{"id":"https://openalex.org/W7204262602","doi":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","title":"Standardization of liquid aqueous and aqueous-alcoholic extracts from Aesculus hippocastanum L. flowers","display_name":"Standardization of liquid aqueous and aqueous-alcoholic extracts from Aesculus hippocastanum L. flowers","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204262602","doi":"https://doi.org/10.33380/2305-2066-2026-15-3-2271"},"language":"en","primary_location":{"id":"doi:10.33380/2305-2066-2026-15-3-2271","doi":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","is_oa":true,"landing_page_url":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","pdf_url":"https://www.pharmjournal.ru/jour/article/download/2445/1536","source":{"id":"https://openalex.org/S4210178334","display_name":"Drug development & registration","issn_l":"2305-2066","issn":["2305-2066","2658-5049"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development &amp; registration","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.pharmjournal.ru/jour/article/download/2445/1536","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026707066","display_name":"Alexander Denisovich Dunilin","orcid":"https://orcid.org/0000-0001-6792-6877","observed_orcids":["https://orcid.org/0000-0001-6792-6877"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. D. Dunilin","raw_affiliation_strings":["Voronezh State University (VSU)"],"raw_orcid":"https://orcid.org/0000-0001-6792-6877","affiliations":[{"raw_affiliation_string":"Voronezh State University (VSU)","institution_ids":["https://openalex.org/I71305448"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088866788","display_name":"\u041e\u043b\u044c\u0433\u0430 \u0412\u0430\u043b\u0435\u0440\u044c\u0435\u0432\u043d\u0430 \u0422\u0440\u0438\u043d\u0435\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-1421-5067","observed_orcids":["https://orcid.org/0000-0002-1421-5067"]},"institutions":[{"id":"https://openalex.org/I71305448","display_name":"Voronezh State University","ror":"https://ror.org/0543j5e78","country_code":"RU","type":"education","lineage":["https://openalex.org/I71305448"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. V. Trineeva","raw_affiliation_strings":["Voronezh State University (VSU)"],"raw_orcid":"https://orcid.org/0000-0002-1421-5067","affiliations":[{"raw_affiliation_string":"Voronezh State University (VSU)","institution_ids":["https://openalex.org/I71305448"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I71305448"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"3","first_page":"180","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.448199987411499,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.44530001282691956,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13238","display_name":"Botanical Studies and Applications","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aesculus-hippocastanum","display_name":"Aesculus hippocastanum","score":0.9950000047683716},{"id":"https://openalex.org/keywords/liquid-dosage-forms","display_name":"liquid dosage forms","score":0.7649999856948853},{"id":"https://openalex.org/keywords/aqueous-extract","display_name":"aqueous extract","score":0.7590000033378601},{"id":"https://openalex.org/keywords/aqueous-alcoholic-extract","display_name":"aqueous-alcoholic extracts","score":0.968999981880188},{"id":"https://openalex.org/keywords/tinctures","display_name":"tinctures","score":0.8460000157356262},{"id":"https://openalex.org/keywords/infusion","display_name":"infusion","score":0.972000002861023},{"id":"https://openalex.org/keywords/liquid-extract","display_name":"fluid extract","score":0.6520000100135803},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.6190000176429749},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8759999871253967},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9700000286102295},{"id":"https://openalex.org/keywords/total-antioxidant-capacity","display_name":"total antioxidant capacity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/heavy-metals","display_name":"heavy metals","score":0.6399999856948853},{"id":"https://openalex.org/keywords/dry-residue","display_name":"dry