{"id":"https://openalex.org/W7204478748","doi":"https://doi.org/10.1016/j.apsb.2026.08.020","title":"Targeted degrader conjugates (TDCs): Modalities for precision delivery of PROTACs and molecular glue degraders","display_name":"Targeted degrader conjugates (TDCs): Modalities for precision delivery of PROTACs and molecular glue degraders","publication_year":2026,"publication_date":"2026-08-01","ids":{"openalex":"https://openalex.org/W7204478748","doi":"https://doi.org/10.1016/j.apsb.2026.08.020"},"language":"en","primary_location":{"id":"doi:10.1016/j.apsb.2026.08.020","doi":"https://doi.org/10.1016/j.apsb.2026.08.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.020","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.apsb.2026.08.020","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148462452","display_name":"Xiaolei Meng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolei Meng","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108857514","display_name":"Mengjun Ma","orcid":"https://orcid.org/0009-0008-6780-3568","observed_orcids":["https://orcid.org/0009-0008-6780-3568","https://orcid.org/0009-0008-2273-065X"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengjun Ma","raw_affiliation_strings":["Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"],"raw_orcid":"https://orcid.org/0009-0008-6780-3568","affiliations":[{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072562668","display_name":"Xiao Wang","orcid":"https://orcid.org/0000-0001-7364-2459","observed_orcids":["https://orcid.org/0000-0001-7364-2459"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Wang","raw_affiliation_strings":["Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"],"raw_orcid":"https://orcid.org/0000-0001-7364-2459","affiliations":[{"raw_affiliation_string":"Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002237394","display_name":"Shumin Ma","orcid":"https://orcid.org/0000-0001-6361-9706","observed_orcids":["https://orcid.org/0000-0001-6361-9706"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shumin Ma","raw_affiliation_strings":["Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033660911","display_name":"Zhuoyue Li","orcid":"https://orcid.org/0000-0002-2334-9059","observed_orcids":["https://orcid.org/0000-0002-2334-9059","https://orcid.org/0009-0001-6279-9386","https://orcid.org/0009-0003-3574-0172"]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoyue Li","raw_affiliation_strings":["Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tingting Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Wu","raw_affiliation_strings":["Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073754378","display_name":"Shaomeng Wang","orcid":"https://orcid.org/0000-0002-8782-6950","observed_orcids":["https://orcid.org/0000-0002-8782-6950"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shaomeng Wang","raw_affiliation_strings":["Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA","Departments of Internal Medicine and Pharmacology, Medical School, University of Michigan, Ann Arbor, MI 48109, USA","Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Departments of Internal Medicine and Pharmacology, Medical School, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4390039285"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004008030","display_name":"Chong Qin","orcid":"https://orcid.org/0000-0001-8108-1698","observed_orcids":["https://orcid.org/0000-0001-8108-1698"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]},{"id":"https://openalex.org/I59028903","display_name":"Ocean University of China","ror":"https://ror.org/04rdtx186","country_code":"CN","type":"education","lineage":["https://openalex.org/I59028903"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chong Qin","raw_affiliation_strings":["Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0001-8108-1698","affiliations":[{"raw_affiliation_string":"Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China","institution_ids":["https://openalex.org/I59028903"]},{"raw_affiliation_string":"State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5004008030","https://openalex.org/A5072562668","https://openalex.org/A5073754378"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I27837315","https://openalex.org/I4390039285","https://openalex.org/I4391768132","https://openalex.org/I59028903"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.9950000047683716},{"id":"https://openalex.org/keywords/molecular-glue-degraders","display_name":"molecular glues","score":0.9990000128746033},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.968999981880188},{"id":"https://openalex.org/keywords/linkers","display_name":"linkers","score":0.5709999799728394},{"id":"https://openalex.org/keywords/intracellular-fate","display_name":"intracellular fate","score":0.6930000185966492},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.8870000243186951},{"id":"https://openalex.org/keywords/drug-delivery-barriers","display_name":"drug delivery barriers","score":0.44600000977516174},{"id":"https://openalex.org/keywords/translational-barriers","display_name":"translational