{"id":"https://openalex.org/W7204279964","doi":"https://doi.org/10.3389/fimmu.2026.1951300","title":"The estrogen\u2013ferroptosis axis in postmenopausal osteoporosis, osteoarthritis, and intervertebral disc degeneration: shared mechanisms and emerging evidence","display_name":"The estrogen\u2013ferroptosis axis in postmenopausal osteoporosis, osteoarthritis, and intervertebral disc degeneration: shared mechanisms and emerging evidence","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204279964","doi":"https://doi.org/10.3389/fimmu.2026.1951300","pmid":"https://pubmed.ncbi.nlm.nih.gov/42719629","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13555382"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1951300","doi":"https://doi.org/10.3389/fimmu.2026.1951300","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1951300","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1951300/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204279964"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1951300/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052181402","display_name":"Kaiyuan Zheng","orcid":"https://orcid.org/0009-0004-0618-3167","observed_orcids":["https://orcid.org/0009-0004-0618-3167"]},"institutions":[{"id":"https://openalex.org/I1336834208","display_name":"Management and Science University","ror":"https://ror.org/027zr9y17","country_code":"MY","type":"education","lineage":["https://openalex.org/I1336834208"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN","MY"],"is_corresponding":false,"raw_author_name":"Kaiyuan Zheng","raw_affiliation_strings":["Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","School of Graduate Studies, Post Graduate Centre, Neuroscience & Mental Well-being Centre (NeuroMIND), International Medical School, Management & Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]},{"raw_affiliation_string":"School of Graduate Studies, Post Graduate Centre, Neuroscience & Mental Well-being Centre (NeuroMIND), International Medical School, Management & Science University","institution_ids":["https://openalex.org/I1336834208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140212238","display_name":"Peiyue Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peiyue Zhang","raw_affiliation_strings":["Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","School of Nursing, North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]},{"raw_affiliation_string":"School of Nursing, North Sichuan Medical College","institution_ids":["https://openalex.org/I105086349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148383514","display_name":"Siyu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Wang","raw_affiliation_strings":["Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148180548","display_name":"Li Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159713506","display_name":"Xiaoyan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336834208","display_name":"Management and Science University","ror":"https://ror.org/027zr9y17","country_code":"MY","type":"education","lineage":["https://openalex.org/I1336834208"]},{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN","MY"],"is_corresponding":false,"raw_author_name":"Xiaoyan Zheng","raw_affiliation_strings":["Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","School of Graduate Studies, Post Graduate Centre, Neuroscience & Mental Well-being Centre (NeuroMIND), International Medical School, Management & Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]},{"raw_affiliation_string":"School of Graduate Studies, Post Graduate Centre, Neuroscience & Mental Well-being Centre (NeuroMIND), International Medical School, Management & Science University","institution_ids":["https://openalex.org/I1336834208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043947534","display_name":"Nik Nasihah Nik Ramli","orcid":"https://orcid.org/0000-0001-7701-8485","observed_orcids":["https://orcid.org/0000-0001-7701-8485"]},"institutions":[{"id":"https://openalex.org/I1336834208","display_name":"Management and Science University","ror":"https://ror.org/027zr9y17","country_code":"MY","type":"education","lineage":["https://openalex.org/I1336834208"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Nik Nasihah Nik Ramli","raw_affiliation_strings":["School of Graduate Studies, Post Graduate Centre, Neuroscience & Mental Well-being Centre (NeuroMIND), International Medical School, Management & Science University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Graduate Studies, Post Graduate Centre, Neuroscience & Mental Well-being Centre (NeuroMIND), International Medical School, Management & Science University","institution_ids":["https://openalex.org/I1336834208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102004319","display_name":"Juan Tan","orcid":"https://orcid.org/0000-0003-3770-918X","observed_orcids":["https://orcid.org/0000-0003-3770-918X"]},"institutions":[{"id":"https://openalex.org/I4210108565","display_name":"Affiliated Hospital of North Sichuan Medical College","ror":"https://ror.org/01673gn35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210108565"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Tan","raw_affiliation_strings":["Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation Medicine, Department of Nursing, Intensive Care Unit, Department of Ultrasound Medicine, Affiliated Hospital of North Sichuan Medical College","institution_ids":["https://openalex.org/I4210108565"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043947534","https://openalex.org/A5102004319"],"corresponding_institution_ids":["https://openalex.org/I1336834208","https://openalex.org/I4210108565"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":"1951300","last_page":"1951300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.07980000227689743,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.07370000332593918,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-deficiency","display_name":"estrogen deficiency","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/postmenopausal-osteoporosis","display_name":"postmenopausal osteoporosis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":1.0},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8769999742507935},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.9789999723434448},{"id":"https://openalex.org/keywords/estrogen-receptor-modulation","display_name":"estrogen receptor modulation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/ferroptosis-inhibitors","display_name":"ferroptosis inhibitors","score":0.8889999985694885},{"id":"https://openalex.org/keywords/local-drug-delivery","display_name":"local drug delivery","score":0.8050000071525574},{"id":"https://openalex.org/keywords/musculoskeletal-degeneration","display_name":"musculoskeletal degeneration","score":0.7039999961853027},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7620999813079834},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6456999778747559},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.602400004863739},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.593999981880188},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5748999714851379},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.5716999769210815},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.5552999973297119},{"id":"https://openalex.org/C2777944059","wikidata":"https://www.wikidata.org/wiki/Q903917","display_name":"Selective estrogen receptor modulator","level":5,"score":0.5397999882698059},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3955000042915344},{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.3799000084400177},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35499998927116394},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.3199000060558319},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.3142000138759613},{"id":"https://openalex.org/C166471694","wikidata":"https://www.wikidata.org/wiki/Q18268232","display_name":"GPER","level":5,"score":0.30489999055862427},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C2909079248","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative Disorder","level":3,"score":0.29840001463890076},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29750001430511475},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.2957000136375427},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.2948000133037567},{"id":"https://openalex.org/C2777176818","wikidata":"https://www.wikidata.org/wiki/Q412178","display_name":"Tamoxifen","level":4,"score":0.27410000562667847},{"id":"https://openalex.org/C96307122","wikidata":"https://www.wikidata.org/wiki/Q15329133","display_name":"Estrogen receptor beta","level":5,"score":0.2705000042915344},{"id":"https://openalex.org/C96526673","wikidata":"https://www.wikidata.org/wiki/Q4867047","display_name":"Basic science","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.26350000500679016},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2624000012874603},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.25440001487731934}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015663","descriptor_name":"Osteoporosis, Postmenopausal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055959","descriptor_name":"Intervertebral Disc Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2026.1951300","doi":"https://doi.org/10.3389/fimmu.2026.1951300","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1951300","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1951300/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13555382","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13555382/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13555382/pdf/fimmu-17-1951300.