{"id":"https://openalex.org/W7204536574","doi":"https://doi.org/10.31557/apjcp.2026.27.8.2871","title":"miR-1294 Upregulation as a Diagnostic Biomarker for Cholangiocarcinoma","display_name":"miR-1294 Upregulation as a Diagnostic Biomarker for Cholangiocarcinoma","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204536574","doi":"https://doi.org/10.31557/apjcp.2026.27.8.2871","pmid":"https://pubmed.ncbi.nlm.nih.gov/42663208"},"language":"en","primary_location":{"id":"doi:10.31557/apjcp.2026.27.8.2871","doi":"https://doi.org/10.31557/apjcp.2026.27.8.2871","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2026.27.8.2871","pdf_url":"https://journal.waocp.org/article_92319_ab67784b390cc926ef38dc3d273fe3e4.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journal.waocp.org/article_92319_ab67784b390cc926ef38dc3d273fe3e4.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012071564","display_name":"Kittiya Supradit","orcid":"https://orcid.org/0009-0005-8049-5991","observed_orcids":["https://orcid.org/0009-0005-8049-5991"]},"institutions":[{"id":"https://openalex.org/I58196637","display_name":"Ramkhamhaeng University","ror":"https://ror.org/00mrw8k38","country_code":"TH","type":"education","lineage":["https://openalex.org/I58196637"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kittiya Supradit","raw_affiliation_strings":["Department of Radiological Technology, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological Technology, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand","institution_ids":["https://openalex.org/I58196637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048040362","display_name":"Teva Phanaksri","orcid":"https://orcid.org/0000-0003-1790-4746","observed_orcids":["https://orcid.org/0000-0003-1790-4746"]},"institutions":[{"id":"https://openalex.org/I108108428","display_name":"Thammasat University","ror":"https://ror.org/002yp7f20","country_code":"TH","type":"education","lineage":["https://openalex.org/I108108428"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Teva Phanaksri","raw_affiliation_strings":["Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038631397","display_name":"Sattrachai Prasopdee","orcid":"https://orcid.org/0000-0003-0175-9679","observed_orcids":["https://orcid.org/0000-0003-0175-9679"]},"institutions":[{"id":"https://openalex.org/I108108428","display_name":"Thammasat University","ror":"https://ror.org/002yp7f20","country_code":"TH","type":"education","lineage":["https://openalex.org/I108108428"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sattrachai Prasopdee","raw_affiliation_strings":["Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand","Thammasat Research Unit in Opisthorchiasis, Cholangiocarcinoma, and Neglected parasitic Diseases (TRU-OCN), Thammasat University, Pathumthani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]},{"raw_affiliation_string":"Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]},{"raw_affiliation_string":"Thammasat Research Unit in Opisthorchiasis, Cholangiocarcinoma, and Neglected parasitic Diseases (TRU-OCN), Thammasat University, Pathumthani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052201974","display_name":"Sithichoke Tangphatsornruang","orcid":"https://orcid.org/0000-0003-2673-0012","observed_orcids":["https://orcid.org/0000-0003-2673-0012"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sithichoke Tangphatsornruang","raw_affiliation_strings":["National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053382453","display_name":"Duangjai Sangsrakru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Duangjai Sangsrakru","raw_affiliation_strings":["National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062676672","display_name":"Kanokpan Wongprasert","orcid":"https://orcid.org/0000-0002-9930-5909","observed_orcids":["https://orcid.org/0000-0002-9930-5909"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kanokpan Wongprasert","raw_affiliation_strings":["Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071997679","display_name":"Montinee Pholhelm","orcid":"https://orcid.org/0009-0002-3583-3582","observed_orcids":["https://orcid.org/0009-0002-3583-3582"]},"institutions":[{"id":"https://openalex.org/I108108428","display_name":"Thammasat University","ror":"https://ror.org/002yp7f20","country_code":"TH","type":"education","lineage":["https://openalex.org/I108108428"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Montinee Pholhelm","raw_affiliation_strings":["Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand","Thammasat Research Unit in Opisthorchiasis, Cholangiocarcinoma, and Neglected parasitic Diseases (TRU-OCN), Thammasat University, Pathumthani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]},{"raw_affiliation_string":"Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]},{"raw_affiliation_string":"Thammasat Research Unit in Opisthorchiasis, Cholangiocarcinoma, and Neglected parasitic Diseases (TRU-OCN), Thammasat University, Pathumthani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013508821","display_name":"Kritiya Butthongkomvong","orcid":"https://orcid.org/0000-0003-3714-7113","observed_orcids":["https://orcid.org/0000-0003-3714-7113"]},"institutions":[{"id":"https://openalex.org/I4405277085","display_name":"Udon Thani Cancer Hospital","ror":"https://ror.org/01dca0547","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I4405277085"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kritiya