{"id":"https://openalex.org/W7204544293","doi":"https://doi.org/10.6084/m9.figshare.33372311","title":"Clinical Features and Visual Outcomes of Pediatric Noninfectious Posterior and Panuveitis","display_name":"Clinical Features and Visual Outcomes of Pediatric Noninfectious Posterior and Panuveitis","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204544293","doi":"https://doi.org/10.6084/m9.figshare.33372311"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.33372311","doi":"https://doi.org/10.6084/m9.figshare.33372311","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33372311","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.33372311","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001276265","display_name":"Justin C. Muste","orcid":"https://orcid.org/0000-0001-8478-038X","observed_orcids":["https://orcid.org/0000-0001-8478-038X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin C. Muste","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121525219","display_name":"Jonathan Martin","orcid":"https://orcid.org/0000-0002-2904-1522","observed_orcids":["https://orcid.org/0000-0002-2904-1522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Martin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111463174","display_name":"Tadashi Yokoi","orcid":"https://orcid.org/0009-0001-4868-0338","observed_orcids":["https://orcid.org/0009-0001-4868-0338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tadashi Yokoi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119121542","display_name":"Rhea W Teng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rhea W. Teng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148529895","display_name":"Sidra Zafar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sidra Zafar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047842177","display_name":"Timothy T. Xu","orcid":"https://orcid.org/0000-0003-4781-985X","observed_orcids":["https://orcid.org/0000-0003-4781-985X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy T. Xu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081017390","display_name":"Collin J. Richards","orcid":"https://orcid.org/0000-0002-9833-5938","observed_orcids":["https://orcid.org/0000-0002-9833-5938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Collin J. Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070167673","display_name":"Erik M. Massenzio","orcid":"https://orcid.org/0000-0002-8161-9491","observed_orcids":["https://orcid.org/0000-0002-8161-9491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik Massenzio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039099781","display_name":"Yoshihiro Yonekawa","orcid":"https://orcid.org/0000-0002-6847-7169","observed_orcids":["https://orcid.org/0000-0002-6847-7169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshihiro Yonekawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027369181","display_name":"Sunir J. Garg","orcid":"https://orcid.org/0000-0002-9115-6080","observed_orcids":["https://orcid.org/0000-0002-9115-6080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunir J. Garg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130937129","display_name":"David Fell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Fell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037098186","display_name":"James P. Dunn","orcid":"https://orcid.org/0000-0002-2944-8111","observed_orcids":["https://orcid.org/0000-0002-2944-8111"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James P. Dunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003115504","display_name":"Jordan D. Deaner","orcid":"https://orcid.org/0000-0002-3899-4456","observed_orcids":["https://orcid.org/0000-0002-3899-4456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan D. Deaner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pediatric-uveitis","display_name":"pediatric uveitis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/non-infectious-uveitis","display_name":"non-infectious uveitis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/posterior-uveitis","display_name":"posterior uveitis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/panuveitis","display_name":"panuveitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/idiopathic-uveitis","display_name":"idiopathic uveitis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/visual-outcome","display_name":"visual outcome","score":0.796999990940094},{"id":"https://openalex.org/keywords/visual-acuity-loss","display_name":"visual acuity loss","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glaucoma","display_name":"glaucoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/vitreous-opacities","display_name":"vitreous opacities","score":0.9959999918937683},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammatory-flares","display_name":"inflammatory flares","score":0.7519999742507935},{"id":"https://openalex.org/keywords/ocular-sequelae","display_name":"ocular sequelae","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.963699996471405},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.7759000062942505},{"id":"https://openalex.org/C2778257484","wikidata":"https://www.wikidata.org/wiki/Q555066","display_name":"Visual