{"id":"https://openalex.org/W7204274367","doi":"https://doi.org/10.21203/rs.3.rs-10292743/v1","title":"Early 72-Hour Weight Loss and Short-Term Neonatal Outcomes in Very Low Birth Weight Infants: A Prospective Cohort Study","display_name":"Early 72-Hour Weight Loss and Short-Term Neonatal Outcomes in Very Low Birth Weight Infants: A Prospective Cohort Study","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204274367","doi":"https://doi.org/10.21203/rs.3.rs-10292743/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-10292743/v1","doi":"https://doi.org/10.21203/rs.3.rs-10292743/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10292743/v1","pdf_url":"https://www.researchsquare.com/article/rs-10292743/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-10292743/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103249991","display_name":"Elif Ya\u015far","orcid":"https://orcid.org/0000-0002-3741-1044","observed_orcids":["https://orcid.org/0000-0002-3741-1044"]},"institutions":[{"id":"https://openalex.org/I4210104067","display_name":"Zeynep Kamil Hospital","ror":"https://ror.org/01h96am38","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210104067"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Elif Ya\u015far","raw_affiliation_strings":["University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital","institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072565550","display_name":"Elif \u00d6zalkaya","orcid":"https://orcid.org/0000-0002-0992-1493","observed_orcids":["https://orcid.org/0000-0002-0992-1493"]},"institutions":[{"id":"https://openalex.org/I4210104067","display_name":"Zeynep Kamil Hospital","ror":"https://ror.org/01h96am38","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210104067"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Elif Ozalkaya","raw_affiliation_strings":["University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital","institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055147819","display_name":"Sevilay Top\u00e7uo\u011flu","orcid":"https://orcid.org/0000-0002-1117-196X","observed_orcids":["https://orcid.org/0000-0002-1117-196X"]},"institutions":[{"id":"https://openalex.org/I4210104067","display_name":"Zeynep Kamil Hospital","ror":"https://ror.org/01h96am38","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210104067"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevilay Topcuoglu","raw_affiliation_strings":["University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital","institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071883260","display_name":"Emre Din\u00e7er","orcid":"https://orcid.org/0000-0003-1429-3206","observed_orcids":["https://orcid.org/0000-0003-1429-3206"]},"institutions":[{"id":"https://openalex.org/I4210104067","display_name":"Zeynep Kamil Hospital","ror":"https://ror.org/01h96am38","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210104067"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emre Dincer","raw_affiliation_strings":["University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital","institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029595206","display_name":"Selim Sancak","orcid":"https://orcid.org/0000-0003-3952-9203","observed_orcids":["https://orcid.org/0000-0003-3952-9203"]},"institutions":[{"id":"https://openalex.org/I4210104067","display_name":"Zeynep Kamil Hospital","ror":"https://ror.org/01h96am38","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210104067"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Selim Sancak","raw_affiliation_strings":["University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital","institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062782280","display_name":"G\u00fcner Karatek\u0131n","orcid":"https://orcid.org/0000-0001-7112-0323","observed_orcids":["https://orcid.org/0000-0001-7112-0323"]},"institutions":[{"id":"https://openalex.org/I4210104067","display_name":"Zeynep Kamil Hospital","ror":"https://ror.org/01h96am38","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4210104067"]},{"id":"https://openalex.org/I4210128276","display_name":"Sa\u011fl\u0131k Bilimleri \u00dcniversitesi","ror":"https://ror.org/03k7bde87","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210128276"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcner Karatekin","raw_affiliation_strings":["University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Health Sciences, Zeynep Kamil Women and Children\u2019s Diseases Training and Research