{"id":"https://openalex.org/W7204267564","doi":"https://doi.org/10.1016/j.redox.2026.104369","title":"Cooperative inhibition of mTORC1 disrupts iron\u2013redox homeostasis and triggers ferritinophagy-dependent ferroptosis in hepatocellular carcinoma","display_name":"Cooperative inhibition of mTORC1 disrupts iron\u2013redox homeostasis and triggers ferritinophagy-dependent ferroptosis in hepatocellular carcinoma","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204267564","doi":"https://doi.org/10.1016/j.redox.2026.104369","pmid":"https://pubmed.ncbi.nlm.nih.gov/42685609","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13559837"},"language":"en","primary_location":{"id":"doi:10.1016/j.redox.2026.104369","doi":"https://doi.org/10.1016/j.redox.2026.104369","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2026.104369","pdf_url":"https://www.sciencedirect.com/science/article/pii/S221323172600368X/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.sciencedirect.com/science/article/pii/S221323172600368X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148200031","display_name":"Xinyu Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Chen","raw_affiliation_strings":["Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China; Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611130, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China; Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Department of Pathology, The Fifth Affiliated People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611130, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148400859","display_name":"Zhen Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Tan","raw_affiliation_strings":["Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210129459","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022889732","display_name":"Shiqiao Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiqiao Zhao","raw_affiliation_strings":["Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140535834","display_name":"Li Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Li","raw_affiliation_strings":["Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210129459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103095215","display_name":"Y. Liu","orcid":"https://orcid.org/0000-0001-8908-6194","observed_orcids":["https://orcid.org/0000-0001-8908-6194"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yilin Liu","raw_affiliation_strings":["Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139907992","display_name":"Cong Ren","orcid":"https://orcid.org/0009-0006-9459-3960","observed_orcids":["https://orcid.org/0009-0006-9459-3960"]},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Cong Ren","raw_affiliation_strings":["Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404202","display_name":"Jiaying Li","orcid":"https://orcid.org/0000-0001-7508-1579","observed_orcids":["https://orcid.org/0000-0001-7508-1579","https://orcid.org/0009-0000-1399-9878","https://orcid.org/0009-0002-2191-6221"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaying Li","raw_affiliation_strings":["Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I4210129459","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068237623","display_name":"Hang Hong Lo","orcid":"https://orcid.org/0000-0002-9392-0214","observed_orcids":["https://orcid.org/0000-0002-9392-0214"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Hanghong Lo","raw_affiliation_strings":["State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, 999078, Macao Special Administrative Region of China"],"raw_orcid":"https://orcid.org/0000-0002-9392-0214","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, 999078, Macao Special Administrative Region of China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148180683","display_name":"Yue Cui","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yue Cui","raw_affiliation_strings":["Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062082800","display_name":"Aie Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aie Zhou","raw_affiliation_strings":["Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5148353363","display_name":"Chuanlin Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chuanlin Zhu","raw_affiliation_strings":["Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103002629","display_name":"Anguo Wu","orcid":"https://orcid.org/0000-0003-4688-6081","observed_orcids":["https://orcid.org/0000-0003-4688-6081","https://orcid.org/0000-0002-9850-7576"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Anguo Wu","raw_affiliation_strings":["Sichuan Key Medical Laboratory of New Drug Discovery and Drug Ability Evaluation, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China. Electronic address: wuanguo1114@swmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sichuan Key Medical Laboratory of New Drug Discovery and Drug Ability Evaluation, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, 646000, China. Electronic address: wuanguo1114@swmu.edu.cn","institution_ids":["https://openalex.org/I3017480383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101553277","display_name":"Ning Jiang","orcid":"https://orcid.org/0000-0002-5784-8622","observed_orcids":["https://orcid.org/0000-0002-5784-8622"]},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"The Affiliated