{"id":"https://openalex.org/W7204453025","doi":"https://doi.org/10.1007/s00431-026-07359-7","title":"Vaccination of children with inborn errors of metabolism: safety, immunogenicity, and practical implications","display_name":"Vaccination of children with inborn errors of metabolism: safety, immunogenicity, and practical implications","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204453025","doi":"https://doi.org/10.1007/s00431-026-07359-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/42658255"},"language":"en","primary_location":{"id":"doi:10.1007/s00431-026-07359-7","doi":"https://doi.org/10.1007/s00431-026-07359-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00431-026-07359-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07359-7.pdf","source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07359-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023586555","display_name":"Patryk Lipi\u0144ski","orcid":"https://orcid.org/0000-0002-1849-8375","observed_orcids":["https://orcid.org/0000-0002-1849-8375"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Patryk Lipi\u0144ski","raw_affiliation_strings":["Third Department of Pediatrics, Center of Postgraduate Medical Education, Dziekan\u00f3w Le\u015bny, Poland. plipinski@cmkp.edu.pl"],"raw_orcid":"https://orcid.org/0000-0002-1849-8375","affiliations":[{"raw_affiliation_string":"Third Department of Pediatrics, Center of Postgraduate Medical Education, Dziekan\u00f3w Le\u015bny, Poland. plipinski@cmkp.edu.pl","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148420490","display_name":"Maria Jaczewska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Jaczewska","raw_affiliation_strings":["Department of Pediatrics, Biela\u0144ski Hospital, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Biela\u0144ski Hospital, Warsaw, Poland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056359451","display_name":"Teresa Jackowska","orcid":"https://orcid.org/0000-0003-0131-7854","observed_orcids":["https://orcid.org/0000-0003-0131-7854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teresa Jackowska","raw_affiliation_strings":["Department of Pediatrics, Biela\u0144ski Hospital, Warsaw, Poland","First Department of Pediatrics, Centre of Postgraduate Medical Education, Warsaw, Poland"],"raw_orcid":"https://orcid.org/0000-0003-0131-7854","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Biela\u0144ski Hospital, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"First Department of Pediatrics, Centre of Postgraduate Medical Education, Warsaw, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023586555"],"corresponding_institution_ids":[],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6980042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"185","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10833","display_name":"Vaccine Coverage and Hesitancy","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/3306","display_name":"Health"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inborn-errors-of-metabolism","display_name":"inborn errors of metabolism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/childhood-immunization","display_name":"childhood immunization","score":0.7459999918937683},{"id":"https://openalex.org/keywords/vaccine-safety","display_name":"vaccine safety","score":0.9919999837875366},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/metabolic-decompensation","display_name":"metabolic decompensation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/live-attenuated-vaccine","display_name":"live attenuated vaccine","score":0.7760000228881836},{"id":"https://openalex.org/keywords/vaccination-contraindications","display_name":"vaccine contraindications","score":0.8460000157356262},{"id":"https://openalex.org/keywords/vaccine-excipients","display_name":"vaccine excipients","score":0.6909999847412109},{"id":"https://openalex.org/keywords/serological-testing","display_name":"serological testing","score":0.6119999885559082},{"id":"https://openalex.org/keywords/vaccine-dosing","display_name":"vaccine dosing","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9327999949455261},{"id":"https://openalex.org/C2776494729","wikidata":"https://www.wikidata.org/wiki/Q1848900","display_name":"Contraindication","level":3,"score":0.7444000244140625},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.7093999981880188},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6000000238418579},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.5540000200271606},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4740000069141388},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C2778721985","wikidata":"https://www.wikidata.org/wiki/Q1183680","display_name":"Decompensation","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C2777466982","wikidata":"https://www.wikidata.org/wiki/Q5227287","display_name":"Data extraction","level":3,"score":0.34549999237060547},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34450000524520874},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3285999894142151},{"id":"https://openalex.org/C986699","wikidata":"https://www.wikidata.org/wiki/Q7939","display_name":"El Ni\u00f1o","level":2,"score":0.31139999628067017},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2808000147342682},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.2605000138282776},{"id":"https://openalex.org/C2779646400","wikidata":"https://www.wikidata.org/wiki/Q1758393","display_name":"Inborn error of metabolism","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.2538999915122986}],"mesh":[{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000071497","descriptor_name":"Immunogenicity, Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000087507","descriptor_name":"Vaccine Efficacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008661","descriptor_name":"Metabolism, Inborn Errors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00431-026-07359-7","doi":"https://doi.org/10.1007/s00431-026-07359-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00431-026-07359-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07359-7.pdf","source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},{"id":"pmid:42658255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42658255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pediatrics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13522025","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13522025/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13522025/pdf/431_2026_Article_7359.