{"id":"https://openalex.org/W7204276139","doi":"https://doi.org/10.1002/jbt.71089","title":"Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives","display_name":"Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204276139","doi":"https://doi.org/10.1002/jbt.71089","pmid":"https://pubmed.ncbi.nlm.nih.gov/42647057"},"language":"en","primary_location":{"id":"doi:10.1002/jbt.71089","doi":"https://doi.org/10.1002/jbt.71089","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.71089","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71089","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71089","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148332224","display_name":"Yitian Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yitian Gao","raw_affiliation_strings":["College of Geographical Sciences, Faculty of Geographical Science and Engineering Henan University Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Geographical Sciences, Faculty of Geographical Science and Engineering Henan University Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148210132","display_name":"Minxiang Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110441","display_name":"Second Affiliated Hospital of Inner Mongolia Medical University","ror":"https://ror.org/01y07zp44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110441"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minxiang Dong","raw_affiliation_strings":["The Second Affiliated Hospital of Inner Mongolia Medical University Inner Mongolia Medical University Hohhot China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Affiliated Hospital of Inner Mongolia Medical University Inner Mongolia Medical University Hohhot China","institution_ids":["https://openalex.org/I4210110441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138935017","display_name":"Chenyang Duan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]},{"id":"https://openalex.org/I4210087761","display_name":"Henan University Huaihe Hospital and Huaihe Clinical Institute","ror":"https://ror.org/002mm7c07","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenyang Duan","raw_affiliation_strings":["Huaihe Hospital of Henan University Henan University Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huaihe Hospital of Henan University Henan University Kaifeng China","institution_ids":["https://openalex.org/I173899330","https://openalex.org/I4210087761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138923596","display_name":"Xiaohan Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Zheng","raw_affiliation_strings":["College of Geographical Sciences, Faculty of Geographical Science and Engineering Henan University Kaifeng China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Geographical Sciences, Faculty of Geographical Science and Engineering Henan University Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]},{"author_position":"last","author":{"id":null,"display_name":"Liming Qu","orcid":"https://orcid.org/0009-0007-3765-3442","observed_orcids":["https://orcid.org/0009-0007-3765-3442"]},"institutions":[{"id":"https://openalex.org/I173899330","display_name":"Henan University","ror":"https://ror.org/003xyzq10","country_code":"CN","type":"education","lineage":["https://openalex.org/I173899330"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liming Qu","raw_affiliation_strings":["College of Geographical Sciences, Faculty of Geographical Science and Engineering Henan University Kaifeng China"],"raw_orcid":"https://orcid.org/0009-0007-3765-3442","affiliations":[{"raw_affiliation_string":"College of Geographical Sciences, Faculty of Geographical Science and Engineering Henan University Kaifeng China","institution_ids":["https://openalex.org/I173899330"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I173899330"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":{"value":4020,"currency":"USD","value_usd":4020},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.67886607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"9","first_page":"e71089","last_page":"e71089"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9919999837875366},{"id":"https://openalex.org/keywords/atmospheric-aerosols","display_name":"atmospheric aerosols","score":0.8740000128746033},{"id":"https://openalex.org/keywords/air-pollution-neurotoxicity","display_name":"air pollution neurotoxicity","score":0.8209999799728394},{"id":"https://openalex.org/keywords/substantia-nigra-dopaminergic-neurons","display_name":"substantia nigra dopaminergic