{"id":"https://openalex.org/W7204451356","doi":"https://doi.org/10.64898/2026.08.26.747295","title":"LGR5-high colorectal cancer defines a Wnt-active stem-like state with multimodal therapeutic vulnerabilities","display_name":"LGR5-high colorectal cancer defines a Wnt-active stem-like state with multimodal therapeutic vulnerabilities","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204451356","doi":"https://doi.org/10.64898/2026.08.26.747295"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.26.747295","doi":"https://doi.org/10.64898/2026.08.26.747295","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747295","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/27/2026.08.26.747295.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/27/2026.08.26.747295.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040852319","display_name":"Luc\u00eda Paniagua\u2010Herranz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luc\u00eda Paniagua-Herranz","raw_affiliation_strings":["Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182","https://openalex.org/I4210158561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108305713","display_name":"Alejandro Feito","orcid":"https://orcid.org/0009-0000-1282-7580","observed_orcids":["https://orcid.org/0009-0000-1282-7580"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandro Feito","raw_affiliation_strings":["Department of Physical Chemistry, Universidad Complutense de Madrid, Av. Complutense s/n, Madrid 28040, Spain","Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry, Universidad Complutense de Madrid, Av. Complutense s/n, Madrid 28040, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040303186","display_name":"Cristian Privat","orcid":"https://orcid.org/0000-0002-8288-6508","observed_orcids":["https://orcid.org/0000-0002-8288-6508"]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristian Privat","raw_affiliation_strings":["Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182","https://openalex.org/I4210158561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043363376","display_name":"Luis \u00c1lvarez\u2010Carri\u00f3n","orcid":"https://orcid.org/0000-0001-9686-672X","observed_orcids":["https://orcid.org/0000-0001-9686-672X"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis \u00c1lvarez-Carri\u00f3n","raw_affiliation_strings":["CANMET research group, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precision, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CANMET research group, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precision, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108763096","display_name":"Bernard Doger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Bernard Doger","raw_affiliation_strings":["START Madrid-FJD, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"START Madrid-FJD, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077472156","display_name":"Andr\u00e9s R. Tejedor","orcid":"https://orcid.org/0000-0002-9437-6169","observed_orcids":["https://orcid.org/0000-0002-9437-6169"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Andr\u00e9s R. Tejedor","raw_affiliation_strings":["Department of Physical Chemistry, Universidad Complutense de Madrid, Av. Complutense s/n, Madrid 28040, Spain","Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9437-6169","affiliations":[{"raw_affiliation_string":"Department of Physical Chemistry, Universidad Complutense de Madrid, Av. Complutense s/n, Madrid 28040, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148428615","display_name":"Juan Antonio Ardua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Antonio Ardura","raw_affiliation_strings":["Bone Physiopathology Laboratory, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precisi\u00f3n, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Physiopathology Laboratory, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precisi\u00f3n, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012988355","display_name":"Ver\u00f3nica Alonso","orcid":"https://orcid.org/0000-0002-2813-3257","observed_orcids":["https://orcid.org/0000-0002-2813-3257"]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ver\u00f3nica Alonso","raw_affiliation_strings":["CANMET research group, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precision, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CANMET research group, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precision, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities ES, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Spain","institution_ids":["https://openalex.org/I118091203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045773639","display_name":"Cristina Nieto\u2010Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-3463-1439","observed_orcids":["https://orcid.org/0000-0002-3463-1439"]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Nieto-Jim\u00e9nez","raw_affiliation_strings":["Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182","https://openalex.org/I4210158561"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033819383","display_name":"Carlos