{"id":"https://openalex.org/W7204521154","doi":"https://doi.org/10.1016/j.jtbi.2026.112577","title":"A stochastic agent-based model for naive CD8+ T cell recirculation dynamics in mice","display_name":"A stochastic agent-based model for naive CD8+ T cell recirculation dynamics in mice","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204521154","doi":"https://doi.org/10.1016/j.jtbi.2026.112577","pmid":"https://pubmed.ncbi.nlm.nih.gov/42660280"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtbi.2026.112577","doi":"https://doi.org/10.1016/j.jtbi.2026.112577","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtbi.2026.112577","pdf_url":"https://www.sciencedirect.com/science/article/pii/S002251932600202X/pdf","source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S002251932600202X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042468546","display_name":"Nagat Elrefaei","orcid":"https://orcid.org/0000-0003-0078-7803","observed_orcids":["https://orcid.org/0000-0003-0078-7803"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nagat Elrefaei","raw_affiliation_strings":["Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada"],"raw_orcid":"https://orcid.org/0000-0003-0078-7803","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061442255","display_name":"David A. Christian","orcid":"https://orcid.org/0000-0002-7160-9900","observed_orcids":["https://orcid.org/0000-0002-7160-9900"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A. Christian","raw_affiliation_strings":["Department of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: dac2@vet.upenn.edu"],"raw_orcid":"https://orcid.org/0000-0002-7160-9900","affiliations":[{"raw_affiliation_string":"Department of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: dac2@vet.upenn.edu","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068181612","display_name":"Thomas A. Adams","orcid":"https://orcid.org/0000-0002-9871-9851","observed_orcids":["https://orcid.org/0000-0002-9871-9851"]},"institutions":[{"id":"https://openalex.org/I204778367","display_name":"Norwegian University of Science and Technology","ror":"https://ror.org/05xg72x27","country_code":"NO","type":"education","lineage":["https://openalex.org/I204778367"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA","NO"],"is_corresponding":true,"raw_author_name":"Thomas A. Adams","raw_affiliation_strings":["Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Energy and Process Engineering, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: thomas.a.adams@ntnu.no"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada; Department of Energy and Process Engineering, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address: thomas.a.adams@ntnu.no","institution_ids":["https://openalex.org/I204778367","https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061442255","https://openalex.org/A5068181612"],"corresponding_institution_ids":["https://openalex.org/I204778367","https://openalex.org/I79576946","https://openalex.org/I98251732"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.59400367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"635","issue":null,"first_page":"112577","last_page":"112577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.18379999697208405,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naive-cd8-t-cells","display_name":"naive CD8+ T cells","score":0.9769999980926514},{"id":"https://openalex.org/keywords/t-cell-recirculation","display_name":"T cell recirculation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/t-cell-migration","display_name":"T cell migration","score":0.8309999704360962},{"id":"https://openalex.org/keywords/stochastic-agent-based-model","display_name":"stochastic agent-based model","score":0.9160000085830688},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9279999732971191},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6284999847412109},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6008999943733215},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5318999886512756},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.49549999833106995},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47380000352859497},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.47189998626708984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46470001339912415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45989999175071716},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.43059998750686646},{"id":"https://openalex.org/C127491075","wikidata":"https://www.wikidata.org/wiki/Q7617825","display_name":"Stochastic