Yongchuan Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ning Jiang","raw_affiliation_strings":["Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, China; Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: jiangning@cqmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0002-5784-8622","affiliations":[{"raw_affiliation_string":"Department of Pathology, College of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, China; Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: jiangning@cqmu.edu.cn","institution_ids":["https://openalex.org/I4210129459","https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101844163","display_name":"Fang Ren","orcid":"https://orcid.org/0000-0003-3971-1072","observed_orcids":["https://orcid.org/0000-0003-3971-1072"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fang Ren","raw_affiliation_strings":["Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China. Electronic address: renifang1993@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, Department of Laboratory Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, China. Electronic address: renifang1993@163.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101553277","https://openalex.org/A5101844163","https://openalex.org/A5103002629","https://openalex.org/A5139907992"],"corresponding_institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210129459","https://openalex.org/I87780372"],"apc_list":{"value":4310,"currency":"USD","value_usd":4310},"apc_paid":{"value":4310,"currency":"USD","value_usd":4310},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54630448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"97","issue":null,"first_page":"104369","last_page":"104369"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9139999747276306},{"id":"https://openalex.org/keywords/ferritinophagy","display_name":"ferritinophagy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/mtorc1-inhibition","display_name":"mTORC1 inhibition","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cryptotanshinone","display_name":"cryptotanshinone","score":0.9409999847412109},{"id":"https://openalex.org/keywords/beta-lapachone","display_name":"\u03b2-lapachone","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ncoa4","display_name":"NCOA4","score":0.9210000038146973},{"id":"https://openalex.org/keywords/raptors","display_name":"raptors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.921999990940094},{"id":"https://openalex.org/keywords/fenton-reaction","display_name":"Fenton reaction","score":0.7289999723434448},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.8560000061988831},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7978000044822693},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7382000088691711},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.66839998960495},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.5927000045776367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41990000009536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38040000200271606},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.3546000123023987},{"id":"https://openalex.org/C2776529522","wikidata":"https://www.wikidata.org/wiki/Q18034700","display_name":"KEAP1","level":4,"score":0.3472999930381775},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31940001249313354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27219998836517334},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26409998536109924},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.25769999623298645}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010616","descriptor_name":"Phenanthrenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056918","descriptor_name":"Nuclear Receptor Coactivators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.redox.2026.104369","doi":"https://doi.org/10.1016/j.redox.2026.104369","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2026.104369","pdf_url":"https://www.sciencedirect.com/science/article/pii/S221323172600368X/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},{"id":"pmid:42685609","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42685609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13559837","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13559837/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:639b1e356cc2462aa0372c191df88157","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/639b1e356cc2462aa0372c191df88157","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Redox Biology, Vol 97, Iss , Pp 104369- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.redox.2026.104369","doi":"https://doi.org/10.1016/j.redox.2026.104369","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.redox.2026.104369","pdf_url":"https://www.sciencedirect.com/science/article/pii/S221323172600368X/pdf","source":{"id":"https://openalex.org/S2764928002","display_name":"Redox Biology","issn_l":"2213-2317","issn":["2213-2317"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Redox Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2237678464","display_name":null,"funder_award_id":"CSTB2024TIAD-LUX0003","funder_id":"https://openalex.org/F4320330194","funder_display_name":"Chongqing Research Program of Technological Innovation and Application Demonstration"},{"id":"https://openalex.org/G6174361874","display_name":null,"funder_award_id":"82304994","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320330194","display_name":"Chongqing Research Program of Technological Innovation and Application Demonstration","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204267564.pdf","grobid_xml":"https://content.openalex.org/works/W7204267564.