Alonso\u2010Moreno","orcid":"https://orcid.org/0000-0002-7588-0781","observed_orcids":["https://orcid.org/0000-0002-7588-0781"]},"institutions":[{"id":"https://openalex.org/I4210143641","display_name":"ORFEO-CINQA Research Network","ror":"https://ror.org/03xw5ev35","country_code":"ES","type":"facility","lineage":["https://openalex.org/I10902133","https://openalex.org/I121748325","https://openalex.org/I123044942","https://openalex.org/I130194489","https://openalex.org/I134820265","https://openalex.org/I165339363","https://openalex.org/I169108374","https://openalex.org/I200284239","https://openalex.org/I255234318","https://openalex.org/I4210143641","https://openalex.org/I4210154396","https://openalex.org/I63634437","https://openalex.org/I79189158","https://openalex.org/I79238269"]},{"id":"https://openalex.org/I79189158","display_name":"University of Castilla-La Mancha","ror":"https://ror.org/05r78ng12","country_code":"ES","type":"education","lineage":["https://openalex.org/I79189158"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Alonso-Moreno","raw_affiliation_strings":["Universidad de Castilla-La Mancha, Departamento de Qu\u00edmica Inorg\u00e1nica, org\u00e1nica y bioqu\u00edmica. Facultad de Farmacia-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, 02008 Albacete, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad de Castilla-La Mancha, Departamento de Qu\u00edmica Inorg\u00e1nica, org\u00e1nica y bioqu\u00edmica. Facultad de Farmacia-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, 02008 Albacete, Spain","institution_ids":["https://openalex.org/I4210143641","https://openalex.org/I79189158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126726513","display_name":"Victor Moreno","orcid":"https://orcid.org/0000-0002-7129-5577","observed_orcids":["https://orcid.org/0000-0002-7129-5577"]},"institutions":[{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"V\u00edctor Moreno","raw_affiliation_strings":["START Madrid-FJD, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"START Madrid-FJD, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053069942","display_name":"Emiliano Calvo","orcid":"https://orcid.org/0000-0003-4921-829X","observed_orcids":["https://orcid.org/0000-0003-4921-829X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emiliano Calvo","raw_affiliation_strings":["START Madrid-CIOCC, Centro Integral Oncol\u00f3gico Clara Campal, 28050 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"START Madrid-CIOCC, Centro Integral Oncol\u00f3gico Clara Campal, 28050 Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023340072","display_name":"Bal\u00e1zs Gy\u0151rffy","orcid":"https://orcid.org/0000-0002-5772-3766","observed_orcids":["https://orcid.org/0000-0002-5772-3766"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I4387152226","display_name":"Hungarian Research Network","ror":"https://ror.org/04w6pnc49","country_code":"HU","type":"other","lineage":["https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Balazs Gyorffy","raw_affiliation_strings":["Cancer Biomarker Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, H-1117, Budapest, Hungary","Department of Bioinformatics, Semmelweis University, H-1094, Budapest, Hungary","Institute of Transdisciplinary Discoveries, Medical School, University of Pecs, H-7624, Pecs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biomarker Research Group, Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, H-1117, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"raw_affiliation_string":"Department of Bioinformatics, Semmelweis University, H-1094, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Institute of Transdisciplinary Discoveries, Medical School, University of Pecs, H-7624, Pecs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148450276","display_name":"Jorge R. Espinosa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118091203","display_name":"Universidad San Pablo CEU","ror":"https://ror.org/00tvate34","country_code":"ES","type":"education","lineage":["https://openalex.org/I118091203","https://openalex.org/I2801318690"]},{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["ES","GB"],"is_corresponding":true,"raw_author_name":"Jorge R. Espinosa","raw_affiliation_strings":["Bone Physiopathology Laboratory, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precisi\u00f3n, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Madrid, Spain","Department of Physical Chemistry, Universidad Complutense de Madrid, Av. Complutense s/n, Madrid 28040, Spain","Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","PhAsIca BioScience SL. Calle Vel\u00e1zquez 27, 1\u00b0 exterior derecha, Madrid, 28001, Spain","Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone Physiopathology Laboratory, C\u00e1tedra INTHEOS-START-CEU de Oncolog\u00eda de precisi\u00f3n, Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, Instituto de Medicina Molecular Aplicada (IMMA), Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28660 Boadilla del Monte, Madrid, Spain","institution_ids":["https://openalex.org/I118091203"]},{"raw_affiliation_string":"Department of Physical Chemistry, Universidad Complutense de Madrid, Av. Complutense s/n, Madrid 28040, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"PhAsIca