modelling","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C55037315","wikidata":"https://www.wikidata.org/wiki/Q5421151","display_name":"Experimental data","level":2,"score":0.3887999951839447},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.3637000024318695},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.35420000553131104},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35190001130104065},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.31850001215934753},{"id":"https://openalex.org/C2775982045","wikidata":"https://www.wikidata.org/wiki/Q6959842","display_name":"Naive T cell","level":5,"score":0.3116999864578247},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.30720001459121704},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.29030001163482666},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.2700999975204468},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.2605000138282776}],"mesh":[{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011409","descriptor_name":"Propylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jtbi.2026.112577","doi":"https://doi.org/10.1016/j.jtbi.2026.112577","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtbi.2026.112577","pdf_url":"https://www.sciencedirect.com/science/article/pii/S002251932600202X/pdf","source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},{"id":"pmid:42660280","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42660280","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of theoretical biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jtbi.2026.112577","doi":"https://doi.org/10.1016/j.jtbi.2026.112577","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtbi.2026.112577","pdf_url":"https://www.sciencedirect.com/science/article/pii/S002251932600202X/pdf","source":{"id":"https://openalex.org/S109682412","display_name":"Journal of Theoretical Biology","issn_l":"0022-5193","issn":["0022-5193","1095-8541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Theoretical Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4264880446","display_name":null,"funder_award_id":"NIAID AI160664","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4617024164","display_name":null,"funder_award_id":"NIAID U01 AI160664","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320311526","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333634","display_name":"Anschutz Medical Campus, University of Colorado","ror":"https://ror.org/03wmf1y16"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204521154.pdf","grobid_xml":"https://content.openalex.org/works/W7204521154.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W37919037","https://openalex.org/W1186450586","https://openalex.org/W1588690200","https://openalex.org/W1632859538","https://openalex.org/W1654241956","https://openalex.org/W1899242698","https://openalex.org/W1949682302","https://openalex.org/W1963496063","https://openalex.org/W1968782720","https://openalex.org/W1986356063","https://openalex.org/W1992031335","https://openalex.org/W1992778083","https://openalex.org/W1995497089","https://openalex.org/W2013687680","https://openalex.org/W2015310734","https://openalex.org/W2021115043","https://openalex.org/W2027434623","https://openalex.org/W2032783083","https://openalex.org/W2033536958","https://openalex.org/W2033787149","https://openalex.org/W2034023273","https://openalex.org/W2034600163","https://openalex.org/W2034750640","https://openalex.org/W2037123168","https://openalex.org/W2039477480","https://openalex.org/W2046866633","https://openalex.org/W2059921365","https://openalex.org/W2065193262","https://openalex.org/W2067780578","https://openalex.org/W2079775429","https://openalex.org/W2110368321","https://openalex.org/W2113813724","https://openalex.org/W2142603939","https://openalex.org/W2142621481","https://openalex.org/W2145894726","https://openalex.org/W2152195021","https://openalex.org/W2154089780","https://openalex.org/W2171844613","https://openalex.org/W2188829391","https://openalex.org/W2255334215","https://openalex.org/W2302894295","https://openalex.org/W2345694874","https://openalex.org/W2418775165","https://openalex.org/W2535715392","https://openalex.org/W2584088501","https://openalex.org/W2735193073","https://openalex.org/W2753939078","https://openalex.org/W2791