{"id":"https://openalex.org/W7204544250","doi":"https://doi.org/10.1186/s41181-026-00516-1","title":"First in vivo evaluation of the radiolabelled Hsp90 inhibitor [11C]onalespib for cancer and brain PET imaging","display_name":"First in vivo evaluation of the radiolabelled Hsp90 inhibitor [11C]onalespib for cancer and brain PET imaging","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7204544250","doi":"https://doi.org/10.1186/s41181-026-00516-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42687991","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13533016"},"language":"en","primary_location":{"id":"doi:10.1186/s41181-026-00516-1","doi":"https://doi.org/10.1186/s41181-026-00516-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41181-026-00516-1","pdf_url":null,"source":{"id":"https://openalex.org/S3035136591","display_name":"EJNMMI Radiopharmacy and Chemistry","issn_l":"2365-421X","issn":["2365-421X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Radiopharmacy and Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s41181-026-00516-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042857691","display_name":"Valeria Narykina","orcid":"https://orcid.org/0000-0003-4285-3629","observed_orcids":["https://orcid.org/0000-0003-4285-3629"]},"institutions":[{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Valeria Narykina","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, Leuven, 3000, Belgium","Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat 49, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Switch Laboratory, VIB Center for Brain and Disease Research, Herestraat 49, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I4210153928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049546280","display_name":"Romy Cools","orcid":"https://orcid.org/0000-0002-6883-4031","observed_orcids":["https://orcid.org/0000-0002-6883-4031"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Romy Cools","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120346271","display_name":"Niels Van Winnendael","orcid":"https://orcid.org/0009-0002-6763-7498","observed_orcids":["https://orcid.org/0009-0002-6763-7498"]},"institutions":[{"id":"https://openalex.org/I4210114391","display_name":"Belgian Nuclear Research Centre","ror":"https://ror.org/020xs5r81","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114391"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Niels Van Winnendael","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","Nuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Nuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium","institution_ids":["https://openalex.org/I4210114391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000222042","display_name":"Koen Vermeulen","orcid":"https://orcid.org/0000-0003-2048-6530","observed_orcids":["https://orcid.org/0000-0003-2048-6530"]},"institutions":[{"id":"https://openalex.org/I4210114391","display_name":"Belgian Nuclear Research Centre","ror":"https://ror.org/020xs5r81","country_code":"BE","type":"facility","lineage":["https://openalex.org/I4210114391"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Vermeulen","raw_affiliation_strings":["Nuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medical Applications, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium","institution_ids":["https://openalex.org/I4210114391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072600244","display_name":"Guy M Bormans","orcid":"https://orcid.org/0000-0002-0335-7190","observed_orcids":["https://orcid.org/0000-0002-0335-7190"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Guy Bormans","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-0335-7190","affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5120334531","display_name":"Ludovic Le Saux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Ludovic Le Saux","raw_affiliation_strings":["Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, 3000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072600244"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.7749999761581421},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.7260000109672546},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"neuroimaging","score":0.6079999804496765},{"id":"https://openalex.org/keywords/tumor-imaging","display_name":"tumor imaging","score":0.878000020980835},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.7609999775886536},{"id":"https://openalex.org/keywords/radiolabeling","display_name":"radiolabeling","score":0.5370000004768372},{"id":"https://openalex.org/keywords/blood-brain-barrier-penetration","display_name":"blood-brain barrier