{"id":"https://openalex.org/W7204367776","doi":null,"title":"Solving lattice protein problems with quantum computing","display_name":"Solving lattice protein problems with quantum computing","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7204367776"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:304061a8-ed85-4b51-b56a-c8c35a4eb677","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/304061a8-ed85-4b51-b56a-c8c35a4eb677","pdf_url":"https://lup.lub.lu.se/search/files/258552384/Lucas_Knuthson_-_WEBB.pdf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/search/files/258552384/Lucas_Knuthson_-_WEBB.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043098785","display_name":"Lucas Knuthson","orcid":"https://orcid.org/0000-0003-1080-200X","observed_orcids":["https://orcid.org/0000-0003-1080-200X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Knuthson, Lucas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043098785"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10682","display_name":"Quantum Computing Algorithms and Architecture","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10682","display_name":"Quantum Computing Algorithms and Architecture","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12029","display_name":"DNA and Biological Computing","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantum-annealing","display_name":"quantum annealing","score":0.9649999737739563},{"id":"https://openalex.org/keywords/quantum-approximate-optimization-algorithm","display_name":"quantum approximate optimization algorithm","score":0.8650000095367432},{"id":"https://openalex.org/keywords/quantum-alternating-operator-ansatz","display_name":"Quantum Alternating Operator Ansatz","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hardware-efficient-ansatz","display_name":"hardware-efficient ansatz","score":0.8050000071525574},{"id":"https://openalex.org/keywords/maximum-independent-set-problem","display_name":"maximum independent set","score":0.6019999980926514},{"id":"https://openalex.org/keywords/soft-constraints","display_name":"soft constraints","score":0.7549999952316284},{"id":"https://openalex.org/keywords/steric-constraints","display_name":"steric constraints","score":0.625},{"id":"https://openalex.org/keywords/hydrophobic-polar-model","display_name":"hydrophobic-polar model","score":0.7379999756813049},{"id":"https://openalex.org/keywords/density-of-states","display_name":"density of states","score":0.8489999771118164},{"id":"https://openalex.org/keywords/heat-capacity","display_name":"heat capacity","score":0.921999990940094},{"id":"https://openalex.org/keywords/d-wave-quantum-annealer","display_name":"D-Wave quantum annealer","score":0.7319999933242798},{"id":"https://openalex.org/keywords/combinatorial-optimization","display_name":"combinatorial optimization","score":0.6399999856948853},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C90408235","wikidata":"https://www.wikidata.org/wiki/Q938141","display_name":"Quantum annealing","level":4,"score":0.569599986076355},{"id":"https://openalex.org/C58053490","wikidata":"https://www.wikidata.org/wiki/Q176555","display_name":"Quantum computer","level":3,"score":0.5687999725341797},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.5638999938964844},{"id":"https://openalex.org/C2781204021","wikidata":"https://www.wikidata.org/wiki/Q6497091","display_name":"Lattice (music)","level":2,"score":0.482699990272522},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.47909998893737793},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45969998836517334},{"id":"https://openalex.org/C137019171","wikidata":"https://www.wikidata.org/wiki/Q2623817","display_name":"Quantum algorithm","level":3,"score":0.4512999951839447},{"id":"https://openalex.org/C130979935","wikidata":"https://www.wikidata.org/wiki/Q568954","display_name":"Ansatz","level":2,"score":0.4018000066280365},{"id":"https://openalex.org/C169699857","wikidata":"https://www.wikidata.org/wiki/Q2122243","display_name":"Quantum information","level":3,"score":0.3977000117301941},{"id":"https://openalex.org/C161166931","wikidata":"https://www.wikidata.org/wiki/Q7269096","display_name":"Quantum simulator","level":4,"score":0.38920000195503235},{"id":"https://openalex.org/C177179195","wikidata":"https://www.wikidata.org/wiki/Q7268372","display_name":"Quadratic unconstrained binary optimization","level":4,"score":0.37860000133514404},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3682999908924103},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3416999876499176},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C15184713","wikidata":"https://www.wikidata.org/wiki/Q7269042","display_name":"Quantum dynamics","level":3,"score":0.30799999833106995},{"id":"https://openalex.org/C11255438","wikidata":"https://www.wikidata.org/wiki/Q7269085","display_name":"Quantum process","level":4,"score":0.30730000138282776},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.2989000082015991},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.2937999963760376},{"id":"https://openalex.org/C2778926657","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum system","level":3,"score":0.28949999809265137},{"id":"https://openalex.org/C129844170","wikidata":"https://www.wikidata.org/wiki/Q41299","display_name":"Quadratic equation","level":2,"score":0.2768000066280365},{"id":"https://openalex.org/C33332235","wikidata":"https://www.wikidata.org/wiki/Q18362","display_name":"Theoretical physics","level":1,"score":0.271699994802475},{"id":"https://openalex.org/C15706264","wikidata":"https://www.wikidata.org/wiki/Q230883","display_name":"Quantum state","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C43682372","wikidata":"https://www.wikidata.org/wiki/Q7269080","display_name":"Quantum