BioScience SL. Calle Vel\u00e1zquez 27, 1\u00b0 exterior derecha, Madrid, 28001, Spain","institution_ids":[]},{"raw_affiliation_string":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074810713","display_name":"Alberto Oca\u00f1a","orcid":"https://orcid.org/0000-0002-1067-9630","observed_orcids":["https://orcid.org/0000-0002-1067-9630","https://orcid.org/0009-0007-2974-5662"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210129357","display_name":"Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz","ror":"https://ror.org/049nvyb15","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210129357"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Ocana","raw_affiliation_strings":["C\u00e1tedra INTHEOS-START-CEU. START Madrid-FJD, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain","Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain","Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","PhAsIca BioScience SL. Calle Vel\u00e1zquez 27, 1\u00b0 exterior derecha, Madrid, 28001, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C\u00e1tedra INTHEOS-START-CEU. START Madrid-FJD, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Madrid, Spain","institution_ids":["https://openalex.org/I4210129357"]},{"raw_affiliation_string":"Experimental Therapeutics CRIS Cancer Unit, Hospital Clinico San Carlos and IdSCC and CIBERONC, Madrid, Spain","institution_ids":["https://openalex.org/I2961216182","https://openalex.org/I4210158561"]},{"raw_affiliation_string":"Instituto Pluridisciplinar, Universidad Complutense de Madrid, P.\u00b0 de Juan XXIII, 1, Moncloa - Aravaca, 28040 Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"PhAsIca BioScience SL. Calle Vel\u00e1zquez 27, 1\u00b0 exterior derecha, Madrid, 28001, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5148450276"],"corresponding_institution_ids":["https://openalex.org/I118091203","https://openalex.org/I121748325","https://openalex.org/I241749"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.32690000534057617,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.32690000534057617,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.31790000200271606,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.14229999482631683,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lgr5","display_name":"Lgr5","score":0.9300000071525574},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/prognostic-stratification","display_name":"prognostic stratification","score":0.906000018119812},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.7770000100135803},{"id":"https://openalex.org/keywords/nkd1","display_name":"NKD1","score":0.6119999885559082},{"id":"https://openalex.org/keywords/phase-separation","display_name":"phase separation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/condensate","display_name":"condensate","score":0.5740000009536743},{"id":"https://openalex.org/keywords/enpp3","display_name":"ENPP3","score":0.7789999842643738},{"id":"https://openalex.org/keywords/plcb4","display_name":"PLCB4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/satb1","display_name":"SATB1","score":0.7770000100135803},{"id":"https://openalex.org/keywords/mex3a","display_name":"MEX3A","score":0.996999979019165},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.6510000228881836},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.6100000143051147},{"id":"https://openalex.org/keywords/surfaceome","display_name":"surfaceome","score":0.5559999942779541},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.8374000191688538},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6348000168800354},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5641999840736389},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5519000291824341},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5370000004768372},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5090000033378601},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4903999865055084},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4787999987602234},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.44609999656677246},{"id":"https://openalex.org/C1009742","wikidata":"https://www.wikidata.org/wiki/Q5333998","display_name":"Ectodomain","level":3,"score":0.3840000033378601},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.35929998755455017},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.35280001163482666},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.34470000863075256},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3361000120639801},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.3222000002861023},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.32019999623298645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3138999938964844},{"id":"https://openalex.org/C2777421810","wikidata":"https://www.wikidata.org/wiki/Q21145188","display_name":"MUC1","level":3,"score":0.3116999864578247},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28209999203681946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2809000015258789},{"id":"https://openalex.org/C98108389","wikidata":"https://www.wikidata.org/wiki/Q412563","display_name":"CRISPR","level":3,"score":0.2768999934196472},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.26330000162124634},{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2621999979019165},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25429999828338623},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.26.747295","doi":"https://doi.org/10.64898/2026.08.26.747295","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747295","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/27/2026.08.26.747295.