{"id":"https://openalex.org/W7204439699","doi":"https://doi.org/10.24110/0031-403x-2026-105-4-68-74","title":"EFFICACY OF VEMURAFENIB COMBINED WITH CYTARABINE AND 2-CHLORO-2\u2032-DEOXYADENOSINE AS FIRST-LINE THERAPY IN CHILDREN WITH MULTISYSTEM LANGERHANS CELL HISTIOCYTOSIS","display_name":"EFFICACY OF VEMURAFENIB COMBINED WITH CYTARABINE AND 2-CHLORO-2\u2032-DEOXYADENOSINE AS FIRST-LINE THERAPY IN CHILDREN WITH MULTISYSTEM LANGERHANS CELL HISTIOCYTOSIS","publication_year":2026,"publication_date":"2026-08-14","ids":{"openalex":"https://openalex.org/W7204439699","doi":"https://doi.org/10.24110/0031-403x-2026-105-4-68-74"},"language":"en","primary_location":{"id":"doi:10.24110/0031-403x-2026-105-4-68-74","doi":"https://doi.org/10.24110/0031-403x-2026-105-4-68-74","is_oa":false,"landing_page_url":"https://doi.org/10.24110/0031-403x-2026-105-4-68-74","pdf_url":null,"source":{"id":"https://openalex.org/S4210181920","display_name":"PEDIATRIA Journal named after G N SPERANSKY","issn_l":"0031-403X","issn":["0031-403X","1990-2182"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatria. Journal named after G.N. Speransky","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038371062","display_name":"\u0415. \u0410. \u0411\u0443\u0440\u0446\u0435\u0432","orcid":"https://orcid.org/0000-0002-3623-6547","observed_orcids":["https://orcid.org/0000-0002-3623-6547"]},"institutions":[{"id":"https://openalex.org/I4210110829","display_name":"Russian Children's Clinical Hospital","ror":"https://ror.org/01wvtht83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210110829"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.A. Burtsev","raw_affiliation_strings":["Morozov Children\u2019s City Clinical Hospital, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3623-6547","affiliations":[{"raw_affiliation_string":"Morozov Children\u2019s City Clinical Hospital, Moscow, Russia","institution_ids":["https://openalex.org/I4210110829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027110831","display_name":"Dmitry A. Evseev","orcid":"https://orcid.org/0000-0001-8610-0624","observed_orcids":["https://orcid.org/0000-0001-8610-0624"]},"institutions":[{"id":"https://openalex.org/I4210127411","display_name":"Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology","ror":"https://ror.org/02h8dsx08","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210127411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.A. Evseev","raw_affiliation_strings":["National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-8610-0624","affiliations":[{"raw_affiliation_string":"National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia","institution_ids":["https://openalex.org/I4210127411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035868561","display_name":"Daria S. Osipova","orcid":"https://orcid.org/0000-0002-9968-9332","observed_orcids":["https://orcid.org/0000-0002-9968-9332"]},"institutions":[{"id":"https://openalex.org/I4210127411","display_name":"Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology","ror":"https://ror.org/02h8dsx08","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210127411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.S. Osipova","raw_affiliation_strings":["National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9968-9332","affiliations":[{"raw_affiliation_string":"National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia","institution_ids":["https://openalex.org/I4210127411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058629344","display_name":"G. Z. Seregin","orcid":"https://orcid.org/0000-0003-3880-4402","observed_orcids":["https://orcid.org/0000-0003-3880-4402"]},"institutions":[{"id":"https://openalex.org/I4210110829","display_name":"Russian Children's Clinical Hospital","ror":"https://ror.org/01wvtht83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210110829"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G.Z. Seregin","raw_affiliation_strings":["Morozov Children\u2019s City Clinical Hospital, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-3880-4402","affiliations":[{"raw_affiliation_string":"Morozov Children\u2019s City Clinical Hospital, Moscow, Russia","institution_ids":["https://openalex.org/I4210110829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065009045","display_name":"D. D. Baydildina","orcid":"https://orcid.org/0000-0001-7130-8596","observed_orcids":["https://orcid.org/0000-0001-7130-8596"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D.D. Baydildina","raw_affiliation_strings":["Pirogov Russian National Research Medical University, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-7130-8596","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University, Moscow, Russia","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013805257","display_name":"\u0418. \u0418. \u041a\u0430\u043b\u0438\u043d\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0002-0813-5626","observed_orcids":["https://orcid.org/0000-0002-0813-5626"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I.I. Kalinina","raw_affiliation_strings":["Pirogov Russian National Research Medical University, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0813-5626","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University, Moscow, Russia","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051660971","display_name":"\u042d. \u0412. \u041a\u0443\u043c\u0438\u0440\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0001-6125-2410","observed_orcids":["https://orcid.org/0000-0001-6125-2410"]},"institutions":[{"id":"https://openalex.org/I4210110829","display_name":"Russian Children's Clinical Hospital","ror":"https://ror.org/01wvtht83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210110829"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E.V. Kumirova","raw_affiliation_strings":["Morozov Children\u2019s City Clinical Hospital, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0001-6125-2410","affiliations":[{"raw_affiliation_string":"Morozov Children\u2019s City Clinical Hospital, Moscow, Russia","institution_ids":["https://openalex.org/I4210110829"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011971433","display_name":"Alexey Maschan","orcid":"https://orcid.org/0000-0002-0016-6698","observed_orcids":["https://orcid.org/0000-0002-0016-6698"]},"institutions":[{"id":"https://openalex.org/I4210110829","display_name":"Russian Children's Clinical Hospital","ror":"https://ror.org/01wvtht83","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210110829"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A.A. Maschan","raw_affiliation_strings":["Morozov Children\u2019s City Clinical Hospital, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0002-0016-6698","affiliations":[{"raw_affiliation_string":"Morozov Children\u2019s City Clinical Hospital, Moscow, Russia","institution_ids":["https://openalex.org/I4210110829"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068428867","display_name":"Michael A Maschan","orcid":"https://orcid.org/0000-0003-1735-0093","observed_orcids":["https://orcid.org/0000-0003-1735-0093"]},"institutions":[{"id":"https://openalex.org/I4210127411","display_name":"Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology","ror":"https://ror.org/02h8dsx08","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210127411"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.A. Maschan","raw_affiliation_strings":["National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia"],"raw_orcid":"https://orcid.org/0000-0003-1735-0093","affiliations":[{"raw_affiliation_string":"National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia","institution_ids":["https://openalex.org/I4210127411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"105","issue":"4","first_page":"68","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multisystem-langerhans-cell-histiocytosis","display_name":"multisystem Langerhans cell histiocytosis","score":0.9380000233650208},{"id":"https://openalex.org/keywords/vemurafenib","display_name":"vemurafenib","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cytarabine","display_name":"cytarabine","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cladribine","display_name":"cladribine","score":0.9710000157356262},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.871999979019165},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.6949999928474426},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5249999761581421},{"id":"https://openalex.org/keywords/disease-reactivation","display_name":"disease reactivation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.8970000147819519},{"id":"https://openalex.org/keywords/disease-activity-score","display_name":"disease activity score","score":0.6830000281333923},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/allelic-burden","display_name":"allelic burden","score":0.6430000066757202},{"id":"https://openalex.org/keywords/risk-organ-involvement","display_name":"risk organ involvement","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.944599986076355},{"id":"https://openalex.org/C2776131300","wikidata":"https://www.wikidata.org/wiki/Q423111","display_name":"Vemurafenib","level":4,"score":0.930899977684021},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6563000082969666},{"id":"https://openalex.org/C2777484599","wikidata":"https://www.wikidata.org/wiki/Q374036","display_name":"Langerhans cell histiocytosis","level":3,"score":0.6528000235557556},{"id":"https://openalex.org/C2779945361","wikidata":"https://www.wikidata.org/wiki/Q1349259","display_name":"Erdheim\u2013Chester disease","level":4,"score":0.571399986743927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5277000069618225},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.5065000057220459},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4072999954223633},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.4000999927520752},{"id":"https://openalex.org/C2780174970","wikidata":"https://www.wikidata.org/wiki/Q1411740","display_name":"Histiocytosis","level":3,"score":0.39480000734329224},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38040000200271606},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.3589000105857849},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.34220001101493835},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3395000100135803},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