{"id":"https://openalex.org/W7204551292","doi":"https://doi.org/10.1016/j.nbd.2026.107588","title":"Selenoprotein I deficiency disrupts iron homeostasis in brain","display_name":"Selenoprotein I deficiency disrupts iron homeostasis in brain","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204551292","doi":"https://doi.org/10.1016/j.nbd.2026.107588","pmid":"https://pubmed.ncbi.nlm.nih.gov/42665029","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13712647"},"language":"en","primary_location":{"id":"doi:10.1016/j.nbd.2026.107588","doi":"https://doi.org/10.1016/j.nbd.2026.107588","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107588","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0969996126003335/pdf","source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0969996126003335/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5116804319","display_name":"Karlin Wurlitzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karlin Wurlitzer","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100667815","display_name":"Chi Ma","orcid":"https://orcid.org/0000-0002-4302-9079","observed_orcids":["https://orcid.org/0000-0002-4302-9079"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Ma","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101837986","display_name":"Lance G. A. Nunes","orcid":"https://orcid.org/0000-0002-4088-458X","observed_orcids":["https://orcid.org/0000-0002-4088-458X"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance G.A. Nunes","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046885431","display_name":"Marissa Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Watanabe","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148485187","display_name":"Cole Griffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cole Griffin","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030130280","display_name":"Vedbar S. Khadka","orcid":"https://orcid.org/0000-0002-8652-2904","observed_orcids":["https://orcid.org/0000-0002-8652-2904"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vedbar S. Khadka","raw_affiliation_strings":["Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121334024","display_name":"Antonio G. Soares","orcid":"https://orcid.org/0000-0001-5814-3475","observed_orcids":["https://orcid.org/0000-0001-5814-3475"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio G. Soares","raw_affiliation_strings":["Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Biosciences Research Center, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068156823","display_name":"FuKun W. Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fukun W. Hoffmann","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064225289","display_name":"Peter R. Hoffmann","orcid":"https://orcid.org/0000-0003-2417-7305","observed_orcids":["https://orcid.org/0000-0003-2417-7305"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R. Hoffmann","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001007618","display_name":"Matthew W. Pitts","orcid":"https://orcid.org/0000-0002-0994-7466","observed_orcids":["https://orcid.org/0000-0002-0994-7466"]},"institutions":[{"id":"https://openalex.org/I117965899","display_name":"University of Hawai\u02bbi at M\u0101noa","ror":"https://ror.org/01wspgy28","country_code":"US","type":"education","lineage":["https://openalex.org/I117965899"]},{"id":"https://openalex.org/I1331384533","display_name":"University of Hawaii System","ror":"https://ror.org/03tzaeb71","country_code":"US","type":"education","lineage":["https://openalex.org/I1331384533"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew W. Pitts","raw_affiliation_strings":["Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. Electronic address: mwpitts@hawaii.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. Electronic address: mwpitts@hawaii.edu","institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001007618"],"corresponding_institution_ids":["https://openalex.org/I117965899","https://openalex.org/I1331384533"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":{"value":4180,"currency":"USD","value_usd":4180},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58596222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"229","issue":null,"first_page":"107588","last_page":"107588"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.32499998807907104,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.32499998807907104,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11107","display_name":"Selenium in Biological Systems","score":0.2842000126838684,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.1662999987602234,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.7860000133514404},{"id":"https://openalex.org/keywords/phospholipid-synthesis","display_name":"phospholipid synthesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/white-matter","display_name":"white matter","score":0.546999990940094},{"id":"https://openalex.org/keywords/oligodendrocyte-proliferation","display_name":"oligodendrocyte proliferation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7360000014305115},{"id":"https://openalex.org/keywords/fenton-reaction","display_name":"Fenton reaction","score":0.6790000200271606},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2911035656","wikidata":"https://www.wikidata.org/wiki/Q5925744","display_name":"Iron homeostasis","level":3,"score":0.6256999969482422},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.5450999736785889},{"id":"https://openalex.org/C2776841403","wikidata":"https://www.wikidata.org/wiki/Q2745644","display_name":"Selenoprotein","level":5,"score":0.5318999886512756},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5234000086784363},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5212000012397766},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5074999928474426},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5037999749183655},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.4300999939441681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3928000032901764},{"id":"https://openalex.org/C2909795905","wikidata":"https://www.wikidata.org/wiki/Q7447908","display_name":"Selenoprotein P","level":5,"score":0.3707999885082245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3596999943256378},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2614000141620636}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009836","descriptor_name":"Oligodendroglia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051140","descriptor_name":"Selenoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D051140","descriptor_name":"Selenoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.nbd.2026.107588","doi":"https://doi.org/10.1016/j.nbd.2026.107588","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107588","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0969996126003335/pdf","source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13712647","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712647/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712647/pdf/nihms-2216001.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiol Dis","raw_type":"Text"},{"id":"pmid:42665029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42665029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f8a5d311762d46068bfd36f68153976c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f8a5d311762d46068bfd36f68153976c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 229, Iss , Pp 107588- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.nbd.2026.107588","doi":"https://doi.org/10.1016/j.nbd.2026.107588","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.nbd.2026.107588","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0969996126003335/pdf","source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1981438495","display_name":"The role of Selenoprotein I in mitigating neurodegeneration.","funder_award_id":"R21NS133944","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6657544808","display_name":"The role of selenoprotein I in phospholipidethanolamine dependent mechanisms that regulate T cell activation","funder_award_id":"R01AI147496","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6900249894","display_name":null,"funder_award_id":"R01AI147496","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000891638","display_name":"COBRE-DIABETES","funder_award_id":"P20GM113134","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000895741","display_name":"Integrative Center for Precision Nutrition and Human Health","funder_award_id":"P20GM139753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000897584","display_name":"Center for Pacific Innovations, Knowledge, and Opportunities (PIKO)","funder_award_id":"U54GM138062","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000899759","display_name":"Training in Cardiovascular Research at the University of Hawaii","funder_award_id":"T32HL115505","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000918954","display_name":"Assessment of the joint influence of methylmercury and selenium upon postnatal brain development and risk for psychiatric disorders","funder_award_id":"R01ES035851","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204551292.pdf","grobid_xml":"https://content.openalex.org/works/W7204551292.