{"id":"https://openalex.org/W7204531713","doi":"https://doi.org/10.1016/j.brci.2026.100128","title":"PACSIN2 deletion impairs transferrin uptake and terminal erythroid maturation in mice","display_name":"PACSIN2 deletion impairs transferrin uptake and terminal erythroid maturation in mice","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204531713","doi":"https://doi.org/10.1016/j.brci.2026.100128"},"language":"en","primary_location":{"id":"doi:10.1016/j.brci.2026.100128","doi":"https://doi.org/10.1016/j.brci.2026.100128","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brci.2026.100128","pdf_url":"https://www.sciencedirect.com/science/article/pii/S3050598426000831/pdf","source":{"id":"https://openalex.org/S5407047418","display_name":"Blood Red Cells & Iron","issn_l":"3050-5984","issn":["3050-5984"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Red Cells & Iron","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S3050598426000831/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016571181","display_name":"Emily K. Boyd","orcid":"https://orcid.org/0000-0001-9925-0824","observed_orcids":["https://orcid.org/0000-0001-9925-0824"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily K. Boyd","raw_affiliation_strings":["Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI","Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0000-0001-9925-0824","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024810225","display_name":"Agata Steenackers","orcid":"https://orcid.org/0000-0002-2110-4322","observed_orcids":["https://orcid.org/0000-0002-2110-4322"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agata Steenackers","raw_affiliation_strings":["Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0000-0002-2110-4322","affiliations":[{"raw_affiliation_string":"Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007963773","display_name":"Katelyn E. Rosenbalm","orcid":"https://orcid.org/0009-0007-0512-2559","observed_orcids":["https://orcid.org/0009-0007-0512-2559"]},"institutions":[{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn E. Rosenbalm","raw_affiliation_strings":["Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0009-0007-0512-2559","affiliations":[{"raw_affiliation_string":"Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017238789","display_name":"Fabienne Proamer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153899","display_name":"Biologie et pharmacologie des plaquettes sanguines : h\u00e9mostase, thrombose, transfusion","ror":"https://ror.org/03qge6j93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210128919","https://openalex.org/I4387153899","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fabienne Proamer","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, INSERM, EFS Grand Est, BPPS UMR S1255, FMTS, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, INSERM, EFS Grand Est, BPPS UMR S1255, FMTS, Strasbourg, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153899","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064705509","display_name":"Phillip A. Doerfler","orcid":"https://orcid.org/0000-0001-7566-9073","observed_orcids":["https://orcid.org/0000-0001-7566-9073"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip A. Doerfler","raw_affiliation_strings":["Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI","Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI","Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0000-0001-7566-9073","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067713940","display_name":"Anita E. Eckly","orcid":"https://orcid.org/0000-0001-9620-4961","observed_orcids":["https://orcid.org/0000-0001-9620-4961"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153899","display_name":"Biologie et pharmacologie des plaquettes sanguines : h\u00e9mostase, thrombose, transfusion","ror":"https://ror.org/03qge6j93","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210128919","https://openalex.org/I4387153899","https://openalex.org/I68947357"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anita Eckly","raw_affiliation_strings":["Universit\u00e9 de Strasbourg, INSERM, EFS Grand Est, BPPS UMR S1255, FMTS, Strasbourg, France"],"raw_orcid":"https://orcid.org/0000-0001-9620-4961","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Strasbourg, INSERM, EFS Grand Est, BPPS UMR S1255, FMTS, Strasbourg, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153899","https://openalex.org/I68947357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019757442","display_name":"Karin M. Hoffmeister","orcid":"https://orcid.org/0000-0001-6526-7919","observed_orcids":["https://orcid.org/0000-0001-6526-7919"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin M. Hoffmeister","raw_affiliation_strings":["Departments of Biochemistry and Medicine, Medical College of Wisconsin, Milwaukee, WI","Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0000-0001-6526-7919","affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Medicine, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI","institution_ids":["https://openalex.org/I4210117001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023521073","display_name":"Herv\u00e9 Falet","orcid":"https://orcid.org/0000-0003-0788-9204","observed_orcids":["https://orcid.org/0000-0003-0788-9204"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]},{"id":"https://openalex.org/I4210117001","display_name":"Versiti Blood Center of Wisconsin","ror":"https://ror.org/02sjnfb25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210117001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Herv\u00e9 Falet","raw_affiliation_strings":["Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI","Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI"],"raw_orcid":"https://orcid.org/0000-0003-0788-9204","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Translational Glycomics Center, Versiti Blood Research Institute, Milwaukee, WI","institution_ids":["https://openalex.org/I4210117001"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63614078,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"4","first_page":"100128","last_page":"100128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.7943999767303467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.1476999968290329,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pacsin2","display_name":"PACSIN2","score":1.0},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/transferrin-uptake","display_name":"transferrin uptake","score":0.8840000033378601},{"id":"https://openalex.org/keywords/erythroblastic-islands","display_name":"erythroblastic islands","score":0.8700000047683716},{"id":"https://openalex.org/keywords/membrane-remodeling","display_name":"membrane remodeling","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.6940000057220459},{"id":"https://openalex.org/keywords/clathrin-mediated-endocytosis","display_name":"clathrin-mediated endocytosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.8519999980926514},{"id":"https://openalex.org/keywords/erythroblasts","display_name":"erythroblasts","score":0.6859999895095825},{"id":"https://openalex.org/keywords/microcytic-hypochromic-anemia","display_name":"microcytic hypochromic anemia","score":0.8569999933242798},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7590000033378601},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.675000011920929},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5989999771118164},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.5819000005722046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45489999651908875},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4075999855995178},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3407000005245209},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.3287000060081482},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3003999888896942},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2969000041484833},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.26820001006126404}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.brci.2026.100128","doi":"https://doi.org/10.1016/j.brci.2026.100128","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brci.2026.100128","pdf_url":"https://www.sciencedirect.com/science/article/pii/S3050598426000831/pdf","source":{"id":"https://openalex.org/S5407047418","display_name":"Blood Red Cells & Iron","issn_l":"3050-5984","issn":["3050-5984"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Red Cells & Iron","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:15a31aa7f3974a0eaeb570bad637368a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/15a31aa7f3974a0eaeb570bad637368a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood Red Cells & Iron, Vol 2, Iss 4, Pp 100128- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.brci.2026.100128","doi":"https://doi.org/10.1016/j.brci.2026.100128","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.brci.2026.100128","pdf_url":"https://www.sciencedirect.com/science/article/pii/S3050598426000831/pdf","source":{"id":"https://openalex.org/S5407047418","display_name":"Blood Red Cells & Iron","issn_l":"3050-5984","issn":["3050-5984"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Red Cells & Iron","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1754476332","display_name":null,"funder_award_id":"HL089224","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2932244038","display_name":null,"funder_award_id":"DK132453","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4950536974","display_name":null,"funder_award_id":"-0001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5754656488","display_name":null,"funder_award_id":"HL151333","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7988749740","display_name":null,"funder_award_id":"HL126743","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8396040624","display_name":null,"funder_award_id":"HL178566","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F1769481633","display_name":"Versiti Blood Research Institute Foundation","ror":null},{"id":"https://openalex.org/F4320310472","display_name":"Bloodcenter Research Foundation","ror":"https://ror.org/01pavyk18"},{"id":"https://openalex.org/F4320315843","display_name":"Office for Science and Technology of the Embassy of France in the United States","ror":"https://ror.org/027wfea20"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204531713.pdf","grobid_xml":"https://content.openalex.org/works/W7204531713.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4389248580","https://openalex.org/W3159393118","https://openalex.org/W2568884450","https://openalex.org/W2062281163","https://openalex.org/W4243175643","https://openalex.org/W3095631088","https://openalex.org/W1967048247","https://openalex.org/W7099529647","https://openalex.org/W2789273754","https://openalex.org/W2605232511"],"abstract_inverted_index":{"Erythropoiesis":[0],"requires":[1],"extensive":[2],"cytoskeletal":[3,25],"and":[4,17,75,82,118,132,187,194],"membrane":[5,178],"remodeling,":[6],"particularly":[7],"during":[8],"terminal":[9,195],"differentiation,":[10],"when":[11],"erythroblasts":[12,147,186],"undergo":[13],"chromatin":[14],"condensation,":[15],"polarization,":[16],"enucleation":[18,137],"within":[19],"erythroblastic":[20],"islands":[21],"(EBIs).":[22],"While":[23],"several":[24],"regulators":[26],"are":[27],"established":[28],"effectors":[29],"of":[30,34,46,108],"erythropoiesis,":[31],"the":[32,44,47,172,177],"contribution":[33,190],"membrane-sculpting":[35],"proteins":[36],"remains":[37],"less":[38],"well":[39],"defined.":[40],"Here,":[41],"we":[42],"investigated":[43],"role":[45,99],"Fes/CIP4":[48],"homology":[49],"Bin\u2013Amphiphysin\u2013Rvs":[50],"(F-BAR)":[51],"protein":[52],"PACSIN2":[53,87,175],"in":[54,100,144,166,176,185],"erythropoiesis":[55],"using":[56],"Pacsin2":[57,60,125,145],"\u2013/\u2013":[58,61,126,146],"mice.":[59],"mice":[62],"developed":[63],"mild":[64],"hypochromic":[65],"microcytic":[66],"anemia":[67],"with":[68,93,124],"preserved":[69],"red":[70,168],"blood":[71],"cell":[72],"(RBC)":[73],"counts":[74],"survival,":[76],"increased":[77],"resistance":[78],"to":[79,114,191],"osmotic":[80],"stress,":[81],"splenomegaly.":[83],"In":[84],"mature":[85],"RBCs,":[86],"localized":[88],"as":[89],"puncta":[90],"partially":[91],"overlapping":[92],"filamentous":[94],"actin":[95],"(F-actin),":[96],"supporting":[97],"a":[98],"membrane\u2013cytoskeleton":[101],"interactions.":[102],"Spectral":[103],"flow":[104],"cytometry":[105],"revealed":[106,163],"expansion":[107],"erythroid-biased":[109],"progenitors,":[110],"suggesting":[111],"compensatory":[112],"adaptation":[113],"impaired":[115,143],"maturation.":[116,197],"Ultrastructural":[117],"immunohistochemical":[119],"analyses":[120],"demonstrated":[121],"disrupted":[122],"EBIs,":[123],"macrophages":[127],"exhibiting":[128],"reduced":[129],"cytoplasmic":[130],"extensions":[131],"fewer":[133],"phagosomes.":[134],"Although":[135],"erythroblast":[136],"was":[138,142],"preserved,":[139],"transferrin":[140,182],"uptake":[141],"despite":[148],"normal":[149],"CD71":[150],"expression,":[151],"indicating":[152],"defective":[153],"clathrin-mediated":[154],"endocytosis":[155],"rather":[156],"than":[157],"receptor":[158,183],"availability.":[159],"Histological":[160],"analysis":[161],"further":[162],"iron":[164,192],"accumulation":[165],"splenic":[167],"pulp":[169],"macrophages.":[170],"Together,":[171],"findings":[173],"implicate":[174],"remodeling":[179],"required":[180],"for":[181],"internalization":[184],"demonstrate":[188],"its":[189],"acquisition":[193],"erythroid":[196]},"counts_by_year":[],"updated_date":"2026-10-11T09:32:39.932853","created_date":"2026-08-29T00:00:00"}