residue","score":0.4309999942779541},{"id":"https://openalex.org/keywords/ethanol-concentration","display_name":"ethanol concentration","score":0.5419999957084656},{"id":"https://openalex.org/keywords/standardization","display_name":"standardization","score":0.4790000021457672},{"id":"https://openalex.org/keywords/medicinal-plant-raw-materials","display_name":"medicinal plant raw materials","score":0.7979999780654907},{"id":"https://openalex.org/keywords/voronezh","display_name":"Voronezh","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2779659934","wikidata":"https://www.wikidata.org/wiki/Q26899","display_name":"Aesculus hippocastanum","level":2,"score":0.9722999930381775},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5677000284194946},{"id":"https://openalex.org/C2993907526","wikidata":"https://www.wikidata.org/wiki/Q1259977","display_name":"Aqueous extract","level":2,"score":0.46650001406669617},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.4584999978542328},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45570001006126404},{"id":"https://openalex.org/C2777594072","wikidata":"https://www.wikidata.org/wiki/Q117247","display_name":"Pharmacopoeia","level":3,"score":0.3758000135421753},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.37439998984336853},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.34769999980926514},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.2971000075340271},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.26969999074935913},{"id":"https://openalex.org/C144027150","wikidata":"https://www.wikidata.org/wiki/Q48803","display_name":"Horticulture","level":1,"score":0.2558000087738037},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.25369998812675476}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.33380/2305-2066-2026-15-3-2271","doi":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","is_oa":true,"landing_page_url":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","pdf_url":"https://www.pharmjournal.ru/jour/article/download/2445/1536","source":{"id":"https://openalex.org/S4210178334","display_name":"Drug development & registration","issn_l":"2305-2066","issn":["2305-2066","2658-5049"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development &amp; registration","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.33380/2305-2066-2026-15-3-2271","doi":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","is_oa":true,"landing_page_url":"https://doi.org/10.33380/2305-2066-2026-15-3-2271","pdf_url":"https://www.pharmjournal.ru/jour/article/download/2445/1536","source":{"id":"https://openalex.org/S4210178334","display_name":"Drug development & registration","issn_l":"2305-2066","issn":["2305-2066","2658-5049"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug development &amp; registration","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204262602.pdf","grobid_xml":"https://content.openalex.org/works/W7204262602.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W2069886199","https://openalex.org/W2069978879","https://openalex.org/W2077581164","https://openalex.org/W2802621137","https://openalex.org/W3004273376","https://openalex.org/W3040860256","https://openalex.org/W4200143140","https://openalex.org/W4308440311","https://openalex.org/W4321599945","https://openalex.org/W4387185140","https://openalex.org/W4400823650","https://openalex.org/W4408971352","https://openalex.org/W4414362555","https://openalex.org/W6888987877","https://openalex.org/W7081648248","https://openalex.org/W7125929932"],"related_works":["https://openalex.org/W7084117591","https://openalex.org/W7204757865","https://openalex.org/W7221208736","https://openalex.org/W2474520028","https://openalex.org/W4394838361","https://openalex.org/W2412213969","https://openalex.org/W1483337282","https://openalex.org/W4380729351","https://openalex.org/W2940871192","https://openalex.org/W7000892066"],"abstract_inverted_index":{"Introduction.":[0],"Phytotherapy":[1],"represents":[2],"an":[3,364],"integrative":[4],"method":[5],"for":[6,40,142,180,233,293,347],"disease":[7],"prevention":[8],"and":[9,58,94,105,115,127,134,153,160,194,197,220,229,236,256,265,269,285,305,328,350,368],"treatment":[10],"using":[11],"complexes":[12],"of":[13,18,30,132,146,158,176