penetration","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7487999796867371},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.7293000221252441},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.6715999841690063},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.574999988079071},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5503000020980835},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5335999727249146},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5109999775886536},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49129998683929443},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46970000863075256},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4641000032424927},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.3921999931335449},{"id":"https://openalex.org/C2776428644","wikidata":"https://www.wikidata.org/wiki/Q2126468","display_name":"Radiosensitizer","level":3,"score":0.38280001282691956},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.36480000615119934},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.36390000581741333},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.3441999852657318},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3330000042915344},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.328000009059906},{"id":"https://openalex.org/C2781305896","wikidata":"https://www.wikidata.org/wiki/Q6875874","display_name":"Misonidazole","level":3,"score":0.3230000138282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31949999928474426},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31450000405311584},{"id":"https://openalex.org/C2776970183","wikidata":"https://www.wikidata.org/wiki/Q20155580","display_name":"Radiosynthesis","level":3,"score":0.30809998512268066},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.2506999969482422}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s41181-026-00516-1","doi":"https://doi.org/10.1186/s41181-026-00516-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41181-026-00516-1","pdf_url":null,"source":{"id":"https://openalex.org/S3035136591","display_name":"EJNMMI Radiopharmacy and Chemistry","issn_l":"2365-421X","issn":["2365-421X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Radiopharmacy and Chemistry","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-10764394/v1","doi":"https://doi.org/10.21203/rs.3.rs-10764394/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10764394/v1","pdf_url":"https://www.researchsquare.com/article/rs-10764394/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13533016","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13533016/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13533016/pdf/nihpp-rs10764394v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Res Sq","raw_type":"Text"},{"id":"pmid:42687991","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42687991","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s41181-026-00516-1","doi":"https://doi.org/10.1186/s41181-026-00516-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41181-026-00516-1","pdf_url":null,"source":{"id":"https://openalex.org/S3035136591","display_name":"EJNMMI Radiopharmacy and Chemistry","issn_l":"2365-421X","issn":["2365-421X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJNMMI Radiopharmacy and Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3050989157","display_name":null,"funder_award_id":"C0401","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G3327512123","display_name":null,"funder_award_id":"C0401","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G3450116582","display_name":null,"funder_award_id":"C24E/19/070","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G3708031204","display_name":null,"funder_award_id":"AKUL15-30/G0H1216N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G4568568794","display_name":"FB-III (\u201cFB triple-I\u201d) : Flanders BioImaging: Integrating Imaging Infrastructure from cell to man.","funder_award_id":"I000321N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5695534749","display_name":null,"funder_award_id":"C14/21/111","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G5698387713","display_name":"Translational investigation of the role of Hsp90 in neurodegenerative proteinopathies using positron emission tomography (PET)","funder_award_id":"G0A6222N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8450093486","display_name":"A high-resolution and high-sensitivity hybrid small animal PET-CT system for combined molecular/functional and anatomical preclinical imaging in neurology, oncology and cardiology.","funder_award_id":"G0H1216N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G9000901352","display_name":"Development of Hsp90 Isoform- Selective Inhibitors as a Novel Opioid Dose-Reduction Therapy","funder_award_id":"R01DA052340","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000904769","display_name":"Engineering the Next Generation of Safer Hsp90 Inhibitors","funder_award_id":"R01CA270147","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335514","display_name":"Universitaire Ziekenhuizen Leuven, KU Leuven","ror":"https://ror.org/0424bsv16"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204544250.pdf","grobid_xml":"https://content.openalex.org/works/W7204544250.