operation","level":4,"score":0.25459998846054077},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2533000111579895},{"id":"https://openalex.org/C17020691","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operator (biology)","level":5,"score":0.2533000111579895},{"id":"https://openalex.org/C190474826","wikidata":"https://www.wikidata.org/wiki/Q2495111","display_name":"Open quantum system","level":3,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:lup.lub.lu.se:304061a8-ed85-4b51-b56a-c8c35a4eb677","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/304061a8-ed85-4b51-b56a-c8c35a4eb677","pdf_url":"https://lup.lub.lu.se/search/files/258552384/Lucas_Knuthson_-_WEBB.pdf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:304061a8-ed85-4b51-b56a-c8c35a4eb677","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/304061a8-ed85-4b51-b56a-c8c35a4eb677","pdf_url":"https://lup.lub.lu.se/search/files/258552384/Lucas_Knuthson_-_WEBB.pdf","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204367776.pdf","grobid_xml":"https://content.openalex.org/works/W7204367776.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4405466504","https://openalex.org/W2118518847","https://openalex.org/W2899133393","https://openalex.org/W4414728143","https://openalex.org/W3014328819","https://openalex.org/W7163128915","https://openalex.org/W2898620356","https://openalex.org/W4280619167","https://openalex.org/W4405974733","https://openalex.org/W4391776223"],"abstract_inverted_index":{"Quantum":[0],"computing":[1,65],"has":[2],"progressed":[3],"from":[4],"a":[5,9,33,72,82,87,90,111,119,161,203],"theoretical":[6],"concept":[7],"to":[8,17,118,151,173,189,234,284,296],"practical":[10],"experimental":[11],"technology.":[12],"By":[13],"processing":[14],"information":[15],"according":[16],"quantum":[18,24,43,64,131,216,218,222,264,278],"mechanics":[19],"rather":[20],"than":[21],"classical":[22],"rules,":[23],"computers":[25,44],"may":[26],"offer":[27],"advantages":[28],"for":[29,66,164,206],"certain":[30],"problems.":[31],"Although":[32],"few":[34],"algorithms":[35,318],"have":[36],"proven":[37],"speedups,":[38],"it":[39],"remains":[40],"unclear":[41],"where":[42],"will":[45,313],"be":[46,136,200,257],"practically":[47],"useful,":[48],"especially":[49],"since":[50],"current":[51],"devices":[52],"are":[53],"noisy,":[54],"small,":[55],"and":[56,123,141,159,178,193,226,237,244,253,260,265,294,319],"not":[57],"yet":[58],"fault":[59],"tolerant.":[60],"This":[61],"thesis":[62],"explores":[63],"biophysically":[67],"motivated":[68],"combinatorial":[69],"problems,":[70],"with":[71,113],"focus":[73],"on":[74,89,130],"lattice":[75,96,127,165,181,212],"protein":[76,83,128,166,213],"models.":[77],"In":[78,155,183,277],"these":[79,247],"simplified":[80],"models,":[81],"is":[84,271],"represented":[85],"as":[86,105,107],"chain":[88,112],"discrete":[91],"lattice.":[92],"Despite":[93],"their":[94,280],"simplicity,":[95],"proteins":[97],"retain":[98],"important":[99],"features":[100],"of":[101,110,240,242,274,325],"real":[102],"proteins,":[103],"such":[104,106],"the":[108,187,190,207,232,238,272,299,323],"folding":[109],"exponentially":[114],"many":[115],"possible":[116],"shapes":[117],"unique":[120],"minimum-energy":[121],"structure":[122],"steric":[124],"constraints.To":[125],"run":[126],"problems":[129],"hardware,":[132,289],"they":[133,290],"must":[134],"first":[135],"formulated":[137],"using":[138,215,262],"binary":[139],"variables":[140],"objective":[142],"functions.":[143],"The":[144],"latter":[145],"typically":[146],"contain":[147],"soft":[148,197,275],"constraints":[149,198],"needed":[150],"ensure":[152],"physical":[153,327],"solutions.":[154],"Papers~\\I--\\II,":[156],"we":[157,185],"developed":[158,205],"extended":[160,231],"coordinate-based":[162],"mapping":[163],"folding,":[167,251],"enabling":[168],"D-Wave's":[169],"hybrid":[170,266],"quantum-classical":[171],"annealer":[172],"fold":[174],"both":[175],"$2$D":[176],"hydrophobic-polar":[177],"$3$D":[179],"Miyazawa-Jernigan":[180],"proteins.":[182],"Paper~\\III,":[184],"adapted":[186],"approach":[188],"gate-based":[191,288],"paradigm":[192],"showed":[194],"how":[195,250],"quadratic":[196],"could":[199],"removed":[201],"by":[202],"mixer":[204],"maximum-independent-set":[208],"problem.":[209],"Papers~\\IV--\\V":[210],"addressed":[211],"design":[214],"annealing,":[217,279],"approximate":[219],"optimization":[220],"algorithm,":[221],"alternating":[223],"operator":[224],"ansatz":[225],"hardware-efficient":[227],"ansatz,":[228],"while":[229,329],"Paper~\\VI":[230],"framework":[233],"multi-chain":[235,254],"thermodynamics":[236,255],"reconstruction":[239],"densities":[241],"states":[243],"heat-capacity":[245],"features.Together,":[246],"papers":[248],"show":[249],"design,":[252],"can":[256,305],"formulated,":[258],"implemented,":[259],"analyzed":[261],"present-day":[263],"hardware.":[267],"A":[268],"recurring":[269],"limitation":[270],"treatment":[273],"constraints.":[276],"high":[281],"connectivity":[282],"leads":[283],"error":[285],"accumulation.":[286],"On":[287],"increase":[291],"circuit":[292],"depth":[293],"sensitivity":[295],"noise.":[297],"At":[298],"same":[300],"time,":[301],"temporary":[302],"constraint":[303],"violations":[304],"provide":[306],"useful":[307],"freedom":[308],"during":[309],"optimization.":[310],"Further":[311],"progress":[312],"therefore":[314],"require":[315],"improved":[316],"formulations,":[317],"hardware":[320],"that":[321],"reduce":[322],"cost":[324],"enforcing":[326],"solutions":[328],"retaining":[330],"this":[331],"flexibility.":[332]},"counts_by_year":[],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2026-08-27T00:00:00"}