,208,296,325,370],"biologically":[14],"active":[15],"substances":[16],"(BAS)":[17],"plant":[19,31,70],"origin.":[20],"Aesculus":[21,63,138,164,279,340],"hippocastanum":[22,64,139,165,280,341],"L.":[23,65,140,166,281,342],"is":[24,361],"recognized":[25],"as":[26,67,102,309,332,363],"a":[27,119],"valuable":[28],"source":[29],"material:":[32],"its":[33],"seeds":[34],"are":[35,46],"used":[36],"in":[37,48,91,122,168],"evidence-based":[38],"medicine":[39],"venous":[41],"insufficiency":[42],"treatment,":[43],"while":[44],"flowers":[45,66,110,141,282,343],"utilized":[47],"traditional":[49],"practice":[50,93],"due":[51],"to":[52,204,244,288,355],"their":[53,89],"pronounced":[54],"venotonic,":[55,113],"anti-inflammatory,":[56],"antioxidant,":[57],"hypolipidemic":[59],"properties.":[60],"This":[61],"establishes":[62],"promising":[68,345],"medicinal":[69],"raw":[71,245],"material":[72,246],"(MPRM)":[73],"with":[74,111,240,376],"substantial":[75],"therapeutic":[76],"potential.":[77],"Liquid":[78],"dosage":[79,150,366,373],"forms":[80],"(LDF)":[81],"based":[82,277],"on":[83,278],"MPRM":[84,346],"possess":[85],"multiple":[86],"advantages":[87],"ensuring":[88],"demand":[90],"pharmaceutical":[92],"among":[95,336],"consumers.":[96],"Accordingly,":[97],"developing":[98,348],"new":[99],"domestic":[100,352],"phytopreparations":[101],"infusions,":[103],"tinctures,":[104,274],"liquid":[106,149,198,275,316,359],"extracts":[107,136,162],"from":[108,137,163],"these":[109],"potential":[112],"capillary-protective,":[114],"antioxidant":[116,303],"effects":[117],"constitutes":[118],"relevant":[120,261],"direction":[121],"pharmacy.":[123],"Aim.":[124],"To":[125],"obtain":[126],"standardize":[128],"experimental":[129],"laboratory":[130,226],"samples":[131,272],"aqueous":[133,159,268],"aqueous-alcoholic":[135,161],"the":[143,147,169,173,205,209,223,322,333],"subsequent":[144],"substantiation":[145],"optimal":[148,334],"form.":[151],"Materials":[152],"methods.":[154],"A":[155],"comparative":[156],"study":[157],"harvested":[167],"Voronezh":[170],"Region":[171],"during":[172],"flowering":[174],"period":[175],"2024":[177],"was":[178],"conducted":[179],"infusions":[181],"(1":[182,186,200,318],":":[183,187,201,319],"10),":[184],"tinctures":[185],"5)":[188],"prepared":[189],"by":[190,250],"maceration,":[191,193],"fractional":[192],"percolation":[195],"methods,":[196],"extract":[199,317,360],"1)":[202,320],"according":[203,287],"State":[206],"Pharmacopoeia":[207],"Russian":[210],"Federation,":[211],"XV":[212],"edition":[213],"(GPM.1.4.1.0019":[214],"\u00abTinctures\u00bb,":[215],"GPM.1.4.1.0021":[216],"\u00abExtracts\u00bb,":[217],"GPM.1.4.1.0018":[218],"\u00abInfusions":[219],"decoctions\u00bb).":[221],"For":[222],"obtained":[224,284],"LDF":[225,271],"samples,":[227],"identification":[228],"quantitative":[230,294],"determination":[231,295],"methods":[232],"flavonoids,":[234,301,327],"saponins,":[235,302,329],"antioxidants":[237,307],"were":[238,283,313],"developed":[239],"yield":[241],"assessment":[242],"relative":[243],"content,":[247],"alongside":[248],"standardization":[249],"\u00abDescription\u00bb,":[251],"\u00abDry":[252],"residue\u00bb,":[253],"\u00abEthyl":[254],"alcohol\u00bb,":[255],"\u00abHeavy":[257],"metals\u00bb":[258],"parameters":[259],"per":[260],"GPM":[262],"requirements.":[263,291],"Results":[264],"discussion.":[266],"Experimental":[267],"hydroalcoholic":[270],"(infusion,":[273],"extract)":[276],"standardized":[286],"regulatory":[289],"documentation":[290],"Methods":[292],"target":[297],"BAS":[298,357],"groups":[299],"\u2013":[300,312],"activity,":[304],"total":[306],"expressed":[308],"ascorbic":[310],"acid":[311],"developed.":[314],"The":[315],"showed":[321],"highest":[323],"content":[324],"antioxidants,":[326],"recommending":[330],"it":[331],"form":[335,367],"those":[337],"studied.":[338],"Conclusion.":[339],"represent":[344],"effective":[349],"safe":[351],"phytopreparations.":[353],"Due":[354],"high":[356],"concentration,":[358],"recommended":[362],"oral":[365],"component":[369],"topical":[371],"semisolid":[372],"forms,":[374],"aligning":[375],"current":[377],"phlebotonic":[378],"drug":[379],"market":[380],"trends.":[381]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-08-27T00:00:00"}
