{"id":"https://openalex.org/W7204468430","doi":"https://doi.org/10.4103/jid.jid_35_26","title":"Damage Signal or Regenerative Cue? Unraveling the Biphasic Paradox of High Mobility Group Box-1 in Periodontal Tissues \u2013 A Scoping Review","display_name":"Damage Signal or Regenerative Cue? Unraveling the Biphasic Paradox of High Mobility Group Box-1 in Periodontal Tissues \u2013 A Scoping Review","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7204468430","doi":"https://doi.org/10.4103/jid.jid_35_26"},"language":"en","primary_location":{"id":"doi:10.4103/jid.jid_35_26","doi":"https://doi.org/10.4103/jid.jid_35_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jid.jid_35_26","pdf_url":null,"source":{"id":"https://openalex.org/S2764570324","display_name":"Journal of Interdisciplinary Dentistry","issn_l":"2229-5194","issn":["2229-5194","2231-2706"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interdisciplinary Dentistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4103/jid.jid_35_26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077012921","display_name":"Devapriya Appukuttan","orcid":"https://orcid.org/0000-0003-2109-1135","observed_orcids":["https://orcid.org/0000-0003-2109-1135"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Devapriya Appukuttan","raw_affiliation_strings":["Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036721618","display_name":"Sangeetha Subramanian","orcid":"https://orcid.org/0000-0002-9352-6081","observed_orcids":["https://orcid.org/0000-0002-9352-6081"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sangeetha Subramanian","raw_affiliation_strings":["Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101597022","display_name":"P. S. G. Prakash","orcid":"https://orcid.org/0000-0003-4243-5865","observed_orcids":["https://orcid.org/0000-0003-4243-5865"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P. S. G. Prakash","raw_affiliation_strings":["Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148421019","display_name":"Sakthi Kamala Vegashini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sakthi Kamala Vegashini","raw_affiliation_strings":["Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061128002","display_name":"Jasmine Crena","orcid":"https://orcid.org/0000-0001-9788-3898","observed_orcids":["https://orcid.org/0000-0001-9788-3898"]},"institutions":[{"id":"https://openalex.org/I4210101314","display_name":"SRM Dental College","ror":"https://ror.org/01bd1sf38","country_code":"IN","type":"education","lineage":["https://openalex.org/I145286018","https://openalex.org/I4210101314"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jasmine Crena","raw_affiliation_strings":["Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India","institution_ids":["https://openalex.org/I4210101314"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065108593","display_name":"Sowmya Reddy Nandipati","orcid":"https://orcid.org/0000-0001-8458-2965","observed_orcids":["https://orcid.org/0000-0001-8458-2965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sowmya Reddy Nandipati","raw_affiliation_strings":["Department of Periodontics, Lenora Institute of Dental Sciences, Rajanagaram, Andra Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Periodontics, Lenora Institute of Dental Sciences, Rajanagaram, Andra Pradesh, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"2","first_page":"281","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.8393999934196472,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.8500000238418579},{"id":"https://openalex.org/keywords/periodontitis","display_name":"periodontitis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/periodontal-regeneration","display_name":"periodontal regeneration","score":0.9629999995231628},{"id":"https://openalex.org/keywords/periodontal-repair","display_name":"periodontal tissue