{"id":"https://openalex.org/W7204263186","doi":"https://doi.org/10.1111/hae.70379","title":"Effects of Manual Therapy and Structured Exercises on Postural Balance and Walking Capacity in Adults With Haemophilia","display_name":"Effects of Manual Therapy and Structured Exercises on Postural Balance and Walking Capacity in Adults With Haemophilia","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204263186","doi":"https://doi.org/10.1111/hae.70379","pmid":"https://pubmed.ncbi.nlm.nih.gov/42649127"},"language":"en","primary_location":{"id":"doi:10.1111/hae.70379","doi":"https://doi.org/10.1111/hae.70379","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.70379","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70379","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7204263186"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70379","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076536751","display_name":"Ay\u015fe Merve Tat","orcid":"https://orcid.org/0000-0001-6232-1860","observed_orcids":["https://orcid.org/0000-0001-6232-1860"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Ay\u015fe Merve Tat","raw_affiliation_strings":["Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Van Yuzuncu Yil University  Van T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Van Yuzuncu Yil University  Van T\u00fcrkiye","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006970713","display_name":"Necati Muhammed Tat","orcid":"https://orcid.org/0000-0001-5858-2718","observed_orcids":["https://orcid.org/0000-0001-5858-2718"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Necati Muhammed Tat","raw_affiliation_strings":["Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Van Yuzuncu Yil University  Van T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Van Yuzuncu Yil University  Van T\u00fcrkiye","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115886917","display_name":"Pervin Ye\u015filo\u011flu","orcid":"https://orcid.org/0009-0005-1409-4719","observed_orcids":["https://orcid.org/0009-0005-1409-4719"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Pervin Ye\u015filo\u011flu K\u0131l\u0131\u00e7lar","raw_affiliation_strings":["Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Van Yuzuncu Yil University  Van T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation Van Yuzuncu Yil University  Van T\u00fcrkiye","institution_ids":["https://openalex.org/I118567650"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089641800","display_name":"Ali Do\u011fan","orcid":"https://orcid.org/0000-0003-0207-3505","observed_orcids":["https://orcid.org/0000-0003-0207-3505"]},"institutions":[{"id":"https://openalex.org/I118567650","display_name":"Van Y\u00fcz\u00fcnc\u00fc Y\u0131l \u00dcniversitesi","ror":"https://ror.org/041jyzp61","country_code":"TR","type":"education","lineage":["https://openalex.org/I118567650"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Do\u011fan","raw_affiliation_strings":["Faculty of Medicine, Division of Internal Medicine, Department of Hematology Van Yuzuncu Yil University  Van T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Division of Internal Medicine, Department of Hematology Van Yuzuncu Yil University  Van T\u00fcrkiye","institution_ids":["https://openalex.org/I118567650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076536751"],"corresponding_institution_ids":["https://openalex.org/I118567650"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10114","display_name":"Balance, Gait, and Falls Prevention","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10084","display_name":"Musculoskeletal pain and rehabilitation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3612","display_name":"Physical Therapy, Sports Therapy and Rehabilitation"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemophilic-arthropathy","display_name":"hemophilic arthropathy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/manual-therapy","display_name":"manual therapy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/structured-exercise","display_name":"structured exercise","score":0.9660000205039978},{"id":"https://openalex.org/keywords/postural-stability","display_name":"postural stability","score":0.8989999890327454},{"id":"https://openalex.org/keywords/walking-capacity","display_name":"walking capacity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/joint-health","display_name":"joint health","score":0.9620000123977661},{"id":"https://openalex.org/keywords/activity-related-pain","display_name":"activity-related pain","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dynamic-balance","display_name":"dynamic balance","score":0.7310000061988831},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"physiotherapy","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2778385053","wikidata":"https://www.wikidata.org/wiki/Q134003","display_name":"Haemophilia","level":2,"score":0.8715000152587891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8607000112533569},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.7767999768257141},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.7231000065803528},{"id":"https://openalex.org/C514863369","wikidata":"https://www.wikidata.org/wiki/Q1427967","display_name":"Manual therapy","level":3,"score":0.6898999810218811},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.6079999804496765},{"id":"https://openalex.org/C166151169","wikidata":"https://www.wikidata.org/wiki/Q16946937","display_name":"Dynamic balance","level":2,"score":0.5649999976158142},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4666000008583069},{"id":"https://openalex.org/C184753264","wikidata":"https://www.wikidata.org/wiki/Q3859741","display_name":"Joint