{"id":"https://openalex.org/W7204570271","doi":"https://doi.org/10.4018/979-8-2600-0161-5.ch011","title":"Artificial Intelligence in Gene and Cell Therapies: From Vector Design and Manufacturing to Safety, Explainability, and Risk Assessment","display_name":"Artificial Intelligence in Gene and Cell Therapies: From Vector Design and Manufacturing to Safety, Explainability, and Risk Assessment","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7204570271","doi":"https://doi.org/10.4018/979-8-2600-0161-5.ch011"},"language":"en","primary_location":{"id":"doi:10.4018/979-8-2600-0161-5.ch011","doi":"https://doi.org/10.4018/979-8-2600-0161-5.ch011","is_oa":false,"landing_page_url":"https://doi.org/10.4018/979-8-2600-0161-5.ch011","pdf_url":null,"source":{"id":"https://openalex.org/S4210180746","display_name":"Advances in computational intelligence and robotics book series","issn_l":"2327-042X","issn":["2327-042X","2327-0411"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Computational Intelligence and Robotics","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W7204537094","display_name":"AI-Driven Innovations in Genome, Epigenome, and Mitochondrial Therapies"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120415975","display_name":"Praveen Javali R.","orcid":"https://orcid.org/0009-0001-3737-5813","observed_orcids":["https://orcid.org/0009-0001-3737-5813"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Praveen Javali R.","raw_affiliation_strings":["Sri Raghavendra College of Pharmacy, Chitradurga, India"],"raw_orcid":"https://orcid.org/0009-0001-3737-5813","affiliations":[{"raw_affiliation_string":"Sri Raghavendra College of Pharmacy, Chitradurga, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051990467","display_name":"Godfred Antony Menezes","orcid":"https://orcid.org/0000-0002-4102-2279","observed_orcids":["https://orcid.org/0000-0002-4102-2279"]},"institutions":[{"id":"https://openalex.org/I2799616653","display_name":"Trinity School of Medicine","ror":"https://ror.org/00z50t224","country_code":"VC","type":"education","lineage":["https://openalex.org/I2799616653"]}],"countries":["VC"],"is_corresponding":false,"raw_author_name":"Godfred Antony Menezes","raw_affiliation_strings":["Trinity Medical Sciences University, Grenada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trinity Medical Sciences University, Grenada","institution_ids":["https://openalex.org/I2799616653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148482585","display_name":"Sathvik Belagodu Sridhar","orcid":"https://orcid.org/0009-0000-6604-9884","observed_orcids":["https://orcid.org/0009-0000-6604-9884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sathvik Belagodu Sridhar","raw_affiliation_strings":["Dubai Medical University, UAE"],"raw_orcid":"https://orcid.org/0009-0000-6604-9884","affiliations":[{"raw_affiliation_string":"Dubai Medical University, UAE","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148563306","display_name":"R. Udayakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I220840466","display_name":"Chettinad Academy of Research and Education","ror":"https://ror.org/0394w2w14","country_code":"IN","type":"education","lineage":["https://openalex.org/I220840466"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"R. Udayakumar","raw_affiliation_strings":["Chettinad School of Pharmaceutical Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chettinad School of Pharmaceutical Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India","institution_ids":["https://openalex.org/I220840466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148558037","display_name":"Sujan Adithyan T.","orcid":"https://orcid.org/0000-0002-8425-1741","observed_orcids":["https://orcid.org/0000-0002-8425-1741"]},"institutions":[{"id":"https://openalex.org/I4210099837","display_name":"Sri Ramakrishna Institute of Paramedical Sciences","ror":"https://ror.org/01t413275","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210099837"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sujan Adithyan T.","raw_affiliation_strings":["College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, India"],"raw_orcid":"https://orcid.org/0000-0002-8425-1741","affiliations":[{"raw_affiliation_string":"College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, India","institution_ids":["https://openalex.org/I4210099837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5120462603","display_name":"Dhanalakshmi Perumal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19926482","display_name":"Dr. M.G.R. Educational and Research Institute","ror":"https://ror.org/053hsst90","country_code":"IN","type":"education","lineage":["https://openalex.org/I19926482"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. Dhanalakshmi","raw_affiliation_strings":["Dr. MGR Educational and Research Institute, India"],"raw_orcid":"https://orcid.org/0009-0004-2804-140X","affiliations":[{"raw_affiliation_string":"Dr. MGR Educational and Research Institute, India","institution_ids":["https://openalex.org/I19926482"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"325","last_page":"350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.055399999022483826,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.020500000566244125,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.5640000104904175},{"id":"https://openalex.org/keywords/viral-vector-design","display_name":"viral vector design","score":0.8569999933242798},{"id":"https://openalex.org/keywords/non-viral-vectors","display_name":"non-viral vectors","score":0.968999981880188},{"id":"https://openalex.org/keywords/crispr-guide-rna-design","display_name":"CRISPR guide RNA design","score":0.9940000176429749},{"id":"https://openalex.org/keywords/synthetic-promoters","display_name":"synthetic promoters","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tissue-targeting","display_name":"tissue