Butthongkomvong","raw_affiliation_strings":["Medical Oncology Unit, Udonthani Cancer Hospital, Udon Thani, 41330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Unit, Udonthani Cancer Hospital, Udon Thani, 41330, Thailand","institution_ids":["https://openalex.org/I4405277085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109076961","display_name":"Jutharat Kulsantiwong","orcid":"https://orcid.org/0009-0004-4711-9233","observed_orcids":["https://orcid.org/0009-0004-4711-9233"]},"institutions":[{"id":"https://openalex.org/I3132704155","display_name":"Udon Thani Rajabhat University","ror":"https://ror.org/05h6yt550","country_code":"TH","type":"education","lineage":["https://openalex.org/I3132704155"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jutharat Kulsantiwong","raw_affiliation_strings":["Faculty of Science, Udon Thani Rajabhat University, Udon Thani, 41000, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Science, Udon Thani Rajabhat University, Udon Thani, 41000, Thailand","institution_ids":["https://openalex.org/I3132704155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042865248","display_name":"Anthicha Kunjantarachot","orcid":"https://orcid.org/0000-0002-1463-6902","observed_orcids":["https://orcid.org/0000-0002-1463-6902"]},"institutions":[{"id":"https://openalex.org/I108108428","display_name":"Thammasat University","ror":"https://ror.org/002yp7f20","country_code":"TH","type":"education","lineage":["https://openalex.org/I108108428"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Anthicha Kunjantarachot","raw_affiliation_strings":["Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043601427","display_name":"Veerachai Thitapakorn","orcid":"https://orcid.org/0000-0001-9350-2146","observed_orcids":["https://orcid.org/0000-0001-9350-2146"]},"institutions":[{"id":"https://openalex.org/I108108428","display_name":"Thammasat University","ror":"https://ror.org/002yp7f20","country_code":"TH","type":"education","lineage":["https://openalex.org/I108108428"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Veerachai Thitapakorn","raw_affiliation_strings":["Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand","Thammasat Research Unit in Opisthorchiasis, Cholangiocarcinoma, and Neglected parasitic Diseases (TRU-OCN), Thammasat University, Pathumthani, 12120, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chulabhorn International College of Medicine (CICM), Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]},{"raw_affiliation_string":"Research Group in Multidimensional Health and Disease (MHD), Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]},{"raw_affiliation_string":"Thammasat Research Unit in Opisthorchiasis, Cholangiocarcinoma, and Neglected parasitic Diseases (TRU-OCN), Thammasat University, Pathumthani, 12120, Thailand","institution_ids":["https://openalex.org/I108108428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200,"currency":"USD","value_usd":200},"apc_paid":{"value":200,"currency":"USD","value_usd":200},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"8","first_page":"2871","last_page":"2877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.18330000340938568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocarcinoma","display_name":"cholangiocarcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasma-mirna","display_name":"plasma microRNA","score":0.8140000104904175},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.9879999756813049},{"id":"https://openalex.org/keywords/non-invasive-cancer-detection","display_name":"non-invasive cancer detection","score":0.7440000176429749},{"id":"https://openalex.org/keywords/mirna-upregulation","display_name":"miRNA upregulation","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8623999953269958},{"id":"https://openalex.org/C2778040090","wikidata":"https://www.wikidata.org/wiki/Q135523","display_name":"Opisthorchis viverrini","level":4,"score":0.8105000257492065},{"id":"https://openalex.org/C3017616150","wikidata":"https://www.wikidata.org/wiki/Q1069330","display_name":"Diagnostic biomarker","level":3,"score":0.7752000093460083},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6759999990463257},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.589900016784668},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5760999917984009},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.47699999809265137},{"id":"https://openalex.org/C2778455985","wikidata":"https://www.wikidata.org/wiki/Q17553105","display_name":"miR-155","level":4,"score":0.4431999921798706},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.42899999022483826},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.36959999799728394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3573000133037567},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32760000228881836},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.32499998807907104},{"id":"https://openalex.org/C2780431383","wikidata":"https://www.wikidata.org/wiki/Q2563380","display_name":"Opisthorchis","level":4,"score":0.32280001044273376},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.30970001220703125},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.29820001125335693},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.295199990272522},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2606000006198883}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009889","descriptor_name":"Opisthorchiasis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009889","descriptor_name":"Opisthorchiasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009889","descriptor_name":"Opisthorchiasis","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D009891","descriptor_name":"Opisthorchis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.31557/apjcp.2026.27.8.2871","doi":"https://doi.org/10.31557/apjcp.2026.27.8.2871","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2026.27.8.2871","pdf_url":"https://journal.waocp.org/article_92319_ab67784b390cc926ef38dc3d273fe3e4.