{"id":"https://openalex.org/W7204472948","doi":"https://doi.org/10.1371/journal.pone.0355495","title":"Expedited pathway portfolios, trial complexity, and FDA approval timelines in oncology and neurology: A comparative analysis","display_name":"Expedited pathway portfolios, trial complexity, and FDA approval timelines in oncology and neurology: A comparative analysis","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204472948","doi":"https://doi.org/10.1371/journal.pone.0355495","pmid":"https://pubmed.ncbi.nlm.nih.gov/42658855"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0355495","doi":"https://doi.org/10.1371/journal.pone.0355495","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0355495","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0355495&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0355495&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072469263","display_name":"Ahmed M. Sayed","orcid":"https://orcid.org/0000-0003-0244-3457","observed_orcids":["https://orcid.org/0000-0003-0244-3457"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ahmed M. Sayed","raw_affiliation_strings":["Department of Chemistry, College of Science, Purdue University, West Lafayette, Indiana, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0244-3457","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science, Purdue University, West Lafayette, Indiana, United States of America","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041707474","display_name":"Nada M. Ezzelarab","orcid":"https://orcid.org/0000-0001-7992-7260","observed_orcids":["https://orcid.org/0000-0001-7992-7260"]},"institutions":[{"id":"https://openalex.org/I80693520","display_name":"American University in Cairo","ror":"https://ror.org/0176yqn58","country_code":"EG","type":"education","lineage":["https://openalex.org/I80693520"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Nada M. Ezzelarab","raw_affiliation_strings":["Department of Biology, School of Sciences and Engineering, The American University in Cairo, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, School of Sciences and Engineering, The American University in Cairo, Cairo, Egypt","institution_ids":["https://openalex.org/I80693520"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070329277","display_name":"Nguyen Tien Huy","orcid":"https://orcid.org/0000-0002-9543-9440","observed_orcids":["https://orcid.org/0000-0002-9543-9440"]},"institutions":[{"id":"https://openalex.org/I170238339","display_name":"Duy Tan University","ror":"https://ror.org/05ezss144","country_code":"VN","type":"education","lineage":["https://openalex.org/I170238339"]}],"countries":["VN"],"is_corresponding":false,"raw_author_name":"Nguyen Tien Huy","raw_affiliation_strings":["Institute of Research and Development, Duy Tan University, Da Nang, Vietnam","School of Medicine and Pharmacy, Duy Tan University, Da Nang, Vietnam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Research and Development, Duy Tan University, Da Nang, Vietnam","institution_ids":["https://openalex.org/I170238339"]},{"raw_affiliation_string":"School of Medicine and Pharmacy, Duy Tan University, Da Nang, Vietnam","institution_ids":["https://openalex.org/I170238339"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072469263"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69400328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"8","first_page":"e0355495","last_page":"e0355495"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.10700000077486038,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11649","display_name":"Pharmaceutical industry and healthcare","score":0.06390000134706497,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.6340000033378601},{"id":"https://openalex.org/keywords/clinical-trial-enrollment","display_name":"clinical trial recruitment","score":0.4860000014305115},{"id":"https://openalex.org/keywords/fast-track-designation","display_name":"fast track designation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/breakthrough-therapy-designation","display_name":"breakthrough therapy designation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/priority-review","display_name":"priority review","score":0.8050000071525574},{"id":"https://openalex.org/keywords/accelerated-approval","display_name":"accelerated approval","score":0.9829999804496765},{"id":"https://openalex.org/keywords/orphan-drug-designation","display_name":"orphan drug designation","score":0.7009999752044678},{"id":"https://openalex.org/keywords/time-to-approval","display_name":"time to approval","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7907999753952026},{"id":"https://openalex.org/C2778917124","wikidata":"https://www.wikidata.org/wiki/Q7309705","display_name":"Regulatory science","level":2,"score":0.7063999772071838},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6205999851226807},{"id":"https://openalex.org/C2992293740","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Drug approval","level":3,"score":0.4986000061035156},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4352000057697296},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.41269999742507935},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40540000796318054},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3977000117301941},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.3926999866962433},{"id":"https://openalex.org/C4438859","wikidata":"https://www.wikidata.org/wiki/Q186117","display_name":"Timeline","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.314300000667572},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.30329999327659607},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2987000048160553},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.296999990940094},{"id":"https://openalex.org/C19648533","wikidata":"https://www.wikidata.org/wiki/Q691640","display_name":"Evidence-based medicine","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C2777106319","wikidata":"https://www.wikidata.org/wiki/Q362104","display_name":"Institutional review board","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C502991105","wikidata":"https://www.wikidata.org/wiki/Q5133849","display_name":"Clinical