{"id":"https://openalex.org/W7204541925","doi":"https://doi.org/10.1016/j.exger.2026.113305","title":"Effects of eccentric overload training on lower-limb muscle strength, gait performance, balance, and explosive power in older adults: A systematic review and meta-analysis","display_name":"Effects of eccentric overload training on lower-limb muscle strength, gait performance, balance, and explosive power in older adults: A systematic review and meta-analysis","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204541925","doi":"https://doi.org/10.1016/j.exger.2026.113305","pmid":"https://pubmed.ncbi.nlm.nih.gov/42660338"},"language":"en","primary_location":{"id":"doi:10.1016/j.exger.2026.113305","doi":"https://doi.org/10.1016/j.exger.2026.113305","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exger.2026.113305","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0531556526002846/pdf","source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S0531556526002846/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134798342","display_name":"Cunyu Lan","orcid":"https://orcid.org/0009-0008-3226-7822","observed_orcids":["https://orcid.org/0009-0008-3226-7822"]},"institutions":[{"id":"https://openalex.org/I4210095228","display_name":"Xi'an Physical Education University","ror":"https://ror.org/00pt5by23","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210095228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cunyu Lan","raw_affiliation_strings":["Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, 710068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, 710068, China","institution_ids":["https://openalex.org/I4210095228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041155014","display_name":"Beibei Lei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354188","display_name":"Henan University of Chinese Medicine","ror":"https://ror.org/01tsmvz08","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354188"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Beibei Lei","raw_affiliation_strings":["REHABILITATION MEDICINE COLLEGE, HENAN UNIVERSITY OF CHINESE MEDICINE, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"REHABILITATION MEDICINE COLLEGE, HENAN UNIVERSITY OF CHINESE MEDICINE, Zhengzhou, China","institution_ids":["https://openalex.org/I160354188"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102616797","display_name":"Wenjie Huang","orcid":"https://orcid.org/0009-0000-1667-0509","observed_orcids":["https://orcid.org/0009-0000-1667-0509"]},"institutions":[{"id":"https://openalex.org/I4210095228","display_name":"Xi'an Physical Education University","ror":"https://ror.org/00pt5by23","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210095228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjie Huang","raw_affiliation_strings":["Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, 710068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, 710068, China","institution_ids":["https://openalex.org/I4210095228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030563189","display_name":"Juerui Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095228","display_name":"Xi'an Physical Education University","ror":"https://ror.org/00pt5by23","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210095228"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juerui Li","raw_affiliation_strings":["Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, 710068, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sport Rehabilitation, School of Graduate, Xi'an Physical Education University, Xi'an, Shaanxi, 710068, China","institution_ids":["https://openalex.org/I4210095228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043914985","display_name":"Bo Gou","orcid":"https://orcid.org/0000-0001-8933-0556","observed_orcids":["https://orcid.org/0000-0001-8933-0556"]},"institutions":[{"id":"https://openalex.org/I4210095228","display_name":"Xi'an Physical Education University","ror":"https://ror.org/00pt5by23","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210095228"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo Gou","raw_affiliation_strings":["Key Laboratory of Sports Technology Analysis and Skill Assessment (Xi'an Physical Education University), General Administration of Sport, Xi'an, 710068, China. Electronic address: gou_bo@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Sports Technology Analysis and Skill Assessment (Xi'an Physical Education University), General Administration of Sport, Xi'an, 710068, China. Electronic address: gou_bo@126.com","institution_ids":["https://openalex.org/I4210095228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043914985"],"corresponding_institution_ids":["https://openalex.org/I4210095228"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":{"value":3400,"currency":"USD","value_usd":3400},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"224","issue":null,"first_page":"113305","last_page":"113305"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.49050000309944153,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10157","display_name":"Sports