{"id":"https://openalex.org/W7204532672","doi":"https://doi.org/10.21037/jgo-2026-0570","title":"Early hypoalbuminemia during zolbetuximab therapy in gastroesophageal adenocarcinoma: a retrospective observational study","display_name":"Early hypoalbuminemia during zolbetuximab therapy in gastroesophageal adenocarcinoma: a retrospective observational study","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204532672","doi":"https://doi.org/10.21037/jgo-2026-0570","pmid":"https://pubmed.ncbi.nlm.nih.gov/42703500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13546564"},"language":"en","primary_location":{"id":"doi:10.21037/jgo-2026-0570","doi":"https://doi.org/10.21037/jgo-2026-0570","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0570","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/jgo-2026-0570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113715271","display_name":"Fares Jamal","orcid":"https://orcid.org/0009-0007-6286-3855","observed_orcids":["https://orcid.org/0009-0007-6286-3855"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fares Jamal","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046692471","display_name":"Cody R. Eslinger","orcid":"https://orcid.org/0000-0002-8057-0841","observed_orcids":["https://orcid.org/0000-0002-8057-0841"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cody Eslinger","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134522152","display_name":"Abdullah Alsulaiman","orcid":"https://orcid.org/0009-0003-5204-8102","observed_orcids":["https://orcid.org/0009-0003-5204-8102"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdullah Alsulaiman","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074891676","display_name":"Tanios Bekaii\u2010Saab","orcid":"https://orcid.org/0000-0001-7721-1699","observed_orcids":["https://orcid.org/0000-0001-7721-1699","https://orcid.org/0000-0003-4653-4537"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanios Bekaii-Saab","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112405214","display_name":"Hao Xie","orcid":"https://orcid.org/0000-0003-1059-049X","observed_orcids":["https://orcid.org/0000-0003-1059-049X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Xie","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125981439","display_name":"Daniel Ahn","orcid":"https://orcid.org/0000-0002-0161-4018","observed_orcids":["https://orcid.org/0000-0002-0161-4018"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Ahn","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054238636","display_name":"Jason Scott Starr","orcid":"https://orcid.org/0000-0002-8674-8102","observed_orcids":["https://orcid.org/0000-0002-8674-8102","https://orcid.org/0000-0003-4922-1392"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason S. Starr","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148551755","display_name":"Jake Jochum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jake Jochum","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041256351","display_name":"Nguyen H. Tran","orcid":"https://orcid.org/0000-0002-6104-6489","observed_orcids":["https://orcid.org/0000-0002-6104-6489"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nguyen H. Tran","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043260959","display_name":"Mojun Zhu","orcid":"https://orcid.org/0000-0003-0146-9452","observed_orcids":["https://orcid.org/0000-0003-0146-9452"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mojun Zhu","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122672590","display_name":"Ben George","orcid":"https://orcid.org/0000-0002-9667-9833","observed_orcids":["https://orcid.org/0000-0002-9667-9833"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben George","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091765092","display_name":"Caitlin B. Conboy","orcid":"https://orcid.org/0000-0001-8280-056X","observed_orcids":["https://orcid.org/0000-0001-8280-056X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlin B. Conboy","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020513765","display_name":"Conor D.J. O\u2019Donnell","orcid":"https://orcid.org/0009-0009-6291-846X","observed_orcids":["https://orcid.org/0009-0009-6291-846X"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Conor D. J. O\u2019Donnell","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Jacksonville, FL, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Jacksonville, FL, USA;","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081189160","display_name":"Jamie