repair","score":0.8640000224113464},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.9760000109672546},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/periodontium","display_name":"periodontium","score":0.675000011920929},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.6420000195503235}],"concepts":[{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.6431999802589417},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.614799976348877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5932000279426575},{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.5304999947547913},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5299000144004822},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5195000171661377},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.48260000348091125},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.4343000054359436},{"id":"https://openalex.org/C3019752601","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory mediator","level":3,"score":0.414000004529953},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.41029998660087585},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.3991999924182892},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.3828999996185303},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3783999979496002},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.37790000438690186},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.35120001435279846},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3474999964237213},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C2780954041","wikidata":"https://www.wikidata.org/wiki/Q25326600","display_name":"Hard tissue","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.31360000371932983},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.3111000061035156},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.2815000116825104},{"id":"https://openalex.org/C2776581183","wikidata":"https://www.wikidata.org/wiki/Q25104725","display_name":"Tissue remodeling","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C3018605307","wikidata":"https://www.wikidata.org/wiki/Q200779","display_name":"Complex disease","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C2778401919","wikidata":"https://www.wikidata.org/wiki/Q7824270","display_name":"Tooth loss","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.25760000944137573}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4103/jid.jid_35_26","doi":"https://doi.org/10.4103/jid.jid_35_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jid.jid_35_26","pdf_url":null,"source":{"id":"https://openalex.org/S2764570324","display_name":"Journal of Interdisciplinary Dentistry","issn_l":"2229-5194","issn":["2229-5194","2231-2706"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interdisciplinary Dentistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4103/jid.jid_35_26","doi":"https://doi.org/10.4103/jid.jid_35_26","is_oa":true,"landing_page_url":"https://doi.org/10.4103/jid.jid_35_26","pdf_url":null,"source":{"id":"https://openalex.org/S2764570324","display_name":"Journal of Interdisciplinary Dentistry","issn_l":"2229-5194","issn":["2229-5194","2231-2706"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320448","host_organization_name":"Medknow","host_organization_lineage":["https://openalex.org/P4310320448","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Medknow","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Interdisciplinary Dentistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W783745786","https://openalex.org/W874898778","https://openalex.org/W1541957757","https://openalex.org/W1974067858","https://openalex.org/W1984419878","https://openalex.org/W1986210310","https://openalex.org/W1993352385","https://openalex.org/W2021717172","https://openalex.org/W2031558790","https://openalex.org/W2035944365","https://openalex.org/W2050488981","https://openalex.org/W2052919564","https://openalex.org/W2075950485","https://openalex.org/W2084154288","https://openalex.org/W2086151095","https://openalex.org/W2099762564","https://openalex.org/W2103456945","https://openalex.org/W2105321265","https://openalex.org/W2105844833","https://openalex.org/W2109882183","https://openalex.org/W2129620503","https://openalex.org/W2132707520","https://openalex.org/W2155352329","https://openalex.org/W2156088168","https://openalex.org/W2164714222","https://openalex.org/W2168290575","https://openalex.org/W2168510930","https://openalex.org/W2202381562","https://openalex.org/W2503319201","https://openalex.org/W2514294261","https://openalex.org/W2526806864","https://openalex.org/W2553059004","https://openalex.org/W2727920027","https://openalex.org/W2789626341","https://openalex.org/W2793819926","https://openalex.org/W2810192425","https://openalex.org/W2891378911","https://openalex.org/W2897435713","https://openalex.org/W3026191912","https://openalex.org/W3043251495","https://openalex.org/W3049299236","https://openalex.org/W3109327940","https://openalex.org/W3159329395","https://openalex.org/W4214511313","https://openalex.org/W4214700578","https://openalex.org/W4241527134","https://openalex.org/W4380792003","https://openalex.org/W4381185469","https://openalex.org/W4391758356","https://openalex.org/W4392792315","https://openalex.org/W4399047826","https://openalex.org/W4414932826"],"related_works":["https://openalex.org/W133943751","https://openalex.org/W3043251495","https://openalex.org/W2129620503","https://openalex.org/W1989597336","https://openalex.org/W4297722481","https://openalex.org/W1993352385","https://openalex.org/W4414932826","https://openalex.org/W2789626341","https://openalex.org/W2109882183","https://openalex.org/W2417778955"],"abstract_inverted_index":{"A":[0],"BSTRACT":[1],"Background":[2],"and":[3,18,31,51,57,60,71,94,104,112,121,147,153,159,190,217,221,235,239,256],"Aims:":[4],"High":[5],"Mobility":[6],"Group":[7],"Box-1":[8],"(HMGB1)":[9],"has":[10],"emerged":[11],"as":[12,173,191,213],"a":[13,42,98,116,181,192,214],"key":[14],"mediator":[15],"in":[16,39,48,85,224,232,265],"inflammation":[17,223],"tissue":[19],"remodeling.":[20],"The":[21,64,165],"goal":[22],"of":[23,62,91,100,119,194],"this":[24,266],"scoping":[25],"review":[26],"is":[27],"to":[28,54,108,126],"comprehensively":[29],"outline":[30],"evaluate":[32],"the":[33,145,246,260],"current":[34],"literature":[35,123],"evidence":[36],"on":[37,44],"HMGB1":[38,172,211,251],"periodontitis,":[40],"with":[41],"focus":[43],"its":[45,229],"mechanistic":[46],"role":[47,231],"disease":[49],"pathogenesis":[50],"potential":[52],"contribution":[53],"periodontal":[55,204,233],"repair":[56,236],"regeneration.":[58],"Guidelines":[59],"Sources":[61],"Evidence:":[63],"Preferred":[65],"Reporting":[66],"Items":[67],"for":[68,75,151,162,262],"Systematic":[69],"Reviews":[70,77],"Meta-Analyses":[72],"(PRISMA)":[73],"Extension":[74],"Scoping":[76],"guidelines":[78],"were":[79,138,142,149,157,160,167],"followed.":[80],"Literature":[81],"search":[82,118],"was":[83,124],"done":[84],"PubMed/Medline,":[86],"Scopus,":[87],"Cochrane":[88],"Library,":[89],"Web":[90],"Science,":[92],"Mendeley,":[93],"Google":[95],"scholar":[96],"using":[97],"blend":[99],"MeSH":[101],"terms,":[102],"keywords,":[103],"non-indexed":[105],"terms":[106],"related":[107],"\u201cHMGB1,\u201d":[109],"\u201cperiodontitis,\u201d":[110],"\u201cregeneration,\u201d":[111],"\u201crepair.\u201d":[113],"In":[114,134],"addition,":[115],"thorough":[117],"bibliographies":[120],"gray":[122],"conducted":[125],"ensure":[127],"comprehensive":[128],"coverage":[129],"until":[130],"August":[131],"2025.":[132],"Results:":[133],"total,":[135],"362":[136],"records":[137],"collected":[139],"initially,":[140],"duplicates":[141],"eliminated,":[143],"thereafter":[144],"titles":[146],"abstracts":[148],"appraised":[150],"relevance,":[152],"finally":[154],"39":[155],"studies":[156,243],"eligible":[158],"retained":[161],"detailed":[163],"analysis.":[164],"articles":[166],"categorized":[168],"into":[169],"those":[170],"examining":[171],"an":[174],"inflammatory":[175,195],"marker":[176,185],"(":[177,186,206],"n":[178,187,207],"=":[179,188,208],"20),":[180],"reparative":[182],"or":[183,197],"regenerative":[184],"8),":[189],"component":[193],"cytokines":[196],"damage-associated":[198],"molecular":[199,248],"patterns":[200],"(DAMPs)":[201],"repertoire":[202],"within":[203],"tissues":[205],"11).":[209],"Conclusions:":[210],"acts":[212],"DAMP,":[215],"pro-inflammatory,":[216],"osteoclastogenic":[218],"cytokine,":[219],"inducing":[220],"amplifying":[222],"periodontitis.":[225],"However,":[226],"data":[227],"substantiating":[228],"definitive":[230],"regeneration":[234],"remain":[237],"limited":[238,242],"inconclusive.":[240],"Furthermore,":[241],"have":[244],"elucidated":[245],"specific":[247],"pathways":[249],"underlying":[250],"receptor":[252],"binding,":[253],"activation":[254],"pathways,":[255],"downstream":[257],"signaling,":[258],"highlighting":[259],"need":[261],"future":[263],"investigations":[264],"largely":[267],"unexplored":[268],"domain.":[269]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-08-28T00:00:00"}