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},{"id":"pmid:42663208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42663208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific journal of cancer prevention : APJCP","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.31557/apjcp.2026.27.8.2871","doi":"https://doi.org/10.31557/apjcp.2026.27.8.2871","is_oa":true,"landing_page_url":"https://doi.org/10.31557/apjcp.2026.27.8.2871","pdf_url":"https://journal.waocp.org/article_92319_ab67784b390cc926ef38dc3d273fe3e4.pdf","source":{"id":"https://openalex.org/S121579133","display_name":"Asian Pacific Journal of Cancer Prevention","issn_l":"1513-7368","issn":["1513-7368","2476-762X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319060","host_organization_name":"West Asia Organization for Cancer Prevention","host_organization_lineage":["https://openalex.org/P4310319060"],"host_organization_lineage_names":["West Asia Organization for Cancer Prevention"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Pacific Journal of Cancer Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6126532520","display_name":null,"funder_award_id":"T3/2562","funder_id":"https://openalex.org/F4320323439","funder_display_name":"Thammasat University"}],"funders":[{"id":"https://openalex.org/F4320323439","display_name":"Thammasat University","ror":"https://ror.org/002yp7f20"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204536574.pdf","grobid_xml":"https://content.openalex.org/works/W7204536574.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1517631474","https://openalex.org/W2067787677","https://openalex.org/W2173594285","https://openalex.org/W2662858192","https://openalex.org/W2921958600","https://openalex.org/W2948012423","https://openalex.org/W3094059892","https://openalex.org/W3203668128","https://openalex.org/W4220962544","https://openalex.org/W4223974005","https://openalex.org/W4229020293","https://openalex.org/W4285401632","https://openalex.org/W4289928579","https://openalex.org/W4307568034","https://openalex.org/W4322721875","https://openalex.org/W4366996413","https://openalex.org/W4375856187","https://openalex.org/W4393065176","https://openalex.org/W4395678035","https://openalex.org/W4400460925","https://openalex.org/W4401560453","https://openalex.org/W4402266154","https://openalex.org/W4402329186","https://openalex.org/W4405097973","https://openalex.org/W4405210681","https://openalex.org/W4406219648","https://openalex.org/W4411011326"],"related_works":["https://openalex.org/W4405210681","https://openalex.org/W4414494485","https://openalex.org/W7171622888","https://openalex.org/W1967252813","https://openalex.org/W4402013024","https://openalex.org/W2014095115","https://openalex.org/W4205273774","https://openalex.org/W4393268023","https://openalex.org/W3141120120","https://openalex.org/W4401560453"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1,19],"investigate":[2],"plasma":[3,28,68,121],"miR-1294":[4,52,69,92,122,137],"levels":[5],"in":[6,70,125,164],"cholangiocarcinoma":[7],"(CCA)":[8],"patients":[9,49,71],"compared":[10,74],"with":[11,50,72,75,107,166],"healthy":[12,39],"individuals":[13],"and":[14,32,47,78,112,152],"Opisthorchis":[15],"viverrini-infected":[16],"subjects.":[17],"METHODS:":[18],"assess":[20],"its":[21,149,156],"potential":[22,157],"as":[23,143,159],"a":[24,64,108,113,144,160],"plasma-based":[25],"diagnostic":[26,146,168],"biomarker,":[27,162],"samples":[29],"were":[30],"collected":[31],"total":[33],"RNA":[34],"was":[35,54,123],"extracted":[36],"from":[37,95],"15":[38],"controls":[40],"(HC),":[41],"12":[42],"O.":[43],"viverrini":[44],"(OV)-infected":[45],"individuals,":[46],"33":[48],"CCA.":[51,174],"expression":[53,61],"quantified":[55],"using":[56],"RT-qPCR":[57],"(MiRXES).":[58],"RESULTS:":[59],"Relative":[60],"analysis":[62,89],"demonstrated":[63],"significant":[65],"upregulation":[66,119],"of":[67,105,110,115,120,173],"CCA":[73,94],"both":[76],"HC":[77],"OV":[79],"groups":[80],"(P":[81],"<":[82],"0.0001).":[83],"Receiver":[84],"operating":[85],"characteristic":[86],"(ROC)":[87],"curve":[88,103],"showed":[90],"that":[91,136],"discriminated":[93],"non-CCA":[96],"subjects,":[97],"yielding":[98],"an":[99],"area":[100],"under":[101],"the":[102,132],"(AUC)":[104],"0.8676,":[106],"specificity":[109,151],"96.30%":[111],"sensitivity":[114,134],"63.64%.":[116],"CONCLUSION:":[117],"The":[118],"investigated":[124],"this":[126],"study.":[127],"Despite":[128],"these":[129],"promising":[130],"findings,":[131],"moderate":[133],"suggests":[135],"alone":[138],"may":[139],"not":[140],"be":[141],"sufficient":[142],"standalone":[145],"marker.":[147],"Nevertheless,":[148],"high":[150],"non-invasive":[153],"detectability":[154],"highlight":[155],"utility":[158],"complementary":[161],"particularly":[163],"combination":[165],"other":[167],"indicators":[169],"for":[170],"improved":[171],"detection":[172]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-29T00:00:00"}