{"id":"https://openalex.org/W7204277731","doi":"https://doi.org/10.21203/rs.3.rs-10402485/v1","title":"Prognostic factors for outcomes in young and middle-aged stroke patients with atrial fibrillation: a hospital-based cohort study in China","display_name":"Prognostic factors for outcomes in young and middle-aged stroke patients with atrial fibrillation: a hospital-based cohort study in China","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204277731","doi":"https://doi.org/10.21203/rs.3.rs-10402485/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10402485/v1","doi":"https://doi.org/10.21203/rs.3.rs-10402485/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10402485/v1","pdf_url":"https://www.researchsquare.com/article/rs-10402485/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10402485/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041466556","display_name":"Liu Yang","orcid":"https://orcid.org/0000-0003-2931-3687","observed_orcids":["https://orcid.org/0000-0003-2931-3687"]},"institutions":[{"id":"https://openalex.org/I4210167027","display_name":"Tangshan Gongren Hospital","ror":"https://ror.org/00sr40296","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Yang","raw_affiliation_strings":["Tangshan Gongren Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tangshan Gongren Hospital","institution_ids":["https://openalex.org/I4210167027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148311327","display_name":"Xin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167027","display_name":"Tangshan Gongren Hospital","ror":"https://ror.org/00sr40296","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":["Tangshan Gongren Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tangshan Gongren Hospital","institution_ids":["https://openalex.org/I4210167027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148403997","display_name":"Xiaofang Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097637","display_name":"Tangshan People's Hospital","ror":"https://ror.org/00xw2x114","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097637"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofang Gu","raw_affiliation_strings":["Tangshan Fengrun District People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tangshan Fengrun District People's Hospital","institution_ids":["https://openalex.org/I4210097637"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148386130","display_name":"Lili Bian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097637","display_name":"Tangshan People's Hospital","ror":"https://ror.org/00xw2x114","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097637"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lili Bian","raw_affiliation_strings":["Tangshan Fengrun District People's Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tangshan Fengrun District People's Hospital","institution_ids":["https://openalex.org/I4210097637"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148225493","display_name":"Haijun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210167027","display_name":"Tangshan Gongren Hospital","ror":"https://ror.org/00sr40296","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167027"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haijun Zhao","raw_affiliation_strings":["Tangshan Gongren Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tangshan Gongren Hospital","institution_ids":["https://openalex.org/I4210167027"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.8148999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.18039999902248383,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9660000205039978},{"id":"https://openalex.org/keywords/post-stroke-mortality","display_name":"post-stroke mortality","score":0.7540000081062317},{"id":"https://openalex.org/keywords/stroke-recurrence","display_name":"stroke recurrence","score":0.9350000023841858},{"id":"https://openalex.org/keywords/functional-dependencies","display_name":"functional dependencies","score":0.796999990940094},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9210000038146973},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.6349999904632568},{"id":"https://openalex.org/keywords/stroke-rehabilitation","display_name":"stroke rehabilitation","score":0.5400000214576721},{"id":"https://openalex.org/keywords/chinese-patients","display_name":"Chinese