{"id":"https://openalex.org/W7204446112","doi":"https://doi.org/10.64898/2026.08.23.746508","title":"Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-\u03b2 impairs astrocytic autophagic flux and exacerbates neuroinflammation","display_name":"Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-\u03b2 impairs astrocytic autophagic flux and exacerbates neuroinflammation","publication_year":2026,"publication_date":"2026-08-27","ids":{"openalex":"https://openalex.org/W7204446112","doi":"https://doi.org/10.64898/2026.08.23.746508"},"language":"en","primary_location":{"id":"doi:10.64898/2026.08.23.746508","doi":"https://doi.org/10.64898/2026.08.23.746508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.23.746508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.08.23.746508","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tai Young Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tai Young Kim","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063451837","display_name":"Mridula Bhalla","orcid":"https://orcid.org/0000-0001-6045-3683","observed_orcids":["https://orcid.org/0000-0001-6045-3683"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mridula Bhalla","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075479301","display_name":"Uiyeol Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140519","display_name":"Korean Association Of Science and Technology Studies","ror":"https://ror.org/04qh86j58","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210140519"]},{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Uiyeol Park","raw_affiliation_strings":["Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210140519","https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081979237","display_name":"Seung Jae Hyeon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140519","display_name":"Korean Association Of Science and Technology Studies","ror":"https://ror.org/04qh86j58","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210140519"]},{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Jae Hyeon","raw_affiliation_strings":["Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210140519","https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008730554","display_name":"In\u2010Young Hwang","orcid":"https://orcid.org/0000-0002-4633-3658","observed_orcids":["https://orcid.org/0000-0002-4633-3658"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"In-Young Hwang","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027761886","display_name":"Youngsuk Seo","orcid":"https://orcid.org/0000-0002-8934-3290","observed_orcids":["https://orcid.org/0000-0002-8934-3290"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngsuk Seo","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000206141","display_name":"Wongu Youn","orcid":"https://orcid.org/0000-0001-6807-141X","observed_orcids":["https://orcid.org/0000-0001-6807-141X"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wongu Youn","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148411362","display_name":"Jin-A Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I112728665","display_name":"Hannam University","ror":"https://ror.org/01cwbae71","country_code":"KR","type":"education","lineage":["https://openalex.org/I112728665"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Jin-A Lee","raw_affiliation_strings":["Boston University Alzheimer\u2019s Disease Center and Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA","Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Alzheimer\u2019s Disease Center and Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I112728665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435068","display_name":"Jung-Hee Lee","orcid":"https://orcid.org/0000-0002-9530-9806","observed_orcids":["https://orcid.org/0000-0002-9530-9806"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I112728665","display_name":"Hannam University","ror":"https://ror.org/01cwbae71","country_code":"KR","type":"education","lineage":["https://openalex.org/I112728665"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Junghee Lee","raw_affiliation_strings":["Boston University Alzheimer\u2019s Disease Center and Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA","Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University Alzheimer\u2019s Disease Center and Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I112728665"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124383626","display_name":"Boyoung Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Boyoung Lee","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055870378","display_name":"Hoon Ryu","orcid":"https://orcid.org/0000-0001-6544-3732","observed_orcids":["https://orcid.org/0000-0001-6544-3732"]},"institutions":[{"id":"https://openalex.org/I4210140519","display_name":"Korean Association Of Science and Technology Studies","ror":"https://ror.org/04qh86j58","country_code":"KR","type":"other","lineage":["https://openalex.org/I4210140519"]},{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hoon Ryu","raw_affiliation_strings":["Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea","institution_ids":["https://openalex.org/I4210140519","https://openalex.org/I58716616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047012149","display_name":"Changjoon