{"id":"https://openalex.org/W7204518271","doi":"https://doi.org/10.5281/zenodo.22150118","title":"Apolipoprotein E isoforms differentially regulate oxylipin and polyunsaturated fatty acid distribution in microglia","display_name":"Apolipoprotein E isoforms differentially regulate oxylipin and polyunsaturated fatty acid distribution in microglia","publication_year":2026,"publication_date":"2026-08-28","ids":{"openalex":"https://openalex.org/W7204518271","doi":"https://doi.org/10.5281/zenodo.22150118"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22150118","doi":"https://doi.org/10.5281/zenodo.22150118","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22150118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22150118","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5135914359","display_name":"Haley Guffey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guffey, Haley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-8763-2798","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041437278","display_name":"Gregory C. Shearer","orcid":"https://orcid.org/0000-0003-4722-9163","observed_orcids":["https://orcid.org/0000-0003-4722-9163"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shearer, Gregory","raw_affiliation_strings":["Pennsylvania State University"],"raw_orcid":"https://orcid.org/0000-0003-4722-9163","affiliations":[{"raw_affiliation_string":"Pennsylvania State University","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042511606","display_name":"Vasanthy Narayanaswami","orcid":"https://orcid.org/0000-0001-7088-4057","observed_orcids":["https://orcid.org/0000-0001-7088-4057"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Narayanaswami, Vasanthy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7088-4057","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e-isoforms","display_name":"apolipoprotein E isoforms","score":0.9890000224113464},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/oxylipins","display_name":"oxylipins","score":0.9760000109672546},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.902999997138977},{"id":"https://openalex.org/keywords/fatty-acid-distribution","display_name":"fatty acid distribution","score":0.5899999737739563},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2779943694","wikidata":"https://www.wikidata.org/wiki/Q425463","display_name":"Oxylipin","level":3,"score":0.9307000041007996},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.7939000129699707},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7059000134468079},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.6718000173568726},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5332000255584717},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5245000123977661},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5170999765396118},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.49540001153945923},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.37599998712539673},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3497999906539917},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3167000114917755},{"id":"https://openalex.org/C2991897288","wikidata":"https://www.wikidata.org/wiki/Q970537","display_name":"Saturated fatty acid","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2777895019","wikidata":"https://www.wikidata.org/wiki/Q1425962","display_name":"Foam cell","level":4,"score":0.2906000018119812},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C2780857362","wikidata":"https://www.wikidata.org/wiki/Q1827455","display_name":"Lipoxygenase","level":3,"score":0.28060001134872437}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22150118","doi":"https://doi.org/10.5281/zenodo.22150118","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22150118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.22150119","doi":"https://doi.org/10.5281/zenodo.22150119","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22150119","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22150118","doi":"https://doi.org/10.5281/zenodo.22150118","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22150118","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1086473585","display_name":"Free fatty acid receptor 4 cardioprotective effects in cardiac ischemic injury","funder_award_id":"R01HL152215","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7128771595","https://openalex.org/W4312086805","https://openalex.org/W7160514915","https://openalex.org/W6925285640","https://openalex.org/W3187369376","https://openalex.org/W6967976437","https://openalex.org/W1993209720","https://openalex.org/W6912246653","https://openalex.org/W4410877579","https://openalex.org/W4415205435"],"abstract_inverted_index":{"This":[0],"dataset":[1,30],"contains":[2],"the":[3,7,10,14,32,36,50],"underlying":[4,35],"data":[5,34],"supporting":[6],"findings":[8],"of":[9,16],"associated":[11,51],"manuscript":[12],"investigating":[13],"effects":[15],"apolipoprotein":[17],"E":[18],"isoforms":[19],"on":[20],"polyunsaturated":[21],"fatty":[22],"acid":[23],"and":[24,44],"oxylipin":[25],"profiles":[26],"in":[27,49],"microglia.":[28],"The":[29],"includes":[31],"numerical":[33],"reported":[37],"lipidomic":[38],"analyses,":[39],"as":[40],"applicable.":[41],"Experimental":[42],"procedures":[43],"statistical":[45],"analyses":[46],"are":[47],"described":[48],"manuscript.":[52]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-08-29T00:00:00"}