{"id":"https://openalex.org/W7204569046","doi":"https://doi.org/10.1080/17425247.2026.2726474","title":"Microenvironment-adaptive drug delivery systems for ulcerative colitis: from pathological constraints to rational design","display_name":"Microenvironment-adaptive drug delivery systems for ulcerative colitis: from pathological constraints to rational design","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204569046","doi":"https://doi.org/10.1080/17425247.2026.2726474","pmid":"https://pubmed.ncbi.nlm.nih.gov/42663519"},"language":"en","primary_location":{"id":"doi:10.1080/17425247.2026.2726474","doi":"https://doi.org/10.1080/17425247.2026.2726474","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425247.2026.2726474","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079055779","display_name":"Xinlu Lin","orcid":"https://orcid.org/0000-0002-0637-9440","observed_orcids":["https://orcid.org/0000-0002-0637-9440"]},"institutions":[{"id":"https://openalex.org/I4210143819","display_name":"Taizhou First People's Hospital","ror":"https://ror.org/04jyt7608","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143819"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinlu Lin","raw_affiliation_strings":["Taizhou First People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210143819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148569587","display_name":"Yingmin Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143819","display_name":"Taizhou First People's Hospital","ror":"https://ror.org/04jyt7608","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143819"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingmin Han","raw_affiliation_strings":["Taizhou First People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210143819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088442213","display_name":"Qiaojing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143819","display_name":"Taizhou First People's Hospital","ror":"https://ror.org/04jyt7608","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143819"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaojing Chen","raw_affiliation_strings":["Taizhou First People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210143819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084818765","display_name":"Longfa Kou","orcid":"https://orcid.org/0000-0001-8502-4279","observed_orcids":["https://orcid.org/0000-0001-8502-4279"]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longfa Kou","raw_affiliation_strings":["The Second Affiliated Hospital of Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055595658","display_name":"Weilan Cao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weilan Cao","raw_affiliation_strings":["The Second Affiliated Hospital of Wenzhou Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Wenzhou Medical University","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101161798","display_name":"Zhenye Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210143819","display_name":"Taizhou First People's Hospital","ror":"https://ror.org/04jyt7608","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143819"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhenye Liang","raw_affiliation_strings":["Taizhou First People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taizhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210143819"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055595658","https://openalex.org/A5101161798"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210143819"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"11","first_page":"1991","last_page":"2009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/epithelial-permeability","display_name":"epithelial permeability","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8429999947547913},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5540000200271606},{"id":"https://openalex.org/keywords/drug-delivery-system-design","display_name":"drug delivery system design","score":0.6230000257492065},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.578000009059906},{"id":"https://openalex.org/keywords/colorectal-cancer-risk","display_name":"colorectal cancer risk","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.65420001745224},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.6539999842643738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6150000095367432},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.5805000066757202},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.5234000086784363},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.447299987077713},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40369999408721924},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3970000147819519},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.3212999999523163},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3206999897956848},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.27709999680519104},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.275299996137619},{"id":"https://openalex.org/C33276779","wikidata":"https://www.wikidata.org/wiki/Q1943363","display_name":"Design