{"id":"https://openalex.org/W7204540751","doi":"https://doi.org/10.1093/crocol/otag094","title":"FUT2 non-secretor status is not associated with disease phenotype or outcomes in patients with Crohn\u2019s disease","display_name":"FUT2 non-secretor status is not associated with disease phenotype or outcomes in patients with Crohn\u2019s disease","publication_year":2026,"publication_date":"2026-07-01","ids":{"openalex":"https://openalex.org/W7204540751","doi":"https://doi.org/10.1093/crocol/otag094","pmid":"https://pubmed.ncbi.nlm.nih.gov/42662997","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13521598"},"language":"en","primary_location":{"id":"doi:10.1093/crocol/otag094","doi":"https://doi.org/10.1093/crocol/otag094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/crocol/otag094","pdf_url":null,"source":{"id":"https://openalex.org/S4210185706","display_name":"Crohn s & Colitis 360","issn_l":"2631-827X","issn":["2631-827X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crohn\u2019s & Colitis 360","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1093/crocol/otag094","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066307444","display_name":"Rachel Lombard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Lombard","raw_affiliation_strings":["University of Chicago Medicine, Department of Medicine , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Department of Medicine , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159965669","display_name":"Wenfei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenfei Wang","raw_affiliation_strings":["University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022795978","display_name":"Alexander V. Chervonsky","orcid":"https://orcid.org/0000-0001-7547-871X","observed_orcids":["https://orcid.org/0000-0001-7547-871X"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Chervonsky","raw_affiliation_strings":["University of Chicago, Committee on Immunology , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Committee on Immunology , Chicago, IL,","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135149664","display_name":"Sushila Dalal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sushila Dalal","raw_affiliation_strings":["University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023182644","display_name":"Russell D. Cohen","orcid":"https://orcid.org/0000-0002-6114-8936","observed_orcids":["https://orcid.org/0000-0002-6114-8936"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell D Cohen","raw_affiliation_strings":["University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063018115","display_name":"Atsushi Sakuraba","orcid":"https://orcid.org/0000-0003-2519-6129","observed_orcids":["https://orcid.org/0000-0003-2519-6129"]},"institutions":[{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atsushi Sakuraba","raw_affiliation_strings":["Rush University, Section of Gastroenterology , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rush University, Section of Gastroenterology , Chicago, IL,","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049169459","display_name":"David T. Rubin","orcid":"https://orcid.org/0000-0001-5647-1723","observed_orcids":["https://orcid.org/0000-0001-5647-1723"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T Rubin","raw_affiliation_strings":["University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148501653","display_name":"Christopher R Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R Weber","raw_affiliation_strings":["University of Chicago Medicine, Department of Pathology , Chicago, IL,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Department of Pathology , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059142660","display_name":"Joel R. Pekow","orcid":"https://orcid.org/0000-0002-4790-8994","observed_orcids":["https://orcid.org/0000-0002-4790-8994"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4210087865","display_name":"University of Chicago Medical Center","ror":"https://ror.org/0076kfe04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087865"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joel Pekow","raw_affiliation_strings":["University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,"],"raw_orcid":"https://orcid.org/0000-0002-4790-8994","affiliations":[{"raw_affiliation_string":"University of Chicago Medicine, Section of Gastroenterology Hepatology, and Nutrition , Chicago, IL,","institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059142660"],"corresponding_institution_ids":["https://openalex.org/I40347166","https://openalex.org/I4210087865"],"apc_list":{"value":3378,"currency":"USD","value_usd":3378},"apc_paid":{"value":3378,"currency":"USD","value_usd":3378},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62755753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"3","first_page":"otag094","last_page":"otag094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9490000009536743},{"id":"https://openalex.org/keywords/fut2","display_name":"FUT2","score":0.8899999856948853},{"id":"https://openalex.org/keywords/blood-group-antigens","display_name":"blood group antigens","score":0.7020000219345093},{"id":"https://openalex.org/keywords/rs601338","display_name":"rs601338","score":0.8119999766349792},{"id":"https://openalex.org/keywords/disease-phenotype","display_name":"disease phenotypes","score":0.5870000123977661},{"id":"https://openalex.org/keywords/extraintestinal-manifestations","display_name":"extraintestinal manifestations","score":0.8159999847412109},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.843999981880188},{"id":"https://openalex.org/keywords/immunomodulators","display_name":"immunomodulators","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.593999981880188},{"id":"https://openalex.org/keywords/disease-outcome","display_name":"disease outcome","score":0.48500001430511475},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5040000081062317},{"id":"https://openalex.org/keywords/host-microbe-symbiosis","display_name":"host-microbe symbiosis","score":0.6669999957084656},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8084999918937683},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.6297000050544739},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5841000080108643},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5651999711990356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5055999755859375},{"id":"https://openalex.org/C96777560","wikidata":"https://www.wikidata.org/wiki/Q518638","display_name":"Nonsense mutation","level":5,"score":0.4205000102519989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4016000032424927},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3898000121116638},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33230000734329224},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3095000088214874},{"id":"https://openalex.org/C2781428731","wikidata":"https://www.wikidata.org/wiki/Q911427","display_name":"Behcet's disease","level":3,"score":0.2980000078678131},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.2766000032424927},{"id":"https://openalex.org/C200844832","wikidata":"https://www.wikidata.org/wiki/Q5533517","display_name":"Genotype-phenotype distinction","level":4,"score":0.2745000123977661},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.2540999948978424}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/crocol/otag094","doi":"https://doi.org/10.1093/crocol/otag094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/crocol/otag094","pdf_url":null,"source":{"id":"https://openalex.org/S4210185706","display_name":"Crohn s & Colitis 360","issn_l":"2631-827X","issn":["2631-827X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crohn\u2019s & Colitis 360","raw_type":"journal-article"},{"id":"pmid:42662997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42662997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crohn's & colitis 360","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13521598","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521598/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crohns Colitis 360","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/crocol/otag094","doi":"https://doi.org/10.1093/crocol/otag094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/crocol/otag094","pdf_url":null,"source":{"id":"https://openalex.org/S4210185706","display_name":"Crohn s & Colitis 360","issn_l":"2631-827X","issn":["2631-827X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Crohn\u2019s & Colitis 