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2074106622","https://openalex.org/W2141715793","https://openalex.org/W3003774948","https://openalex.org/W3080887649","https://openalex.org/W4292484859","https://openalex.org/W4378904025","https://openalex.org/W4392376447","https://openalex.org/W4402756064","https://openalex.org/W4406713887","https://openalex.org/W4409393085","https://openalex.org/W4410019262","https://openalex.org/W4414555077","https://openalex.org/W7160216336"],"related_works":["https://openalex.org/W4414555077","https://openalex.org/W4416086009","https://openalex.org/W7005214314","https://openalex.org/W3202230566","https://openalex.org/W2898145413","https://openalex.org/W7154457371","https://openalex.org/W2909039182","https://openalex.org/W7160216336","https://openalex.org/W35260151","https://openalex.org/W4318478040"],"abstract_inverted_index":{"Heat":[0],"shock":[1],"protein":[2],"90":[3],"(Hsp90)":[4],"is":[5],"a":[6,68,79,130,269,346],"key":[7],"molecular":[8],"chaperone":[9],"involved":[10],"in":[11,30,82,121,146,178,187,207,229,239,244,260,284,287,305,312],"maintaining":[12],"proteostasis,":[13],"and":[14,17,25,32,76,115,129,153,192,204,236,292,301,309,317,326,340],"its":[15,106],"function":[16],"aberrant":[18],"expression":[19],"are":[20],"linked":[21],"to":[22,26,57,104,344],"tumour":[23,114,151,231,306,324],"progression":[24],"neurodegeneration.":[27],"Its":[28],"overexpression":[29],"cancers":[31],"the":[33,40,51,98,158,167,188,224,255,282,333],"clinical":[34],"development":[35],"of":[36,102,190,252,272,337],"Hsp90":[37,59,144,194],"inhibitors,":[38],"including":[39],"recently":[41],"approved":[42],"pimitespib":[43],"(TAS-116,":[44],"trade":[45],"name":[46],"Jeselhy":[47],"\u00ae":[48],"),":[49],"highlights":[50],"need":[52],"for":[53,113,134],"non\u2011invasive":[54],"imaging":[55,228],"tools":[56],"assess":[58,105],"expression.":[60],"Current":[61],"PET/SPECT":[62],"tracers":[63],"show":[64],"limited":[65,250],"performance.":[66],"Onalespib,":[67],"clinically":[69],"evaluated":[70],"inhibitor":[71,170],"with":[72,124,143,157,164,184,219,249,267,298],"favourable":[73],"chemical":[74],"flexibility":[75],"identified":[77],"as":[78,108],"promising":[80],"radiosensitizer":[81],"glioblastoma,":[83],"suggesting":[84],"blood-brain":[85],"barrier":[86],"(BBB)":[87],"penetration,":[88],"offers":[89],"an":[90,109,125],"attractive":[91],"alternative.":[92],"In":[93,137,314],"this":[94],"work,":[95],"we":[96],"report":[97],"first":[99],"preclinical":[100],"evaluation":[101],"[\u00b9\u00b9C]onalespib":[103,253],"suitability":[107],"Hsp90\u2011targeted":[110],"PET":[111],"radiotracer":[112],"brain":[116,155,221,310,328],"imaging.":[117],"[\u00b9\u00b9C]Onalespib":[118,295],"was":[119,296],"produced":[120],"high":[122,299,320],"purity,":[123],"appropriate":[126],"radiochemical":[127],"profile":[128],"molar":[131],"activity":[132,203],"suitable":[133],"biological":[135],"studies.":[136],"vitro":[138,285],"autoradiography":[139],"demonstrated":[140],"binding":[141,173,304,339],"consistent":[142],"engagement":[145],"U\u201187":[147,208,245],"MG,":[148],"MDA\u2011MB\u2011231,":[149],"PC-3":[150],"tissues":[152],"mouse":[154,290],"sections,":[156],"signal":[159,222],"markedly":[160],"reduced":[161],"after":[162],"preincubation":[163],"onalespib":[165,191],"or":[166],"structurally":[168],"unrelated":[169],"HSP990.":[171],"Cell":[172],"assays":[174],"showed":[175,214,237,302],"saturable":[176],"uptake":[177,206,325],"all":[179,277],"three":[180],"cancer":[181],"cell":[182],"lines,":[183],"substantial":[185],"inhibition":[186,241],"presence":[189],"other":[193],"inhibitors.":[195],"Ex":[196],"vivo":[197,240,315],"biodistribution":[198,318],"studies":[199],"revealed":[200],"pronounced":[201],"abdominal":[202,321],"moderate":[205,323],"MG":[209,246],"xenografts,":[210,247],"whereas":[211],"MDA\u2011MB\u2011231":[212],"tumours":[213],"only":[215,268],"minimal":[216],"uptake,":[217],"both":[218,230],"negligible":[220,327],"under":[223],"same":[225],"conditions.":[226],"PET/CT":[227,316],"models":[232],"corroborated":[233],"these":[234],"findings":[235],"significant":[238],"by":[242],"HSP990":[243],"together":[248],"penetration":[251],"into":[254],"brain.":[256],"Plasma":[257],"metabolite":[258],"analysis":[259],"healthy":[261],"mice":[262],"indicated":[263],"rapid":[264,331],"metabolic":[265],"degradation,":[266],"small":[270],"fraction":[271],"intact":[273],"tracer":[274,334],"remaining":[275],"at":[276],"measured":[278],"time":[279],"points,":[280],"despite":[281],"good":[283],"stability":[286],"phosphate":[288],"buffer,":[289],"serum":[291],"human":[293],"serum.":[294],"obtained":[297],"purity":[300],"Hsp90-associated":[303],"tissues,":[307],"cells":[308],"tissue":[311],"vitro.":[313],"confirmed":[319],"accumulation,":[322],"penetration.":[329],"Despite":[330],"metabolism,":[332],"demonstrates":[335],"indications":[336],"Hsp90-specific":[338],"requires":[341],"further":[342],"optimisation":[343],"develop":[345],"Hsp90-targeted":[347],"radiotracers.":[348],"Not":[349],"applicable.":[350]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-08-29T00:00:00"}
