{"id":"https://openalex.org/W7204259131","doi":"https://doi.org/10.1016/j.waojou.2026.101446","title":"Analyzing the clinical profile and potential biomarkers to differentiate idiopathic angioedema from hereditary or mast cell-mediated angioedema","display_name":"Analyzing the clinical profile and potential biomarkers to differentiate idiopathic angioedema from hereditary or mast cell-mediated angioedema","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204259131","doi":"https://doi.org/10.1016/j.waojou.2026.101446","pmid":"https://pubmed.ncbi.nlm.nih.gov/42699750"},"language":"en","primary_location":{"id":"doi:10.1016/j.waojou.2026.101446","doi":"https://doi.org/10.1016/j.waojou.2026.101446","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.waojou.2026.101446","pdf_url":"https://www.worldallergyorganizationjournal.org/article/S1939-4551(26)00279-6/pdf","source":{"id":"https://openalex.org/S49523212","display_name":"World Allergy Organization Journal","issn_l":"1939-4551","issn":["1939-4551"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Allergy Organization Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.worldallergyorganizationjournal.org/article/S1939-4551(26)00279-6/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134547110","display_name":"Juan Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121848891","display_name":"Xiangyi Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangyi Cui","raw_affiliation_strings":["Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5138360388","display_name":"Nan Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zhou","raw_affiliation_strings":["Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073315295","display_name":"Yuxiang Zhi","orcid":"https://orcid.org/0000-0001-7539-6650","observed_orcids":["https://orcid.org/0000-0001-7539-6650"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuxiang Zhi","raw_affiliation_strings":["Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-7539-6650","affiliations":[{"raw_affiliation_string":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5073315295"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"],"apc_list":{"value":2840,"currency":"EUR","value_usd":3508},"apc_paid":{"value":2840,"currency":"EUR","value_usd":3508},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66557853,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"9","first_page":"101446","last_page":"101446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-angioedema","display_name":"idiopathic angioedema","score":0.996999979019165},{"id":"https://openalex.org/keywords/hereditary-angioedema","display_name":"hereditary angioedema","score":0.9869999885559082},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.8399999737739563},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.6520000100135803},{"id":"https://openalex.org/keywords/tie2","display_name":"Tie2","score":0.7250000238418579},{"id":"https://openalex.org/keywords/igg4","display_name":"IgG4","score":0.7250000238418579},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.8159999847412109},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.7110000252723694},{"id":"https://openalex.org/keywords/inflammatory-markers","display_name":"inflammatory markers","score":0.6209999918937683},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.4519999921321869},{"id":"https://openalex.org/keywords/facial-swelling","display_name":"facial swelling","score":0.7260000109672546},{"id":"https://openalex.org/keywords/omalizumab","display_name":"omalizumab","score":0.671999990940094},{"id":"https://openalex.org/keywords/mast-cell-stabilizers","display_name":"mast cell stabilizers","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.972599983215332},{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.8621000051498413},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.6969000101089478},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.555400013923645},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3741999864578247},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C2779655021","wikidata":"https://www.wikidata.org/wiki/Q1907811","display_name":"Mast (botany)","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2572999894618988},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.22669999301433563},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.21089999377727509}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.waojou.2026.101446","doi":"https://doi.org/10.1016/j.waojou.2026.101446","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.waojou.2026.101446","pdf_url":"https://www.worldallergyorganizationjournal.org/article/S1939-4551(26)00279-6/pdf","source":{"id":"https://openalex.org/S49523212","display_name":"World Allergy Organization Journal","issn_l":"1939-4551","issn":["1939-4551"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Allergy Organization Journal","raw_type":"journal-article"},{"id":"pmid:42699750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42699750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The World Allergy Organization journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13544275","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42699750/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13544275/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"World Allergy Organ J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.waojou.2026.101446","doi":"https://doi.org/10.1016/j.waojou.2026.101446","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.waojou.2026.101446","pdf_url":"https://www.worldallergyorganizationjournal.org/article/S1939-4551(26)00279-6/pdf","source":{"id":"https://openalex.org/S49523212","display_name":"World Allergy Organization Journal","issn_l":"1939-4551","issn":["1939-4551"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Allergy Organization Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5256659081","display_name":null,"funder_award_id":"3332024108","funder_id":"https://openalex.org/F4320326853","funder_display_name":"Peking Union Medical College"},{"id":"https://openalex.org/G7637505305","display_name":null,"funder_award_id":"3332024108","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G8277056759","display_name":null,"funder_award_id":"B063220","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324962","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35"},{"id":"https://openalex.org/F4320326853","display_name":"Peking Union Medical College","ror":"https://ror.org/02drdmm93"},{"id":"https://openalex.org/F4320328119","display_name":"National University's Basic Research Foundation of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7204259131.pdf","grobid_xml":"https://content.openalex.org/works/W7204259131.