Performance and Training","score":0.49050000309944153,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.28029999136924744,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.09560000151395798,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7820000052452087},{"id":"https://openalex.org/keywords/lower-limb-muscle-strength","display_name":"lower limb muscle strength","score":0.9869999885559082},{"id":"https://openalex.org/keywords/explosive-power","display_name":"explosive power","score":0.8220000267028809},{"id":"https://openalex.org/keywords/gait-performance","display_name":"gait performance","score":0.968999981880188},{"id":"https://openalex.org/keywords/balance","display_name":"balance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/flywheel-resistance-training","display_name":"flywheel resistance training","score":0.7839999794960022},{"id":"https://openalex.org/keywords/resistance-training","display_name":"resistance training","score":0.7149999737739563},{"id":"https://openalex.org/keywords/exercise-frequency","display_name":"exercise frequency","score":0.9760000109672546},{"id":"https://openalex.org/keywords/training-duration","display_name":"training duration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/exercise-prescription","display_name":"exercise prescription","score":0.8700000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6715999841690063},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.65829998254776},{"id":"https://openalex.org/C100784341","wikidata":"https://www.wikidata.org/wiki/Q1340491","display_name":"Eccentric","level":2,"score":0.6549000144004822},{"id":"https://openalex.org/C154238967","wikidata":"https://www.wikidata.org/wiki/Q12870","display_name":"Explosive material","level":2,"score":0.5885999798774719},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5095999836921692},{"id":"https://openalex.org/C2778104025","wikidata":"https://www.wikidata.org/wiki/Q5332180","display_name":"Eccentric training","level":3,"score":0.49320000410079956},{"id":"https://openalex.org/C3019424981","wikidata":"https://www.wikidata.org/wiki/Q12834857","display_name":"Resistance training","level":2,"score":0.44859999418258667},{"id":"https://openalex.org/C123550912","wikidata":"https://www.wikidata.org/wiki/Q12834857","display_name":"Strength training","level":2,"score":0.4406000077724457},{"id":"https://openalex.org/C3020194493","wikidata":"https://www.wikidata.org/wiki/Q3738671","display_name":"Explosive strength","level":2,"score":0.4390000104904175},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41359999775886536},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4056999981403351},{"id":"https://openalex.org/C2776868573","wikidata":"https://www.wikidata.org/wiki/Q46855","display_name":"Sprint","level":2,"score":0.40549999475479126},{"id":"https://openalex.org/C151800584","wikidata":"https://www.wikidata.org/wiki/Q2370000","display_name":"Gait","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.3610999882221222},{"id":"https://openalex.org/C2988918651","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Muscle strength","level":2,"score":0.3458999991416931},{"id":"https://openalex.org/C153396756","wikidata":"https://www.wikidata.org/wiki/Q1785966","display_name":"Physical strength","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2840999960899353},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C31107917","wikidata":"https://www.wikidata.org/wiki/Q183576","display_name":"Flywheel","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C2781054738","wikidata":"https://www.wikidata.org/wiki/Q4813730","display_name":"Athletes","level":2,"score":0.25699999928474426}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004856","descriptor_name":"Postural Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035002","descriptor_name":"Lower Extremity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053580","descriptor_name":"Muscle Strength","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055070","descriptor_name":"Resistance Training","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.exger.2026.113305","doi":"https://doi.org/10.1016/j.exger.2026.113305","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exger.2026.113305","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0531556526002846/pdf","source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},{"id":"pmid:42660338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42660338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental gerontology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.exger.2026.113305","doi":"https://doi.org/10.1016/j.exger.2026.113305","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exger.2026.113305","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0531556526002846/pdf","source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204541925.pdf","grobid_xml":"https://content.openalex.org/works/W7204541925.