Bering","orcid":"https://orcid.org/0000-0001-6161-7088","observed_orcids":["https://orcid.org/0000-0001-6161-7088"]},"institutions":[{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Bering","raw_affiliation_strings":["Department of Gastroenterology & Hepatology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology & Hepatology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4390039332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045186065","display_name":"Harry H. Yoon","orcid":"https://orcid.org/0000-0001-6208-3487","observed_orcids":["https://orcid.org/0000-0001-6208-3487"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry H. Yoon","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059366804","display_name":"Mohamad Bassam Sonbol","orcid":"https://orcid.org/0000-0002-6931-242X","observed_orcids":["https://orcid.org/0000-0002-6931-242X"]},"institutions":[{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]},{"id":"https://openalex.org/I4390039332","display_name":"Mayo Clinic Comprehensive Cancer Center (Arizona)","ror":"https://ror.org/003xpy695","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4390039332"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mohamad Bassam Sonbol","raw_affiliation_strings":["Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology & Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Phoenix, AZ, USA","institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5059366804"],"corresponding_institution_ids":["https://openalex.org/I4210127938","https://openalex.org/I4390039332"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59460279,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"4","first_page":"210","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zolbetuximab","display_name":"zolbetuximab","score":1.0},{"id":"https://openalex.org/keywords/hypoalbuminemia","display_name":"hypoalbuminemia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.777999997138977},{"id":"https://openalex.org/keywords/total-protein","display_name":"total protein","score":0.8190000057220459},{"id":"https://openalex.org/keywords/claudin-18-2","display_name":"claudin 18.2","score":0.902999997138977},{"id":"https://openalex.org/keywords/gastroesophageal-adenocarcinoma","display_name":"gastroesophageal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/edema","display_name":"edema","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ascites","display_name":"ascites","score":1.0},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.6710000038146973},{"id":"https://openalex.org/keywords/laboratory-monitoring","display_name":"laboratory monitoring","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2776009029","wikidata":"https://www.wikidata.org/wiki/Q1640780","display_name":"Hypoalbuminemia","level":2,"score":0.9743000268936157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9524999856948853},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6970999836921692},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.6780999898910522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6543999910354614},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5990999937057495},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5695000290870667},{"id":"https://openalex.org/C165616093","wikidata":"https://www.wikidata.org/wiki/Q424232","display_name":"Serum albumin","level":2,"score":0.551800012588501},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5004000067710876},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.48809999227523804},{"id":"https://openalex.org/C2779225474","wikidata":"https://www.wikidata.org/wiki/Q842424","display_name":"Urinalysis","level":3,"score":0.38339999318122864},{"id":"https://openalex.org/C2777482430","wikidata":"https://www.wikidata.org/wiki/Q7168709","display_name":"Peripheral edema","level":3,"score":0.34380000829696655},{"id":"https://openalex.org/C2776924286","wikidata":"https://www.wikidata.org/wiki/Q284070","display_name":"Protein losing enteropathy","level":4,"score":0.31769999861717224},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.29269999265670776},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2565000057220459}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/jgo-2026-0570","doi":"https://doi.org/10.21037/jgo-2026-0570","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0570","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13546564","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13546564/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13546564/pdf/jgo-17-04-210.