{"id":"https://openalex.org/W7204275132","doi":"https://doi.org/10.1097/bpo.0000000000003448","title":"Defining Postoperative Weight Trends in Pediatric Patients Undergoing Limb Reconstruction Surgery by Distraction Osteogenesis","display_name":"Defining Postoperative Weight Trends in Pediatric Patients Undergoing Limb Reconstruction Surgery by Distraction Osteogenesis","publication_year":2026,"publication_date":"2026-08-25","ids":{"openalex":"https://openalex.org/W7204275132","doi":"https://doi.org/10.1097/bpo.0000000000003448","pmid":"https://pubmed.ncbi.nlm.nih.gov/42647442"},"language":"en","primary_location":{"id":"doi:10.1097/bpo.0000000000003448","doi":"https://doi.org/10.1097/bpo.0000000000003448","is_oa":false,"landing_page_url":"https://doi.org/10.1097/bpo.0000000000003448","pdf_url":null,"source":{"id":"https://openalex.org/S44433048","display_name":"Journal of Pediatric Orthopaedics","issn_l":"0271-6798","issn":["0271-6798","1539-2570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Orthopaedics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045542080","display_name":"Ali Yal\u00e7\u0131nkaya","orcid":"https://orcid.org/0000-0002-5427-8118","observed_orcids":["https://orcid.org/0000-0002-5427-8118"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Ali Yalcinkaya","raw_affiliation_strings":["Orthopaedic Surgery, Interdisciplinary Orthopaedics, Aalborg University Hospital","Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedic Surgery, Interdisciplinary Orthopaedics, Aalborg University Hospital","institution_ids":["https://openalex.org/I2799976261"]},{"raw_affiliation_string":"Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148243894","display_name":"Ali Sepas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ali Sepas","raw_affiliation_strings":["Materials and Production, Aalborg University, Aalborg, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials and Production, Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108608282","display_name":"Bicheng Yong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bicheng Yong","raw_affiliation_strings":["Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046959501","display_name":"Anirejuoritse Bafor","orcid":"https://orcid.org/0000-0001-9278-5324","observed_orcids":["https://orcid.org/0000-0001-9278-5324"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirejuoritse Bafor","raw_affiliation_strings":["Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH"],"raw_orcid":"https://orcid.org/0000-0001-9278-5324","affiliations":[{"raw_affiliation_string":"Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028932698","display_name":"Christopher Iobst","orcid":"https://orcid.org/0000-0002-0329-5321","observed_orcids":["https://orcid.org/0000-0002-0329-5321"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Iobst","raw_affiliation_strings":["Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopaedics, Center for Limb Lengthening and Reconstruction, Nationwide Children\u2019s Hospital, Columbus, OH","institution_ids":["https://openalex.org/I1314135232"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.69737769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10599","display_name":"Reconstructive Surgery and Microvascular Techniques","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/distraction-osteogenesis","display_name":"distraction osteogenesis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/limb-reconstruction","display_name":"limb reconstruction","score":0.7170000076293945},{"id":"https://openalex.org/keywords/postoperative-weight-loss","display_name":"postoperative weight loss","score":0.8130000233650208},{"id":"https://openalex.org/keywords/body-weight-trajectories","display_name":"body weight trajectories","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.6340000033378601},{"id":"https://openalex.org/keywords/external-fixation","display_name":"external fixation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/leg-length-discrepancy","display_name":"limb length discrepancy","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.671999990940094},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9717000126838684},{"id":"https://openalex.org/C2776819169","wikidata":"https://www.wikidata.org/wiki/Q1722542","display_name":"Distraction osteogenesis","level":3,"score":0.810699999332428},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.7192000150680542},{"id":"https://openalex.org/C92162645","wikidata":"https://www.wikidata.org/wiki/Q655955","display_name":"Intramedullary rod","level":2,"score":0.7142000198364258},{"id":"https://openalex.org/C2779982284","wikidata":"https://www.wikidata.org/wiki/Q1182746","display_name":"Deformity","level":2,"score":0.5200999975204468},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4657000005245209},{"id":"https://openalex.org/C2780204347","wikidata":"https://www.wikidata.org/wiki/Q17126173","display_name":"Weight-bearing","level":2,"score":0.4587000012397766},{"id":"https://openalex.org/C2910514461","wikidata":"https://www.wikidata.org/wiki/Q1188542","display_name":"Ilizarov Technique","level":3,"score":0.45649999380111694},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.44440001249313354},{"id":"https://openalex.org/C3017894415","wikidata":"https://www.wikidata.org/wiki/Q7979883","display_name":"Weight change","level":4,"score":0.44269999861717224},{"id":"https://openalex.org/C68312169","wikidata":"https://www.wikidata.org/wiki/Q216685","display_name":"Orthopedic surgery","level":2,"score":0.3700999915599823},{"id":"https://openalex.org/C146249460","wikidata":"https://www.wikidata.org/wiki/Q2914991","display_name":"Fixation (population