32420000433921814},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.3131999969482422},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C43100952","wikidata":"https://www.wikidata.org/wiki/Q654612","display_name":"Histiocyte","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C2777642821","wikidata":"https://www.wikidata.org/wiki/Q206060","display_name":"Scars","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26190000772476196},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.2605000138282776},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2526000142097473},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.25110000371932983},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.24110/0031-403x-2026-105-4-68-74","doi":"https://doi.org/10.24110/0031-403x-2026-105-4-68-74","is_oa":false,"landing_page_url":"https://doi.org/10.24110/0031-403x-2026-105-4-68-74","pdf_url":null,"source":{"id":"https://openalex.org/S4210181920","display_name":"PEDIATRIA Journal named after G N SPERANSKY","issn_l":"0031-403X","issn":["0031-403X","1990-2182"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatria. Journal named after G.N. Speransky","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4394943622","https://openalex.org/W4377294890","https://openalex.org/W4391110078","https://openalex.org/W3118490972","https://openalex.org/W2972707815","https://openalex.org/W4200107010","https://openalex.org/W2799937938","https://openalex.org/W4213183667","https://openalex.org/W3191999041","https://openalex.org/W4414109558"],"abstract_inverted_index":{"Langerhans":[0],"cell":[1],"histiocytosis":[2],"(LCH)":[3],"is":[4,40],"the":[5,17,29,50,59,103,144,165,168,191,215,222],"most":[6,213],"common":[7],"histiocytic":[8],"disorder":[9],"of":[10,16,63,67,117,124,237],"childhood,":[11],"driven":[12],"by":[13,164,214],"pathological":[14],"activation":[15],"MAPK":[18],"signaling":[19],"pathway.":[20],"The":[21,112],"multisystem":[22,83,96,298],"form":[23],"with":[24,42,69,81,94,102,122,143,273,281,297],"riskorgan":[25],"involvement":[26],"(RO+)":[27],"carries":[28],"worst":[30],"prognosis.":[31],"BRAF":[32],"inhibitors":[33],"show":[34],"high":[35,44],"initial":[36],"efficacy,":[37],"but":[38],"monotherapy":[39],"associated":[41],"a":[43,64],"reactivation":[45],"rate":[46],"after":[47,179],"discontinuation,":[48],"underscoring":[49],"need":[51],"to":[52,174,291],"optimize":[53],"first-line":[54,77,106,293],"therapy.":[55],"Objective:":[56],"To":[57],"evaluate":[58],"efficacy":[60],"and":[61,73,86,99,128,178,200,232,285,302],"tolerability":[62],"combined":[65,272],"protocol":[66,104,113],"vemurafenib":[68,118,271],"reduced-dose":[70,274],"cytarabine":[71],"(ARA-C)":[72],"2-chloro-2\u2032-deoxyadenosine":[74],"(2-CdA)":[75],"as":[76,105,156],"therapy":[78,107,239],"in":[79,108,208,221,229,242,258,264,278,295],"children":[80,296],"BRAF-positive":[82],"LCH.":[84],"Materials":[85],"Methods:":[87],"A":[88,256],"retrospective":[89],"two-center":[90],"observational":[91],"study.":[92],"Children":[93],"BRAF+":[95],"LCH":[97],"(RO+":[98],"RO\u2013)":[100],"treated":[101],"2022\u20132025":[109],"were":[110,184],"included.":[111],"comprised":[114],"4":[115],"courses":[116],"(20":[119],"mg/kg/day)":[120],"alternating":[121],"blocks":[123],"ARA-C":[125],"(200":[126],"mg/m2/day)":[127,131],"2-CdA":[129],"(6":[130],"at":[132],"reduced":[133],"doses;":[134],"total":[135],"duration":[136],"196":[137],"days.":[138],"Disease":[139,145],"activity":[140],"was":[141,154,162,172,196,206,225,240,254,262],"assessed":[142],"Activity":[146],"Score":[147],"(DAS);":[148],"complete":[149],"response":[150],"(non-active":[151],"disease,":[152],"NAD)":[153],"defined":[155],"0":[157],"points.":[158],"Event-free":[159],"survival":[160],"(EFS)":[161],"estimated":[163],"Kaplan\u2013Meier":[166],"method;":[167],"Wilcoxon":[169],"signed-rank":[170],"test":[171],"used":[173],"compare":[175],"DAS":[176,202],"before":[177],"treatment.":[180],"Results:":[181],"Twenty":[182],"patients":[183,280],"enrolled":[185],"(RO+,":[186],"n=16;":[187],"RO\u2013,":[188],"n=4).":[189],"In":[190],"RO+":[192,223,231,301],"group,":[193],"median":[194,201],"age":[195],"9":[197],"(1\u201322)":[198],"months":[199],"13":[203],"(5\u201316).":[204],"NAD":[205,277],"achieved":[207],"all":[209,243,265,279],"20":[210],"(100%)":[211],"patients,":[212],"first":[216],"assessment":[217],"point.":[218],"Five-year":[219],"EFS":[220],"group":[224],"75%.":[226],"Reactivation":[227],"occurred":[228],"3/16":[230],"1/4":[233],"RO\u2013":[234],"patients;":[235],"re-initiation":[236],"targeted":[238],"effective":[241],"cases.":[244],"No":[245],"grade":[246],"III\u2013IV":[247],"toxicity":[248,284],"(CTCAE":[249],"v5.0)":[250],"or":[251],"disease":[252],"progression":[253],"observed.":[255],"decline":[257],"BRAF-V600E":[259],"allelic":[260],"burden":[261],"seen":[263],"8":[266],"evaluated":[267],"patients.":[268],"Conclusion:":[269],"First-line":[270],"ARA-C/2-CdA":[275],"achieves":[276],"low":[282],"organ":[283],"may":[286],"be":[287],"considered":[288],"an":[289],"alternative":[290],"existing":[292],"regimens":[294],"LCH,":[299],"both":[300],"RO\u2013.":[303]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-28T00:00:00"}