{"id":"https://openalex.org/W7204275073","doi":"https://doi.org/10.1016/j.apsb.2026.08.013","title":"Mapping neutrophil membrane bioactivity to therapeutic interfaces: Biology, disease targeting, and activity-guided biomimetic therapy","display_name":"Mapping neutrophil membrane bioactivity to therapeutic interfaces: Biology, disease targeting, and activity-guided biomimetic therapy","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204275073","doi":"https://doi.org/10.1016/j.apsb.2026.08.013","pmid":"https://pubmed.ncbi.nlm.nih.gov/42948691","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13712293"},"language":"en","primary_location":{"id":"doi:10.1016/j.apsb.2026.08.013","doi":"https://doi.org/10.1016/j.apsb.2026.08.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.013","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.apsb.2026.08.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042912637","display_name":"Qingqing Yang","orcid":"https://orcid.org/0000-0002-9950-8984","observed_orcids":["https://orcid.org/0000-0002-9950-8984","https://orcid.org/0009-0005-9670-0662","https://orcid.org/0009-0008-3074-7515"]},"institutions":[{"id":"https://openalex.org/I50632499","display_name":"Chongqing University of Technology","ror":"https://ror.org/04vgbd477","country_code":"CN","type":"education","lineage":["https://openalex.org/I50632499"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Yang","raw_affiliation_strings":["School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China","institution_ids":["https://openalex.org/I50632499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109787128","display_name":"Mingjing Leng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I50632499","display_name":"Chongqing University of Technology","ror":"https://ror.org/04vgbd477","country_code":"CN","type":"education","lineage":["https://openalex.org/I50632499"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingjing Leng","raw_affiliation_strings":["School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China","institution_ids":["https://openalex.org/I50632499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148364525","display_name":"Wenbi Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbi Jiang","raw_affiliation_strings":["Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148315623","display_name":"Huan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Yang","raw_affiliation_strings":["Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140467111","display_name":"Tong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Wu","raw_affiliation_strings":["Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148252647","display_name":"Ting Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151075929","display_name":"Army Medical University","ror":"https://ror.org/05w21nn13","country_code":"CN","type":"education","lineage":["https://openalex.org/I151075929"]},{"id":"https://openalex.org/I4210117763","display_name":"Xinqiao Hospital","ror":"https://ror.org/02d217z27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117763"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ting Zhou","raw_affiliation_strings":["Department of Neurology, Xinqiao Hospital, The Army Medical University (Third Military Medical University), Chongqing 400033, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Xinqiao Hospital, The Army Medical University (Third Military Medical University), Chongqing 400033, China","institution_ids":["https://openalex.org/I151075929","https://openalex.org/I4210117763"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028358447","display_name":"Zhennan She","orcid":"https://orcid.org/0009-0006-9009-6449","observed_orcids":["https://orcid.org/0009-0006-9009-6449"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhennan She","raw_affiliation_strings":["School of Pharmacy, Kunming Medical University, Kunming 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Kunming Medical University, Kunming 650500, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103111836","display_name":"Gang Xiang","orcid":"https://orcid.org/0000-0001-7488-2809","observed_orcids":["https://orcid.org/0000-0001-7488-2809"]},"institutions":[{"id":"https://openalex.org/I50632499","display_name":"Chongqing University of Technology","ror":"https://ror.org/04vgbd477","country_code":"CN","type":"education","lineage":["https://openalex.org/I50632499"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang Xiang","raw_affiliation_strings":["School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China"],"raw_orcid":"https://orcid.org/0000-0001-7488-2809","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400054, China","institution_ids":["https://openalex.org/I50632499"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066186474","display_name":"Xing Wang Zhou","orcid":"https://orcid.org/0000-0003-0852-0687","observed_orcids":["https://orcid.org/0000-0003-0852-0687"]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xing Zhou","raw_affiliation_strings":["Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China"],"raw_orcid":"https://orcid.org/0000-0003-0852-0687","affiliations":[{"raw_affiliation_string":"Yunnan Key Laboratory of Stem Cell and Regenerative Medicine, Rehabilitation School, Kunming Medical University, Kunming 