Hospital","institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072565550"],"corresponding_institution_ids":["https://openalex.org/I4210104067","https://openalex.org/I4210128276"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11060","display_name":"Infant Development and Preterm Care","score":0.7372999787330627,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.13289999961853027,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/very-low-birth-weight-infants","display_name":"very low birth weight infants","score":0.9789999723434448},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neonatal-outcomes","display_name":"neonatal outcomes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fluid-balance","display_name":"fluid balance","score":0.5989999771118164},{"id":"https://openalex.org/keywords/surfactant-requirement","display_name":"surfactant requirement","score":0.7279999852180481},{"id":"https://openalex.org/keywords/patent-ductus-arteriosus","display_name":"patent ductus arteriosus","score":0.9010000228881836},{"id":"https://openalex.org/keywords/intraventricular-hemorrhage","display_name":"intraventricular hemorrhage","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inotropic-support","display_name":"inotropic support","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neonatal-mortality","display_name":"neonatal mortality","score":0.6449999809265137},{"id":"https://openalex.org/keywords/renal-maturation","display_name":"renal maturation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neonatal-intensive-care","display_name":"neonatal intensive care","score":0.5910000205039978},{"id":"https://openalex.org/keywords/fluid-management","display_name":"fluid management","score":0.42399999499320984},{"id":"https://openalex.org/keywords/respiratory-distress-syndrome","display_name":"respiratory distress syndrome","score":0.6520000100135803},{"id":"https://openalex.org/keywords/early-onset-sepsis","display_name":"early-onset sepsis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/feeding-intolerance","display_name":"feeding intolerance","score":0.9879999756813049},{"id":"https://openalex.org/keywords/extracellular-fluid","display_name":"extracellular fluid","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8873000144958496},{"id":"https://openalex.org/C2779083892","wikidata":"https://www.wikidata.org/wiki/Q6692979","display_name":"Low birth weight","level":3,"score":0.7019000053405762},{"id":"https://openalex.org/C2777091541","wikidata":"https://www.wikidata.org/wiki/Q9008292","display_name":"Neonatal intensive care unit","level":2,"score":0.6543999910354614},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.6424000263214111},{"id":"https://openalex.org/C66322754","wikidata":"https://www.wikidata.org/wiki/Q4128476","display_name":"Birth weight","level":3,"score":0.6384000182151794},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.6189000010490417},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5665000081062317},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.49720001220703125},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.48190000653266907},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.40700000524520874},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.3865000009536743},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.36800000071525574},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3375000059604645},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.3061000108718872},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.3059999942779541},{"id":"https://openalex.org/C3017894415","wikidata":"https://www.wikidata.org/wiki/Q7979883","display_name":"Weight change","level":4,"score":0.30169999599456787},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.26750001311302185},{"id":"https://openalex.org/C2780395437","wikidata":"https://www.wikidata.org/wiki/Q754348","display_name":"Neonatal respiratory distress syndrome","level":4,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-10292743/v1","doi":"https://doi.org/10.21203/rs.3.rs-10292743/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10292743/v1","pdf_url":"https://www.researchsquare.com/article/rs-10292743/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-10292743/v1","doi":"https://doi.org/10.21203/rs.3.rs-10292743/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-10292743/v1","pdf_url":"https://www.researchsquare.com/article/rs-10292743/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9976000189781189,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"},{"score":0.40450000762939453,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204274367.pdf","grobid_xml":"https://content.openalex.org/works/W7204274367.