targeting","score":0.9610000252723694},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7919999957084656},{"id":"https://openalex.org/keywords/digital-twin","display_name":"digital twin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.8970000147819519},{"id":"https://openalex.org/keywords/process-analytical-technology","display_name":"process analytical technology","score":0.9070000052452087},{"id":"https://openalex.org/keywords/gmp-compliance","display_name":"GMP compliance","score":0.9779999852180481},{"id":"https://openalex.org/keywords/explainable-ai","display_name":"explainable AI","score":0.9810000061988831},{"id":"https://openalex.org/keywords/regulatory-pathways","display_name":"regulatory pathways","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2775893736","wikidata":"https://www.wikidata.org/wiki/Q25324110","display_name":"Biomanufacturing","level":2,"score":0.7759000062942505},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5322999954223633},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.5242000222206116},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.49129998683929443},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.48829999566078186},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42260000109672546},{"id":"https://openalex.org/C105339364","wikidata":"https://www.wikidata.org/wiki/Q2297740","display_name":"Software deployment","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.39739999175071716},{"id":"https://openalex.org/C157170001","wikidata":"https://www.wikidata.org/wiki/Q4781507","display_name":"Applications of artificial intelligence","level":2,"score":0.3961000144481659},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.35589998960494995},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.31279999017715454},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3043000102043152},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2989000082015991}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4018/979-8-2600-0161-5.ch011","doi":"https://doi.org/10.4018/979-8-2600-0161-5.ch011","is_oa":false,"landing_page_url":"https://doi.org/10.4018/979-8-2600-0161-5.ch011","pdf_url":null,"source":{"id":"https://openalex.org/S4210180746","display_name":"Advances in computational intelligence and robotics book series","issn_l":"2327-042X","issn":["2327-042X","2327-0411"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320424","host_organization_name":"IGI Global","host_organization_lineage":["https://openalex.org/P4310320424"],"host_organization_lineage_names":["IGI Global"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Computational Intelligence and Robotics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W4315650911","https://openalex.org/W4384926075","https://openalex.org/W4389987395","https://openalex.org/W4390059959","https://openalex.org/W4390666110","https://openalex.org/W4391534156","https://openalex.org/W4392517630","https://openalex.org/W4392561142","https://openalex.org/W4396939865","https://openalex.org/W4400612253","https://openalex.org/W4403230933","https://openalex.org/W4403540098","https://openalex.org/W4403845104","https://openalex.org/W4406033696","https://openalex.org/W4406338128","https://openalex.org/W4407087887","https://openalex.org/W4407165342","https://openalex.org/W4407263126","https://openalex.org/W4407385788","https://openalex.org/W4412184032","https://openalex.org/W4412366549","https://openalex.org/W4413757884","https://openalex.org/W4416336877","https://openalex.org/W4416997559","https://openalex.org/W7117409363","https://openalex.org/W7122471954","https://openalex.org/W7125595344","https://openalex.org/W7131788694","https://openalex.org/W7147059604","https://openalex.org/W7154988754","https://openalex.org/W7159571651","https://openalex.org/W7161144750","https://openalex.org/W7162438691","https://openalex.org/W7162654897","https://openalex.org/W7163711846","https://openalex.org/W7164313325"],"related_works":["https://openalex.org/W7204554781","https://openalex.org/W7214118982","https://openalex.org/W7204575726","https://openalex.org/W7204588217","https://openalex.org/W7196983362","https://openalex.org/W7135082757","https://openalex.org/W4383480858","https://openalex.org/W7135227096","https://openalex.org/W7160090152","https://openalex.org/W4416231836"],"abstract_inverted_index":{"This":[0],"chapter":[1,34,69,100],"per":[2,35,70,101],"the":[3,10,36,71,74,102,105],"authors":[4,37,72,103],"provides":[5],"a":[6],"comprehensive":[7],"analysis":[8],"of":[9,32,76,107],"shift":[11],"in":[12,112],"gene":[13],"and":[14,47,55,84,93,121],"cell":[15],"therapies":[16],"(GCTs)":[17],"from":[18],"trial-and-error":[19],"discovery":[20],"to":[21,39,59,89,117],"predictive":[22],"rational":[23],"design":[24,50],"powered":[25],"by":[26,81],"artificial":[27],"intelligence":[28],"(AI).":[29],"The":[30],"purpose":[31],"this":[33,68,99],"is":[38],"detail":[40],"how":[41],"deep":[42],"learning":[43],"models":[44],"optimize":[45],"viral":[46],"non-viral":[48],"vectors,":[49],"precise":[51],"CRISPR":[52],"guide":[53],"RNAs,":[54],"map":[56],"synthetic":[57],"promoters":[58],"improve":[60],"tissue":[61],"targeting":[62],"while":[63],"minimizing":[64],"host":[65],"immunogenicity.":[66],"Furthermore,":[67],"summarizes":[73],"deployment":[75],"AI-driven":[77],"digital":[78],"twins,":[79],"Quality":[80],"Design":[82],"(QbD),":[83],"Process":[85],"Analytical":[86],"Technology":[87],"(PAT)":[88],"streamline":[90],"biomanufacturing":[91],"scale-up":[92],"ensure":[94],"strict":[95],"GMP":[96],"compliance.":[97],"Lastly,":[98],"highlights":[104],"role":[106],"Explainable":[108],"AI":[109],"(XAI)":[110],"frameworks":[111],"overcoming":[113],"\u201cblack":[114],"box\u201d":[115],"challenges":[116],"secure":[118],"clinical":[119],"trust":[120],"navigate":[122],"modern":[123],"regulatory":[124],"pathways.":[125]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-29T00:00:00"}