{"id":"https://openalex.org/W7204458249","doi":"https://doi.org/10.1093/neuonc/noag172.085","title":"52 Access to non-standard treatments: Insights from a UK-wide review of adult brain tumour services (2024-2026)","display_name":"52 Access to non-standard treatments: Insights from a UK-wide review of adult brain tumour services (2024-2026)","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204458249","doi":"https://doi.org/10.1093/neuonc/noag172.085"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noag172.085","doi":"https://doi.org/10.1093/neuonc/noag172.085","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noag172.085","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/28/Supplement_1/noag172.085/70805929/noag172.085.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/28/Supplement_1/noag172.085/70805929/noag172.085.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103148825","display_name":"Joanne Lewis","orcid":"https://orcid.org/0000-0001-8035-4420","observed_orcids":["https://orcid.org/0000-0001-8035-4420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanne Lewis","raw_affiliation_strings":["Northern Centre For Cancer Care , Newcastle,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northern Centre For Cancer Care , Newcastle,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141058063","display_name":"Andrew Wright","orcid":"https://orcid.org/0009-0002-2143-9218","observed_orcids":["https://orcid.org/0009-0002-2143-9218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Wright","raw_affiliation_strings":["Tessa Jowell Brain Cancer Mission , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tessa Jowell Brain Cancer Mission , London,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119517502","display_name":"Eloise Lines","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eloise Lines","raw_affiliation_strings":["Tessa Jowell Brain Cancer Mission , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tessa Jowell Brain Cancer Mission , London,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111041043","display_name":"Camille Goetz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camille Goetz","raw_affiliation_strings":["Tessa Jowell Brain Cancer Mission , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tessa Jowell Brain Cancer Mission , London,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006521870","display_name":"Nicky Huskens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicky Huskens","raw_affiliation_strings":["Tessa Jowell Brain Cancer Mission , London,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tessa Jowell Brain Cancer Mission , London,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66964091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"28","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13417","display_name":"Biomedical Ethics and Regulation","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11792","display_name":"Pharmaceutical Economics and Policy","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adult-brain-tumors","display_name":"adult brain tumors","score":0.8050000071525574},{"id":"https://openalex.org/keywords/access-to-experimental-treatments","display_name":"access to experimental treatments","score":0.5540000200271606},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.9359999895095825},{"id":"https://openalex.org/keywords/treatment-delay","display_name":"treatment delay","score":0.49399998784065247},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dabrafenib-and-trametinib","display_name":"dabrafenib/trametinib","score":0.9700000286102295},{"id":"https://openalex.org/keywords/vorasidenib","display_name":"vorasidenib","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-treating-fields","display_name":"tumor treating fields","score":0.9229999780654907},{"id":"https://openalex.org/keywords/onc201","display_name":"ONC201","score":0.9459999799728394},{"id":"https://openalex.org/keywords/treatment-disparities","display_name":"treatment disparities","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.79830002784729},{"id":"https://openalex.org/C2775832928","wikidata":"https://www.wikidata.org/wiki/Q407954","display_name":"Expanded access","level":2,"score":0.6775000095367432},{"id":"https://openalex.org/C2777352838","wikidata":"https://www.wikidata.org/wiki/Q5419420","display_name":"Excellence","level":2,"score":0.6308000087738037},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.6083999872207642},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.5971999764442444},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4032000005245209},{"id":"https://openalex.org/C2778760837","wikidata":"https://www.wikidata.org/wiki/Q5059994","display_name":"Center of excellence","level":2,"score":0.3499999940395355},{"id":"https://openalex.org/C3019492093","wikidata":"https://www.wikidata.org/wiki/Q29468924","display_name":"Access to medicines","level":3,"score":0.3450999855995178},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3382999897003174},{"id":"https://openalex.org/C190248442","wikidata":"https://www.wikidata.org/wiki/Q839486","display_name":"Qualitative