{"id":"https://openalex.org/W7204269059","doi":"https://doi.org/10.3390/ijms27177651","title":"Baicalein Attenuates Eosinophilic Rhinosinusitis by Suppressing ALOX15-Mediated M2 Macrophage Function","display_name":"Baicalein Attenuates Eosinophilic Rhinosinusitis by Suppressing ALOX15-Mediated M2 Macrophage Function","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204269059","doi":"https://doi.org/10.3390/ijms27177651","pmid":"https://pubmed.ncbi.nlm.nih.gov/42737549","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13566850"},"language":"en","primary_location":{"id":"doi:10.3390/ijms27177651","doi":"https://doi.org/10.3390/ijms27177651","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27177651","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/ijms27177651","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112321162","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0001-8686-8764","observed_orcids":["https://orcid.org/0000-0001-8686-8764"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":"https://orcid.org/0000-0001-8686-8764","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041171335","display_name":"Zhenzhen Zhu","orcid":"https://orcid.org/0000-0003-3245-3306","observed_orcids":["https://orcid.org/0000-0003-3245-3306"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenzhen Zhu","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012332773","display_name":"Yuzhuo Liu","orcid":"https://orcid.org/0000-0002-7942-1769","observed_orcids":["https://orcid.org/0000-0002-7942-1769"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhuo Liu","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":"https://orcid.org/0000-0002-7942-1769","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031491250","display_name":"Surita Aodeng","orcid":"https://orcid.org/0009-0003-7825-3569","observed_orcids":["https://orcid.org/0009-0003-7825-3569"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Surita Aodeng","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":"https://orcid.org/0009-0003-7825-3569","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135280653","display_name":"Tianhui Kang","orcid":"https://orcid.org/0009-0001-4178-1275","observed_orcids":["https://orcid.org/0009-0001-4178-1275"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianhui Kang","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":"https://orcid.org/0009-0001-4178-1275","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100372963","display_name":"Weiqing Wang","orcid":"https://orcid.org/0000-0002-9440-1117","observed_orcids":["https://orcid.org/0000-0002-9440-1117"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Weiqing Wang","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":"https://orcid.org/0000-0002-9440-1117","affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101847844","display_name":"Wei Lv","orcid":"https://orcid.org/0000-0002-8945-7693","observed_orcids":["https://orcid.org/0000-0002-8945-7693"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Lv","raw_affiliation_strings":["Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100372963","https://openalex.org/A5101847844"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.62129187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"17","first_page":"7651","last_page":"7651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baicalein","display_name":"baicalein","score":0.996999979019165},{"id":"https://openalex.org/keywords/eosinophilic-chronic-rhinosinusitis-with-nasal-polyps","display_name":"eosinophilic chronic rhinosinusitis with nasal polyps","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alox15","display_name":"ALOX15","score":0.9580000042915344},{"id":"https://openalex.org/keywords/15-lipoxygenase","display_name":"15-lipoxygenase","score":0.8820000290870667},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9290000200271606},{"id":"https://openalex.org/keywords/type-2-inflammation","display_name":"type 2 inflammation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C2781466915","wikidata":"https://www.wikidata.org/wiki/Q2879363","display_name":"Baicalein","level":2,"score":0.95660001039505},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5099999904632568},{"id":"https://openalex.org/C2781390199","wikidata":"https://www.wikidata.org/wiki/Q8055111","display_name":"Nasal polyps","level":2,"score":0.4731999933719635},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47200000286102295},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.44350001215934753},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.43230000138282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.429500013589859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42899999022483826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4090999960899353},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3653999865055084},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.33500000834465027},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3142000138759613},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.31040000915527344},{"id":"https://openalex.org/C2777768476","wikidata":"https://www.wikidata.org/wiki/Q183344","display_name":"Sinusitis","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.2930000126361847},{"id":"https://openalex.org/C157081693","wikidata":"https://www.wikidata.org/wiki/Q21113934","display_name":"CCL18","level":4,"score":0.27320000529289246},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27230000495910645},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.2597000002861023}],"mesh":[{"descriptor_ui":"D000074084","descriptor_name":"THP-1 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096825","descriptor_name":"Rhinosinusitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000096825","descriptor_name":"Rhinosinusitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000096825","descriptor_name":"Rhinosinusitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001093","descriptor_name":"Arachidonate 15-Lipoxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004802","descriptor_name":"Eosinophilia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009298","descriptor_name":"Nasal