{"id":"https://openalex.org/W7204272015","doi":"https://doi.org/10.1038/s41434-026-00641-1","title":"Mapping the global trends and hotspots of research on gene therapy and hair cell regeneration for hearing loss: a comprehensive data-mining-based study","display_name":"Mapping the global trends and hotspots of research on gene therapy and hair cell regeneration for hearing loss: a comprehensive data-mining-based study","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204272015","doi":"https://doi.org/10.1038/s41434-026-00641-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42649271"},"language":"en","primary_location":{"id":"doi:10.1038/s41434-026-00641-1","doi":"https://doi.org/10.1038/s41434-026-00641-1","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41434-026-00641-1","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122793767","display_name":"Yunsheng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunsheng Liu","raw_affiliation_strings":["Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127831590","display_name":"Bing Hu","orcid":"https://orcid.org/0000-0001-8996-345X","observed_orcids":["https://orcid.org/0000-0001-8996-345X"]},"institutions":[{"id":"https://openalex.org/I4210107571","display_name":"Jiangxi Provincial People's Hospital","ror":"https://ror.org/01dspcb60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107571"]},{"id":"https://openalex.org/I4405282134","display_name":"Nanchang Medical College","ror":"https://ror.org/05cgtpd39","country_code":"CN","type":"education","lineage":["https://openalex.org/I4405282134"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bing Hu","raw_affiliation_strings":["Department of Otolaryngology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Jiangxi Provincial People's Hospital, the First Affiliated Hospital of Nanchang Medical College, Nanchang, China","institution_ids":["https://openalex.org/I4210107571","https://openalex.org/I4405282134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692119","display_name":"Jinfang Zhang","orcid":"https://orcid.org/0000-0001-8487-6007","observed_orcids":["https://orcid.org/0000-0001-8487-6007"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinfang Zhang","raw_affiliation_strings":["Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134295290","display_name":"Xianlin Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianlin Wu","raw_affiliation_strings":["Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123461438","display_name":"Qinghui Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghui Lu","raw_affiliation_strings":["Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China","institution_ids":["https://openalex.org/I117532281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101728287","display_name":"Yanyan Jia","orcid":"https://orcid.org/0000-0001-7089-0959","observed_orcids":["https://orcid.org/0000-0001-7089-0959"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210112065","display_name":"Eye & ENT Hospital of Fudan University","ror":"https://ror.org/02wc1yz29","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210112065"]},{"id":"https://openalex.org/I4391768195","display_name":"State Key Laboratory of Medical Neurobiology","ror":"https://ror.org/00nn53y54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768195"]},{"id":"https://openalex.org/I4405273316","display_name":"Frontiers Center for Brain Science of the Ministry of Education","ror":"https://ror.org/05n8v1c41","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273316"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanyan Jia","raw_affiliation_strings":["ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. jiayanyan@fudan.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China. jiayanyan@fudan.edu.cn","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210112065","https://openalex.org/I4391768195","https://openalex.org/I4405273316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022045214","display_name":"Zengwei Kou","orcid":"https://orcid.org/0009-0004-8779-7186","observed_orcids":["https://orcid.org/0009-0004-8779-7186"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA","CN"],"is_corresponding":true,"raw_author_name":"Zengwei Kou","raw_affiliation_strings":["College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, China. zengwei.kou@utoronto.ca","Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. zengwei.kou@utoronto.ca"],"raw_orcid":"https://orcid.org/0009-0004-8779-7186","affiliations":[{"raw_affiliation_string":"College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, China. zengwei.kou@utoronto.ca","institution_ids":["https://openalex.org/I167383011"]},{"raw_affiliation_string":"Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. zengwei.kou@utoronto.ca","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5022045214","https://openalex.org/A5101728287"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I167383011","https://openalex.org/I185261750","https://openalex.org/I24943067","https://openalex.org/I4210112065","https://openalex.org/I4391768195","https://openalex.org/I4405273316"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62443052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10102","display_name":"scientometrics and bibliometrics research","score":0.07329999655485153,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-cell-regeneration","display_name":"hair cell regeneration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hearing-loss","display_name":"hearing