360","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1581010761","https://openalex.org/W1965301687","https://openalex.org/W1997993215","https://openalex.org/W2055741797","https://openalex.org/W2142671825","https://openalex.org/W2167700091","https://openalex.org/W2571503386","https://openalex.org/W2576956426","https://openalex.org/W2806496112","https://openalex.org/W3135877689","https://openalex.org/W3210492059","https://openalex.org/W4285800842","https://openalex.org/W4405458918"],"related_works":["https://openalex.org/W2979866842","https://openalex.org/W2587363976","https://openalex.org/W3210492059","https://openalex.org/W2167700091","https://openalex.org/W2912378906","https://openalex.org/W2953943846","https://openalex.org/W2607023186","https://openalex.org/W1541774397","https://openalex.org/W2605923554","https://openalex.org/W1995854943"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"The":[2,57,176,252],"fucosyltransferase":[3],"2":[4,185],"gene":[5,35],"(FUT2)":[6],"is":[7,48,62,85,369],"responsible":[8],"for":[9,22,111],"the":[10,38,51,75,119,124,161,306,347],"regulation":[11],"of":[12,40,53,59,72,77,179,206,209,255,276,282,290,294,308,342,367],"mucosal":[13],"blood":[14,110],"type":[15],"antigens":[16],"which":[17,122],"can":[18],"act":[19],"as":[20,223,225],"receptors":[21],"bacterial":[23],"adhesion":[24],"and":[25,47,83,140,146,171,184,204,219,228,240,243,245,247,292],"regulate":[26],"intestinal":[27],"flora.":[28],"A":[29],"homozygous":[30,173],"nonsense":[31,125],"mutation":[32,126],"in":[33,66,160,273,305,381],"this":[34,60,339],"leads":[36],"to":[37,129,233,288],"absence":[39],"these":[41],"antigens,":[42],"termed":[43],"FUT2":[44,78,151,165,348],"non-secretor":[45,132],"status,":[46,201],"associated":[49,352,370],"with":[50,101,156,270,345,353,371],"development":[52,71],"Crohn\u2019s":[54],"disease":[55,136,226,354,356,383],"(CD).":[56],"mechanism":[58],"association":[61],"likely":[63],"via":[64],"changes":[65],"homeostatic":[67],"symbiosis,":[68],"thus":[69],"promoting":[70],"inflammation.":[73],"However,":[74],"impact":[76],"genotype":[79,349],"on":[80,150],"CD":[81,102,157],"phenotype":[82],"outcomes":[84],"not":[86,351,376],"known.":[87],"Methods":[88],"Subjects":[89],"were":[90,113,142,158,188,230,300],"prospectively":[91],"enrolled":[92],"into":[93],"a":[94,378],"single-center":[95,340],"translational":[96],"IBD":[97],"registry.":[98],"All":[99],"patients":[100,155,284,309,344],"who":[103,310],"had":[104],"available":[105],"DNA":[106],"extracted":[107],"from":[108],"peripheral":[109],"genotyping":[112],"included.":[114],"Genotyping":[115],"was":[116,181,260,350],"performed":[117],"using":[118],"rs601338-AA":[120],"SNP,":[121],"represents":[123],"(428GA)":[127],"shown":[128],"be":[130,234],"causing":[131],"status.":[133],"Baseline":[134],"demographics,":[135],"phenotype,":[137,355],"CD-related":[138,315],"surgeries,":[139],"hospitalizations":[141],"also":[143,231],"assessed":[144],"retrospectively":[145],"statistically":[147,190],"compared":[148,237,287],"based":[149],"genotype.":[152],"Results":[153],"635":[154,343],"included":[159],"analysis,":[162],"including":[163,212],"178":[164],"wild-type":[166],"(WT),":[167],"314":[168],"heterozygous":[169],"(HET)":[170],"143":[172],"(O)":[174],"patients.":[175,296],"mean":[177,253],"duration":[178,275],"follow-up":[180],"8":[182],"years":[183],"months.":[186],"There":[187],"no":[189,271,301],"significant":[191],"differences":[192,302],"detected":[193],"between":[194,238,258,279,303],"genotypes":[195],"when":[196,236],"comparing":[197],"sex,":[198],"race,":[199],"smoking":[200],"body-mass":[202],"index,":[203],"age":[205],"onset.":[207],"Presence":[208],"extra-intestinal":[210],"manifestations":[211],"arthritis,":[213],"uveitis,":[214],"erythema":[215],"nodosum,":[216],"pyoderma":[217],"gangrenosum":[218],"primary":[220],"sclerosing":[221],"cholangitis,":[222],"well":[224],"location":[227],"behavior":[229],"found":[232],"similar":[235],"O":[239,242,246,283],"WT,":[241],"HET,":[244],"HET":[248,291,320,331],"plus":[249],"WT":[250,295,323,334],"populations.":[251],"number":[254,307],"biologics":[256],"used":[257,285],"groups":[259,304],"1.50":[261],"(O),":[262],"1.39":[263],"(HET)and":[264],"1.42":[265],"(WT)":[266],"(P":[267],"=":[268,318,321,324,329,332,335],".55),":[269],"difference":[272],"total":[274],"biologic":[277],"therapy":[278],"groups.":[280],"60.8%":[281],"immunomodulators":[286],"54.8%":[289],"59.6%":[293],"In":[297,338],"addition,":[298],"there":[299],"required":[311],"more":[312],"than":[313],"one":[314],"hospitalization":[316],"(O":[317,328],"30.1%,":[319],"34.1%,":[322],"30.3%)":[325],"or":[326,358],"surgery":[327],"32.2%,":[330],"39.5%,":[333],"32%).":[336],"Conclusion":[337],"analysis":[341],"CD,":[346,373],"severity,":[357],"clinical":[359],"outcomes.":[360],"These":[361],"data":[362],"suggest":[363],"that":[364],"while":[365],"lack":[366],"fucosylation":[368],"developing":[372],"it":[374],"does":[375],"play":[377],"major":[379],"role":[380],"driving":[382],"progression.":[384]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-08-29T00:00:00"}