Justin Lee","orcid":"https://orcid.org/0000-0002-3555-0980","observed_orcids":["https://orcid.org/0000-0002-3555-0980","https://orcid.org/0000-0002-6217-9574"]},"institutions":[{"id":"https://openalex.org/I4210104335","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210104335"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"C. Justin Lee","raw_affiliation_strings":["Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3555-0980","affiliations":[{"raw_affiliation_string":"Center for Memory and Glioscience, Institute for Basic Science, Daejeon 34126, Republic of Korea","institution_ids":["https://openalex.org/I4210104335"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5047012149"],"corresponding_institution_ids":["https://openalex.org/I4210104335"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/axl-receptor","display_name":"AXL receptor","score":0.7059999704360962},{"id":"https://openalex.org/keywords/sirt2","display_name":"SIRT2","score":0.7350000143051147},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.925000011920929},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9570000171661377},{"id":"https://openalex.org/keywords/autophagic-flux","display_name":"autophagic flux","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gamma-secretase-cleavage","display_name":"gamma-secretase cleavage","score":0.8090000152587891},{"id":"https://openalex.org/keywords/phase-separated-condensates","display_name":"phase-separated condensates","score":0.9110000133514404},{"id":"https://openalex.org/keywords/chromatin-remodeling","display_name":"chromatin remodeling","score":0.968999981880188},{"id":"https://openalex.org/keywords/alpha-tubulin-acetylation","display_name":"alpha-tubulin acetylation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/autophagosome-lysosome-fusion","display_name":"autophagosome-lysosome fusion","score":0.9940000176429749},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.781000018119812},{"id":"https://openalex.org/keywords/astrocyte-activation","display_name":"astrocyte activation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.9002000093460083},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8526999950408936},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7793999910354614},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.5932000279426575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5871000289916992},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4302999973297119},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.42890000343322754},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.42320001125335693},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.352400004863739},{"id":"https://openalex.org/C2777682930","wikidata":"https://www.wikidata.org/wiki/Q1531490","display_name":"Gliosis","level":2,"score":0.34310001134872437},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3327000141143799},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3287000060081482},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32659998536109924},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30720001459121704},{"id":"https://openalex.org/C2776598214","wikidata":"https://www.wikidata.org/wiki/Q6606395","display_name":"Withaferin A","level":4,"score":0.29899999499320984},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2879999876022339},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.28450000286102295},{"id":"https://openalex.org/C168296220","wikidata":"https://www.wikidata.org/wiki/Q14882441","display_name":"Autophagosome","level":4,"score":0.2702000141143799},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2517000138759613},{"id":"https://openalex.org/C2778366672","wikidata":"https://www.wikidata.org/wiki/Q5957687","display_name":"Hyperactivation","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.08.23.746508","doi":"https://doi.org/10.64898/2026.08.23.746508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.23.746508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.08.23.746508","doi":"https://doi.org/10.64898/2026.08.23.746508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.08.23.746508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G893988286","display_name":null,"funder_award_id":"IBSR001-D2","funder_id":"https://openalex.org/F4320326441","funder_display_name":"Institute for Basic Science"}],"funders":[{"id":"https://openalex.org/F4320326441","display_name":"Institute for Basic