Polyps","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012220","descriptor_name":"Rhinitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012852","descriptor_name":"Sinusitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044950","descriptor_name":"Flavanones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms27177651","doi":"https://doi.org/10.3390/ijms27177651","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27177651","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:42737549","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42737549","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13566850","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13566850/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/ijms27177651","doi":"https://doi.org/10.3390/ijms27177651","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms27177651","pdf_url":null,"source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1513405298","https://openalex.org/W1924842828","https://openalex.org/W1972945811","https://openalex.org/W1978302597","https://openalex.org/W1993734178","https://openalex.org/W1996477014","https://openalex.org/W1997341093","https://openalex.org/W2024207154","https://openalex.org/W2024405339","https://openalex.org/W2025490382","https://openalex.org/W2046208657","https://openalex.org/W2061123122","https://openalex.org/W2065210647","https://openalex.org/W2093705034","https://openalex.org/W2109843249","https://openalex.org/W2128518753","https://openalex.org/W2150464681","https://openalex.org/W2153960708","https://openalex.org/W2159560463","https://openalex.org/W2184888523","https://openalex.org/W2289316671","https://openalex.org/W2301044272","https://openalex.org/W2462860861","https://openalex.org/W2471128678","https://openalex.org/W2473631582","https://openalex.org/W2550324626","https://openalex.org/W2567558689","https://openalex.org/W2593448862","https://openalex.org/W2736285557","https://openalex.org/W2755753624","https://openalex.org/W2784066183","https://openalex.org/W2791610321","https://openalex.org/W2804102163","https://openalex.org/W2895522803","https://openalex.org/W2902539991","https://openalex.org/W2910127585","https://openalex.org/W2953909155","https://openalex.org/W2961981645","https://openalex.org/W3009076370","https://openalex.org/W3012852765","https://openalex.org/W3022184763","https://openalex.org/W3102518757","https://openalex.org/W3194199190","https://openalex.org/W3196697637","https://openalex.org/W3215051637","https://openalex.org/W4296689812","https://openalex.org/W4366827861","https://openalex.org/W4382182481","https://openalex.org/W4386092023","https://openalex.org/W4387473805","https://openalex.org/W4392386304","https://openalex.org/W4396623899","https://openalex.org/W4401856131","https://openalex.org/W4404454662","https://openalex.org/W4404874254","https://openalex.org/W4416020398","https://openalex.org/W7137864972","https://openalex.org/W7139989135","https://openalex.org/W7147029784","https://openalex.org/W7155380610"],"related_works":["https://openalex.org/W2901367142","https://openalex.org/W4396623899","https://openalex.org/W7169567533","https://openalex.org/W3102518757","https://openalex.org/W4412595029","https://openalex.org/W4391885082","https://openalex.org/W3125568119","https://openalex.org/W2378601790","https://openalex.org/W2983936338","https://openalex.org/W3085627017"],"abstract_inverted_index":{"Eosinophilic":[0],"chronic":[1],"rhinosinusitis":[2,38,108],"with":[3,21],"nasal":[4,54],"polyps":[5],"(eCRSwNP)":[6],"is":[7,18],"characterized":[8],"by":[9,112,117,237],"type":[10],"2":[11,125],"inflammation,":[12,121],"including":[13],"M2":[14,50,77,144,148,191,243],"macrophage":[15,51,244,249],"infiltration.":[16],"Baicalein":[17,156,223],"a":[19,35,253],"flavonoid":[20],"anti-inflammatory":[22],"properties.":[23],"This":[24],"study":[25],"aimed":[26],"to":[27,41,142],"investigate":[28],"the":[29,80,163],"therapeutic":[30,255],"effect":[31,181],"of":[32,82,165,211],"baicalein":[33,83,118,177,194,232],"in":[34,137,190],"papain-induced":[36,234],"eosinophilic":[37,107],"model":[39,109],"and":[40,61,68,74,79,91,128,140,153,162,170,176,209,219,241],"determine":[42],"whether":[43],"it":[44],"acts":[45],"through":[46],"arachidonate":[47],"15-lipoxygenase":[48],"(ALOX15)-dependent":[49],"function.":[52,246],"Clinical":[53],"samples":[55],"from":[56],"controls,":[57],"non-eosinophilic":[58],"CRSwNP":[59],"(neCRSwNP),":[60],"eCRSwNP":[62,138],"were":[63,72,94,132],"analyzed":[64],"for":[65,102,257],"ALOX15":[66,85,97,134,151,158,183],"expression":[67,152],"localization.":[69],"THP-1":[70],"cells":[71],"differentiated":[73],"polarized":[75],"toward":[76],"macrophages,":[78,218],"effects":[81],"on":[84],"expression,":[86,127,159],"lipid":[87,154,160,239],"peroxidation,":[88,161],"cytokine":[89],"secretion,":[90],"transcriptomic":[92],"profile":[93],"examined.":[95],"The":[96,247],"inhibitor":[98],"PD146176":[99,172],"was":[100,110,135],"used":[101],"target":[103,256],"validation.":[104],"A":[105],"murine":[106],"established":[111],"intranasal":[113],"papain":[114,198],"instillation,":[115],"followed":[116],"treatment.":[119,195],"Mucosal":[120],"IgE":[122],"levels,":[123],"proteoglycan":[124],"(PRG2)/ALOX15":[126],"immune":[129,213],"cell":[130],"infiltration":[131,210],"evaluated.":[133],"upregulated":[136],"tissues":[139],"localized":[141],"CD68+CD206+":[143],"macrophages.":[145],"In":[146,196,230],"vitro,":[147],"polarization":[149],"increased":[150,199],"peroxidation.":[155],"suppressed":[157],"secretion":[164],"CCL22,":[166],"CCL2,":[167],"CXCL12,":[168],"FGF-2,":[169],"IL-15.":[171],"produced":[173],"similar":[174],"effects,":[175],"showed":[178],"no":[179],"additional":[180],"after":[182,193],"blockade.":[184],"RNA":[185],"sequencing":[186],"revealed":[187],"transcriptional":[188],"remodeling":[189],"macrophages":[192],"vivo,":[197],"ethmoid":[200],"sinus":[201],"mucosal":[202],"thickening,":[203],"serum":[204],"IgE,":[205],"PRG2/ALOX15":[206],"positive":[207],"cells,":[208,214],"CD45+":[212],"CD170+":[215],"eosinophils,":[216],"F4/80+":[217],"B220+":[220],"B":[221],"cells.":[222],"significantly":[224],"alleviated":[225],"all":[226],"these":[227],"pathological":[228],"changes.":[229],"conclusion,":[231],"attenuates":[233],"eCRSwNP-like":[235],"inflammation":[236],"inhibiting":[238],"peroxidation":[240],"ALOX15-associated":[242],"secretory":[245],"ALOX15/M2":[248],"axis":[250],"may":[251],"represent":[252],"potential":[254],"eCRSwNP.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-27T00:00:00"}