genetics)","level":3,"score":0.3693000078201294},{"id":"https://openalex.org/C2776813713","wikidata":"https://www.wikidata.org/wiki/Q920565","display_name":"External fixation","level":3,"score":0.3319000005722046},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.29679998755455017},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.2800999879837036},{"id":"https://openalex.org/C2779779000","wikidata":"https://www.wikidata.org/wiki/Q25036443","display_name":"Malunion","level":3,"score":0.26030001044273376}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/bpo.0000000000003448","doi":"https://doi.org/10.1097/bpo.0000000000003448","is_oa":false,"landing_page_url":"https://doi.org/10.1097/bpo.0000000000003448","pdf_url":null,"source":{"id":"https://openalex.org/S44433048","display_name":"Journal of Pediatric Orthopaedics","issn_l":"0271-6798","issn":["0271-6798","1539-2570"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pediatric Orthopaedics","raw_type":"journal-article"},{"id":"pmid:42647442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42647442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pediatric orthopedics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9976000189781189,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6631975173950195,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W592998629","https://openalex.org/W1788770751","https://openalex.org/W2021189984","https://openalex.org/W2025422403","https://openalex.org/W2094505452","https://openalex.org/W2101419103","https://openalex.org/W2137305295","https://openalex.org/W2159733957","https://openalex.org/W2276553567","https://openalex.org/W3112643460","https://openalex.org/W3127079005","https://openalex.org/W4292425573","https://openalex.org/W4391449334","https://openalex.org/W4393167215","https://openalex.org/W4403133333","https://openalex.org/W4405978524","https://openalex.org/W7160610033"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Distraction":[1],"osteogenesis":[2],"(DO)":[3],"is":[4,56,76],"widely":[5],"used":[6],"to":[7,23,61],"treat":[8],"limb":[9,68,87,180],"length":[10,181],"discrepancy,":[11],"deformity,":[12],"and":[13,35,49,70,95,113,142,146,149,187],"segmental":[14],"defects.":[15],"During":[16],"recovery,":[17],"body":[18,121],"weight":[19,41,54,64,122,194,218,242,267,287],"may":[20,43],"change":[21,42,65,119],"due":[22],"surgical":[24],"stress,":[25],"increased":[26],"osteogenic":[27],"metabolic":[28],"demand,":[29],"pain,":[30],"reduced":[31],"mobility,":[32],"appetite":[33],"changes,":[34],"disuse-related":[36],"muscle":[37],"loss.":[38],"Because":[39],"early":[40,63,241,281],"affect":[44],"wound":[45],"healing,":[46,257],"infection":[47],"risk,":[48],"regeneration":[50],"quality,":[51],"defining":[52],"postoperative":[53,129,193],"trajectories":[55,268],"clinically":[57],"relevant.":[58],"We":[59,79],"aimed":[60],"characterize":[62],"after":[66,205,269],"DO-based":[67],"reconstruction":[69,88],"determine":[71],"when":[72],"deviation":[73],"from":[74,123],"baseline":[75,124,225],"greatest.":[77],"METHODS:":[78],"performed":[80,90],"a":[81,138,220,291],"single-center":[82],"retrospective":[83],"review":[84],"of":[85,104,151,162,222],"major":[86],"procedures":[89],"between":[91],"January":[92],"1,":[93],"2016,":[94],"December":[96],"31,":[97],"2022,":[98],"with":[99,133,156,217,247,296],"at":[100,226],"least":[101],"1":[102],"year":[103],"follow-up.":[105],"Demographics,":[106],"treatment":[107,167,273],"group,":[108],"implant":[109],"type,":[110],"healing":[111],"milestones,":[112],"serial":[114],"weights":[115],"were":[116,154,261],"collected.":[117],"Percent":[118],"in":[120],"during":[125],"the":[126,152,213,237,278],"first":[127],"84":[128],"days":[130],"was":[131,202,244],"analyzed":[132],"linear":[134],"mixed-effects":[135],"regression":[136],"using":[137],"quadratic":[139],"time":[140],"term":[141],"patient-specific":[143],"random":[144],"intercepts":[145],"slopes.":[147],"Timing":[148],"magnitude":[150],"nadir":[153,221],"estimated":[155],"95%":[157],"CIs.":[158],"RESULTS:":[159],"A":[160],"total":[161],"175":[163],"patients":[164],"across":[165],"4":[166],"groups:":[168],"(1)":[169],"external":[170,177],"fixation":[171,178],"for":[172,179],"deformity":[173],"correction":[174],"alone;":[175],"(2)":[176],"discrepancy":[182],"equalization;":[183],"(3)":[184],"extramedullary":[185],"lengthening;":[186],"(4)":[188],"intramedullary":[189,210],"lengthening,":[190],"contributed":[191],"1066":[192],"measurements":[195],"(mean:":[196],"6.1":[197],"per":[198],"patient).":[199],"Weight":[200],"status":[201],"similar":[203],"immediately":[204],"surgery.":[206],"Over":[207],"12":[208],"weeks,":[209],"lengthening":[211,239,276],"showed":[212,277,290],"clearest":[214],"U-shaped":[215],"trajectory,":[216],"reaching":[219],"\u223c2%":[223],"below":[224],"about":[227],"6":[228],"weeks":[229],"(45":[230],"d),":[231],"followed":[232,283],"by":[233,272,284],"gradual":[234],"recovery.":[235,285],"Across":[236],"3":[238],"cohorts,":[240],"loss":[243,288],"consistently":[245],"associated":[246],"higher":[248,297],"Bone":[249],"Healing":[250],"Index/External":[251],"Fixation":[252],"Index":[253],"(BHI/EFI),":[254],"suggesting":[255],"slower":[256],"although":[258],"these":[259],"differences":[260],"not":[262],"statistically":[263],"significant.":[264],"CONCLUSIONS:":[265],"Postoperative":[266],"DO":[270],"vary":[271],"group.":[274],"Intramedullary":[275],"most":[279],"pronounced":[280],"decline,":[282],"Early":[286],"also":[289],"consistent,":[292],"though":[293],"nonsignificant,":[294],"association":[295],"BHI/EFI.":[298],"LEVEL":[299],"OF":[300],"EVIDENCE:":[301],"Level":[302],"III-retrospective":[303],"comparative":[304],"study.":[305]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2026-08-27T00:00:00"}