patients","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9330000281333923},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8554999828338623},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.8310999870300293},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5529000163078308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5443000197410583},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.5440999865531921},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5430999994277954},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4643999934196472},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.453900009393692},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.41990000009536743},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.362199991941452},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3605000078678131},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.3596999943256378},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3301999866962433},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.319599986076355},{"id":"https://openalex.org/C3020200829","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Stroke risk","level":4,"score":0.31360000371932983},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C3020166492","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Acute stroke","level":3,"score":0.2745000123977661},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2558000087738037},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2540999948978424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10402485/v1","doi":"https://doi.org/10.21203/rs.3.rs-10402485/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10402485/v1","pdf_url":"https://www.researchsquare.com/article/rs-10402485/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10402485/v1","doi":"https://doi.org/10.21203/rs.3.rs-10402485/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10402485/v1","pdf_url":"https://www.researchsquare.com/article/rs-10402485/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204277731.pdf","grobid_xml":"https://content.openalex.org/works/W7204277731.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3087627443"],"related_works":["https://openalex.org/W2591461720","https://openalex.org/W2329859686","https://openalex.org/W4321093806","https://openalex.org/W2087237893","https://openalex.org/W2083298061","https://openalex.org/W2027734648","https://openalex.org/W3028652429","https://openalex.org/W3021220001","https://openalex.org/W2902496959","https://openalex.org/W2149422425"],"abstract_inverted_index":{"Abstract":[0],"Objective:":[1],"Atrial":[2],"fibrillation":[3],"(AF)":[4],"is":[5,14],"a":[6,46],"well-established":[7],"risk":[8,204,222],"factor":[9],"for":[10,228],"ischemic":[11],"stroke":[12,33,53,67,81,169,200,235],"and":[13,19,29,50,59,63,74,85,88,95,109,117,121,128,150,155,174,188,197,202,224,232,236],"associated":[15,106,125,147,166],"with":[16,41,55,102,107,126,143,148,167,177],"substantial":[17],"mortality":[18,116,154,170,187],"disease":[20],"burden.":[21],"This":[22,183],"study":[23,49,184],"aimed":[24],"to":[25,215],"evaluate":[26],"the":[27,113,213,229],"3-":[28],"12-month":[30],"prognosis":[31],"after":[32,66,80],"in":[34,112,131,153,171],"Chinese":[35],"patients":[36,54,176,193],"aged":[37],"<":[38,137,161],"65":[39],"years":[40],"AF.":[42,56],"Methods:":[43],"We":[44],"conducted":[45],"hospital-based":[47],"cohort":[48],"enrolled":[51],"230":[52],"Clinical":[57],"characteristics":[58],"outcomes":[60],"at":[61,77,89],"3":[62,78,99],"12":[64,90,140],"months":[65,79,91],"were":[68,82,92,124],"assessed.":[69],"Results:":[70],"The":[71],"mortality,":[72],"recurrence,":[73],"dependency":[75,156,189],"rates":[76,190],"13.3%,":[83],"5.1%,":[84],"23.1%,":[86],"respectively,":[87],"17.2%,":[93],"19.0%,":[94],"36.8%,":[96],"respectively.":[97,119],"At":[98,139],"months,":[100,141],"compared":[101,142],"POCI,":[103,144],"PACI":[104,145],"was":[105,164],"4.79-fold":[108],"2.27-fold":[110],"increases":[111,130,152],"risks":[114],"of":[115,234],"dependency,":[118],"Obesity":[120],"current":[122],"smoking":[123],"3.71-fold":[127],"6.87-fold":[129],"recurrence":[132],"risk,":[133],"respectively":[134,158],"(all":[135,159],"P":[136,160],"0.05).":[138,162],"remained":[146],"3.10-fold":[149],"3.73-fold":[151],"risks,":[157],"Hypertension":[163],"not":[165],"increased":[168],"these":[172],"young":[173],"middle-aged":[175],"AF":[178],"(P":[179],"=":[180],"0.122).":[181],"Conclusions:":[182],"demonstrates":[185],"that":[186,198],"among":[191],"post-stroke":[192],"increase":[194],"over":[195],"time,":[196],"specific":[199],"subtypes":[201],"modifiable":[203],"factors":[205],"substantially":[206],"elevate":[207],"health":[208],"risks.":[209],"These":[210],"findings":[211],"underscore":[212],"need":[214],"optimize":[216],"blood":[217],"pressure":[218],"management,":[219],"prioritize":[220],"influential":[221],"factors,":[223],"develop":[225],"targeted":[226],"strategies":[227],"prevention,":[230],"treatment,":[231],"rehabilitation":[233],"atrial":[237],"fibrillation.":[238]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-08-27T00:00:00"}