research","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.2791000008583069},{"id":"https://openalex.org/C2776598537","wikidata":"https://www.wikidata.org/wiki/Q1812651","display_name":"Clinical Oncology","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26969999074935913},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C2780416959","wikidata":"https://www.wikidata.org/wiki/Q22907415","display_name":"Companion diagnostic","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C2778111679","wikidata":"https://www.wikidata.org/wiki/Q5155639","display_name":"Comparative effectiveness research","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C2780821815","wikidata":"https://www.wikidata.org/wiki/Q5340806","display_name":"Portfolio","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C141341695","wikidata":"https://www.wikidata.org/wiki/Q2368661","display_name":"Surrogate endpoint","level":2,"score":0.2547999918460846}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008495","descriptor_name":"Medical Oncology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009462","descriptor_name":"Neurology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009462","descriptor_name":"Neurology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pone.0355495","doi":"https://doi.org/10.1371/journal.pone.0355495","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0355495","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0355495&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},{"id":"pmid:42658855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42658855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13521384","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521384/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521384/pdf/pone.0355495.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0355495","doi":"https://doi.org/10.1371/journal.pone.0355495","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0355495","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0355495&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS One","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204472948.pdf","grobid_xml":"https://content.openalex.org/works/W7204472948.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W2140922502","https://openalex.org/W2721901041","https://openalex.org/W2746717271","https://openalex.org/W3017195870","https://openalex.org/W4308043995","https://openalex.org/W4390659545","https://openalex.org/W4394063884","https://openalex.org/W4417321287"],"related_works":[],"abstract_inverted_index":{"FDA":[0,36,77,93,106,280],"expedited":[1,55,312],"programs":[2],"are":[3],"intended":[4],"to":[5,45,47,120,164,224,263,288],"facilitate":[6],"development":[7,160,219],"and":[8,41,83,108,111,151,166,221,238,285,293],"review":[9,109],"for":[10],"therapies":[11],"addressing":[12],"serious":[13],"conditions":[14],"with":[15,31,179,269],"unmet":[16],"medical":[17],"need,":[18],"but":[19],"their":[20],"use":[21],"may":[22],"depend":[23],"on":[24],"whether":[25,49],"the":[26,65,264],"evidentiary":[27],"package":[28],"is":[29],"compatible":[30],"regulatory":[32,88,156,198],"acceleration.":[33],"We":[34,67],"compared":[35],"original":[37,76],"approvals":[38],"in":[39,51,279,309],"oncology":[40,81,202,242,265,284],"neurology":[42,85,177,260,286],"from":[43,92,105],"2015":[44],"2024":[46],"evaluate":[48],"differences":[50],"approval":[52,94,102,157,199,225,281],"timing":[53,282],"reflected":[54],"pathway":[56,174,261,291],"portfolio":[57],"intensity,":[58],"pivotal":[59,167,231,294],"evidence":[60,124,168,232,243,295],"architecture,":[61],"or":[62,97],"alignment":[63,302],"between":[64,283],"two.":[66],"conducted":[68],"a":[69,137,270,300,306],"retrospective":[70],"comparative":[71],"cohort":[72],"study":[73],"of":[74,275],"195":[75],"approvals,":[78],"including":[79],"136":[80],"products":[82,171,195],"59":[84],"products.":[86],"Product-level":[87],"data":[89],"were":[90,103],"curated":[91,128],"materials.":[95],"Pivotal":[96],"registrational":[98],"trials":[99],"supporting":[100],"first":[101],"identified":[104],"labels":[107],"documents":[110],"enriched":[112],"through":[113],"exact":[114],"National":[115],"Clinical":[116],"Trial":[117,249],"identifier":[118],"matching":[119],"AACT.":[121],"The":[122],"final":[123],"dataset":[125],"included":[126,155],"221":[127],"product-trial":[129],"links.":[130],"Regulatory":[131,138,181],"pathway-portfolio":[132],"intensity":[133,175,262],"was":[134,233,244,267],"summarized":[135],"using":[136],"Bundling":[139,182],"Index":[140,183],"incorporating":[141],"Fast":[142],"Track,":[143],"Breakthrough":[144],"Therapy":[145],"designation,":[146],"Priority":[147],"Review,":[148],"Accelerated":[149],"Approval,":[150],"Orphan":[152],"designation.":[153],"Outcomes":[154],"time,":[158,161],"clinical":[159,218],"total":[162,222],"time":[163,200,220,223],"approval,":[165],"architecture.":[169,296],"Oncology":[170],"had":[172,196],"higher":[173],"than":[176,201,305],"products,":[178],"median":[180,266,271],"3":[184],"[IQR,":[185,189,206,211],"2-4]":[186],"versus":[187,208],"2":[188],"0-3]":[190],"(p":[191,213],"<":[192,214],"0.001).":[193,215],"Neurology":[194,230],"longer":[197],"products:":[203],"362":[204],"days":[205,210],"245-366]":[207],"234":[209],"182-329]":[212],"In":[216,255],"contrast,":[217],"did":[226,251],"not":[227,252],"differ":[228,253],"significantly.":[229,254],"more":[234,245,311],"often":[235,246],"randomized,":[236],"masked,":[237],"late":[239],"phase,":[240],"while":[241],"single":[247],"group.":[248],"enrollment":[250],"exploratory":[256],"counterfactual":[257],"analyses,":[258],"increasing":[259],"associated":[268],"predicted":[272],"review-time":[273],"reduction":[274],"37.8":[276],"days.":[277],"Differences":[278],"appear":[287],"reflect":[289],"both":[290],"configuration":[292],"These":[297],"findings":[298],"support":[299],"pathway-evidence":[301],"framework":[303],"rather":[304],"simple":[307],"model":[308],"which":[310],"designations":[313],"alone":[314],"explain":[315],"faster":[316],"approval.":[317]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2026-08-28T00:00:00"}