research","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C87156501","wikidata":"https://www.wikidata.org/wiki/Q7268708","display_name":"Qualitative property","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C3020493868","wikidata":"https://www.wikidata.org/wiki/Q55631277","display_name":"Real world data","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C2982933515","wikidata":"https://www.wikidata.org/wiki/Q104381823","display_name":"Public access","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C2908902254","wikidata":"https://www.wikidata.org/wiki/Q407954","display_name":"Compassionate Use","level":3,"score":0.2596000134944916}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noag172.085","doi":"https://doi.org/10.1093/neuonc/noag172.085","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noag172.085","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/28/Supplement_1/noag172.085/70805929/noag172.085.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13519677","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13519677/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noag172.085","doi":"https://doi.org/10.1093/neuonc/noag172.085","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noag172.085","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/28/Supplement_1/noag172.085/70805929/noag172.085.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.7578999996185303,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"sustainable_development_goals_aurora":[{"score":0.556739091873169,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204458249.pdf","grobid_xml":"https://content.openalex.org/works/W7204458249.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Patients":[2],"with":[3],"high":[4],"grade":[5],"primary":[6],"brain":[7,69],"tumours":[8],"often":[9],"face":[10],"poor":[11],"outcomes":[12],"and":[13,39,52,101,134,156,169,192,212,234,254,276],"limited":[14],"treatment":[15,135],"options.":[16],"Access":[17,43],"to":[18,36,58,63,226,242,265,267],"non-standard":[19,64,182,228],"treatments":[20,65],"-":[21,32],"interventions":[22],"not":[23,201],"routinely":[24],"available":[25],"or":[26],"funded":[27],"for":[28],"this":[29,274],"patient":[30],"group":[31],"may":[33,240],"offer":[34],"opportunities":[35],"improve":[37],"survival":[38],"quality":[40],"of":[41,83,92],"life.":[42],"routes":[44,224],"include":[45],"individual":[46],"funding":[47,158],"requests":[48,174],"(IFRs),":[49],"clinical":[50,149],"trials,":[51],"early/managed":[53],"access":[54,62,146,153,227,264],"programmes.":[55],"We":[56],"aimed":[57],"examine":[59],"variation":[60,221,275],"in":[61,118,161,222],"across":[66],"UK":[67,85],"adult":[68],"tumour":[70],"services.":[71],"Method":[72],"Data":[73],"were":[74,98,104,200],"collected":[75],"from":[76],"24":[77],"NHS":[78],"neuro-oncology":[79],"centres":[80,110,140,196],"(covering":[81],">90%":[82],"the":[84,88,119,162,223,248],"population)":[86],"through":[87],"Tessa":[89,249],"Jowell":[90,250],"Centre":[91],"Excellence":[93],"programme":[94],"(2024\u20132026).":[95],"Quantitative":[96],"data":[97],"analysed":[99,105],"descriptively,":[100],"qualitative":[102],"findings":[103],"thematically.":[106],"Results":[107],"Only":[108],"45%":[109],"(11/24)":[111],"reported":[112,141,165,179,219],"a":[113],"successful":[114,173],"IFR":[115,231],"(or":[116],"equivalent)":[117],"past":[120],"year.":[121],"Reported":[122],"barriers":[123,167],"included":[124,205],"low":[125],"success":[126,232],"rates":[127,233],"(12/24,":[128],"50%),":[129],"time":[130],"burden":[131],"(8/24,":[132],"33%),":[133],"delays":[136],"(4/24,":[137],"17%).":[138],"Many":[139],"using":[142],"alternative":[143,237],"routes:":[144],"early":[145],"schemes":[147,239],"(9/24),":[148,209],"trials":[150],"(6/24),":[151,191],"managed":[152],"programmes":[154],"(4/24),":[155],"hospital":[157],"(3/24).":[159],"Centres":[160,178,218],"devolved":[163],"nations":[164],"fewer":[166],"overall":[168],"submitted":[170],"significantly":[171],"more":[172],"than":[175],"English":[176],"centres.":[177],"offering":[180],"21":[181],"treatments,":[183],"most":[184],"commonly":[185],"ONC201":[186],"(8/24),":[187],"dabrafenib/trametinib":[188,208],"(7/24),":[189,211],"bevacizumab":[190,206,266],"vorasidenib":[193,210],"(5/24).":[194],"Treatments":[195],"wanted":[197],"to,":[198,203],"but":[199],"able":[202],"provide":[204],"(11/24),":[207],"Tumour":[213],"Treating":[214],"Fields":[215],"(6/24).":[216],"Conclusions":[217],"substantial":[220],"used":[225],"treatments.":[229],"Varying":[230],"reliance":[235],"on":[236,263,272],"local":[238],"contribute":[241],"inequitable":[243],"access.":[244,278],"Further":[245],"work":[246],"by":[247],"Brain":[251],"Cancer":[252],"Mission":[253],"its":[255],"partners,":[256],"such":[257],"as":[258],"an":[259],"upcoming":[260],"position":[261],"statement":[262],"treat":[268],"radionecrosis,":[269],"will":[270],"focus":[271],"reducing":[273],"standardising":[277]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-08-28T00:00:00"}