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W2094097558","https://openalex.org/W2103410171","https://openalex.org/W2124243546","https://openalex.org/W2133859216","https://openalex.org/W2162647242","https://openalex.org/W2552192905","https://openalex.org/W2884650192","https://openalex.org/W2912941855","https://openalex.org/W2964621187","https://openalex.org/W2994680393","https://openalex.org/W3017304234","https://openalex.org/W3042459231","https://openalex.org/W3127297674","https://openalex.org/W3127674858","https://openalex.org/W3129093809","https://openalex.org/W3158631877","https://openalex.org/W3186781013","https://openalex.org/W3210182329","https://openalex.org/W4220861723","https://openalex.org/W4246423891","https://openalex.org/W4292674913","https://openalex.org/W4317830473","https://openalex.org/W4382939884","https://openalex.org/W4385716807","https://openalex.org/W4391957193","https://openalex.org/W4395461131","https://openalex.org/W4396706560","https://openalex.org/W4399295519","https://openalex.org/W4400000332","https://openalex.org/W4401344433","https://openalex.org/W4402901268","https://openalex.org/W4402966886","https://openalex.org/W4406893888","https://openalex.org/W4407766827","https://openalex.org/W4408240162"],"related_works":[],"abstract_inverted_index":{"Purpose:":[0],"Idiopathic":[1],"angioedema":[2,74,81,91,222,334],"(AE-UN)":[3],"is":[4],"a":[5,12,43,65,102,129,188,213,238,320,324],"heterogeneous,":[6],"exclusion-based":[7,343],"clinical":[8,17,37,104],"category":[9],"rather":[10,231,318],"than":[11,195,232,319],"single":[13],"disease":[14,171],"entity.":[15],"The":[16],"characteristics":[18],"and":[19,39,83,98,101,131,148,160,176,218,236,249,276,289,299,329,347],"potential":[20],"exploratory":[21,310],"markers":[22,155],"in":[23,42,206,229,254,267,271,313],"patients":[24,47,59,71,77],"currently":[25],"classified":[26,60,142],"as":[27,61,143,163,358],"AE-UN":[28,62,168,207,230,272,316],"remain":[29],"poorly":[30],"understood.":[31],"This":[32],"study":[33],"aimed":[34],"to":[35,64,106,113,174,258,274,297],"evaluate":[36],"features":[38],"laboratory":[40,149],"mediators":[41],"selected":[44,315],"cohort":[45],"of":[46,53,156,192,337,345,350],"fulfilling":[48],"the":[49,262,291,338,342,348],"current":[50],"diagnostic":[51,67,321,351],"definition":[52],"AE-UN.":[54,144],"Methods:":[55],"We":[56,209],"compared":[57,173,257,273,296],"16":[58],"according":[63],"stepwise":[66],"approach":[68],"with":[69,72,78,92,241],"20":[70,76],"hereditary":[73],"(HAE),":[75],"mast":[79,107],"cell-mediated":[80],"(AE-MC),":[82],"24":[84],"healthy":[85],"controls.":[86,259],"AE-MC":[87,175,196,275],"classification":[88],"required":[89],"recurrent":[90],"or":[93,121,137],"without":[94,127,132],"wheals,":[95],"normal":[96],"C4":[97],"C1-inhibitor":[99],"levels,":[100],"convincing":[103],"response":[105,130],"cell-directed":[108],"therapy,":[109],"including":[110,153],"H1-antihistamines":[111],"up":[112],"four-fold":[114],"standard":[115],"dose":[116],"when":[117],"clinically":[118],"indicated,":[119],"corticosteroids,":[120],"standard-dose":[122],"omalizumab":[123],"(4-6":[124],"months).":[125],"Patients":[126],"such":[128],"confirmed":[133],"HAE,":[134,277],"drug-induced":[135],"angioedema,":[136],"other":[138,233],"recognized":[139],"causes":[140],"were":[141,151,227,251,331],"Baseline":[145],"features,":[146],"treatments,":[147],"factors":[150],"analyzed,":[152],"serum":[154],"inflammation,":[157],"endothelial":[158],"dysfunction,":[159],"serine":[161],"proteases,":[162],"determined":[164],"by":[165],"ELISA.":[166],"Results:":[167],"showed":[169],"shorter":[170],"duration":[172],"HAE":[177,242],"(2.26":[178],"vs.":[179,181,198],"3.02":[180],"15.78,":[182],"p":[183],"<":[184],"0.0001),":[185],"but":[186],"experienced":[187],"relatively":[189],"higher":[190],"frequency":[191],"life-threatening":[193],"attacks":[194],"(25%":[197],"10%).":[199],"Meanwhile,":[200],"facial":[201],"edema":[202],"was":[203,265,283,293],"most":[204],"common":[205],"(68.75%).":[208],"did":[210],"not":[211,294],"find":[212],"significant":[214,295],"difference":[215,240,292],"regarding":[216],"age":[217],"sex":[219],"among":[220,300],"all":[221,255],"(AE)":[223],"subtypes.":[224,302],"IgG4":[225],"levels":[226,306],"increased":[228,332],"AE":[234,256,268,301],"groups,":[235],"demonstrated":[237],"statistical":[239],"(p":[243],"=":[244],"0.049).":[245],"Besides,":[246],"Ang-1,":[247,327],"Ang-2,":[248,328],"Tie-2":[250,330],"significantly":[252,284],"elevated":[253],"By":[260],"contrast,":[261],"Ang-2/Ang-1":[263],"ratio":[264],"decreased":[266],"patients.":[269],"Notably,":[270],"Fibroblast":[278],"Activation":[279],"Protein":[280],"(FAP)":[281],"concentration":[282],"reduced,":[285],"whereas":[286],"for":[287,323],"tPA":[288],"PLA2G7,":[290],"controls":[298],"Conclusions:":[303],"Lower":[304],"FAP":[305],"may":[307],"represent":[308],"an":[309],"biomarker":[311],"candidate":[312],"this":[314],"cohort,":[317],"marker":[322],"homogeneous":[325],"disease.":[326],"across":[333],"groups.":[335],"Because":[336],"small":[339],"sample":[340],"size,":[341],"nature":[344],"AE-UN,":[346],"possibility":[349],"reclassification,":[352],"these":[353],"findings":[354],"should":[355],"be":[356],"interpreted":[357],"hypothesis-generating.":[359]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-08-27T00:00:00"}
