{"id":"https://openalex.org/W7204259130","doi":"https://doi.org/10.5281/zenodo.22113928","title":"Caffeine and Cardiovascular Responses in Children and Adolescents: Quantitative Analysis and Comparison With Adult Evidence","display_name":"Caffeine and Cardiovascular Responses in Children and Adolescents: Quantitative Analysis and Comparison With Adult Evidence","publication_year":2026,"publication_date":"2026-08-26","ids":{"openalex":"https://openalex.org/W7204259130","doi":"https://doi.org/10.5281/zenodo.22113928"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.22113928","doi":"https://doi.org/10.5281/zenodo.22113928","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22113928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"volume":null,"type":"dataset","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.22113928","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144241165","display_name":"Abiya Ahad","orcid":"https://orcid.org/0009-0008-5767-0722","observed_orcids":["https://orcid.org/0009-0008-5767-0722"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ahad, Abiya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-5767-0722","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5144241165"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11264","display_name":"Coffee research and impacts","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cardiovascular-response","display_name":"cardiovascular response","score":0.8360000252723694},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.7559999823570251},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":1.0},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7649999856948853},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure","display_name":"ambulatory blood pressure","score":0.9660000205039978},{"id":"https://openalex.org/keywords/arterial-stiffness","display_name":"arterial stiffness","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ventricular-arterial-coupling","display_name":"ventricular-arterial coupling","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cardiac-efficiency","display_name":"cardiac efficiency","score":0.7429999709129333},{"id":"https://openalex.org/keywords/ventricular-contractility","display_name":"ventricular contractility","score":0.9750000238418579},{"id":"https://openalex.org/keywords/pressure-volume-loops","display_name":"pressure-volume loops","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.7940000295639038},{"id":"https://openalex.org/keywords/weight-based-dosing","display_name":"weight-based dosing","score":0.6740000247955322},{"id":"https://openalex.org/keywords/caffeine-dose-response","display_name":"caffeine dose-response","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7404999732971191},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5906000137329102},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.5307000279426575},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.47530001401901245},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.45500001311302185},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.4196999967098236},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.412200003862381},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.3912000060081482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3555000126361847},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3346000015735626},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.31029999256134033},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C986699","wikidata":"https://www.wikidata.org/wiki/Q7939","display_name":"El Ni\u00f1o","level":2,"score":0.27559998631477356},{"id":"https://openalex.org/C183683566","wikidata":"https://www.wikidata.org/wiki/Q5038741","display_name":"Cardiovascular physiology","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C26170363","wikidata":"https://www.wikidata.org/wiki/Q1981408","display_name":"Haemodynamic response","level":4,"score":0.2574999928474426},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.2513999938964844}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.22113928","doi":"https://doi.org/10.5281/zenodo.22113928","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22113928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},{"id":"doi:10.5281/zenodo.22113929","doi":"https://doi.org/10.5281/zenodo.22113929","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22113929","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.5281/zenodo.22113928","doi":"https://doi.org/10.5281/zenodo.22113928","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.22113928","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002558574","https://openalex.org/W2802948815","https://openalex.org/W2523859727","https://openalex.org/W2025727026","https://openalex.org/W2409660956","https://openalex.org/W2149177605","https://openalex.org/W2019156972","https://openalex.org/W1966905192","https://openalex.org/W2035921087","https://openalex.org/W4401872271"],"abstract_inverted_index":{"This":[0,192],"repository":[1,121,217],"contains":[2],"the":[3,64,98,126,146,163,184,199,203,228,232,293,296],"statistical":[4,229,240,265],"analysis":[5,32,65,147,173,254,258],"and":[6,21,37,56,136,139,181,224,261,267,271,302,309],"supporting":[7,268],"code":[8,238],"for":[9,239,305],"a":[10,24,67,84,194],"quantitative":[11,195],"investigation":[12],"of":[13,63,86,129,165,197,227,295],"cardiovascular":[14,36,58,106,143,210,244],"responses":[15,107,211],"to":[16,162,212,220],"caffeine":[17,41,77,213],"exposure":[18],"in":[19,35,108,115,183,292],"children":[20,109,180,206],"adolescents,":[22],"with":[23],"formal":[25,68],"comparison":[26,72,103],"against":[27],"pooled":[28],"adult":[29,71,172,250],"evidence.":[30],"The":[31,102,120,169,216,273],"examines":[33],"changes":[34],"haemodynamic":[38],"parameters":[39],"following":[40],"exposure,":[42],"including":[43],"blood":[44,47,158],"pressure,":[45,48],"ambulatory":[46],"arterial":[49,137],"stiffness,":[50],"cardiac":[51],"efficiency,":[52],"ventricular\u2013arterial":[53],"coupling,":[54],"contractility,":[55],"related":[57],"measures.":[59,168],"A":[60],"key":[61],"component":[62],"is":[66,218],"paediatric":[69,93,100,170,243,248],"versus":[70,171,249],"at":[73,117,188],"approximately":[74],"matched":[75,189],"weight-adjusted":[76,190],"doses.":[78,119,191],"Adult":[79],"estimates":[80,94,266],"were":[81,95],"derived":[82,132],"from":[83,112,153],"synthesis":[85],"19":[87],"trials":[88],"involving":[89],"385":[90],"participants,":[91],"while":[92],"based":[96,276],"on":[97,277],"available":[99,200,297],"data.":[101,280],"evaluates":[104],"whether":[105,198],"differ":[110],"significantly":[111],"those":[113],"observed":[114],"adults":[116,182],"comparable":[118],"also":[122],"includes":[123],"analyses":[124,230,241,246,274],"examining":[125],"internal":[127,150],"consistency":[128,152,262],"pressure-volume":[130,166],"loop":[131,167],"measures,":[133],"ventricular":[134],"contractility":[135],"load,":[138],"directional":[140],"concordance":[141,257],"across":[142],"domains.":[144],"Importantly,":[145],"explicitly":[148],"distinguishes":[149],"arithmetic":[151],"independent":[154,225],"cross-modality":[155],"validation":[156,260],"because":[157],"pressure":[159],"measurements":[160],"contribute":[161],"construction":[164],"found":[174],"no":[175],"statistically":[176],"significant":[177],"difference":[178],"between":[179],"evaluated":[185],"time":[186],"bands":[187],"provides":[193],"assessment":[196],"evidence":[201],"supports":[202],"hypothesis":[204],"that":[205],"experience":[207],"substantially":[208],"greater":[209],"than":[214],"adults.":[215],"intended":[219],"promote":[221],"transparency,":[222],"reproducibility,":[223],"evaluation":[226],"underlying":[231],"associated":[233],"research":[234],"manuscript.":[235],"Contents":[236],"R":[237],"Quantitative":[242],"response":[245],"Formal":[247],"comparisons":[251],"Bayesian":[252],"sensitivity":[253],"Cardiovascular":[255],"domain":[256],"Internal":[259],"checks":[263],"Derived":[264],"calculations":[269],"Data":[270],"interpretation":[272],"are":[275,285],"published":[278,298],"aggregate-level":[279],"No":[281],"individual":[282],"participant-level":[283],"data":[284],"included.":[286],"Interpretations":[287],"should":[288],"therefore":[289],"be":[290],"considered":[291],"context":[294],"evidence,":[299],"sample":[300],"sizes,":[301],"assumptions":[303],"required":[304],"deriving":[306],"standard":[307],"errors":[308],"comparative":[310],"estimates.":[311]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-08-27T00:00:00"}