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Pediatr","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00431-026-07359-7","doi":"https://doi.org/10.1007/s00431-026-07359-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00431-026-07359-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00431-026-07359-7.pdf","source":{"id":"https://openalex.org/S48201647","display_name":"European Journal of Pediatrics","issn_l":"0340-6199","issn":["0340-6199","1432-1076"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pediatrics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5998892188072205}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204453025.pdf","grobid_xml":"https://content.openalex.org/works/W7204453025.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1862427049","https://openalex.org/W1975945245","https://openalex.org/W1978138739","https://openalex.org/W2048032822","https://openalex.org/W2055883251","https://openalex.org/W2070476795","https://openalex.org/W2097882740","https://openalex.org/W2146013163","https://openalex.org/W2161662557","https://openalex.org/W2742011265","https://openalex.org/W2761810763","https://openalex.org/W2937766364","https://openalex.org/W3039377240","https://openalex.org/W3091056013","https://openalex.org/W3094262672","https://openalex.org/W3206216603","https://openalex.org/W4220769394","https://openalex.org/W4297539943","https://openalex.org/W4297964569","https://openalex.org/W4312156991","https://openalex.org/W4313561470","https://openalex.org/W4409031700"],"related_works":[],"abstract_inverted_index":{"Children":[0],"with":[1,153,183,213,262,308],"inborn":[2],"errors":[3],"of":[4,21,73,139,149,209,270,304,333],"metabolism":[5],"(IEMs)":[6],"are":[7],"vulnerable":[8],"to":[9,54,86,186,220,244],"infection-induced":[10],"catabolism":[11],"and":[12,41,48,64,69,106,112,121,171,195,237,248,278,292,320],"metabolic":[13,145,187,249,258],"decompensation,":[14],"yet":[15],"vaccination":[16,148,208,218,265,303],"may":[17],"be":[18,241],"delayed":[19,268],"because":[20,269],"concerns":[22],"that":[23],"fever":[24],"or":[25,89,144],"reduced":[26],"intake":[27],"after":[28,147,302],"immunization":[29],"could":[30],"produce":[31],"similar":[32],"effects.":[33],"This":[34,311],"review":[35,312],"evaluates":[36],"vaccine":[37,196,276],"safety,":[38],"immunogenicity,":[39],"effectiveness,":[40],"practical":[42,326],"precautions":[43,184,280],"in":[44,260],"pediatric":[45,65,87,92,98,156,200,288,314],"IEMs.":[46,154,214,309],"PubMed/MEDLINE":[47],"Embase":[49],"were":[50,76,100,107,115,123],"searched":[51,77],"from":[52,129,316],"inception":[53],"30":[55],"June":[56],"2026":[57],"using":[58],"predefined":[59],"terms":[60],"for":[61,167,207],"IEMs,":[62,263],"vaccination,":[63,182],"populations.":[66],"Google":[67],"Scholar":[68],"the":[70,163,245,330,334],"reference":[71],"lists":[72],"relevant":[74],"publications":[75],"as":[78,103],"supplementary":[79],"sources.":[80],"Primary":[81],"evidence":[82,105,164,201,289,319],"synthesis":[83],"was":[84],"restricted":[85],"studies":[88,95,157],"separately":[90],"extractable":[91],"results.":[93],"Mixed-age":[94],"without":[96],"separable":[97],"outcomes":[99],"retained":[101],"only":[102],"contextual":[104,318],"explicitly":[108],"identified.":[109],"Study":[110],"selection":[111],"data":[113],"extraction":[114],"performed":[116],"independently":[117],"by":[118],"two":[119],"reviewers,":[120],"findings":[122,315],"synthesized":[124],"narratively.":[125],"Pediatric":[126],"evidence,":[127],"predominantly":[128],"small":[130],"observational":[131],"studies,":[132],"did":[133],"not":[134,173,296],"identify":[135],"a":[136,224,298],"consistent":[137,299],"signal":[138,301],"increased":[140],"serious":[141],"adverse":[142],"events":[143],"decompensation":[146,259],"clinically":[150,210,305],"stable":[151,211,306],"children":[152,212,261,307],"Limited":[155],"reported":[158],"measurable":[159],"humoral":[160],"responses,":[161],"but":[162,204,264,294],"is":[165,202,227,266,290],"insufficient":[166],"many":[168],"individual":[169],"disorders":[170],"does":[172],"establish":[174],"clinical":[175],"effectiveness.":[176],"Published":[177],"guidance":[178,216,323],"generally":[179,205],"favors":[180],"age-appropriate":[181],"individualized":[185,242],"stability,":[188],"catabolic":[189],"risk,":[190],"immune":[191,247],"dysfunction,":[192],"comorbidities,":[193],"treatment,":[194],"excipients.":[197],"CONCLUSION:":[198],"Available":[199],"limited":[203,291],"reassuring":[206],"Current":[215],"supports":[217],"according":[219,243],"national":[221],"schedules":[222],"unless":[223],"vaccine-specific":[225],"contraindication":[226],"present.":[228],"Decisions":[229],"concerning":[230],"live":[231],"vaccines,":[232],"serological":[233],"testing,":[234],"additional":[235],"doses,":[236],"peri-vaccination":[238],"measures":[239],"should":[240],"complete":[246],"phenotype.":[250],"WHAT":[251,283],"IS":[252,284],"KNOWN:":[253],"\u2022":[254,273,286,310],"Infections":[255],"can":[256],"precipitate":[257],"often":[267],"safety":[271,300],"concerns.":[272],"Evidence":[274],"on":[275],"immunogenicity":[277],"disease-specific":[279],"remains":[281],"limited.":[282],"NEW:":[285],"Direct":[287],"heterogeneous":[293],"has":[295],"identified":[297],"separates":[313],"mixed-age":[317],"translates":[321],"published":[322],"into":[324],"phenotype-based":[325],"considerations,":[327],"while":[328],"highlighting":[329],"low":[331],"certainty":[332],"evidence.":[335]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-08-28T00:00:00"}