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42719629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42719629","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:32e90bbe757341658679d76077c7faa0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/32e90bbe757341658679d76077c7faa0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1951300","doi":"https://doi.org/10.3389/fimmu.2026.1951300","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1951300","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1951300/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329536","display_name":"Sichuan Provincial Administration of Traditional Chinese Medicine","ror":"https://ror.org/03x55t826"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204279964.pdf","grobid_xml":"https://content.openalex.org/works/W7204279964.grobid-xml"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W1562938684","https://openalex.org/W1593442063","https://openalex.org/W1607254709","https://openalex.org/W1969945802","https://openalex.org/W1979703805","https://openalex.org/W1981525203","https://openalex.org/W2002387722","https://openalex.org/W2003762301","https://openalex.org/W2004070583","https://openalex.org/W2020238012","https://openalex.org/W2023917616","https://openalex.org/W2037790531","https://openalex.org/W2038773696","https://openalex.org/W2046279838","https://openalex.org/W2046913259","https://openalex.org/W2057294869","https://openalex.org/W2064891767","https://openalex.org/W2066667513","https://openalex.org/W2077560035","https://openalex.org/W2088222871","https://openalex.org/W2089219182","https://openalex.org/W2092798278","https://openalex.org/W2098796887","https://openalex.org/W2103584061","https://openalex.org/W2117025246","https://openalex.org/W2119221073","https://openalex.org/W2130423015","https://openalex.org/W2133281510","https://openalex.org/W2137539390","https://openalex.org/W2165554095","https://openalex.org/W2165807863","https://openalex.org/W2221436343","https://openalex.org/W2251687555","https://openalex.org/W2344815836","https://openalex.org/W2547656064","https://openalex.org/W2559963991","https://openalex.org/W2764259382","https://openalex.org/W2796347307","https://openalex.org/W2898003829","https://openalex.org/W2906076417","https://openalex.org/W2913973491","https://openalex.org/W2921277883","https://openalex.org/W2943383073","https://openalex.org/W2943536221","https://openalex.org/W2947054202","https://openalex.org/W2953316520","https://openalex.org/W3003960907","https://openalex.org/W3012782412","https://openalex.org/W3044600719","https://openalex.org/W3083501626","https://openalex.org/W3108493784","https://openalex.org/W3110019719","https://openalex.org/W3110061620","https://openalex.org/W3112135797","https://openalex.org/W3123922203","https://openalex.org/W3127467396","https://openalex.org/W3132528388","https://openalex.org/W3167334201","https://openalex.org/W3191260202","https://openalex.org/W3191946901","https://openalex.org/W3198729893","https://openalex.org/W4200412221","https://openalex.org/W4210396866","https://openalex.org/W4211221406","https://openalex.org/W4220665246","https://openalex.org/W4220877707","https://openalex.org/W4239731496","https://openalex.org/W4280623755","https://openalex.org/W4282932656","https://openalex.org/W4283718094","https://openalex.org/W4283835704","https://openalex.org/W4285796666","https://openalex.org/W4291004652","https://openalex.org/W4291784796","https://openalex.org/W4293420778","https://openalex.org/W4294415573","https://openalex.org/W4304690797","https://openalex.org/W4306928547","https://openalex.org/W4308475797","https://openalex.org/W4309436494","https://openalex.org/W4318068398","https://openalex.org/W4319080389","https://openalex.org/W4319262133","https://openalex.org/W4320709498","https://openalex.org/W4322621387","https://openalex.org/W4328128251","https://openalex.org/W4360599729","https://openalex.org/W4376639723","https://openalex.org