loss","score":0.9279999732971191},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/crispr-cas9","display_name":"CRISPR/Cas9","score":0.9860000014305115},{"id":"https://openalex.org/keywords/otoferlin","display_name":"otoferlin","score":0.7960000038146973},{"id":"https://openalex.org/keywords/research-trends","display_name":"research trends","score":0.7350000143051147},{"id":"https://openalex.org/keywords/research-hotspots","display_name":"research hotspots","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gene-therapy-clinical-trials","display_name":"gene therapy clinical trials","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6432999968528748},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.5135999917984009},{"id":"https://openalex.org/C83867959","wikidata":"https://www.wikidata.org/wiki/Q371467","display_name":"Scopus","level":3,"score":0.47699999809265137},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4699000120162964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45239999890327454},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4221999943256378},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3984000086784363},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C144501496","wikidata":"https://www.wikidata.org/wiki/Q5533489","display_name":"Genome editing","level":4,"score":0.3700999915599823},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.3650999963283539},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3619999885559082},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35260000824928284},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.3361999988555908},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.3353999853134155},{"id":"https://openalex.org/C46578552","wikidata":"https://www.wikidata.org/wiki/Q2725393","display_name":"Global health","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C105345328","wikidata":"https://www.wikidata.org/wiki/Q206276","display_name":"Citation analysis","level":3,"score":0.30480000376701355},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.2833000123500824},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.26109999418258667},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.25780001282691956}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s41434-026-00641-1","doi":"https://doi.org/10.1038/s41434-026-00641-1","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41434-026-00641-1","pdf_url":null,"source":{"id":"https://openalex.org/S65405509","display_name":"Gene Therapy","issn_l":"0969-7128","issn":["0969-7128","1476-5462"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Therapy","raw_type":"journal-article"},{"id":"pmid:42649271","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42649271","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7411576070","display_name":null,"funder_award_id":"32100762","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1861297144","https://openalex.org/W1968968769","https://openalex.org/W2018514799","https://openalex.org/W2027318031","https://openalex.org/W2034060287","https://openalex.org/W2035924524","https://openalex.org/W2105493567","https://openalex.org/W2140348457","https://openalex.org/W2141569557","https://openalex.org/W2586573214","https://openalex.org/W2755950973","https://openalex.org/W2768910598","https://openalex.org/W2778806019","https://openalex.org/W2780646907","https://openalex.org/W2794911441","https://openalex.org/W2902016625","https://openalex.org/W2909347581","https://openalex.org/W2913533437","https://openalex.org/W2915061779","https://openalex.org/W2945984140","https://openalex.org/W2953107155","https://openalex.org/W2969527757","https://openalex.org/W2990909175","https://openalex.org/W3105524336","https://openalex.org/W3134601984","https://openalex.org/W3169682926","https://openalex.org/W4220775758","https://openalex.org/W4220971806","https://openalex.org/W4225794735","https://openalex.org/W4238591974","https://openalex.org/W4282600216","https://openalex.org/W4318020351","https://openalex.org/W4318473437","https://openalex.org/W4386025829","https://openalex.org/W4388153345","https://openalex.org/W4388213746","https://openalex.org/W4388974102","https://openalex.org/W4391166207","https://openalex.org/W4400658294","https://openalex.org/W4405056405","https://openalex.org/W4405511853","https://openalex.org/W4408218826","https://openalex.org/W4408731893","https://openalex.org/W4409627189","https://openalex.org/W4409752025","https://openalex.org/W4411106656","https://openalex.org/W4411498857","https://openalex.org/W4411924376","https://openalex.org/W4412381678","https://openalex.org/W4412528121","https://openalex.org/W4413447519","https://openalex.org/W4413990784","https://openalex.org/W4414104285","https://openalex.org/W4415085736","https://openalex.org/W4415092715","https://openalex.org/W4415479501","https://openalex.org/W4417075982","https://openalex.org/W4417182266","https://openalex.org/W7116440216","https://openalex.org/W7155155450"],"related_works":["https://openalex.org/W4410522689","https://openalex.org/W7203715333","https://openalex.org/W4407024833","https://openalex.org/W4399083378","https://openalex.org/W4403273109","https://openalex.org/W4200181905","https://openalex.org/W4387966745","https://openalex.org/W7156165612","https://openalex.org/W7171509288","https://openalex.org/W4415782860"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-08-27T00:00:00"}