mobilization","level":3,"score":0.3856000006198883},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.36309999227523804},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.3521000146865845},{"id":"https://openalex.org/C2779146052","wikidata":"https://www.wikidata.org/wiki/Q708176","display_name":"Arthropathy","level":4,"score":0.3375999927520752},{"id":"https://openalex.org/C2777771302","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Exercise therapy","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27869999408721924},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C79544238","wikidata":"https://www.wikidata.org/wiki/Q423243","display_name":"Activities of daily living","level":2,"score":0.26179999113082886},{"id":"https://openalex.org/C70770792","wikidata":"https://www.wikidata.org/wiki/Q7239848","display_name":"Preferred walking speed","level":2,"score":0.2554999887943268}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/hae.70379","doi":"https://doi.org/10.1111/hae.70379","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.70379","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70379","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},{"id":"pmid:42649127","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42649127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia : the official journal of the World Federation of Hemophilia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/hae.70379","doi":"https://doi.org/10.1111/hae.70379","is_oa":true,"landing_page_url":"https://doi.org/10.1111/hae.70379","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hae.70379","source":{"id":"https://openalex.org/S37667796","display_name":"Haemophilia","issn_l":"1351-8216","issn":["1351-8216","1355-0691","1365-2516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haemophilia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204263186.pdf","grobid_xml":"https://content.openalex.org/works/W7204263186.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1940426470","https://openalex.org/W1964084872","https://openalex.org/W1997439780","https://openalex.org/W2003240945","https://openalex.org/W2067855865","https://openalex.org/W2106225623","https://openalex.org/W2132309748","https://openalex.org/W2158536057","https://openalex.org/W2566302777","https://openalex.org/W2975630056","https://openalex.org/W2981003265","https://openalex.org/W3038326407","https://openalex.org/W3039129234","https://openalex.org/W3047046471","https://openalex.org/W3048933618","https://openalex.org/W3090357255","https://openalex.org/W3093551992","https://openalex.org/W3120268613","https://openalex.org/W3125993485","https://openalex.org/W3130938136","https://openalex.org/W3133585882","https://openalex.org/W3205254134","https://openalex.org/W4220692493","https://openalex.org/W4220880186","https://openalex.org/W4245666729","https://openalex.org/W4391809440","https://openalex.org/W4392658852","https://openalex.org/W4407255989","https://openalex.org/W4408972809","https://openalex.org/W4409150879","https://openalex.org/W4410831126","https://openalex.org/W4412509398","https://openalex.org/W7160519691"],"related_works":["https://openalex.org/W4409150879","https://openalex.org/W4414017245","https://openalex.org/W3205254134","https://openalex.org/W3120268613","https://openalex.org/W3093551992","https://openalex.org/W2158536057","https://openalex.org/W2981715196","https://openalex.org/W7160519691","https://openalex.org/W2067855865","https://openalex.org/W2575668047"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Haemophilic":[1],"arthropathy":[2],"(HA)":[3],"impairs":[4],"joint":[5,46,211],"health,":[6,47,212],"walking":[7,50,215],"capacity,":[8,51,216],"and":[9,25,52,54,84,114,121,135,161,195,217,231],"postural":[10,29,115],"balance":[11,30,56,116,199,219],"in":[12,57,157,173,184,188,220],"adults":[13],"with":[14,42,206],"haemophilia":[15],"(AwH).":[16],"Evidence":[17],"regarding":[18],"the":[19,36,93,100,150,152,174,185,189,225],"combined":[20,41,205,228],"effects":[21,37],"of":[22,38,123,227,235],"manual":[23,39,82,229],"therapy":[24,40,83,204,230],"structured":[26,43,207],"exercise":[27,44,86,209,232],"on":[28,45],"remains":[31],"limited.":[32],"AIM:":[33],"To":[34],"investigate":[35],"activity-related":[48,213],"pain,":[49,214],"static":[53,119,198],"dynamic":[55,218],"AwH.":[58,221],"METHODS:":[59],"This":[60],"randomized":[61],"controlled":[62],"trial":[63],"included":[64,99],"35":[65],"AwH":[66],"(control":[67],"group":[68,74],"[CG],":[69],"n":[70,76],"=":[71,77],"17;":[72],"physiotherapy":[73,236],"[PG],":[75],"18).":[78],"The":[79],"PG":[80,153,186],"received":[81,95],"supervised":[85],"twice":[87],"weekly":[88],"for":[89,191,238],"six":[90],"weeks,":[91],"whereas":[92,167,197],"CG":[94,190],"routine":[96],"care.":[97],"Outcomes":[98],"Hemophilia":[101],"Joint":[102],"Health":[103],"Score":[104],"(HJHS),":[105],"Numeric":[106],"Pain":[107],"Scale":[108],"(NPS),":[109],"6-Minute":[110],"Walking":[111],"Test":[112],"(6MWT),":[113],"assessed":[117],"using":[118],"stability":[120],"Limits":[122],"Stability":[124],"(LoS)":[125],"tests.":[126],"Analyses":[127],"were":[128,141,171],"performed":[129],"according":[130],"to":[131],"both":[132],"intention-to-treat":[133],"(ITT)":[134],"per-protocol":[136],"(PP)":[137],"principles.":[138],"RESULTS:":[139],"Groups":[140],"comparable":[142],"at":[143],"baseline":[144],"(all":[145,163],"p":[146,164],">":[147],"0.05).":[148],"Following":[149],"intervention,":[151],"showed":[154,178],"significant":[155,169],"improvements":[156,181],"HJHS,":[158,192],"NPS,":[159,193],"6MWT,":[160,194],"LoS":[162],"<":[165],"0.001),":[166],"no":[168],"changes":[170],"observed":[172],"CG.":[175],"Repeated-measures":[176],"ANOVA":[177],"significantly":[179],"greater":[180],"over":[182],"time":[183],"than":[187],"LoS,":[196],"remained":[200],"unchanged.":[201],"CONCLUSION:":[202],"Manual":[203],"progressive":[208],"improves":[210],"These":[222],"findings":[223],"support":[224],"use":[226],"as":[233],"part":[234],"management":[237],"HA.":[239]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-08-27T00:00:00"}