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastrointest Oncol","raw_type":"Text"},{"id":"pmid:42703500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42703500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/jgo-2026-0570","doi":"https://doi.org/10.21037/jgo-2026-0570","is_oa":true,"landing_page_url":"https://doi.org/10.21037/jgo-2026-0570","pdf_url":null,"source":{"id":"https://openalex.org/S2764940779","display_name":"Journal of Gastrointestinal Oncology","issn_l":"2078-6891","issn":["2078-6891","2219-679X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204532672.pdf","grobid_xml":"https://content.openalex.org/works/W7204532672.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7170207234","https://openalex.org/W7169756269","https://openalex.org/W7221761579","https://openalex.org/W4415218002","https://openalex.org/W7222981747","https://openalex.org/W7128803318","https://openalex.org/W4416167155","https://openalex.org/W4409350547","https://openalex.org/W4409228894","https://openalex.org/W4414710083"],"abstract_inverted_index":{"Background:":[0],"Zolbetuximab":[1,202],"has":[2],"improved":[3],"survival":[4],"in":[5,15,39,78,96,112,128,135,210,216],"claudin":[6],"18.2":[7],"(CLDN18.2)-positive":[8],"gastroesophageal":[9],"adenocarcinoma":[10],"(GEA).":[11],"Hypoalbuminemia":[12],"was":[13,75],"reported":[14],"phase":[16],"III":[17],"trials.":[18],"However,":[19],"the":[20,84,143],"timing,":[21],"magnitude,":[22],"and":[23,42,48,110,114,131,153,169,186,192,213,225,244,249,261],"clinical":[24,51,262],"phenotype":[25],"of":[26,60,100],"serum":[27,40,79,211],"protein":[28,44,116,133,155,215],"decline":[29,209],"remain":[30],"incompletely":[31],"characterized.":[32],"This":[33],"study":[34,59],"aimed":[35],"to":[36,83,107,258],"characterize":[37],"changes":[38,111],"albumin":[41,80,113,126,147,212],"total":[43,97,115,132,154,214],"during":[45,252],"zolbetuximab":[46,67],"therapy":[47,89,203],"their":[49],"associated":[50,205],"findings.":[52],"Methods:":[53],"We":[54],"performed":[55],"a":[56,239],"retrospective":[57],"cohort":[58],"patients":[61,122,164],"with":[62,66,174,206],"CLDN18.2-positive":[63],"GEA":[64],"treated":[65],"at":[68],"Mayo":[69],"Clinic":[70],"sites.":[71],"The":[72],"primary":[73],"endpoint":[74],"percent":[76,94],"change":[77,95],"from":[81,161],"baseline":[82],"first":[85,144],"post-treatment":[86],"measurement":[87],"following":[88,139],"initiation.":[90,141],"Secondary":[91],"endpoints":[92],"included":[93],"protein,":[98],"development":[99],"new":[101,167],"edema":[102,168,222],"or":[103,223,231],"ascites":[104,224],"not":[105,195,226],"attributable":[106],"disease":[108,183,233],"progression,":[109],"after":[117],"treatment":[118,140],"discontinuation.":[119],"Results:":[120],"Twenty-four":[121],"were":[123],"included.":[124],"Serum":[125],"declined":[127,134],"all":[129],"patients,":[130],"23/24":[136],"(95.8%)":[137],"immediately":[138],"After":[142],"cycle,":[145],"median":[146],"decreased":[148,156],"by":[149,157,221,228],"0.9":[150],"g/dL":[151,159],"(22.5%),":[152],"1.5":[158],"(23.7%)":[160],"baseline.":[162],"Ten":[163],"(41.7%)":[165],"developed":[166,172],"6":[170],"(25%)":[171],"ascites,":[173],"8":[175],"(33.3%)":[176],"requiring":[177],"diuretics":[178],"and/or":[179],"paracentesis,":[180],"without":[181],"radiographic":[182],"progression.":[184],"Renal":[185],"hepatic":[187],"laboratory":[188,247],"parameters":[189],"remained":[190],"stable,":[191],"urinalysis":[193],"did":[194],"demonstrate":[196],"nephrotic-range":[197],"(grade":[198],"3+)":[199],"proteinuria.":[200],"Conclusions:":[201],"is":[204],"an":[207],"early":[208],"real-world":[217],"practice,":[218],"frequently":[219],"accompanied":[220],"explained":[227],"renal,":[229],"hepatic,":[230],"progressive":[232],"factors.":[234],"These":[235],"findings":[236],"may":[237],"reflect":[238],"treatment-related":[240],"gastrointestinal":[241],"protein-losing":[242],"process":[243],"support":[245],"close":[246],"monitoring":[248],"supportive":[250],"management":[251],"therapy.":[253],"Further":[254],"studies":[255],"are":[256],"warranted":[257],"clarify":[259],"mechanism":[260],"impact.":[263]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-29T00:00:00"}