acuity","level":2,"score":0.616599977016449},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5874000191688538},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5443999767303467},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.476500004529953},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.47119998931884766},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45879998803138733},{"id":"https://openalex.org/C2776148792","wikidata":"https://www.wikidata.org/wiki/Q3041498","display_name":"Eye disease","level":2,"score":0.36660000681877136},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3456000089645386},{"id":"https://openalex.org/C2779368723","wikidata":"https://www.wikidata.org/wiki/Q8511208","display_name":"Intermediate uveitis","level":4,"score":0.3416000008583069},{"id":"https://openalex.org/C2776713392","wikidata":"https://www.wikidata.org/wiki/Q278859","display_name":"Uvea","level":3,"score":0.3328999876976013},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C113520495","wikidata":"https://www.wikidata.org/wiki/Q2359854","display_name":"Posterior segment of eyeball","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2815999984741211},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.2581000030040741}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.33372311","doi":"https://doi.org/10.6084/m9.figshare.33372311","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33372311","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.33372311.v1","doi":"https://doi.org/10.6084/m9.figshare.33372311.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33372311.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.33372311","doi":"https://doi.org/10.6084/m9.figshare.33372311","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.33372311","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4317861417","https://openalex.org/W7064787454","https://openalex.org/W4404597781","https://openalex.org/W2966672483","https://openalex.org/W3210857229","https://openalex.org/W4411944679","https://openalex.org/W2912868703","https://openalex.org/W4411953662","https://openalex.org/W2885250711","https://openalex.org/W4391573205"],"abstract_inverted_index":{"To":[0],"describe":[1],"the":[2,159,199,244],"demographics,":[3,48],"clinical":[4,49],"characteristics,":[5,50],"treatment":[6],"patterns,":[7],"and":[8,16,30,35,54,68,98,158,189,228,240],"outcomes":[9],"of":[10,25,62,72,95,101,112,121,127,149,161,247],"pediatric":[11],"patients":[12,75,103,162],"with":[13,28,57,123,163,204,211,236,254],"noninfectious":[14,226],"posterior":[15,29,227],"panuveitis":[17,31,229],"at":[18,134],"a":[19,70,93,124,212],"single":[20],"center.":[21],"Retrospective":[22],"cohort":[23],"study":[24],"all":[26,131],"eyes":[27,100,132],"between":[32],"June":[33,36],"2015":[34,67],"2025":[37],"that":[38],"were":[39,45,64,78,90,145,154,243],"identified":[40,180],"using":[41],"ICD":[42],"codes.":[43],"Charts":[44],"reviewed":[46],"for":[47,80,92],"disease":[51,108,235],"evolution,":[52],"sequelae,":[53],"treatment.":[55],"Eyes":[56],"less":[58],"than":[59],"3":[60],"months":[61],"follow-up":[63,126,173],"excluded.":[65],"Between":[66],"2025,":[69],"total":[71],"12":[73],"004":[74],"(16,810":[76],"eyes)":[77,89],"seen":[79],"any":[81],"uveitis":[82,97,119],"diagnosis.":[83],"Of":[84],"them,":[85],"281":[86],"children":[87],"(449":[88],"referred":[91],"diagnosis":[94,116],"non-infectious":[96],"106":[99],"69":[102],"met":[104],"inclusion":[105],"criteria.":[106],"Bilateral":[107],"occurred":[109],"in":[110,261],"50.7%":[111],"patients.":[113],"The":[114],"leading":[115],"was":[117,208,252],"idiopathic":[118],"(51.9%":[120],"eyes),":[122],"mean":[125],"42":[128],"months.":[129],"Nearly":[130],"experienced":[133],"least":[135],"one":[136],"inflammatory":[137],"flare":[138],"(mean":[139],"1.1":[140],"per":[141],"eye).":[142],"Topical":[143],"corticosteroids":[144],"most":[146,201],"used":[147],"(60.9%":[148],"treated":[150],"eyes).":[151],"Ocular":[152],"sequelae":[153,200],"nearly":[155],"universal":[156],"(98.1%),":[157],"proportion":[160],"vision":[164],"20/200":[165],"or":[166],"worse":[167],"remained":[168],"stable":[169],"from":[170],"baseline":[171],"to":[172],"(39.1%":[174],"vs":[175],"40.6%).":[176],"Linear":[177],"mixed-effects":[178],"modeling":[179],"glaucoma":[181],"(\u03b2\u00d7t":[182,192,218],"=":[183,193,196,219],"+0.0141":[184],"logMAR/month,":[185,221],"p":[186,195,222],"<":[187,223],"0.001)":[188],"vitreous":[190,241],"opacities":[191,242],"+0.0096,":[194],"0.005)":[197],"as":[198],"strongly":[202],"associated":[203,210,253],"visual":[205,215,248,255],"decline.":[206],"Methotrexate":[207],"independently":[209],"more":[213],"favorable":[214],"acuity":[216],"trajectory":[217],"\u22120.0071":[220],"0.001).":[224],"Pediatric":[225],"is":[230],"characterized":[231],"by":[232],"chronic,":[233],"bilateral":[234],"near-universal":[237],"sequelae.":[238],"Glaucoma":[239],"strongest":[245],"drivers":[246],"decline,":[249],"while":[250],"methotrexate":[251],"preservation,":[256],"supporting":[257],"its":[258],"early":[259],"use":[260],"this":[262],"population.":[263]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-29T00:00:00"}