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W7449367","https://openalex.org/W1560871346","https://openalex.org/W1742765381","https://openalex.org/W1963970055","https://openalex.org/W1967190893","https://openalex.org/W1973507003","https://openalex.org/W1985842394","https://openalex.org/W2005729509","https://openalex.org/W2009766349","https://openalex.org/W2016926967","https://openalex.org/W2019048519","https://openalex.org/W2025880887","https://openalex.org/W2026429356","https://openalex.org/W2029967096","https://openalex.org/W2034365997","https://openalex.org/W2037259851","https://openalex.org/W2040160279","https://openalex.org/W2047899819","https://openalex.org/W2057082849","https://openalex.org/W2062815027","https://openalex.org/W2066912376","https://openalex.org/W2069665561","https://openalex.org/W2076733103","https://openalex.org/W2086567353","https://openalex.org/W2087747373","https://openalex.org/W2101855054","https://openalex.org/W2108234281","https://openalex.org/W2112698641","https://openalex.org/W2124836276","https://openalex.org/W2131271579","https://openalex.org/W2134526812","https://openalex.org/W2142409356","https://openalex.org/W2166772109","https://openalex.org/W2167489650","https://openalex.org/W2179438025","https://openalex.org/W2332419762","https://openalex.org/W2353246370","https://openalex.org/W2542350582","https://openalex.org/W2550324626","https://openalex.org/W2790395337","https://openalex.org/W2909817598","https://openalex.org/W2914888345","https://openalex.org/W2947015482","https://openalex.org/W2964849163","https://openalex.org/W2964907930","https://openalex.org/W3009746164","https://openalex.org/W3011306000","https://openalex.org/W3011868091","https://openalex.org/W3013318516","https://openalex.org/W3033545887","https://openalex.org/W3083278736","https://openalex.org/W3087176574","https://openalex.org/W3094147004","https://openalex.org/W3108594926","https://openalex.org/W3119287419","https://openalex.org/W3126951521","https://openalex.org/W3130437983","https://openalex.org/W3134259195","https://openalex.org/W3165494433","https://openalex.org/W3178309457","https://openalex.org/W3193622607","https://openalex.org/W4300903703","https://openalex.org/W4378212353","https://openalex.org/W4393972932","https://openalex.org/W4396978920","https://openalex.org/W4403790865","https://openalex.org/W4404832729"],"related_works":["https://openalex.org/W4411265294","https://openalex.org/W4393972932","https://openalex.org/W7155565726","https://openalex.org/W4380853181","https://openalex.org/W4409954535","https://openalex.org/W2037946468","https://openalex.org/W2010454129","https://openalex.org/W4308032665","https://openalex.org/W2165249745","https://openalex.org/W2123138049"],"abstract_inverted_index":{"Selenoprotein":[0],"I":[1],"(SELENOI)":[2],"is":[3,74,171],"an":[4,101,159],"essential":[5],"enzyme":[6],"for":[7],"phospholipid":[8],"synthesis":[9],"that":[10,22,39,122,167],"catalyzes":[11],"the":[12,63,174],"production":[13],"of":[14,20,33,66,103,149,162],"plasmenyl-phosphatidylethanolamine":[15],"(plasmenyl-PE),":[16],"a":[17,30,75],"key":[18],"component":[19],"myelin":[21],"protects":[23],"and":[24,57,109,135,146,165],"insulates":[25],"axons.":[26],"We":[27],"recently":[28],"generated":[29],"mouse":[31,126],"model":[32],"central":[34],"nervous":[35],"system-restricted":[36],"SELENOI":[37,48,123,170],"deficiency":[38,124],"recapitulates":[40],"features":[41],"observed":[42],"in":[43,71,125,131,152,177],"humans":[44],"with":[45],"rare":[46],"loss-of-function":[47],"gene":[49],"mutations":[50],"such":[51],"as":[52],"motor":[53],"deficits,":[54],"diminished":[55],"plasmenyl-PE,":[56],"hypomyelination.":[58],"Crucially,":[59],"myelin-producing":[60],"oligodendrocytes":[61],"have":[62],"highest":[64],"concentration":[65],"iron":[67,105,137,179],"among":[68],"cell":[69,113],"types":[70],"brain.":[72],"Iron":[73],"vital":[76],"metal":[77],"cofactor":[78],"due":[79],"to":[80,83,92,112,129],"its":[81],"contribution":[82],"redox":[84],"reactions,":[85],"but":[86],"this":[87,118],"property":[88],"also":[89],"predisposes":[90],"it":[91],"generating":[93],"reactive":[94],"oxygen":[95],"species":[96],"via":[97,115],"Fenton":[98],"reactions.":[99],"Moreover,":[100],"excess":[102],"redox-active":[104],"promotes":[106,136],"lipid":[107],"peroxidation":[108],"increases":[110],"susceptibility":[111],"death":[114,164],"ferroptosis.":[116],"In":[117],"report,":[119],"we":[120],"show":[121],"brain":[127],"leads":[128],"ferroptosis":[130],"white":[132],"matter":[133],"tracts":[134],"accumulation.":[138],"These":[139],"alterations":[140],"are":[141],"accompanied":[142],"by":[143],"oligodendrocyte":[144,163],"proliferation":[145,166],"elevated":[147],"numbers":[148],"ferritin-positive":[150],"microglia":[151],"affected":[153],"regions.":[154],"Overall,":[155],"our":[156],"findings":[157],"detail":[158],"intermittent":[160],"cycle":[161],"occurs":[168],"when":[169],"absent":[172],"from":[173],"brain,":[175],"resulting":[176],"accelerated":[178],"accrual.":[180]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-08-29T00:00:00"}