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408929320","https://openalex.org/W2060600126","https://openalex.org/W4283159864","https://openalex.org/W2808112881","https://openalex.org/W4408187137","https://openalex.org/W56959058","https://openalex.org/W7221164867","https://openalex.org/W1198102087","https://openalex.org/W2074109063","https://openalex.org/W2023269972"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Early":[2],"postnatal":[3,45,291,350,388],"weight":[4,46,52,72,91,131,181,187,194,209,264,286,292,343,351,389,395],"loss":[5,47,73,132,210,265,293,352,390],"is":[6],"an":[7,308,365],"important":[8],"component":[9],"of":[10,43,79,138,172,271,285,299,359,367,386],"neonatal":[11,38,83,113,147,159,199,314,361],"adaptation":[12,362],"and":[13,27,81,120,143,146,151,155,161,189,198,229,277,380],"reflects":[14],"the":[15,40,69,75,134,166,204,218,295,383],"complex":[16],"interplay":[17],"between":[18,71,117],"extracellular":[19],"fluid":[20,28,32,215],"contraction,":[21],"renal":[22],"maturation,":[23],"insensible":[24],"water":[25],"loss,":[26,182,188],"management.":[29],"Although":[30,316],"early":[31,44,149,290,349,387],"balance":[33],"has":[34],"been":[35],"associated":[36,302],"with":[37,88,103,207,262,282,303,341],"morbidity,":[39],"clinical":[41,150],"significance":[42],"in":[48,59,85,241,310,391],"very":[49,392],"low":[50,393],"birth":[51,90,104,394],"(VLBW)":[53],"infants":[54,60,87,102,174,261,340],"remains":[55],"incompletely":[56],"understood,":[57],"particularly":[58],"weighing":[61],"less":[62],"than":[63,280,364],"1250":[64,93,107],"g.":[65,94],"Objective":[66],"To":[67],"investigate":[68],"association":[70],"during":[74,133,217,294],"first":[76,135,219,296],"72":[77,136,220,297],"hours":[78,137,221,298],"life":[80,139,300],"short-term":[82,369],"outcomes":[84,334],"preterm":[86,101],"a":[89,111,355],"below":[92,106],"Methods:":[95],"In":[96],"this":[97],"prospective":[98],"cohort":[99],"study,":[100],"weights":[105],"g":[108],"admitted":[109],"to":[110,129,376,381],"tertiary":[112],"intensive":[114],"care":[115],"unit":[116],"February":[118,121],"2023":[119],"2024":[122],"were":[123,126,163,175,201,239,320],"enrolled.":[124],"Infants":[125,206],"categorized":[127],"according":[128],"percentage":[130],"as":[140],"<5%,":[141],"5\u201310%,":[142],">10%.":[144],"Maternal":[145],"characteristics,":[148],"laboratory":[152],"findings,":[153],"respiratory":[154,242,245],"cardiovascular":[156],"outcomes,":[157],"major":[158,313],"morbidities,":[160],"mortality":[162,311],"compared":[164],"among":[165,203,339],"three":[167,333],"groups.":[168,205],"Results:":[169],"A":[170],"total":[171],"98":[173],"included:":[176],"48":[177],"(49.0%)":[178],"had":[179,185,192,223],"<5%":[180],"36":[183],"(36.7%)":[184],"5\u201310%":[186],"14":[190],"(14.3%)":[191],">10%":[193,208,263],"loss.":[195,287,344],"Baseline":[196],"maternal":[197],"characteristics":[200],"comparable":[202],"received":[211],"significantly":[212],"higher":[213],"cumulative":[214],"volumes":[216],"(p<0.001),":[222],"lower":[224,269,283],"serum":[225],"creatinine":[226],"concentrations":[227],"(p=0.018),":[228],"required":[230],"fewer":[231],"surfactant":[232,305],"doses":[233],"(p=0.042).":[234],"No":[235],"statistically":[236,317],"significant":[237,318],"differences":[238,319],"observed":[240,322],"distress":[243],"syndrome,":[244],"support,":[246,253,331],"patent":[247,272,324],"ductus":[248,273,325],"arteriosus,":[249,274,326],"intraventricular":[250,275,327],"hemorrhage,":[251,276,328],"inotropic":[252,278,330],"feeding":[254],"intolerance,":[255],"early-onset":[256],"sepsis,":[257],"or":[258,312,329],"mortality.":[259],"Nevertheless,":[260],"consistently":[266],"demonstrated":[267,335],"numerically":[268],"rates":[270],"support":[279],"those":[281],"degrees":[284],"Conclusions:":[288],"Greater":[289],"was":[301],"reduced":[304],"requirements":[306],"without":[307],"increase":[309],"morbidities.":[315],"not":[321],"for":[323],"all":[332],"consistent":[336],"numerical":[337],"reductions":[338],"greater":[342],"These":[345],"findings":[346,379],"suggest":[347],"that":[348],"may":[353],"represent":[354],"clinically":[356],"useful":[357],"marker":[358],"successful":[360],"rather":[363],"indicator":[366],"adverse":[368],"outcomes.":[370],"Larger":[371],"multicenter":[372],"studies":[373],"are":[374],"warranted":[375],"validate":[377],"these":[378],"determine":[382],"optimal":[384],"range":[385],"infants.":[396]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-08-27T00:00:00"}