Science","ror":"https://ror.org/00y0zf565"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W1919353","https://openalex.org/W1505098134","https://openalex.org/W1562156325","https://openalex.org/W1572225000","https://openalex.org/W1581216242","https://openalex.org/W1965938007","https://openalex.org/W1970637701","https://openalex.org/W1974559428","https://openalex.org/W1975200363","https://openalex.org/W1977919654","https://openalex.org/W1978177805","https://openalex.org/W1979783084","https://openalex.org/W1981172452","https://openalex.org/W1981549228","https://openalex.org/W1985124617","https://openalex.org/W1995176982","https://openalex.org/W2000225222","https://openalex.org/W2007775311","https://openalex.org/W2010476270","https://openalex.org/W2031699523","https://openalex.org/W2045992894","https://openalex.org/W2046232891","https://openalex.org/W2071174827","https://openalex.org/W2089936534","https://openalex.org/W2106782035","https://openalex.org/W2119981278","https://openalex.org/W2120956575","https://openalex.org/W2127312027","https://openalex.org/W2153326117","https://openalex.org/W2155768517","https://openalex.org/W2157096314","https://openalex.org/W2168702014","https://openalex.org/W2229833364","https://openalex.org/W2237384747","https://openalex.org/W2424808248","https://openalex.org/W2435000040","https://openalex.org/W2544622388","https://openalex.org/W2563570608","https://openalex.org/W2618927598","https://openalex.org/W2767765728","https://openalex.org/W2768858549","https://openalex.org/W2775650492","https://openalex.org/W2802630688","https://openalex.org/W2903876796","https://openalex.org/W2909477364","https://openalex.org/W2914907359","https://openalex.org/W2923272749","https://openalex.org/W2966203512","https://openalex.org/W3005303475","https://openalex.org/W3032947695","https://openalex.org/W3091877976","https://openalex.org/W3092966039","https://openalex.org/W3094993828","https://openalex.org/W3101789682","https://openalex.org/W3108936441","https://openalex.org/W3152525961","https://openalex.org/W3156849358","https://openalex.org/W3158781730","https://openalex.org/W3164883837","https://openalex.org/W3169888655","https://openalex.org/W3201206728","https://openalex.org/W3214318481","https://openalex.org/W4205335396","https://openalex.org/W4206337645","https://openalex.org/W4224263590","https://openalex.org/W4281616414","https://openalex.org/W4283395386","https://openalex.org/W4286488496","https://openalex.org/W4293200026","https://openalex.org/W4306406676","https://openalex.org/W4315641042","https://openalex.org/W4378713804","https://openalex.org/W4386009517","https://openalex.org/W4387196264","https://openalex.org/W4387340888","https://openalex.org/W4388222613","https://openalex.org/W4391537373","https://openalex.org/W4399906597","https://openalex.org/W4400916244","https://openalex.org/W4401363901","https://openalex.org/W4406396125","https://openalex.org/W4410182880","https://openalex.org/W4413440595","https://openalex.org/W4416197087","https://openalex.org/W6987763405","https://openalex.org/W7154509695","https://openalex.org/W7164020038"],"related_works":["https://openalex.org/W4385777654","https://openalex.org/W4291148925","https://openalex.org/W2052859130","https://openalex.org/W1112655644","https://openalex.org/W2774583035","https://openalex.org/W4400916244","https://openalex.org/W4394874185","https://openalex.org/W4407175045","https://openalex.org/W6908507803","https://openalex.org/W3166682272"],"abstract_inverted_index":{"Abstract":[0],"Autophagy":[1],"dysfunction":[2],"and":[3,21,46,66,97,105,126,132,152,160,179],"neuroinflammation":[4,23,47,180],"are":[5],"central":[6],"to":[7,17,41,92,175],"Alzheimer\u2019s":[8],"disease":[9],"(AD),":[10],"yet":[11],"how":[12],"extracellular":[13],"amyloid-\u03b2":[14],"(A\u03b2)":[15],"couples":[16,38],"impaired":[18],"autophagic":[19,114,147],"flux":[20],"heightened":[22],"remains":[24],"unknown.":[25],"Here,":[26],"we":[27],"identify":[28],"the":[29,42,75,93,143,167],"TAM":[30],"receptor":[31],"AXL":[32],"as":[33,170],"a":[34,57],"molecular":[35],"transducer":[36],"that":[37,62],"A\u03b2":[39,50,177],"sensing":[40],"regulation":[43],"of":[44,54,74,85,130],"autophagy":[45,68],"in":[48,83,162,181],"astrocytes.":[49],"induces":[51],"\u03b3-secretase-dependent":[52],"cleavage":[53],"AXL,":[55],"generating":[56],"nuclear":[58],"intracellular":[59],"domain":[60,96],"(AXL-ICD)":[61],"forms":[63],"phase-separated":[64],"condensates":[65],"activates":[67],"gene":[69],"transcription":[70],"through":[71],"SIRT2-mediated":[72],"recruitment":[73],"RUVBL1/2-INO80":[76],"chromatin-remodeling":[77],"complex.":[78],"This":[79],"axis":[80,169],"is":[81],"activated":[82],"astrocytes":[84],"postmortem":[86],"AD":[87],"brains.":[88],"Concurrently,":[89],"AXL-ICD":[90,111],"binds":[91],"SIRT2":[94],"catalytic":[95],"suppresses":[98],"its":[99],"deacetylase":[100],"activity,":[101],"increasing":[102],"\u03b1-tubulin":[103],"acetylation":[104],"altering":[106],"microtubule":[107,120],"dynamics.":[108],"While":[109],"moderate":[110],"levels":[112],"promote":[113],"flux,":[115,148],"excessive":[116],"elevation":[117],"paradoxically":[118],"triggers":[119],"hyperstabilization,":[121],"thereby":[122],"impairing":[123],"autophagosome-lysosome":[124],"fusion":[125],"causing":[127],"pathological":[128],"accumulation":[129],"autophagosomes":[131],"H":[133,155],"2":[134,136,156,158],"O":[135,157],".":[137],"The":[138],"inhibitory":[139],"peptide":[140],"AxSBiP":[141],"disrupts":[142],"AXL-ICD/SIRT2":[144,168],"interaction,":[145],"restores":[146],"reduces":[149],"plaque":[150],"burden,":[151],"normalizes":[153],"A\u03b2-induced":[154],"production":[159],"astrogliosis":[161],"APP/PS1":[163],"mice.":[164],"We":[165],"propose":[166],"an":[171],"effective":[172],"therapeutic":[173],"target":[174],"reduce":[176],"burden":[178],"AD.":[182]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-28T00:00:00"}