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1860145234","https://openalex.org/W2016455713","https://openalex.org/W2019627189","https://openalex.org/W2074374126","https://openalex.org/W2121206484","https://openalex.org/W2122458271","https://openalex.org/W2140060664","https://openalex.org/W2142835243","https://openalex.org/W2153564334","https://openalex.org/W2166232154","https://openalex.org/W2523467156","https://openalex.org/W2625024547","https://openalex.org/W3004587787","https://openalex.org/W3005418011","https://openalex.org/W3020669297","https://openalex.org/W3109886056","https://openalex.org/W4401331941","https://openalex.org/W4406893781","https://openalex.org/W4411622315","https://openalex.org/W4411978553","https://openalex.org/W4414418007","https://openalex.org/W4415828360"],"related_works":["https://openalex.org/W2996427658","https://openalex.org/W4415949299","https://openalex.org/W4415828360","https://openalex.org/W2942550078","https://openalex.org/W2618857303","https://openalex.org/W2387452242","https://openalex.org/W2944102717","https://openalex.org/W2786716034","https://openalex.org/W2969938698","https://openalex.org/W4312386215"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,108,260,278],"efficacy":[4,158],"of":[5,32],"eccentric":[6],"overload":[7],"training":[8,140,192,206,220,253,266],"(EOT)":[9],"in":[10,107,141,159,226,249,256],"enhancing":[11,201],"lower-limb":[12,52,88,123,144,161,202,228,240],"muscle":[13],"strength,":[14,203],"gait":[15],"performance,":[16],"balance,":[17,58],"and":[18,61,66,74,97,146,169,230,244,264,285],"explosive":[19,59,98,147,170,216,231,245],"power":[20,99,171,246],"among":[21],"older":[22,250],"adults.":[23,251],"METHODS:":[24],"We":[25],"systematically":[26],"searched":[27],"seven":[28],"databases":[29],"(PubMed,":[30],"Web":[31],"Science,":[33],"Embase,":[34],"Ovid,":[35],"Cochrane":[36],"Library,":[37],"EBSCO,":[38],"CINAHL)":[39],"through":[40],"March":[41],"2026":[42],"for":[43,200,214,238,277],"randomised":[44],"controlled":[45],"trials":[46],"(RCTs).":[47],"The":[48],"primary":[49],"outcome":[50],"was":[51,197],"strength;":[53],"secondary":[54],"outcomes":[55],"included":[56],"gait,":[57],"power,":[60],"adverse":[62],"events.":[63],"Methodological":[64],"quality":[65],"evidence":[67],"certainty":[68],"were":[69,83],"evaluated":[70],"using":[71],"RoB":[72],"2.0":[73],"GRADEpro,":[75],"respectively.":[76],"RESULTS:":[77],"Fifteen":[78],"RCTs":[79],"(n":[80],"=":[81,91,101,164,167,173,176],"438)":[82],"included.":[84],"EOT":[85,120,234],"may":[86],"enhance":[87],"strength":[89,124,145,162,229,241],"(SMD":[90,100,163,172],"0.50,":[92],"95%":[93,103],"CI":[94,104],"[0.12,":[95],"0.87])":[96],"0.39,":[102],"[0.07,":[105],"0.71])":[106],"elderly":[109,279],"population.":[110],"A":[111],"post-hoc":[112],"subgroup":[113,150],"analysis":[114],"by":[115],"comparator":[116],"type":[117],"indicated":[118],"that":[119,153],"significantly":[121,184],"improved":[122],"relative":[125],"to":[126,270],"inactive":[127],"controls,":[128],"while":[129,178,259],"showing":[130],"at":[131],"least":[132],"a":[133],"non-inferiority":[134],"trend":[135],"compared":[136],"with":[137],"conventional":[138],"resistance":[139],"improving":[142,160,215,239],"both":[143,227,283],"power.":[148,217,232],"Exploratory":[149],"analyses":[151],"revealed":[152],"flywheel":[154],"devices":[155],"demonstrated":[156],"superior":[157],"0.54,":[165],"P":[166,175],"0.04)":[168],"0.44,":[174],"0.03),":[177],"physical":[179],"health":[180],"status":[181],"did":[182],"not":[183],"influence":[185],"effect":[186],"sizes.":[187],"Regarding":[188],"intervention":[189],"frequency,":[190],"high-frequency":[191,263],"(>2":[193],"sessions":[194,208],"per":[195,209],"week)":[196,210],"more":[198,212],"effective":[199],"whereas":[204],"low-frequency":[205,265],"(\u22642":[207],"appeared":[211],"beneficial":[213],"Furthermore,":[218],"long-term":[219],"(\u22658":[221],"weeks)":[222],"yielded":[223],"greater":[224,257],"improvements":[225],"CONCLUSION(S):":[233],"shows":[235],"promising":[236],"potential":[237],"(moderate":[242],"certainty)":[243,248],"(high":[247],"Long-term":[252],"protocols":[254],"result":[255],"efficacy,":[258],"choice":[261],"between":[262],"should":[267,281],"be":[268],"tailored":[269],"specific":[271],"clinical":[272],"objectives.":[273],"Future":[274],"exercise":[275],"prescriptions":[276],"population":[280],"prioritize":[282],"standardization":[284],"personalization.":[286]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-08-29T00:00:00"}