{"id":"https://openalex.org/W7204275015","doi":"https://doi.org/10.1186/s12915-026-02719-z","title":"Cry2 linked silkworm domestication to highly synchronized eclosion and rhythmic head transcriptomes","display_name":"Cry2 linked silkworm domestication to highly synchronized eclosion and rhythmic head transcriptomes","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204275015","doi":"https://doi.org/10.1186/s12915-026-02719-z"},"language":"en","primary_location":{"id":"doi:10.1186/s12915-026-02719-z","doi":"https://doi.org/10.1186/s12915-026-02719-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-026-02719-z","pdf_url":null,"source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12915-026-02719-z","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019012514","display_name":"Man Wang","orcid":"https://orcid.org/0000-0001-8767-5489","observed_orcids":["https://orcid.org/0000-0001-8767-5489"]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Wang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125244569","display_name":"Jiahao Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahao Xiang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148271551","display_name":"Yuling Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuling Peng","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148285637","display_name":"Zefei Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zefei Lai","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148253571","display_name":"Yihuan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihuan Xu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076201375","display_name":"Meiyan Yi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiyan Yi","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136973085","display_name":"Jieling Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieling Zhang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049794772","display_name":"Kesen Zhu","orcid":"https://orcid.org/0000-0001-8038-7652","observed_orcids":["https://orcid.org/0000-0001-8038-7652"]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kesen Zhu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368218","display_name":"Na Li","orcid":"https://orcid.org/0000-0003-4202-6375","observed_orcids":["https://orcid.org/0000-0003-4202-6375"]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148178108","display_name":"Sheng Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Li","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081161232","display_name":"Feng Qili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qili Feng","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136982931","display_name":"Hui Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I187400657","display_name":"South China Normal University","ror":"https://ror.org/01kq0pv72","country_code":"CN","type":"education","lineage":["https://openalex.org/I187400657"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Xiang","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, 510631, China","institution_ids":["https://openalex.org/I187400657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5136982931"],"corresponding_institution_ids":["https://openalex.org/I187400657"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.65534805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14048","display_name":"Silkworms and Sericulture Research","score":0.014600000344216824,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bombyx-mori","display_name":"Bombyx mori","score":0.9860000014305115},{"id":"https://openalex.org/keywords/bombyx-mandarina","display_name":"Bombyx mandarina","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cryptochrome-2","display_name":"CRY2","score":0.7710000276565552},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.7699999809265137},{"id":"https://openalex.org/keywords/eclosion-rhythm","display_name":"eclosion rhythm","score":0.890999972820282},{"id":"https://openalex.org/keywords/rhythmic-gene-expression","display_name":"rhythmic gene expression","score":0.7039999961853027},{"id":"https://openalex.org/keywords/head-transcriptome","display_name":"head transcriptome","score":0.7379999756813049},{"id":"https://openalex.org/keywords/phase-advance","display_name":"phase advance","score":0.40700000524520874},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-protein-processing","display_name":"endoplasmic reticulum protein processing","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dopamine-synthesis","display_name":"dopamine synthesis","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9390000104904175},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6381999850273132},{"id":"https://openalex.org/C2778880379","wikidata":"https://www.wikidata.org/wiki/Q7805543","display_name":"Timeless","level":3,"score":0.6000000238418579},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.597100019454956},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5472999811172485},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.5436999797821045},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.53329998254776},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.5304999947547913},{"id":"https://openalex.org/C134387633","wikidata":"https://www.wikidata.org/wiki/Q11395","display_name":"Domestication","level":2,"score":0.5292999744415283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5217000246047974},{"id":"https://openalex.org/C125168821","wikidata":"https://www.wikidata.org/wiki/Q7106408","display_name":"Oscillating