650500, China","institution_ids":["https://openalex.org/I26080491"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100338546","display_name":"Xiaohui Li","orcid":"https://orcid.org/0000-0002-7320-4958","observed_orcids":["https://orcid.org/0000-0002-7320-4958"]},"institutions":[{"id":"https://openalex.org/I105086349","display_name":"North Sichuan Medical University","ror":"https://ror.org/05k3sdc46","country_code":"CN","type":"education","lineage":["https://openalex.org/I105086349"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohui Li","raw_affiliation_strings":["Nuclear Medicine and Radiation Safety Key Laboratory of Sichuan Province, Major Disease Research & Translational Innovation Center, North Sichuan Medical College, Nanchong 637100, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine and Radiation Safety Key Laboratory of Sichuan Province, Major Disease Research & Translational Innovation Center, North Sichuan Medical College, Nanchong 637100, China","institution_ids":["https://openalex.org/I105086349"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066186474","https://openalex.org/A5100338546","https://openalex.org/A5103111836","https://openalex.org/A5148252647"],"corresponding_institution_ids":["https://openalex.org/I105086349","https://openalex.org/I151075929","https://openalex.org/I26080491","https://openalex.org/I4210117763","https://openalex.org/I50632499"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38888889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"6574","last_page":"6605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.48019999265670776,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.48019999265670776,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-membrane","display_name":"neutrophil membrane","score":0.9279999732971191},{"id":"https://openalex.org/keywords/endothelial-cell-adhesion","display_name":"endothelial cell adhesion","score":0.8119999766349792},{"id":"https://openalex.org/keywords/selectin-ligands","display_name":"selectin ligands","score":0.9509999752044678},{"id":"https://openalex.org/keywords/beta2-integrins","display_name":"beta2 integrins","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/complement-receptors","display_name":"complement receptors","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.9900000095367432},{"id":"https://openalex.org/keywords/vesicles","display_name":"vesicles","score":0.5879999995231628},{"id":"https://openalex.org/keywords/sterile-inflammation","display_name":"sterile inflammation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6010000109672546},{"id":"https://openalex.org/keywords/infection","display_name":"infection","score":0.6039999723434448},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5787000060081482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4771000146865845},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.46810001134872437},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44519999623298645},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36059999465942383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35740000009536743},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31189998984336853},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.3095000088214874},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.29269999265670776},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.28850001096725464},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2653000056743622},{"id":"https://openalex.org/C39629487","wikidata":"https://www.wikidata.org/wiki/Q4915146","display_name":"Biomimetic materials","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.25110000371932983},{"id":"https://openalex.org/C24440939","wikidata":"https://www.wikidata.org/wiki/Q16842168","display_name":"Biomimetic synthesis","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.apsb.2026.08.013","doi":"https://doi.org/10.1016/j.apsb.2026.08.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.013","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13712293","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712293/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13712293/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharm Sin B","raw_type":"Text"},{"id":"pmid:42948691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42948691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmaceutica Sinica. B","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cea54aaf3b11464da64d0bbe1c257537","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cea54aaf3b11464da64d0bbe1c257537","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Pharmaceutica Sinica B, Vol 16, Iss 10, Pp 6574-6605 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.apsb.2026.08.013","doi":"https://doi.org/10.1016/j.apsb.2026.08.