688946","https://openalex.org/W2885248918","https://openalex.org/W2886680903","https://openalex.org/W2910114383","https://openalex.org/W2910271149","https://openalex.org/W2918621261","https://openalex.org/W2920799020","https://openalex.org/W2938973274","https://openalex.org/W2950914969","https://openalex.org/W2952658094","https://openalex.org/W2982546565","https://openalex.org/W2996249107","https://openalex.org/W3008758147","https://openalex.org/W3025320502","https://openalex.org/W3036518265","https://openalex.org/W3106657028","https://openalex.org/W3117751160","https://openalex.org/W3118806168","https://openalex.org/W3127161424","https://openalex.org/W3133261845","https://openalex.org/W3191075266","https://openalex.org/W4238461487","https://openalex.org/W4243365954","https://openalex.org/W4281838386","https://openalex.org/W4286587456","https://openalex.org/W4290052847","https://openalex.org/W4298127173","https://openalex.org/W4312002008","https://openalex.org/W4312115162","https://openalex.org/W4367050257","https://openalex.org/W4388072673","https://openalex.org/W4394890441","https://openalex.org/W4402622704","https://openalex.org/W4408059014","https://openalex.org/W4409987086","https://openalex.org/W7117483935"],"related_works":["https://openalex.org/W2046699406","https://openalex.org/W1964942209","https://openalex.org/W4253702004","https://openalex.org/W2015310734","https://openalex.org/W7203693823","https://openalex.org/W7095572845","https://openalex.org/W7099198375","https://openalex.org/W1561150608","https://openalex.org/W2109430719","https://openalex.org/W4415957562"],"abstract_inverted_index":{"Understanding":[0],"the":[1,46,50,74,92,101,118,122,133,149,158,162,201,207,217,226,236],"dynamics":[2,37],"of":[3,53,73,100,121,143,200,209,228],"T":[4,18,35,54,105,154,170,194,213,248,257],"cell":[5,19,36,55,155,171,195,214,249,258],"recirculation":[6,39,196,250],"is":[7,79,110,232],"vital":[8],"for":[9,31,246,256],"predicting":[10],"immune":[11],"responses":[12],"and":[13,38,97,180,184,224,252],"providing":[14],"mechanistic":[15],"insights":[16],"into":[17],"migration.":[20],"In":[21],"this":[22],"work":[23,44,241],"we":[24],"present":[25],"a":[26,58,140,243],"stochastic":[27],"agent-based":[28],"mathematical":[29],"model":[30,89,109,134,174,202],"naive":[32,104,151,191],"CD8":[33,152,192],"+":[34,153,193],"patterns":[40],"in":[41,82,157,216],"mice.":[42],"This":[43,240],"includes":[45,91],"ability":[47],"to":[48,117,131,135,166,188],"interrogate":[49],"earliest":[51],"stages":[52],"trafficking":[56],"using":[57],"dataset":[59],"with":[60,84],"uniquely":[61],"dense":[62],"temporal":[63],"sampling.":[64],"Measurements":[65],"beginning":[66],"at":[67,219],"10":[68],"min":[69],"post-transfer":[70],"enabled":[71],"characterization":[72],"rapid":[75],"redistribution":[76],"phase":[77],"that":[78,148],"often":[80],"missed":[81],"studies":[83],"coarser":[85],"sampling":[86],"intervals.":[87],"The":[88,108,145,173,198],"structure":[90],"bloodstream,":[93],"lymph":[94,176],"nodes,":[95],"spleen,":[96],"other":[98],"parts":[99],"body":[102],"where":[103],"cells":[106],"recirculate.":[107],"governed":[111],"by":[112,205],"migration":[113],"parameters":[114,251],"designed":[115],"according":[116],"physiological":[119],"nature":[120],"system":[123],"components.":[124],"A":[125],"parameter":[126],"estimation":[127],"technique":[128],"was":[129,203],"used":[130],"fit":[132],"experimental":[136,163],"data":[137,164],"while":[138],"maintaining":[139],"reasonable":[141],"level":[142],"stochasticity.":[144],"results":[146],"show":[147],"simulated":[150],"counts":[156,215],"different":[159,221],"tissues":[160],"matched":[161],"up":[165],"47":[167],"h":[168],"post":[169],"transfer.":[172],"incorporates":[175],"node":[177],"size":[178],"heterogeneity":[179],"distinct":[181],"splenic":[182],"red":[183],"white":[185],"pulp":[186],"compartments":[187],"better":[189],"capture":[190],"dynamics.":[197,259],"robustness":[199],"demonstrated":[204],"simulating":[206],"effect":[208],"FTY720":[210],"drug":[211,222],"on":[212],"bloodstream":[218],"two":[220],"doses":[223],"over":[225],"span":[227],"one":[229],"week,":[230],"which":[231],"much":[233],"longer":[234],"than":[235],"original":[237],"training":[238],"period.":[239],"offers":[242],"novel":[244],"tool":[245],"quantifying":[247],"enables":[253],"predictive":[254],"capabilities":[255]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2026-08-29T00:00:00"}