neurons","score":0.9139999747276306},{"id":"https://openalex.org/keywords/olfactory-pathway","display_name":"olfactory pathway","score":0.8519999980926514},{"id":"https://openalex.org/keywords/blood-brain-barrier-permeability","display_name":"blood-brain barrier permeability","score":0.9549999833106995},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/proteostasis","display_name":"proteostasis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/multiple-hit-hypothesis","display_name":"multiple-hit hypothesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/persistent-organic-pollutants","display_name":"persistent organic pollutants","score":0.8169999718666077},{"id":"https://openalex.org/keywords/metal-particles","display_name":"metal particles","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ultrafine-particles","display_name":"ultrafine particles","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neurodegeneration-risk-factors","display_name":"neurodegeneration risk factors","score":0.5580000281333923}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.7060999870300293},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.7057999968528748},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.6330999732017517},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5672000050544739},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5311999917030334},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4893999993801117},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.460999995470047},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4578000009059906},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.4426000118255615},{"id":"https://openalex.org/C2776773494","wikidata":"https://www.wikidata.org/wiki/Q3366041","display_name":"Pars compacta","level":5,"score":0.430400013923645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42719998955726624},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37380000948905945},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.33730000257492065},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3046000003814697},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2953000068664551},{"id":"https://openalex.org/C42251903","wikidata":"https://www.wikidata.org/wiki/Q18391002","display_name":"Monoaminergic","level":4,"score":0.2897000014781952},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.27869999408721924},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.272599995136261},{"id":"https://openalex.org/C43310041","wikidata":"https://www.wikidata.org/wiki/Q1981297","display_name":"Neuromelanin","level":5,"score":0.27070000767707825},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25679999589920044}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000393","descriptor_name":"Air Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/jbt.71089","doi":"https://doi.org/10.1002/jbt.71089","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.71089","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71089","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},{"id":"pmid:42647057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42647057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biochemical and molecular toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13521653","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521653/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13521653/pdf/JBT-40-e71089.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Biochem Mol Toxicol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/jbt.71089","doi":"https://doi.org/10.1002/jbt.71089","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jbt.71089","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.71089","source":{"id":"https://openalex.org/S124830628","display_name":"Journal of Biochemical and Molecular Toxicology","issn_l":"0887-2082","issn":["0887-2082","1095-6670","1099-0461","1522-7146"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biochemical and Molecular Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323845","display_name":"Natural Science Foundation of Henan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204276139.pdf","grobid_xml":"https://content.openalex.org/works/W7204276139.