{"id":"https://openalex.org/W7204483649","doi":"https://doi.org/10.2139/ssrn.7344811","title":"Bacteriocin-Loaded DNA Nanogels Improve Vancomycin Therapy for Clostridioides difficile Infection and Foster Gut Microbiota Rebalancing","display_name":"Bacteriocin-Loaded DNA Nanogels Improve Vancomycin Therapy for Clostridioides difficile Infection and Foster Gut Microbiota Rebalancing","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204483649","doi":"https://doi.org/10.2139/ssrn.7344811"},"language":"en","primary_location":{"id":"doi:10.2139/ssrn.7344811","doi":"https://doi.org/10.2139/ssrn.7344811","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7344811","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.7344811","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051227595","display_name":"I\u2010Fan Lin","orcid":"https://orcid.org/0000-0001-5898-3730","observed_orcids":["https://orcid.org/0000-0001-5898-3730"]},"institutions":[{"id":"https://openalex.org/I4210091198","display_name":"E-Da Hospital","ror":"https://ror.org/00eh7f421","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210091198"]},{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Fan Lin","raw_affiliation_strings":["I-Shou University - E-Da Hospital, Kaohsiung, Taiwan"],"raw_orcid":"https://orcid.org/0000-0001-5898-3730","affiliations":[{"raw_affiliation_string":"I-Shou University - E-Da Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210091198","https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064058500","display_name":"Yu\u2010Fon Chen","orcid":"https://orcid.org/0000-0003-4646-185X","observed_orcids":["https://orcid.org/0000-0003-4646-185X","https://orcid.org/0000-0002-8201-3635"]},"institutions":[{"id":"https://openalex.org/I178613991","display_name":"National Taitung University","ror":"https://ror.org/05j9d8v51","country_code":"TW","type":"education","lineage":["https://openalex.org/I178613991"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Fon Chen","raw_affiliation_strings":["National Taitung University - Master Program in Biomedicine"],"raw_orcid":"https://orcid.org/0000-0003-4646-185X","affiliations":[{"raw_affiliation_string":"National Taitung University - Master Program in Biomedicine","institution_ids":["https://openalex.org/I178613991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036309862","display_name":"Yao\u2010Tsung Yeh","orcid":"https://orcid.org/0000-0002-7780-7983","observed_orcids":["https://orcid.org/0000-0002-7780-7983"]},"institutions":[{"id":"https://openalex.org/I64045040","display_name":"Fooyin University","ror":"https://ror.org/03pfmgq50","country_code":"TW","type":"education","lineage":["https://openalex.org/I64045040"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yao-Tsung Yeh","raw_affiliation_strings":["Fooyin University, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-7780-7983","affiliations":[{"raw_affiliation_string":"Fooyin University, Taiwan","institution_ids":["https://openalex.org/I64045040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148452526","display_name":"Hsiao-Chieh Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hsiao-Chieh Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079674488","display_name":"Ching\u2010Chi Lee","orcid":"https://orcid.org/0000-0002-4949-2742","observed_orcids":["https://orcid.org/0000-0002-4949-2742","https://orcid.org/0000-0003-4445-7005"]},"institutions":[{"id":"https://openalex.org/I4210158999","display_name":"National Cheng Kung University Hospital","ror":"https://ror.org/04zx3rq17","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158999"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Chi Lee","raw_affiliation_strings":["National Cheng Kung University - National Cheng Kung University Hospital, Tainan, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-4949-2742","affiliations":[{"raw_affiliation_string":"National Cheng Kung University - National Cheng Kung University Hospital, Tainan, Taiwan","institution_ids":["https://openalex.org/I4210158999","https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048084506","display_name":"Jeng\u2010Shiung Jan","orcid":"https://orcid.org/0000-0002-8379-404X","observed_orcids":["https://orcid.org/0000-0002-8379-404X"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jeng-Shiung Jan","raw_affiliation_strings":["National Cheng Kung University, No.1, University Road, Tainan, Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-8379-404X","affiliations":[{"raw_affiliation_string":"National Cheng Kung University, No.1, University Road, Tainan, Taiwan","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026751257","display_name":"Yuan\u2010Pin Hung","orcid":"https://orcid.org/0000-0003-1006-705X","observed_orcids":["https://orcid.org/0000-0003-1006-705X"]},"institutions":[{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuan-Pin Hung","raw_affiliation_strings":["National Cheng Kung University - Department of Internal Medicine"],"raw_orcid":"https://orcid.org/0000-0003-1006-705X","affiliations":[{"raw_affiliation_string":"National Cheng Kung University - Department of Internal Medicine","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048084506"],"corresponding_institution_ids":["https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genipin-crosslinking","display_name":"genipin crosslinking","score":0.8360000252723694},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.8090000152587891},{"id":"https://openalex.org/keywords/intestinal-drug-delivery","display_name":"intestinal drug delivery","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2910067853","wikidata":"https://www.wikidata.org/wiki/Q27438828","display_name":"Clostridioides","level":2,"score":0.6991000175476074},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5590999722480774},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.48190000653266907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46869999170303345},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.46790000796318054},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4422000050544739},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4300999939441681},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.39079999923706055},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.38040000200271606},{"id":"https://openalex.org/C134424308","wikidata":"https://www.wikidata.org/wiki/Q4119000","display_name":"Nanogel","level":3,"score":0.350600004196167},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.336899995803833},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3082999885082245},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.304500013589859},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2858999967575073},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C2993328841","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotic therapy","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26159998774528503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2139/ssrn.7344811","doi":"https://doi.org/10.2139/ssrn.7344811","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7344811","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2139/ssrn.7344811","doi":"https://doi.org/10.2139/ssrn.7344811","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.7344811","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7118705991","https://openalex.org/W4411390528","https://openalex.org/W4410132903","https://openalex.org/W6906678257","https://openalex.org/W1497410973","https://openalex.org/W4416667913","https://openalex.org/W2944035856","https://openalex.org/W7214070960","https://openalex.org/W2196848880","https://openalex.org/W7168336513"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-28T00:00:00"}
