{"id":"https://openalex.org/W7204556741","doi":"https://doi.org/10.1038/s41598-026-66465-6","title":"Ecological associations of environmental and behavioral factors with provincial urinary system mortality trajectories in T\u00fcrkiye","display_name":"Ecological associations of environmental and behavioral factors with provincial urinary system mortality trajectories in T\u00fcrkiye","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204556741","doi":"https://doi.org/10.1038/s41598-026-66465-6"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-66465-6","doi":"https://doi.org/10.1038/s41598-026-66465-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-66465-6","pdf_url":"https://www.nature.com/articles/s41598-026-66465-6_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-66465-6_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016812694","display_name":"Mehmet Ko\u00e7ak","orcid":"https://orcid.org/0000-0002-3386-1734","observed_orcids":["https://orcid.org/0000-0002-3386-1734","https://orcid.org/0000-0003-0782-390X"]},"institutions":[{"id":"https://openalex.org/I3125470973","display_name":"Istanbul Medipol University","ror":"https://ror.org/037jwzz50","country_code":"TR","type":"education","lineage":["https://openalex.org/I3125470973"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Mehmet Kocak","raw_affiliation_strings":["International School of Medicine, Istanbul Medipol University, SABITA, Istanbul, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3386-1734","affiliations":[{"raw_affiliation_string":"International School of Medicine, Istanbul Medipol University, SABITA, Istanbul, Turkey","institution_ids":["https://openalex.org/I3125470973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016812694"],"corresponding_institution_ids":["https://openalex.org/I3125470973"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6536136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12935","display_name":"Healthcare Systems and Public Health","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11244","display_name":"Climate Change and Health Impacts","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7580000162124634},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":1.0},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mortality-trajectories","display_name":"mortality trajectories","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ecological-associations","display_name":"ecological associations","score":0.6079999804496765},{"id":"https://openalex.org/keywords/atmospheric-pressure","display_name":"atmospheric pressure","score":0.7519999742507935},{"id":"https://openalex.org/keywords/pm10","display_name":"PM10","score":0.7699999809265137},{"id":"https://openalex.org/keywords/humidity","display_name":"humidity","score":0.5090000033378601},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.7059999704360962},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.953000009059906},{"id":"https://openalex.org/keywords/passive-smoking","display_name":"passive smoking","score":0.7059999704360962},{"id":"https://openalex.org/keywords/weather-variability","display_name":"weather variability","score":0.9800000190734863},{"id":"https://openalex.org/keywords/turkiye-provinces","display_name":"T\u00fcrkiye provinces","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5958999991416931},{"id":"https://openalex.org/C25511272","wikidata":"https://www.wikidata.org/wiki/Q295136","display_name":"Ecological study","level":3,"score":0.4643999934196472},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.4512999951839447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42010000348091125},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.4194999933242798},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.41909998655319214},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.40639999508857727},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4000000059604645},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.38199999928474426},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.31450000405311584},{"id":"https://openalex.org/C3020672099","wikidata":"https://www.wikidata.org/wiki/Q857354","display_name":"Longitudinal data","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.28130000829696655},{"id":"https://openalex.org/C194648359","wikidata":"https://www.wikidata.org/wiki/Q3318054","display_name":"Generalized additive model","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.2720000147819519}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41598-026-66465-6","doi":"https://doi.org/10.1038/s41598-026-66465-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-66465-6","pdf_url":"https://www.nature.com/articles/s41598-026-66465-6_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-8247075/v1","doi":"https://doi.org/10.21203/rs.3.rs-8247075/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-8247075/v1","pdf_url":"https://www.researchsquare.com/article/rs-8247075/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-66465-6","doi":"https://doi.org/10.1038/s41598-026-66465-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-66465-6","pdf_url":"https://www.nature.com/articles/s41598-026-66465-6_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8619207143783569,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1578799492","display_name":null,"funder_award_id":"118C306","funder_id":"https://openalex.org/F4320322626","funder_display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu"}],"funders":[{"id":"https://openalex.org/F4320319219","display_name":"\u0130stanbul Medipol \u00dcniversitesi","ror":"https://ror.org/037jwzz50"},{"id":"https://openalex.org/F4320322626","display_name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","ror":"https://ror.org/04w9kkr77"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204556741.pdf","grobid_xml":"https://content.openalex.org/works/W7204556741.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1984405714","https://openalex.org/W2013071495","https://openalex.org/W2066673338","https://openalex.org/W2108107087","https://openalex.org/W2109046819","https://openalex.org/W2110065044","https://openalex.org/W2120079020","https://openalex.org/W2125575764","https://openalex.org/W2150751323","https://openalex.org/W2154180993","https://openalex.org/W2164960433","https://openalex.org/W2260317608"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"This":[2],"study":[3],"aimed":[4],"to":[5,35,39,49,122],"analyze":[6],"mortality":[7,42,60,68,118,158],"trajectories":[8,69],"and":[9,13,22,53,84,125,145,159,168,184],"identify":[10,50],"significant":[11,114],"environmental":[12,52,93,132,160,169],"behavioral":[14],"markers":[15,55,133],"associated":[16,57,88],"with":[17,58,66,89,104,127,131],"bladder":[18,76],"cancer,":[19,21,77,103],"prostate":[20,102],"renal":[23],"failure":[24,117],"utilizing":[25],"the":[26,163,177,188],"SAS":[27],"TRAJ":[28],"procedure.":[29],"Methods:":[30],"Retrospective":[31],"data":[32],"from":[33],"2010":[34],"2019":[36],"were":[37,47,70,86,99,147],"analyzed":[38],"model":[40],"disease-specific":[41,59],"trajectories.":[43],"Logistic":[44],"Regression":[45],"models":[46],"used":[48],"key":[51],"lifestyle":[54,140],"significantly":[56,87],"rates.":[61],"Results:":[62],"Three":[63],"distinct":[64],"clusters":[65],"unique":[67],"identified":[71,111],"for":[72,101,179],"each":[73],"disease.":[74],"For":[75],"increased":[78],"median":[79],"air":[80,136],"pressure,":[81],"alcohol":[82,123,143],"consumption,":[83],"smoking":[85,146],"higher":[90],"mortality,":[91],"while":[92],"variability":[94,161],"appeared":[95],"protective.":[96],"Similar":[97],"associations":[98,129],"found":[100],"second-hand":[105],"smoke":[106],"exposure":[107],"at":[108],"home":[109],"also":[110],"as":[112,135],"a":[113],"marker.":[115],"Renal":[116],"was":[119],"likewise":[120],"linked":[121],"use":[124,144],"smoking,":[126],"additional":[128],"observed":[130],"such":[134],"quality.":[137],"Conclusion:":[138],"Persistent":[139],"factors":[141,150,170],"like":[142],"common":[148],"risk":[149],"across":[151],"all":[152],"conditions.":[153],"The":[154],"inverse":[155],"association":[156],"between":[157],"indicates":[162],"potential":[164],"importance":[165],"of":[166],"climate":[167],"in":[171],"disease":[172],"outcomes.":[173],"These":[174],"findings":[175],"suggest":[176],"need":[178],"targeted":[180],"public":[181],"health":[182],"interventions":[183],"further":[185],"research":[186],"into":[187],"causal":[189],"mechanisms":[190],"underlying":[191],"these":[192],"associations.":[193]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-08-29T00:00:00"}