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1997684038","https://openalex.org/W2139769169","https://openalex.org/W2778262854","https://openalex.org/W2794350466","https://openalex.org/W2897152103","https://openalex.org/W2914643529","https://openalex.org/W2915957789","https://openalex.org/W2921575300","https://openalex.org/W3012491782","https://openalex.org/W3035408975","https://openalex.org/W3048384926","https://openalex.org/W3077764649","https://openalex.org/W3090413519","https://openalex.org/W3094424280","https://openalex.org/W3121378959","https://openalex.org/W3126486010","https://openalex.org/W3135213615","https://openalex.org/W3157282498","https://openalex.org/W3177828909","https://openalex.org/W3211795435","https://openalex.org/W4224305988","https://openalex.org/W4225302233","https://openalex.org/W4283701282","https://openalex.org/W4284889683","https://openalex.org/W4294152357","https://openalex.org/W4294833186","https://openalex.org/W4312223097","https://openalex.org/W4324344296","https://openalex.org/W4376866162","https://openalex.org/W4377826561","https://openalex.org/W4385238118","https://openalex.org/W4387256971","https://openalex.org/W4387357874","https://openalex.org/W4389506435","https://openalex.org/W4391172254","https://openalex.org/W4391598414","https://openalex.org/W4391878282","https://openalex.org/W4391910418","https://openalex.org/W4394997839","https://openalex.org/W4398160090","https://openalex.org/W4399805119","https://openalex.org/W4400641569","https://openalex.org/W4401103611","https://openalex.org/W4401417711","https://openalex.org/W4402201861","https://openalex.org/W4403908835","https://openalex.org/W4410119752","https://openalex.org/W4411084997","https://openalex.org/W4414690617"],"related_works":["https://openalex.org/W4390584138","https://openalex.org/W3024451066","https://openalex.org/W7169525254","https://openalex.org/W4312115173","https://openalex.org/W4390754074","https://openalex.org/W4405431386","https://openalex.org/W4389347284","https://openalex.org/W7158341947","https://openalex.org/W4392748483","https://openalex.org/W2998019762"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"remains":[3],"a":[4,27,35,83,144,189,200],"leading":[5],"cause":[6],"of":[7,14,68,93,106,138],"cancer":[8],"mortality,":[9],"and":[10,54,61,73,77,104,124,163,178,196,203],"the":[11,107,139,152,165],"clinical":[12],"utility":[13],"\u03b2-lapachone":[15],"(\u03b2-Lap)":[16],"is":[17],"limited":[18],"by":[19],"dose-dependent":[20],"toxicity.":[21],"Here,":[22],"we":[23],"identify":[24],"cryptotanshinone":[25],"(CPT),":[26],"bioactive":[28],"compound":[29],"derived":[30],"from":[31],"Salvia":[32],"miltiorrhiza,":[33],"as":[34,188],"synergistic":[36],"partner":[37],"that":[38,59],"enables":[39],"dose":[40],"reduction":[41],"while":[42],"enhancing":[43],"antitumor":[44],"efficacy.":[45],"Integrated":[46],"transcriptomic":[47],"profiling,":[48],"biochemical":[49],"analyses,":[50],"target":[51],"engagement":[52],"assays,":[53],"in":[55,80,128,169],"vivo":[56],"validation":[57],"support":[58,184],"\u03b2-Lap":[60,72],"CPT":[62,74],"cooperatively":[63],"induce":[64],"ferroptosis":[65,147],"through":[66],"disruption":[67],"iron\u2013redox":[69,194],"homeostasis.":[70],"Mechanistically,":[71],"engage":[75],"Raptor":[76],"mTOR,":[78],"respectively,":[79],"vitro,":[81,170],"supporting":[82],"model":[84],"wherein":[85],"their":[86],"cooperative":[87,185],"action":[88],"leads":[89],"to":[90,191],"dual":[91],"suppression":[92],"mTORC1":[94,96,172,186],"signaling.":[95],"inhibition":[97,187],"activates":[98],"NCOA4-mediated":[99],"ferritinophagy,":[100,175],"promoting":[101],"ferritin":[102],"degradation":[103],"expansion":[105],"labile":[108],"Fe":[109],"2+":[110],"pool.":[111],"The":[112],"consequent":[113],"iron-dependent":[114],"Fenton":[115],"reaction":[116],"drives":[117],"excessive":[118],"reactive":[119],"oxygen":[120],"species":[121],"(ROS)":[122],"accumulation":[123],"lipid":[125,179],"peroxidation,":[126],"culminating":[127],"ferroptotic":[129],"cell":[130],"death.":[131],"Notably,":[132],"this":[133],"process":[134],"occurs":[135],"without":[136,159],"downregulation":[137],"canonical":[140],"GPX4-SLC7A11":[141],"axis,":[142],"defining":[143],"non-canonical,":[145],"iron-amplified":[146],"pathway.":[148],"In":[149],"xenograft":[150],"models,":[151],"combination":[153],"therapy":[154],"significantly":[155],"suppressed":[156],"tumor":[157],"growth":[158],"detectable":[160],"systemic":[161],"toxicity":[162],"recapitulated":[164],"molecular":[166],"hallmarks":[167],"observed":[168],"including":[171],"inhibition,":[173],"enhanced":[174],"iron":[176],"overload,":[177],"peroxidation.":[180],"Collectively,":[181],"our":[182],"findings":[183],"strategy":[190],"trigger":[192],"ferritinophagy-dependent":[193],"collapse":[195],"non-canonical":[197],"ferroptosis,":[198],"providing":[199],"mechanistically":[201],"informed":[202],"low-toxicity":[204],"therapeutic":[205],"approach":[206],"for":[207],"HCC.":[208]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-08-27T00:00:00"}