elements and principles","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C148482608","wikidata":"https://www.wikidata.org/wiki/Q17007018","display_name":"Clinical study design","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.2705000042915344},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.2639000117778778},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26330000162124634},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.251800000667572}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050997","descriptor_name":"Nanomedicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/17425247.2026.2726474","doi":"https://doi.org/10.1080/17425247.2026.2726474","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425247.2026.2726474","pdf_url":null,"source":{"id":"https://openalex.org/S51663496","display_name":"Expert Opinion on Drug Delivery","issn_l":"1742-5247","issn":["1742-5247","1744-7593"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Delivery","raw_type":"journal-article"},{"id":"pmid:42663519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42663519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug delivery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1118981124","display_name":null,"funder_award_id":"24ywa31","funder_id":"https://openalex.org/F4320327078","funder_display_name":"Taizhou Municipal Science and Technology Bureau"}],"funders":[{"id":"https://openalex.org/F4320327078","display_name":"Taizhou Municipal Science and Technology Bureau","ror":"https://ror.org/041fzeq08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W84286934","https://openalex.org/W2040071171","https://openalex.org/W2112981618","https://openalex.org/W2121752597","https://openalex.org/W2275979875","https://openalex.org/W2553062788","https://openalex.org/W2583464358","https://openalex.org/W2771478918","https://openalex.org/W2796439254","https://openalex.org/W2893905632","https://openalex.org/W2895397303","https://openalex.org/W2919464773","https://openalex.org/W2944726119","https://openalex.org/W2988133514","https://openalex.org/W2996732414","https://openalex.org/W3000124921","https://openalex.org/W3021491219","https://openalex.org/W3033320057","https://openalex.org/W3037194019","https://openalex.org/W3041638543","https://openalex.org/W3046601338","https://openalex.org/W3047259787","https://openalex.org/W3080785846","https://openalex.org/W3086885273","https://openalex.org/W3089703056","https://openalex.org/W3095291274","https://openalex.org/W3095353222","https://openalex.org/W3096570720","https://openalex.org/W3127977488","https://openalex.org/W3132733467","https://openalex.org/W3133913503","https://openalex.org/W3151127971","https://openalex.org/W3153452775","https://openalex.org/W3162881442","https://openalex.org/W3182900632","https://openalex.org/W3210087486","https://openalex.org/W3210596355","https://openalex.org/W3213133224","https://openalex.org/W3213927789","https://openalex.org/W3215661837","https://openalex.org/W4200104154","https://openalex.org/W4205965662","https://openalex.org/W4210638841","https://openalex.org/W4210972027","https://openalex.org/W4214671786","https://openalex.org/W4220962047","https://openalex.org/W4220972783","https://openalex.org/W4223518444","https://openalex.org/W4223969474","https://openalex.org/W4229052139","https://openalex.org/W4229060313","https://openalex.org/W4280652689","https://openalex.org/W4283741169","https://openalex.org/W4284883841","https://openalex.org/W4292396183","https://openalex.org/W4294953426","https://openalex.org/W4295277458","https://openalex.org/W4296984762","https://openalex.org/W4297474392","https://openalex.org/W4310136189","https://openalex.org/W4312198107","https://openalex.org/W4315928343","https://openalex.org/W4317036381","https://openalex.org/W4321378810","https://openalex.org/W4321490850","https://openalex.org/W4327547010","https://openalex.org/W4364355592","https://openalex.org/W4366140902","https://openalex.org/W4376106927","https://openalex.org/W4376226254","https://openalex.org/W4378839946","https://openalex.org/W4381335885","https://openalex.org/W4383998698","https://openalex.org/W4384820136","https://openalex.org/W4385202529","https://openalex.org/W4385294803","https://openalex.org/W4385983925","https://openalex.org/W4386529459","https://openalex.org/W4387611106","https://openalex.org/W4388850978","https://openalex.org/W4389581132","https://openalex.org/W4390033247","https