barriers","score":0.47699999809265137}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.6680999994277954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5817999839782715},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5503000020980835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5227000117301941},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.47850000858306885},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.40720000863075256},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.40230000019073486},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.38839998841285706},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3871999979019165},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3758000135421753},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.357699990272522},{"id":"https://openalex.org/C2780430158","wikidata":"https://www.wikidata.org/wiki/Q7685902","display_name":"Target protein","level":3,"score":0.3497999906539917},{"id":"https://openalex.org/C3019692148","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Therapeutic modalities","level":2,"score":0.33570000529289246},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C3020606620","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Treatment modality","level":2,"score":0.3034999966621399},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2874000072479248},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27559998631477356},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.apsb.2026.08.020","doi":"https://doi.org/10.1016/j.apsb.2026.08.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.020","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.apsb.2026.08.020","doi":"https://doi.org/10.1016/j.apsb.2026.08.020","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.020","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4748274284","display_name":null,"funder_award_id":"25-1-1-sfgc-2-gx","funder_id":"https://openalex.org/F4320326700","funder_display_name":"Qingdao Municipal Science and Technology Bureau"},{"id":"https://openalex.org/G7428689584","display_name":null,"funder_award_id":"ZR2025LSW005","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320326700","display_name":"Qingdao Municipal Science and Technology Bureau","ror":"https://ror.org/03ze5ke63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":165,"referenced_works":["https://openalex.org/W1512690422","https://openalex.org/W1521738036","https://openalex.org/W1977388865","https://openalex.org/W1986353574","https://openalex.org/W1995666127","https://openalex.org/W2013909550","https://openalex.org/W2014080346","https://openalex.org/W2015345028","https://openalex.org/W2025344276","https://openalex.org/W2040273584","https://openalex.org/W2043915025","https://openalex.org/W2053152764","https://openalex.org/W2063649715","https://openalex.org/W2068455168","https://openalex.org/W2112093679","https://openalex.org/W2139807366","https://openalex.org/W2151683271","https://openalex.org/W2157364449","https://openalex.org/W2157963288","https://openalex.org/W2161577298","https://openalex.org/W2175340293","https://openalex.org/W2176791592","https://openalex.org/W2193821265","https://openalex.org/W2303817381","https://openalex.org/W2319893966","https://openalex.org/W2465229910","https://openalex.org/W2470671857","https://openalex.org/W2515327483","https://openalex.org/W2516258544","https://openalex.org/W2588442572","https://openalex.org/W2740376051","https://openalex.org/W2763578259","https://openalex.org/W2767856718","https://openalex.org/W2767966404","https://openalex.org/W2779730509","https://openalex.org/W2790734639","https://openalex.org/W2792921066","https://openalex.org/W2793567263","https://openalex.org/W2808772760","https://openalex.org/W2888598609","https://openalex.org/W2890063360","https://openalex.org/W2890382682","https://openalex.org/W2895850607","https://openalex.org/W2898544952","https://openalex.org/W2901319364","https://openalex.org/W2908747386","https://openalex.org/W2913409050","https://openalex.org/W2913446986","https://openalex.org/W2914587883","https://openalex.org/W2921110755","https://openalex.org/W2922524042","https://openalex.org/W2931729368","https://openalex.org/W2936661052","https://openalex.org/W2940945106","https://openalex.org/W2964799408","https://openalex.org/W2971579444","https://openalex.org/W2982554531","https://openalex.org/W2986752244","https://openalex.org/W2987291349","https://openalex.org/W2988906435","https://openalex.org/W2994869094","https://openalex.org/W2999975329","https://openalex.org/W3000975117","https://openalex.org/W3004874245","https://openalex.org/W3019413018","https://openalex.org/W3035439141","https://openalex.org/W3043787135","https://openalex.org/W3044448118","https://openalex.org/W3046236678","https://openalex.org/W3093395956","https://openalex.org/W3095901003","https://openalex.org/W3120313360","https://openalex.org/W3122254526","https://openalex.org/W3130648111","https://openalex.org/W3150479130","https://openalex.org/W3156335568","https://openalex.org/W3156955099","https://openalex.org/W3161698207","https://openalex.org/W3163700030","https://openalex.org/W3165143074","https://openalex.org/W3166945479","https://openalex.org/W3170587263","https://openalex.org/W3173513673","https://openalex.org/W3176208875","https://openalex.org/W3178147999","https://openalex.org/W3186572052","https://openalex.org/W3188341649","https://openalex.org/W3190204410","https://openalex.org/W3199680482","https://openalex.org/W3207337024","https://openalex.org/W3214791440","https://openalex.org/W4200195437","https://openalex.org/W4200302906","https://openalex.org/W4205379795","https://openalex.org/W4221032937","https://openalex.org/W4225687325","https://openalex.org/W4280616471","https://openalex.org/W4283779344","https://openalex.org/W4286001165","https://openalex.org/W4291396326","https://openalex.org/W4300427410","https://openalex.org/W4307039472","https://openalex.org/W4310096388","https://openalex.org/W4313278730","https://openalex.org/W4313575457","https://openalex.org/W4319073917","https://openalex.org/W4319438069","https://openalex.org/W4360814074","https://openalex.org/W4378907603","https://openalex.org/W4379329200","https://openalex.org/W4380875428","https://openalex.org/W4382775858","https://openalex.org/W4388212701","https://openalex.org/W4388288412","https://openalex.org/W4388400386","https://openalex.org/W4389420028","https://openalex.org/W4390881763","https://openalex.org/W4391167138","https://openalex.org/W4391436075","https://openalex.org/W4391513192","https://openalex.org/W4391652256","https://openalex.org/W4392867823","https://openalex.org/W4392879330","https://openalex.org/W4394747404","https://openalex.org/W4394954522","https://openalex.org/W4396578245","https://openalex.org/W4398783346","https://openalex.org/W4399121655","https://openalex.org/W4400417920","https://openalex.org/W4402120375","https://openalex.org/W4402170913","https://openalex.org/W4402273659","https://openalex.org/W4402276259","https://openalex.org/W4403745200","https://openalex.org/W4404448137","https://openalex.org/W4404867111","https://openalex.org/W4404933387","https://openalex.org/W4405953913","https://openalex.org/W4406080278","https://openalex.org/W4407881158","https://openalex.org/W4408569681","https://openalex.org/W4408967804","https://openalex.org/W4409025657","https://openalex.org/W4410042082","https://openalex.org/W4410170016","https://openalex.org/W4410972694","https://openalex.org/W4411206153","https://openalex.org/W4411377768","https://openalex.org/W4411659113","https://openalex.org/W4411745201","https://openalex.org/W4411783791","https://openalex.org/W4412867339","https://openalex.org/W4413051653","https://openalex.org/W4413139638","https://openalex.org/W4413257794","https://openalex.org/W4413258198","https://openalex.org/W4413408909","https://openalex.org/W4414035450","https://openalex.org/W4414314651","https://openalex.org/W4415566161","https://openalex.org/W4415808337","https://openalex.org/W4416119503","https://openalex.org/W7108458077","https://openalex.org/W7118173250","https://openalex.org/W7161601606"],"related_works":["https://openalex.org/W7166351903","https://openalex.org/W4387190804","https://openalex.org/W4411840584","https://openalex.org/W7131432566","https://openalex.org/W7222328715","https://openalex.org/W7204995923","https://openalex.org/W4393187854","https://openalex.org/W7215318042","https://openalex.org/W4413915696","https://openalex.org/W7203556148"],"abstract_inverted_index":{"Proteolysis":[0],"targeting":[1,81],"chimeras":[2],"(PROTACs)":[3],"and":[4,43,100,137,144,156],"molecular":[5],"glue":[6],"degraders":[7],"(MGDs)":[8],"have":[9],"revolutionized":[10],"drug":[11],"discovery":[12],"by":[13,34],"exploiting":[14],"the":[15,79,122,150,163],"intracellular":[16,123],"ubiquitin\u2013proteasome":[17],"system":[18],"(UPS)":[19],"to":[20,62,78],"induce":[21],"selective":[22],"degradation":[23,145,169],"of":[24,125,133,166],"pathogenic":[25],"proteins.":[26],"However,":[27],"their":[28],"clinical":[29],"development":[30,165],"is":[31],"frequently":[32],"constrained":[33],"poor":[35],"drug-like":[36],"properties,":[37],"limited":[38],"cell":[39],"permeability,":[40],"unfavorable":[41],"pharmacokinetics,":[42],"systemic":[44],"off-target":[45],"toxicities.":[46],"To":[47],"overcome":[48],"these":[49],"limitations,":[50],"targeted":[51,167],"degrader":[52],"conjugates":[53,88,91,94,98,102],"(TDCs)\u2014innovative":[54],"platforms":[55,136],"that":[56,160],"covalently":[57],"tether":[58],"PROTACs":[59],"or":[60],"MGDs":[61],"disease-targeting":[63],"moieties":[64],"via":[65],"specialized":[66],"linkers\u2014have":[67],"emerged":[68],"as":[69,86,116],"a":[70,111,130],"promising":[71],"tissue-restricted":[72],"delivery":[73,113,143],"modality":[74],"for":[75,120],"degraders.":[76],"According":[77],"different":[80],"moieties,":[82],"TDCs":[83],"are":[84],"classified":[85],"degrader\u2012antibody":[87],"(DACs),":[89],"degrader\u2012peptide":[90],"(DPCs),":[92],"degrader\u2012aptamer":[93],"(DApCs),":[95],"degrader\u2012small":[96],"molecule":[97],"(DSMCs),":[99],"degrader\u2012protein":[101],"(DProCs).":[103],"Beyond":[104],"summarizing":[105],"recent":[106],"advances,":[107],"this":[108],"review":[109],"introduces":[110],"seven-step":[112],"cascade":[114],"model":[115],"an":[117],"organizing":[118],"tool":[119],"understanding":[121],"fate":[124],"TDCs.":[126],"This":[127],"framework":[128],"facilitates":[129],"systematic":[131],"comparison":[132],"distinct":[134],"TDC":[135],"helps":[138],"identify":[139],"critical":[140],"factors":[141],"in":[142],"efficiency.":[146],"We":[147],"further":[148,164],"highlight":[149],"key":[151],"biological":[152],"bottlenecks,":[153],"translational":[154],"hurdles,":[155],"emerging":[157],"engineering":[158],"strategies":[159],"may":[161],"support":[162],"protein":[168],"therapies.":[170]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-28T00:00:00"}
