{"id":"https://openalex.org/W7204497767","doi":"https://doi.org/10.1111/liv.70847","title":"Impact of PD \u20101 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib\u2010Based Triple Therapy","display_name":"Impact of PD \u20101 Inhibitor Timing Relative to Locoregional Therapy on Outcomes in uHCC Treated With Lenvatinib\u2010Based Triple Therapy","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204497767","doi":"https://doi.org/10.1111/liv.70847","pmid":"https://pubmed.ncbi.nlm.nih.gov/42661423"},"language":"en","primary_location":{"id":"doi:10.1111/liv.70847","doi":"https://doi.org/10.1111/liv.70847","is_oa":true,"landing_page_url":"https://doi.org/10.1111/liv.70847","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.70847","source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.70847","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104100762","display_name":"Jian He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian He","raw_affiliation_strings":["Department of Interventional Radiology Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210115910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148549832","display_name":"Jian Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Chen","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137223214","display_name":"Bohua Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bohua Yu","raw_affiliation_strings":["Department of Hepatobiliary Surgery Nanping First Hospital Affiliated to Fujian Medical University  Nanping China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery Nanping First Hospital Affiliated to Fujian Medical University  Nanping China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090631941","display_name":"Fuqun Wei","orcid":"https://orcid.org/0000-0001-7611-7529","observed_orcids":["https://orcid.org/0000-0001-7611-7529"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuqun Wei","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":"https://orcid.org/0000-0001-7611-7529","affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002671721","display_name":"Weifu Liu","orcid":"https://orcid.org/0000-0001-5673-9259","observed_orcids":["https://orcid.org/0000-0001-5673-9259","https://orcid.org/0009-0008-0014-5791"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210148548","display_name":"Fujian Provincial Cancer Hospital","ror":"https://ror.org/058ms9w43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148548"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weifu Liu","raw_affiliation_strings":["Department of Oncology and Vascular Interventional Therapy Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology and Vascular Interventional Therapy Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210148548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017895781","display_name":"\u9ec3\u57f9\u66f8","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peishu Huang","raw_affiliation_strings":["Department of Radiology Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian Campus)  Jinjiang China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology Jinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian Campus)  Jinjiang China","institution_ids":["https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086769589","display_name":"Songhui Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songhui Wu","raw_affiliation_strings":["Department of Interventional Radiology Zhangzhou Affiliated Hospital of Fujian Medical University  Zhangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology Zhangzhou Affiliated Hospital of Fujian Medical University  Zhangzhou China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046027480","display_name":"Xiang You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang You","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148566660","display_name":"Zhisheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhisheng Chen","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148566660","display_name":"Zhisheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhisheng Chen","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148513940","display_name":"Ziqi Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqi Lin","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110039","display_name":"Wuhua Guo","orcid":"https://orcid.org/0000-0002-6516-3025","observed_orcids":["https://orcid.org/0000-0002-6516-3025"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wuhua Guo","raw_affiliation_strings":["Department of Interventional Radiology Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology Mengchao Hepatobiliary Hospital of Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210115910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014570930","display_name":"\u5e84\u5c11\u9e49","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaowu Zhuang","raw_affiliation_strings":["Department of Interventional Radiology Zhangzhou Affiliated Hospital of Fujian Medical University  Zhangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology Zhangzhou Affiliated Hospital of Fujian Medical University  Zhangzhou China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148564644","display_name":"Yiping Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yiping Chen","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043152263","display_name":"Zhongwu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhongwu Chen","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":"https://orcid.org/0000-0002-2426-8656","affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043152263","display_name":"Zhongwu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210121761","display_name":"First Affiliated Hospital of Fujian Medical University","ror":"https://ror.org/030e09f60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongwu Chen","raw_affiliation_strings":["Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China"],"raw_orcid":"https://orcid.org/0000-0002-2426-8656","affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]},{"raw_affiliation_string":"Department of Interventional Radiology, The First Affiliated Hospital Fujian Medical University  Fuzhou China","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210121761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014570930","https://openalex.org/A5043152263","https://openalex.org/A5104110039","https://openalex.org/A5148564644","https://openalex.org/A5148566660"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210115910","https://openalex.org/I4210121761"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":{"value":4780,"currency":"USD","value_usd":4780},"fwci":3.7779,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.94849926,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"46","issue":"10","first_page":"e70847","last_page":"e70847"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unresectable-hepatocellular-carcinoma","display_name":"unresectable hepatocellular carcinoma","score":0.9039999842643738},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.953000009059906},{"id":"https://openalex.org/keywords/lenvatinib","display_name":"lenvatinib","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hepatic-arterial-infusion-chemotherapy","display_name":"hepatic arterial infusion chemotherapy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/transarterial-chemoembolization","display_name":"transarterial chemoembolization","score":0.9919999837875366},{"id":"https://openalex.org/keywords/locoregional-therapy","display_name":"locoregional