/W4377564241","https://openalex.org/W4378980763","https://openalex.org/W4385584116","https://openalex.org/W4385725820","https://openalex.org/W4388537087","https://openalex.org/W4389435915","https://openalex.org/W4390511280","https://openalex.org/W4390988919","https://openalex.org/W4391108210","https://openalex.org/W4391286193","https://openalex.org/W4391878282","https://openalex.org/W4392354744","https://openalex.org/W4393118573","https://openalex.org/W4393317135","https://openalex.org/W4394903706","https://openalex.org/W4398223119","https://openalex.org/W4399895112","https://openalex.org/W4399951766","https://openalex.org/W4400424590","https://openalex.org/W4400959990","https://openalex.org/W4401219799","https://openalex.org/W4401703860","https://openalex.org/W4401826389","https://openalex.org/W4402424576","https://openalex.org/W4404491133","https://openalex.org/W4404814575","https://openalex.org/W4404893983","https://openalex.org/W4405559179","https://openalex.org/W4405947079","https://openalex.org/W4406472645","https://openalex.org/W4406537394","https://openalex.org/W4406620157","https://openalex.org/W4406705936","https://openalex.org/W4407821006","https://openalex.org/W4407979107","https://openalex.org/W4409052913","https://openalex.org/W4409118871","https://openalex.org/W4409324258","https://openalex.org/W4410202767","https://openalex.org/W4410879665","https://openalex.org/W4411107344","https://openalex.org/W4412027601","https://openalex.org/W4412063830","https://openalex.org/W4412439913","https://openalex.org/W4412700811","https://openalex.org/W4413117496","https://openalex.org/W4413416881","https://openalex.org/W4413962426","https://openalex.org/W4415105840","https://openalex.org/W4416430961","https://openalex.org/W7118006895","https://openalex.org/W7127456271","https://openalex.org/W7129542694","https://openalex.org/W7133186285","https://openalex.org/W7138423432"],"related_works":["https://openalex.org/W7204013563","https://openalex.org/W4390988919","https://openalex.org/W7160331891","https://openalex.org/W4402824132","https://openalex.org/W4414500837","https://openalex.org/W4304196134","https://openalex.org/W4323664649","https://openalex.org/W7169804596","https://openalex.org/W7138423432","https://openalex.org/W4319081902"],"abstract_inverted_index":{"Estrogen":[0,67],"deficiency":[1,68],"is":[2,111],"a":[3,157],"major":[4],"risk":[5],"factor":[6],"for":[7,160,169],"degenerative":[8,101,170],"disorders":[9],"of":[10,22,32,91,106,120],"the":[11,30,89,104,114,152],"musculoskeletal":[12,84,163,171],"system":[13],"in":[14,29,51,56,62,97],"postmenopausal":[15,52,162],"women,":[16],"while":[17],"ferroptosis,":[18,45],"an":[19,39],"iron-dependent":[20],"form":[21],"programmed":[23],"cell":[24],"death,":[25],"has":[26],"been":[27],"implicated":[28],"pathogenesis":[31],"various":[33],"osteoarticular":[34],"diseases.":[35,126],"Recent":[36],"studies":[37],"indicate":[38],"interplay":[40],"between":[41],"estrogen":[42,92,141],"signaling":[43],"and":[44,59,75,93,117,132,147,165],"with":[46,136],"evidence":[47],"relatively":[48],"well":[49],"supported":[50],"osteoporosis":[53],"(PMOP),":[54],"emerging":[55],"osteoarthritis":[57],"(OA),":[58],"still":[60],"limited":[61],"intervertebral":[63],"disc":[64],"degeneration":[65],"(IVDD).":[66],"may":[69,155],"disrupt":[70],"iron":[71],"homeostasis,":[72],"lipid":[73],"metabolism,":[74],"antioxidant":[76],"defense":[77],"systems,":[78],"thereby":[79],"increasing":[80],"ferroptosis":[81,145],"susceptibility":[82],"across":[83,124],"tissues.":[85],"This":[86],"review":[87],"summarizes":[88],"roles":[90],"recent":[94],"research":[95],"progress":[96],"these":[98,125],"three":[99],"common":[100],"diseases":[102],"from":[103],"perspective":[105],"ferroptosis-related":[107],"mechanisms.":[108],"Particular":[109],"emphasis":[110],"placed":[112],"on":[113],"shared":[115],"mechanisms":[116],"tissue-specific":[118],"manifestations":[119],"this":[121,138],"regulatory":[122],"axis":[123,154],"Finally,":[127],"we":[128],"highlight":[129],"therapeutic":[130],"opportunities":[131],"translational":[133],"challenges":[134],"associated":[135],"targeting":[137],"axis,":[139],"including":[140],"receptor":[142],"subtype":[143],"modulation,":[144],"inhibition,":[146],"local":[148],"delivery":[149],"strategies.":[150],"Overall,":[151],"estrogen-ferroptosis":[153],"provide":[156],"mechanistic":[158],"framework":[159],"understanding":[161],"comorbidity":[164],"developing":[166],"targeted":[167],"interventions":[168],"disorders.":[172]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-27T00:00:00"}