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.apsb.2026.08.013","pdf_url":null,"source":{"id":"https://openalex.org/S2736993989","display_name":"Acta Pharmaceutica Sinica B","issn_l":"2211-3835","issn":["2211-3835","2211-3843"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-140"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmaceutica Sinica B","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1833301761","display_name":null,"funder_award_id":"KJQN202301168","funder_id":"https://openalex.org/F4320324805","funder_display_name":"Chongqing Municipal Education Commission"},{"id":"https://openalex.org/G517523103","display_name":null,"funder_award_id":"82460703","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6892761941","display_name":null,"funder_award_id":"CSTB2025NSCQ","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"},{"id":"https://openalex.org/G7310372663","display_name":null,"funder_award_id":"gzlcx20253293","funder_id":"https://openalex.org/F4320321135","funder_display_name":"Chongqing University"},{"id":"https://openalex.org/G7513377371","display_name":null,"funder_award_id":"CSTB2025NSCQ-GPX0221","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321135","display_name":"Chongqing University","ror":"https://ror.org/023rhb549"},{"id":"https://openalex.org/F4320322955","display_name":"Chongqing University of Technology","ror":"https://ror.org/04vgbd477"},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324805","display_name":"Chongqing Municipal Education Commission","ror":"https://ror.org/031nm5713"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204275073.pdf","grobid_xml":"https://content.openalex.org/works/W7204275073.grobid-xml"},"referenced_works_count":186,"referenced_works":["https://openalex.org/W1680182901","https://openalex.org/W1773516416","https://openalex.org/W1879047861","https://openalex.org/W1914229765","https://openalex.org/W1918928165","https://openalex.org/W1922600631","https://openalex.org/W1938835738","https://openalex.org/W1967441216","https://openalex.org/W1971799714","https://openalex.org/W1975009229","https://openalex.org/W1976646654","https://openalex.org/W1980052502","https://openalex.org/W1992351167","https://openalex.org/W1999517476","https://openalex.org/W2024318406","https://openalex.org/W2026694037","https://openalex.org/W2032227357","https://openalex.org/W2034359425","https://openalex.org/W2035809865","https://openalex.org/W2036124306","https://openalex.org/W2041606646","https://openalex.org/W2043222263","https://openalex.org/W2045819100","https://openalex.org/W2049698725","https://openalex.org/W2054895562","https://openalex.org/W2056116287","https://openalex.org/W2058624823","https://openalex.org/W2059010990","https://openalex.org/W2059621384","https://openalex.org/W2060512529","https://openalex.org/W2063330553","https://openalex.org/W2066234893","https://openalex.org/W2067528927","https://openalex.org/W2071046100","https://openalex.org/W2072406547","https://openalex.org/W2072805330","https://openalex.org/W2072813591","https://openalex.org/W2075414447","https://openalex.org/W2076966331","https://openalex.org/W2082011949","https://openalex.org/W2082160392","https://openalex.org/W2095891614","https://openalex.org/W2100902668","https://openalex.org/W2104934425","https://openalex.org/W2111421688","https://openalex.org/W2111939342","https://openalex.org/W2116805516","https://openalex.org/W2122028809","https://openalex.org/W2125872855","https://openalex.org/W2130117150","https://openalex.org/W2135137305","https://openalex.org/W2138694950","https://openalex.org/W2140995313","https://openalex.org/W2143730398","https://openalex.org/W2145479354","https://openalex.org/W2154141105","https://openalex.org/W2170176013","https://openalex.org/W2206238858","https://openalex.org/W2217159274","https://openalex.org/W2270245312","https://openalex.org/W2371948111","https://openalex.org/W2396611672","https://openalex.org/W2509526511","https://openalex.org/W2510557718","https://openalex.org/W2510806142","https://openalex.org/W2545368922","https://openalex.org/W2593371437","https://openalex.org/W2593852474","https://openalex.org/W2599649240","https://openalex.org/W2610061835","https://openalex.org/W2610344331","https://openalex.org/W2618696573","https://openalex.org/W2624807369","https://openalex.org/W2749596444","https://openalex.org/W2759253724","https://openalex.org/W2762418691","https://openalex.org/W2762816177","https://openalex.org/W2785177677","https://openalex.org/W2787698240","https://openalex.org/W2794683780","https://openalex.org/W2806248784","https://openalex.org/W2887748476","https://openalex.org/W2887997430","https://openalex.org/W2888621936","https://openalex.org/W2889191136","https://openalex.org/W2900424636","https://openalex.org/W2900499839","https://openalex.org/W2902868033","https://openalex.org/W2905629425","https://openalex.org/W2912471195","https://openalex.org/W2912696928","https://openalex.org/W2912815018","https://openalex.org/W2923394609","https://openalex.org/W2925230746","https://openalex.org/W2929288288","https://openalex.org/W2942754201","https://openalex.org/W2946833774","https://openalex.org/W2948132055","https://openalex.org/W2966314303","https://openalex.org/W2979430791","https://openalex.org/W2980297323","https://openalex.org/W2982049472","https://openalex.org/W2990372320","https://openalex.org/W3010838109","https://openalex.org/W3012714065","https://openalex.org/W3014824156","https://openalex.org/W3044222890","https://openalex.org/W3046237344","https://openalex.org/W3089813041","https://openalex.org/W3122188274","https://openalex.org/W3122393270","https://openalex.org/W3132762885","https://openalex.org/W3142766369","https://openalex.org/W3157841475","https://openalex.org/W3168173367","https://openalex.org/W3180177748","https://openalex.org/W3204905970","https://openalex.org/W3205480029","https://openalex.org/W3208430225","https://openalex.org/W3213884986","https://openalex.org/W3214720083","