://openalex.org/W4390080356","https://openalex.org/W4390794500","https://openalex.org/W4391347598","https://openalex.org/W4391744388","https://openalex.org/W4394968957","https://openalex.org/W4396777841","https://openalex.org/W4398212574","https://openalex.org/W4398975368","https://openalex.org/W4399021600","https://openalex.org/W4399090062","https://openalex.org/W4399652801","https://openalex.org/W4400548560","https://openalex.org/W4400614768","https://openalex.org/W4400664149","https://openalex.org/W4400665023","https://openalex.org/W4400901468","https://openalex.org/W4401372318","https://openalex.org/W4401698446","https://openalex.org/W4401827793","https://openalex.org/W4401845953","https://openalex.org/W4402739103","https://openalex.org/W4403064309","https://openalex.org/W4403502198","https://openalex.org/W4404001560","https://openalex.org/W4404171178","https://openalex.org/W4404358384","https://openalex.org/W4405741333","https://openalex.org/W4405911107","https://openalex.org/W4407079257","https://openalex.org/W4407099442","https://openalex.org/W4407553838","https://openalex.org/W4408884421","https://openalex.org/W4409208202","https://openalex.org/W4409300328","https://openalex.org/W4409434336","https://openalex.org/W4409514794","https://openalex.org/W4410244041","https://openalex.org/W4410470910","https://openalex.org/W4410570992","https://openalex.org/W4410976582","https://openalex.org/W4411227592","https://openalex.org/W4411779134","https://openalex.org/W4412141622","https://openalex.org/W4413106486","https://openalex.org/W4413307436","https://openalex.org/W4413347569","https://openalex.org/W4414190098","https://openalex.org/W4414520104","https://openalex.org/W4415723027","https://openalex.org/W4416094714","https://openalex.org/W4416642835","https://openalex.org/W4416676008","https://openalex.org/W4416839158","https://openalex.org/W7117747902","https://openalex.org/W7118177393","https://openalex.org/W7128023904"],"related_works":["https://openalex.org/W7118177393","https://openalex.org/W4386575224","https://openalex.org/W4409530567","https://openalex.org/W7172336486","https://openalex.org/W7117703874","https://openalex.org/W3119750045","https://openalex.org/W7128677365","https://openalex.org/W7128731125","https://openalex.org/W7127916026","https://openalex.org/W4412901719"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Ulcerative":[1],"colitis":[2],"(UC)":[3],"is":[4,14],"characterized":[5,37],"by":[6,38,153],"recurrent,":[7],"chronic,":[8],"and":[9,47,77,104,115,133,161,176],"nonspecific":[10],"intestinal":[11],"inflammation.":[12],"It":[13],"strongly":[15],"associated":[16],"with":[17,94],"an":[18],"increased":[19,42],"risk":[20],"of":[21,35,55,86,138,156,183],"colorectal":[22],"cancer,":[23],"representing":[24],"a":[25,95,129,154],"global":[26],"public":[27],"health":[28],"challenge.":[29],"However,":[30],"the":[31,52,83,136,144,180],"complex":[32],"pathological":[33,146],"microenvironment":[34],"UC,":[36],"mucus":[39],"barrier":[40],"disruption,":[41],"epithelial":[43],"permeability,":[44],"immune":[45],"dysregulation,":[46],"oxidative":[48],"stress,":[49],"substantially":[50],"compromises":[51],"therapeutic":[53,84,170],"efficacy":[54],"conventional":[56],"drugs.":[57],"AREAS":[58],"COVERED:":[59],"Nanomedicine":[60],"delivery":[61,116,140,162],"systems":[62,71,185],"have":[63],"offered":[64],"new":[65,177],"opportunities":[66],"for":[67,179,186],"UC":[68],"treatment,":[69],"these":[70],"can":[72,164],"optimize":[73],"drug":[74],"transport,":[75],"distribution,":[76],"controlled":[78],"release,":[79],"thereby":[80],"better":[81],"addressing":[82],"requirements":[85],"UC.":[87,187],"Relevant":[88],"literature":[89],"was":[90],"identified":[91],"through":[92],"PubMed,":[93],"primary":[96],"focus":[97],"on":[98],"studies":[99],"published":[100],"between":[101,112],"January":[102],"2016":[103],"August":[105],"2026.":[106],"EXPERT":[107],"OPINION:":[108],"The":[109],"fundamental":[110],"relationship":[111],"disease":[113],"pathology":[114],"system":[117],"design":[118,150,182],"remains":[119],"insufficiently":[120],"explored.":[121],"To":[122],"address":[123],"this":[124,126],"gap,":[125],"review":[127,173],"proposes":[128],"pathology-driven":[130],"microenvironment-adaptive":[131,169,184],"framework":[132],"critically":[134],"evaluates":[135],"limitations":[137],"current":[139],"strategies.":[141,171],"We":[142],"translate":[143],"key":[145],"barriers":[147],"into":[148],"actionable":[149],"criteria,":[151],"followed":[152],"discussion":[155],"how":[157],"molecular":[158],"building":[159],"blocks":[160],"platforms":[163],"be":[165],"engineered":[166],"to":[167],"realize":[168],"This":[172],"provides":[174],"insights":[175],"perspectives":[178],"rational":[181]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-29T00:00:00"}