therapy","score":0.902999997138977},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.8980000019073486},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6240000128746033},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9929999709129333},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.8220000267028809},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9322999715805054},{"id":"https://openalex.org/C2776264508","wikidata":"https://www.wikidata.org/wiki/Q6523413","display_name":"Lenvatinib","level":4,"score":0.9089999794960022},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.7013999819755554},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7002000212669373},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6473000049591064},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6319000124931335},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5871999859809875},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3991999924182892},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.39089998602867126},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.3813000023365021},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.3427000045776367},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.29840001463890076},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2953000068664551},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.29120001196861267},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.2793000042438507},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.27379998564720154},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.27250000834465027},{"id":"https://openalex.org/C2780558122","wikidata":"https://www.wikidata.org/wiki/Q7310803","display_name":"Relative survival","level":4,"score":0.26420000195503235},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2778424827","wikidata":"https://www.wikidata.org/wiki/Q5090613","display_name":"Chemoradiotherapy","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2558000087738037},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2549999952316284}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016461","descriptor_name":"Chemoembolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057216","descriptor_name":"Propensity Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/liv.70847","doi":"https://doi.org/10.1111/liv.70847","is_oa":true,"landing_page_url":"https://doi.org/10.1111/liv.70847","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.70847","source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},{"id":"pmid:42661423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42661423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver international : official journal of the International Association for the Study of the Liver","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13522736","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13522736/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13522736/pdf/LIV-46-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liver Int","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/liv.70847","doi":"https://doi.org/10.1111/liv.70847","is_oa":true,"landing_page_url":"https://doi.org/10.1111/liv.70847","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.70847","source":{"id":"https://openalex.org/S206392846","display_name":"Liver International","issn_l":"0106-9543","issn":["0106-9543","1478-3223","1478-3231","1600-0676"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liver International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7326973080635071,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204497767.pdf","grobid_xml":"https://content.openalex.org/works/W7204497767.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W2019607817","https://openalex.org/W2079586464","https://openalex.org/W2155163959","https://openalex.org/W2601414401","https://openalex.org/W2883800164","https://openalex.org/W2911028788","https://openalex.org/W2913558101","https://openalex.org/W2965281875","https://openalex.org/W2975736685","https://openalex.org/W3003310139","https://openalex.org/W3094602125","https://openalex.org/W3137254944","https://openalex.org/W3138484572","https://openalex.org/W3152534107","https://openalex.org/W3212903603","https://openalex.org/W3213277274","https://openalex.org/W4200520492","https://openalex.org/W4220718712","https://openalex.org/W4233201482","https://openalex.org/W4310601716","https://openalex.org/W4323321646","https://openalex.org/W4361223288","https://openalex.org/W4385956055","https://openalex.org/W4413270563"],"related_works":[],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"The":[3],"optimal":[4],"sequencing":[5],"of":[6,31,126,191,243],"programmed":[7],"cell":[8],"death":[9],"protein":[10],"1":[11],"(PD-1)":[12],"inhibitors":[13,68,245],"relative":[14],"to":[15,119,211,247],"locoregional":[16],"therapy":[17],"(LRT)":[18],"in":[19,37,62,133,139,152,206],"unresectable":[20],"hepatocellular":[21],"carcinoma":[22],"(uHCC)":[23],"remains":[24],"undefined.":[25],"This":[26],"study":[27],"evaluated":[28],"the":[29,107,134,140,153,159,164,188,207,215],"impact":[30],"PD-1":[32,52,67,88,92,95,144,193,198,217,240,244],"inhibitor":[33,89],"timing":[34,90],"on":[35,87],"outcomes":[36],"patients":[38,128,231],"receiving":[39,234],"hepatic":[40],"arterial":[41],"infusion":[42],"chemotherapy":[43],"(HAIC)":[44],"or":[45],"transarterial":[46],"chemoembolisation":[47],"(TACE)":[48],"plus":[49],"lenvatinib":[50,65,238],"and":[51,66,81,93,100,114,137,181,239],"inhibitors.":[53],"METHODS:":[54],"Patients":[55],"with":[56,64,131,148,202,232,237,251],"initially":[57],"uHCC":[58,233],"who":[59],"received":[60],"LRT":[61,76],"combination":[63],"across":[69],"six":[70],"academic":[71],"centres":[72],"were":[73,104,117,129],"stratified":[74],"by":[75,158],"modality":[77],"(HAIC":[78],"vs.":[79,169],"TACE)":[80],"categorised":[82],"into":[83],"two":[84],"groups":[85],"based":[86],"(Pre-LRT":[91],"Post-LRT":[94],"group).":[96],"Overall":[97],"survival":[98,102,189,253],"(OS)":[99],"progression-free":[101],"(PFS)":[103],"estimated":[105],"using":[106],"Kaplan-Meier":[108],"method;":[109],"propensity":[110],"score":[111],"matching":[112],"(PSM)":[113],"landmark":[115,182],"analyses":[116,185],"applied":[118],"mitigate":[120],"potential":[121],"biases.":[122],"RESULTS:":[123],"A":[124],"total":[125],"350":[127],"included,":[130],"185":[132],"HAIC":[135,160,208,235,248],"cohort":[136,161,166],"165":[138],"TACE":[141,165],"cohort.":[142,209],"Pre-LRT":[143,192,197,216],"group":[145,218],"was":[146,199],"associated":[147,201,250],"significantly":[149,203],"improved":[150],"OS":[151],"overall":[154],"population,":[155],"driven":[156],"primarily":[157],"rather":[162],"than":[163],"(34.03":[167],"m":[168],"30.6":[170],"m,":[171],"p":[172],"=":[173,227],"0.032);":[174],"these":[175],"findings":[176],"remained":[177],"consistent":[178],"after":[179],"PSM":[180],"analyses.":[183],"Subgroup":[184],"further":[186],"supported":[187],"benefit":[190],"initiation.":[194],"After":[195],"PSM,":[196],"also":[200],"prolonged":[204],"PFS":[205],"According":[210],"RECIST":[212],"1.1":[213],"criteria,":[214],"showed":[219],"a":[220],"higher":[221],"objective":[222],"response":[223],"rate":[224],"(ORR)":[225],"(p":[226],"0.002).":[228],"CONCLUSIONS:":[229],"In":[230],"combined":[236],"inhibitors,":[241],"initiation":[242],"prior":[246],"is":[249],"superior":[252],"outcomes.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-08-28T00:00:00"}