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.26.747295","doi":"https://doi.org/10.64898/2026.08.26.747295","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.26.747295","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/08/27/2026.08.26.747295.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1801066649","display_name":null,"funder_award_id":"000/2023","funder_id":"https://openalex.org/F4320332150","funder_display_name":"CRIS Cancer Foundation"},{"id":"https://openalex.org/G3443088370","display_name":null,"funder_award_id":"RYC2021-030937-I","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G4212894969","display_name":null,"funder_award_id":"PID2022","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G7908645599","display_name":null,"funder_award_id":"000/2023","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8484266922","display_name":null,"funder_award_id":"JDC2024-053759-I","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"}],"funders":[{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320323113","display_name":"Banco Bilbao Vizcaya Argentaria","ror":"https://ror.org/0537dnd74"},{"id":"https://openalex.org/F4320323868","display_name":"Barcelona Supercomputing Center","ror":"https://ror.org/05sd8tv96"},{"id":"https://openalex.org/F4320332150","display_name":"CRIS Cancer Foundation","ror":"https://ror.org/05qdgvk25"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338463","display_name":"CHIST-ERA","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204451356.pdf","grobid_xml":"https://content.openalex.org/works/W7204451356.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7150891679","https://openalex.org/W2313731002","https://openalex.org/W2801493934","https://openalex.org/W4294243400","https://openalex.org/W4407232586","https://openalex.org/W4409805253","https://openalex.org/W2345779625","https://openalex.org/W1989258758","https://openalex.org/W2171759387","https://openalex.org/W4393088549"],"abstract_inverted_index":{"Abstract":[0],"Leucine-rich":[1],"repeat-containing":[2],"G":[3],"protein-coupled":[4],"receptor":[5],"5":[6],"(LGR5)":[7],"marks":[8],"a":[9,59,171,178],"stem-like":[10,62],"colorectal":[11,40,168],"cancer":[12,169],"population":[13],"but":[14,145],"is":[15],"difficult":[16],"to":[17,42],"target":[18],"directly":[19],"because":[20],"of":[21],"its":[22,133],"expression":[23],"in":[24,160],"normal":[25],"intestinal":[26],"stem":[27],"cells.":[28],"Here,":[29],"we":[30],"integrated":[31],"transcriptomic,":[32],"somatic":[33],"mutation,":[34],"and":[35,48,72,97,118,136,149,157,176],"copy-number":[36],"data":[37],"from":[38],"396":[39],"tumors":[41,57],"define":[43,166],"the":[44,81,104,125],"LGR5-high":[45,56,167],"molecular":[46,161,174],"state":[47,175],"identify":[49],"therapeutic":[50,188],"vulnerabilities":[51],"through":[52],"modality-matched":[53,179],"tractability":[54],"analysis.":[55],"displayed":[58],"coordinated":[60],"Wnt-active,":[61],"transcriptional":[63],"program":[64],"associated":[65],"with":[66,129],"extracellular":[67],"matrix":[68],"remodeling,":[69],"APC":[70],"mutations,":[71],"IGF2":[73],"amplification,":[74],"yet":[75],"lacked":[76,141],"selective":[77],"genetic":[78],"dependencies":[79],"among":[80],"identified":[82],"genes.":[83],"We":[84],"therefore":[85],"assessed":[86],"candidate":[87,106],"targets":[88],"across":[89],"three":[90],"complementary":[91],"dimensions:":[92],"surface":[93],"accessibility,":[94],"structural":[95,127],"ligandability,":[96,128],"biomolecular":[98],"condensate":[99],"behavior.":[100],"ENPP3":[101],"emerged":[102],"as":[103,170],"strongest":[105,126],"for":[107,181],"antibody-based":[108],"delivery,":[109],"combining":[110],"tumor-associated":[111,183],"expression,":[112],"an":[113],"accessible":[114],"ectodomain,":[115],"internalization":[116],"capacity,":[117],"clinical":[119],"antibody-drug":[120],"conjugate":[121],"precedent.":[122],"PLCB4":[123],"showed":[124],"independent":[130],"algorithms":[131],"identifying":[132],"catalytic":[134],"site":[135],"additional":[137],"predicted":[138],"cavities.":[139],"NKD1":[140],"conventional":[142],"ligandable":[143],"pockets":[144],"formed":[146],"RNA-stabilized":[147],"condensates":[148],"partitioned":[150],"into":[151,185],"DVL2\u2013AXIN1":[152,158],"assemblies,":[153],"reducing":[154],"AXIN1":[155],"self-association":[156],"contacts":[159],"simulations.":[162],"Together,":[163],"these":[164],"findings":[165],"therapeutically":[172],"tractable":[173],"establish":[177],"framework":[180],"translating":[182],"signatures":[184],"experimentally":[186],"testable":[187],"hypotheses.":[189]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-08-28T00:00:00"}
