki/Q2697787","display_name":"Hair loss","level":2,"score":0.35749998688697815},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3240000009536743},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.31139999628067017},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2687000036239624},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.257099986076355},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2533000111579895},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.25209999084472656}],"mesh":[{"descriptor_ui":"D000089804","descriptor_name":"Shelterin Complex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000089804","descriptor_name":"Shelterin Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018859","descriptor_name":"Hair Follicle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D035341","descriptor_name":"Telomeric Repeat Binding Protein 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059505","descriptor_name":"Telomere Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/acel.70692","doi":"https://doi.org/10.1111/acel.70692","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70692","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:42663085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42663085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13522991","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13522991/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/acel.70692","doi":"https://doi.org/10.1111/acel.70692","is_oa":true,"landing_page_url":"https://doi.org/10.1111/acel.70692","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2565947008","display_name":null,"funder_award_id":"92149302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2695382128","display_name":null,"funder_award_id":"82271594","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4132603349","display_name":null,"funder_award_id":"2021ZD0202402","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5955769324","display_name":null,"funder_award_id":"2022YFA1103800","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6094782400","display_name":null,"funder_award_id":"82130044","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7514213368","display_name":null,"funder_award_id":"91949207","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W1500703123","https://openalex.org/W1964872204","https://openalex.org/W1967266026","https://openalex.org/W1980332250","https://openalex.org/W1982006042","https://openalex.org/W1982098423","https://openalex.org/W1988086159","https://openalex.org/W2001801229","https://openalex.org/W2011882274","https://openalex.org/W2011982665","https://openalex.org/W2016835212","https://openalex.org/W2020969391","https://openalex.org/W2021264577","https://openalex.org/W2021689495","https://openalex.org/W2024209230","https://openalex.org/W2027330624","https://openalex.org/W2034986957","https://openalex.org/W2037146644","https://openalex.org/W2042377388","https://openalex.org/W2050166933","https://openalex.org/W2053549195","https://openalex.org/W2062772596","https://openalex.org/W2065841924","https://openalex.org/W2081588299","https://openalex.org/W2085786821","https://openalex.org/W2088823531","https://openalex.org/W2104293217","https://openalex.org/W2116358704","https://openalex.org/W2138977668","https://openalex.org/W2139867317","https://openalex.org/W2148197898","https://openalex.org/W2151011478","https://openalex.org/W2151034792","https://openalex.org/W2152203075","https://openalex.org/W2161092951","https://openalex.org/W2169630576","https://openalex.org/W2219142985","https://openalex.org/W2266122743","https://openalex.org/W2508099675","https://openalex.org/W2553534905","https://openalex.org/W2786421413","https://openalex.org/W2796689110","https://openalex.org/W2893877805","https://openalex.org/W2951351982","https://openalex.org/W2973194155","https://openalex.org/W2995359774","https://openalex.org/W3008878431","https://openalex.org/W3016764122","https://openalex.org/W3030641692","https://openalex.org/W3044753068","https://openalex.org/W3047493479","https://openalex.org/W3093938386","https://openalex.org/W3121770542","https://openalex.org/W3131256500","https://openalex.org/W3165921003","https://openalex.org/W3175982467","https://openalex.org/W3204674240","https://openalex.org/W4214854173","https://openalex.org/W4281492131","https://openalex.org/W4309909006","https://openalex.org/W4321377304","https://openalex.org/W4390604475","https://openalex.org/W4410489449"],"related_works":["https://openalex.org/W2587442051","https://openalex.org/W2085786821","https://openalex.org/W4386438949","https://openalex.org/W7167974283","https://openalex.org/W3121770542","https://openalex.org/W4403987788","https://openalex.org/W4213414565","https://openalex.org/W2418415173","https://openalex.org/W2676312360","https://openalex.org/W4214645614"],"abstract_inverted_index":{"Telomere":[0],"shortening":[1],"drives":[2,99],"hair":[3,38,60,67,86,114,133],"follicle":[4,68],"senescence,":[5],"yet":[6],"successful":[7],"reversal":[8],"of":[9,23,43,49,85,113],"this":[10],"aging":[11],"process":[12],"has":[13],"remained":[14],"elusive.":[15],"Here,":[16],"we":[17],"report":[18],"that":[19,35,54,123],"stem":[20,69],"cell":[21],"overexpression":[22],"Acd,":[24],"the":[25,81,89,94],"gene":[26],"encoding":[27],"TPP1":[28,44,56,64,98,108],"(telomere":[29],"protection":[30],"protein":[31,45],"1)-a":[32],"shelterin":[33],"component":[34],"recruits":[36],"telomerase-accelerates":[37],"regeneration":[39,115],"in":[40],"mice.":[41],"Stabilization":[42],"via":[46],"topical":[47,124],"application":[48],"TELODIN,":[50],"a":[51,110,127,138],"synthetic":[52],"octapeptide":[53],"inhibits":[55],"degradation,":[57],"similarly":[58],"promotes":[59],"regeneration.":[61],"Mechanistically,":[62],"increased":[63],"mobilizes":[65],"bulge":[66],"cells":[70],"(bHFSCs)":[71],"by":[72],"coordinating":[73],"telomere":[74,117],"capping":[75,118],"and":[76,83,103,119,121],"telomerase":[77],"recruitment.":[78],"By":[79],"facilitating":[80],"synchronization":[82],"transition":[84],"follicles":[87],"from":[88],"quiescent":[90],"telogen":[91],"phase":[92],"to":[93],"proliferative":[95],"anagen":[96],"phase,":[97],"bHFSCs":[100],"proliferation,":[101],"differentiation,":[102],"migration.":[104],"These":[105],"findings":[106],"identify":[107],"as":[109],"master":[111],"regulator":[112],"through":[116],"elongation,":[120],"suggest":[122],"TELODIN":[125],"represents":[126],"novel":[128],"therapeutic":[129,139],"strategy":[130],"for":[131,141],"advancing":[132],"growth.":[134],"This":[135],"work":[136],"establishes":[137],"framework":[140],"telomere-targeted":[142],"interventions":[143],"against":[144],"alopecia.":[145]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-29T00:00:00"}