https://openalex.org/W4200250643","https://openalex.org/W4200597828","https://openalex.org/W4206320827","https://openalex.org/W4211077900","https://openalex.org/W4213119767","https://openalex.org/W4223422746","https://openalex.org/W4283447256","https://openalex.org/W4285387346","https://openalex.org/W4291003339","https://openalex.org/W4292265585","https://openalex.org/W4297464547","https://openalex.org/W4304808795","https://openalex.org/W4306730671","https://openalex.org/W4306750531","https://openalex.org/W4308792297","https://openalex.org/W4309729082","https://openalex.org/W4310810023","https://openalex.org/W4316041189","https://openalex.org/W4318165720","https://openalex.org/W4319596680","https://openalex.org/W4319662695","https://openalex.org/W4362659823","https://openalex.org/W4362717949","https://openalex.org/W4366589759","https://openalex.org/W4366772284","https://openalex.org/W4367624131","https://openalex.org/W4378528443","https://openalex.org/W4378745178","https://openalex.org/W4378952882","https://openalex.org/W4381685685","https://openalex.org/W4388040974","https://openalex.org/W4388406709","https://openalex.org/W4388856940","https://openalex.org/W4390012420","https://openalex.org/W4390544881","https://openalex.org/W4391015708","https://openalex.org/W4391174682","https://openalex.org/W4392283388","https://openalex.org/W4392456271","https://openalex.org/W4392908883","https://openalex.org/W4393058457","https://openalex.org/W4393992681","https://openalex.org/W4394623467","https://openalex.org/W4399532526","https://openalex.org/W4400958385","https://openalex.org/W4401814298","https://openalex.org/W4402630519","https://openalex.org/W4402739576","https://openalex.org/W4403610853","https://openalex.org/W4403736808","https://openalex.org/W4404070354","https://openalex.org/W4405035217","https://openalex.org/W4405194442","https://openalex.org/W4407264315","https://openalex.org/W4407305108","https://openalex.org/W4408647716","https://openalex.org/W4409210389","https://openalex.org/W4410185090","https://openalex.org/W4410974102","https://openalex.org/W4410980498","https://openalex.org/W4411272701","https://openalex.org/W4411371205","https://openalex.org/W4412956718","https://openalex.org/W6928782553","https://openalex.org/W6929057842"],"related_works":["https://openalex.org/W1849821766","https://openalex.org/W2036923484","https://openalex.org/W7095206025","https://openalex.org/W4405212147","https://openalex.org/W4377142752","https://openalex.org/W2791578198","https://openalex.org/W4376132880","https://openalex.org/W2106086463","https://openalex.org/W2294015452","https://openalex.org/W3040617421"],"abstract_inverted_index":{"Neutrophil":[0],"plasma":[1],"membranes":[2],"encode":[3],"a":[4,28,37,170,175,182],"tightly":[5],"coordinated":[6,76],"set":[7],"of":[8,124,132],"bioactivities":[9],"that":[10,31],"control":[11],"inflammatory":[12,192],"trafficking,":[13],"endothelial":[14],"adhesion":[15,81],"under":[16],"shear,":[17],"effector":[18,45,83],"activation,":[19],"and":[20,44,64,70,85,94,129,139,155,161,194],"immune":[21],"regulation.":[22,46],"In":[23],"this":[24,113,179],"review,":[25],"we":[26,96,115],"present":[27],"membrane-centric":[29],"framework":[30],"conceptualizes":[32],"the":[33,166],"neutrophil":[34,125,133,167],"membrane":[35,50,100,126,149,168],"as":[36,148,169],"programmable":[38,171],"therapeutic":[39,109],"interface":[40,172],"integrating":[41],"targeting,":[42,80],"adhesion,":[43],"We":[47,142],"delineate":[48],"core":[49],"modules\u2014including":[51],"chemokine-sensing":[52],"G":[53],"protein-coupled":[54],"receptors":[55,68],"(GPCRs),":[56],"selectin":[57],"ligands,":[58],"\u03b2":[59],"2":[60],"integrins,":[61],"Fc":[62],"\u03b3":[63],"complement":[65],"receptors,":[66],"pattern-recognition":[67],"(PRRs),":[69],"lipid-raft":[71],"microdomains\u2014and":[72],"examine":[73],"how":[74,98],"their":[75,105],"dynamics":[77],"govern":[78],"tissue":[79],"kinetics,":[82],"thresholds,":[84],"resolution.":[86],"Integrating":[87],"evidence":[88],"from":[89],"infection,":[90,191],"sterile":[91],"inflammation,":[92],"autoimmunity,":[93],"cancer,":[95],"highlight":[97],"dysregulated":[99],"programs":[101],"drive":[102],"pathology,":[103],"while":[104],"selective":[106],"tuning":[107],"enables":[108],"benefit.":[110],"Building":[111],"on":[112],"biology,":[114],"discuss":[116],"two":[117],"convergent":[118],"intervention":[119],"strategies:":[120],"direct":[121],"pharmacological":[122],"modulation":[123],"signaling":[127],"axes,":[128],"activity-guided":[130],"engineering":[131,146],"membrane-derived":[134],"therapeutics,":[135],"including":[136],"native":[137],"vesicles":[138],"membrane-coated":[140],"nanomaterials.":[141],"further":[143],"link":[144],"key":[145],"parameters\u2014such":[147],"orientation,":[150],"ligand":[151],"density,":[152],"glycan":[153],"architecture,":[154],"microdomain":[156],"integrity\u2014to":[157],"mechanism-based":[158],"potency,":[159],"safety,":[160],"translational":[162],"control.":[163],"By":[164],"positioning":[165],"rather":[173],"than":[174],"static":[176],"biomimetic":[177],"shell,":[178],"review":[180],"outlines":[181],"rational":[183],"roadmap":[184],"for":[185,190],"developing":[186],"predictable,":[187],"dose-controlled":[188],"therapies":[189],"diseases,":[193],"cancer.":[195]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-27T00:00:00"}