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W1838767738","https://openalex.org/W1976947942","https://openalex.org/W1989399200","https://openalex.org/W1996375332","https://openalex.org/W2020473888","https://openalex.org/W2029206809","https://openalex.org/W2125655085","https://openalex.org/W2401927658","https://openalex.org/W2802560741","https://openalex.org/W2876758010","https://openalex.org/W2885518311","https://openalex.org/W2899031631","https://openalex.org/W2914211729","https://openalex.org/W2947175315","https://openalex.org/W2953037856","https://openalex.org/W2966419047","https://openalex.org/W2967966308","https://openalex.org/W3012602783","https://openalex.org/W3023656339","https://openalex.org/W3025275524","https://openalex.org/W3027341006","https://openalex.org/W3033829306","https://openalex.org/W3080285028","https://openalex.org/W3080901962","https://openalex.org/W3084100763","https://openalex.org/W3089608377","https://openalex.org/W3094573143","https://openalex.org/W3096865429","https://openalex.org/W3111927179","https://openalex.org/W3122429426","https://openalex.org/W3143154634","https://openalex.org/W3143821622","https://openalex.org/W3150238284","https://openalex.org/W3157129664","https://openalex.org/W3158897265","https://openalex.org/W3160850947","https://openalex.org/W3162250976","https://openalex.org/W3181241636","https://openalex.org/W3194235344","https://openalex.org/W3196654473","https://openalex.org/W3202683854","https://openalex.org/W3203683730","https://openalex.org/W3205986596","https://openalex.org/W3209137682","https://openalex.org/W3216682602","https://openalex.org/W4200267559","https://openalex.org/W4200498259","https://openalex.org/W4206121140","https://openalex.org/W4206412997","https://openalex.org/W4214833982","https://openalex.org/W4214907302","https://openalex.org/W4224985451","https://openalex.org/W4229016882","https://openalex.org/W4229054631","https://openalex.org/W4281250620","https://openalex.org/W4282925920","https://openalex.org/W4283155313","https://openalex.org/W4283320833","https://openalex.org/W4285590747","https://openalex.org/W4292595966","https://openalex.org/W4295102758","https://openalex.org/W4302283330","https://openalex.org/W4307054621","https://openalex.org/W4307940238","https://openalex.org/W4308770722","https://openalex.org/W4309475267","https://openalex.org/W4309575422","https://openalex.org/W4311909149","https://openalex.org/W4312190989","https://openalex.org/W4313814284","https://openalex.org/W4315471845","https://openalex.org/W4318695213","https://openalex.org/W4361228898","https://openalex.org/W4365452065","https://openalex.org/W4375824763","https://openalex.org/W4377205881","https://openalex.org/W4378675088","https://openalex.org/W4379803743","https://openalex.org/W4380149105","https://openalex.org/W4380291067","https://openalex.org/W4385064431","https://openalex.org/W4385563999","https://openalex.org/W4385999933","https://openalex.org/W4386715594","https://openalex.org/W4386913845","https://openalex.org/W4388573959","https://openalex.org/W4389728702","https://openalex.org/W4390663346","https://openalex.org/W4390827838","https://openalex.org/W4391069533","https://openalex.org/W4391682128","https://openalex.org/W4392287228","https://openalex.org/W4392348195","https://openalex.org/W4392379154","https://openalex.org/W4392561117","https://openalex.org/W4392715239","https://openalex.org/W4392872605","https://openalex.org/W4393045424","https://openalex.org/W4394603745","https://openalex.org/W4395026585","https://openalex.org/W4395685943","https://openalex.org/W4396831264","https://openalex.org/W4396917535","https://openalex.org/W4396952613","https://openalex.org/W4398202838","https://openalex.org/W4400269431","https://openalex.org/W4400273428","https://openalex.org/W4400612523","https://openalex.org/W4401317816","https://openalex.org/W4401345208","https://openalex.org/W4401363901","https://openalex.org/W4401715015","https://openalex.org/W4402419936","https://openalex.org/W4402580874","https://openalex.org/W4403000489","https://openalex.org/W4403073137","https://openalex.org/W4403321433","https://openalex.org/W4403468648","https://openalex.org/W4403484202","https://openalex.org/W4403504273","https://openalex.org/W4403917815","https://openalex.org/W4404199401","https://openalex.org/W4404469912","https://openalex.org/W4404760489","https://openalex.org/W4404960529","https://openalex.org/W4405496363","https://openalex.org/W4405658261","https://openalex.org/W4405871808","https://openalex.org/W4406263847","https://openalex.org/W4407679709","https://openalex.org/W4407879331","https://openalex.org/W4408151792","https://openalex.org/W4408208852","https://openalex.org/W4408315937","https://openalex.org/W4408819324","https://openalex.org/W4408820519","https://openalex.org/W4408954553","https://openalex.org/W4409171397","https://openalex.org/W4409441082","https://openalex.org/W4409582717","https://openalex.org/W4410065043","https://openalex.org/W4410202926","https://openalex.org/W4410906900","https://openalex.org/W4411023106","https://openalex.org/W4411060408","https://openalex.org/W4411192949","https://openalex.org/W4411205666","https://openalex.org/W4411230855","https://openalex.org/W4411338963","https://openalex.org/W4411475871","https://openalex.org/W4412477541","https://openalex.org/W4412517447","https://openalex.org/W4413365249","https://openalex.org/W4413806139","https://openalex.org/W4414068650","https://openalex.org/W4415045048","https://openalex.org/W4415144039","https://openalex.org/W4415215940","https://openalex.org/W4415666798","https://openalex.org/W4415678885","https://openalex.org/W4415769253","https://openalex.org/W4415812367","https://openalex.org/W4416416258","https://openalex.org/W4416425365","https://openalex.org/W4417238057","https://openalex.org/W7117662069","https://openalex.org/W7117689590","https://openalex.org/W7117708102","https://openalex.org/W7125914375","https://openalex.org/W7131648376","https://openalex.org/W7154729612","https://openalex.org/W7162530560"],"related_works":[],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1,7],"(PD)":[2],"is":[3,36],"a":[4,37,45],"common":[5],"neurodegenerative":[6],"threatening":[8],"the":[9,12,19,80,83,88,145,152,162,168,180,211,234],"health":[10],"of":[11,22,129,149,155,171,183,237,260],"middle-aged":[13],"and":[14,27,62,91,115,119,126,158,161,176,192,197,205,221,224,240,258],"elderly":[15],"population,":[16],"triggered":[17],"by":[18],"combined":[20],"effects":[21,140],"genetic":[23],"susceptibility,":[24],"environmental":[25],"exposure":[26,35,108],"nervous":[28],"system":[29],"aging,":[30],"among":[31],"which":[32,65],"atmospheric":[33,49],"aerosol":[34,107],"key":[38],"risk":[39],"factor":[40],"for":[41,250,254],"sporadic":[42,110],"PD.":[43,261],"As":[44],"complex":[46],"heterogeneous":[47],"mixture,":[48],"aerosols":[50],"contain":[51],"neurotoxic":[52,139],"components":[53,170,239],"such":[54,186],"as":[55,132,134,187,245],"metal":[56],"particles,":[57,64],"persistent":[58],"organic":[59],"pollutants":[60],"(POPs),":[61],"nano/ultrafine":[63],"appear":[66],"to":[67,105,109,246],"target":[68],"midbrain":[69],"substantia":[70],"nigra":[71],"dopaminergic":[72],"neurons":[73],"through":[74],"pathways":[75],"including":[76,202],"direct":[77],"entry":[78],"into":[79],"brain":[81],"via":[82,144],"olfactory":[84],"pathway,":[85],"penetration":[86],"across":[87],"lung-blood-brain":[89],"barrier,":[90],"inflammation-mediated":[92],"alterations":[93],"in":[94,188,193,214],"barrier":[95],"permeability.":[96],"The":[97],"core":[98],"molecular":[99],"mechanisms":[100,236],"that":[101,227],"have":[102],"been":[103],"proposed":[104],"link":[106],"PD":[111],"include":[112],"oxidative":[113,150],"stress":[114],"mitochondrial":[116],"dysfunction,":[117],"neuroinflammation":[118],"aberrant":[120],"microglial":[121],"activation,":[122],"disrupted":[123],"protein":[124,159],"homeostasis":[125],"abnormal":[127],"aggregation":[128],"\u03b1-synuclein":[130],"(\u03b1-syn),":[131],"well":[133],"altered":[135],"epigenetic":[136,206],"regulation.":[137,207],"Moreover,":[138],"may":[141],"be":[142],"amplified":[143],"positive":[146],"feedback":[147],"loop":[148],"stress-neuroinflammation,":[151],"vicious":[153],"cycle":[154],"mitophagy":[156],"defects":[157],"aggregation,":[160],"\"multiple-hit":[163],"hypothesis\".":[164],"This":[165],"review":[166],"summarizes":[167],"toxic":[169],"aerosols,":[172],"their":[173],"brain-entry":[174],"routes":[175],"pathogenic":[177],"mechanisms,":[178,217],"outlines":[179],"application":[181],"status":[182],"emerging":[184],"technologies":[185],"vitro":[189],"cell":[190],"models":[191],"vivo":[194],"animal":[195],"models,":[196,218,243],"sorts":[198],"out":[199,226],"intervention":[200,222],"strategies":[201,253],"pharmacological":[203],"therapy":[204],"It":[208],"also":[209],"analyzes":[210],"current":[212],"challenges":[213],"research":[215,229,242],"on":[216,232],"population":[219],"studies":[220],"strategies,":[223],"points":[225],"future":[228],"should":[230],"focus":[231],"dissecting":[233],"synergistic":[235],"multiple":[238],"optimizing":[241],"so":[244],"provide":[247],"theoretical":[248],"support":[249],"exploring":[251],"potential":[252],"precise":[255],"prevention,":[256],"control":[257],"treatment":[259]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-08-27T00:00:00"}