gene","level":5,"score":0.4823000133037567},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.46299999952316284},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.400299996137619},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.3995000123977661},{"id":"https://openalex.org/C2778875234","wikidata":"https://www.wikidata.org/wiki/Q36626","display_name":"PAS domain","level":4,"score":0.38839998841285706},{"id":"https://openalex.org/C144543706","wikidata":"https://www.wikidata.org/wiki/Q85754737","display_name":"Cryptochrome","level":4,"score":0.38350000977516174},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.31940001249313354},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3149000108242035},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.305400013923645},{"id":"https://openalex.org/C112795245","wikidata":"https://www.wikidata.org/wiki/Q1400734","display_name":"Clockwork","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.2727999985218048},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C196662502","wikidata":"https://www.wikidata.org/wiki/Q827541","display_name":"Molecular clock","level":4,"score":0.26829999685287476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12915-026-02719-z","doi":"https://doi.org/10.1186/s12915-026-02719-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-026-02719-z","pdf_url":null,"source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12915-026-02719-z","doi":"https://doi.org/10.1186/s12915-026-02719-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-026-02719-z","pdf_url":null,"source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Domestication":[0],"often":[1],"enhances":[2],"the":[3,10,20,34,52,55,92,123,130,192,199,222,249],"temporal":[4],"synchronization":[5,25,77,121,262],"of":[6,23,54,122,134,142,150,158,165,178,188,201,263],"life-history":[7],"events;":[8],"yet":[9],"underlying":[11],"molecular":[12],"mechanisms":[13],"remain":[14],"poorly":[15],"understood.":[16],"Here,":[17],"we":[18,144],"investigated":[19],"circadian":[21,31,269],"basis":[22],"domestication-associated":[24],"by":[26,265],"comparing":[27],"eclosion":[28,69,106,124,136,264],"rhythms":[29],"and":[30,41,49,78,120,132,153,161,227,252,267],"transcriptomes":[32],"between":[33],"domesticated":[35],"silkworm":[36],"(":[37,45],"Bombyx":[38],"mori":[39,73,173,215],")":[40],"its":[42],"wild":[43,253],"ancestor":[44],"B.":[46,72,97,172,184,214],"mandarina":[47,98,185],"),":[48],"functionally":[50],"dissected":[51],"role":[53],"clock":[56,167],"gene":[57,280],"Cry2":[58,100,128,154,189,250,274],".":[59,99,186],"Under":[60],"14:10":[61],"light\u2013dark":[62],"cycles,":[63,110],"both":[64,248],"species":[65],"exhibited":[66],"significant":[67],"daily":[68],"rhythms;":[70],"however,":[71],"showed":[74],"markedly":[75],"higher":[76],"a":[79,85,277],"distinct":[80],"phase":[81],"advance,":[82],"resulting":[83],"in":[84,96,171,183,213,218,221,247],"sharply":[86],"clustered":[87],"early-morning":[88],"peak":[89],"compared":[90],"with":[91],"broader":[93],"afternoon":[94],"pattern":[95],"knockout":[101],"did":[102],"not":[103],"substantially":[104],"affect":[105],"timing":[107],"under":[108,112],"LD":[109],"but":[111],"constant":[113],"darkness":[114],"it":[115],"delayed":[116],"phase,":[117],"reduced":[118,191],"robustness":[119],"rhythm,":[125],"suggesting":[126,272],"that":[127,238,258,273],"promotes":[129,260],"precision":[131],"synchrony":[133],"endogenous":[135],"rhythms.":[137],"To":[138],"uncover":[139],"transcriptional":[140,196,270],"signatures":[141],"domestication,":[143],"performed":[145],"24-h":[146],"RNA-seq":[147],"on":[148],"heads":[149],"domestic,":[151],"wild,":[152],"-mutant":[155],"silkworms.":[156,254],"Thousands":[157],"rhythmic":[159,179,195,202,285],"genes":[160,168,203],"broad":[162],"oscillatory":[163],"expression":[164],"core":[166],"were":[169,181,216],"detected":[170],",":[174],"whereas":[175],"only":[176],"dozens":[177],"transcripts":[180],"found":[182],"Disruption":[187],"strongly":[190],"detectable":[193],"domestication-expanded":[194],"program,":[197],"reducing":[198],"number":[200],"from":[204],"thousands":[205],"to":[206,282],"fewer":[207],"than":[208],"one":[209],"hundred.":[210],"Rhythmic":[211],"outputs":[212],"enriched":[217],"protein":[219],"processing":[220],"endoplasmic":[223],"reticulum,":[224],"Toll/Imd":[225],"signaling,":[226],"daytime-biased":[228],"tyrosine":[229],"metabolism/dopamine":[230],"biosynthesis":[231],"pathways.":[232],"Co-expression":[233],"network":[234],"analysis":[235],"further":[236],"revealed":[237],"domestication":[239,259],"strengthened":[240],"clock-linked":[241],"regulatory":[242],"networks,":[243],"which":[244],"became":[245],"fragmented":[246],"mutant":[251],"These":[255],"findings":[256],"demonstrate":[257],"interindividual":[261],"expanding":[266],"coordinating":[268],"programs,":[271],"acts":[275],"as":[276],"potential":[278],"candidate":[279],"contributing":[281],"this":[283],"adaptive":[284],"network.":[286]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-08-27T00:00:00"}